L-xylitol metabolic process
Definition
Target type: biologicalprocess
The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets. [GOC:ai]
The L-xylitol metabolic process is a crucial pathway in the metabolism of the sugar alcohol L-xylitol. This process involves a series of enzymatic reactions that convert L-xylitol into other essential metabolites, ultimately contributing to energy production and the biosynthesis of various cellular components.
L-xylitol is commonly found in fruits, vegetables, and mushrooms, and it can also be produced industrially through the fermentation of xylose, a sugar derived from plant biomass. The metabolism of L-xylitol begins with its phosphorylation by the enzyme L-xylitol kinase, which adds a phosphate group to the molecule, creating L-xylitol 5-phosphate. This phosphorylation step is essential for the subsequent metabolic reactions.
L-xylitol 5-phosphate is then converted to D-xylulose 5-phosphate by the enzyme L-xylulose reductase. This reaction involves the reduction of the carbonyl group of L-xylitol 5-phosphate to a hydroxyl group, resulting in the formation of D-xylulose 5-phosphate. D-xylulose 5-phosphate is an important intermediate in the pentose phosphate pathway, a metabolic pathway that generates reducing power in the form of NADPH and produces precursors for nucleotide biosynthesis.
The fate of D-xylulose 5-phosphate depends on the specific metabolic needs of the organism. It can either be further metabolized through the pentose phosphate pathway or enter glycolysis, the central pathway for glucose metabolism, ultimately leading to the production of ATP, the primary energy currency of cells.
In summary, the L-xylitol metabolic process plays a significant role in the utilization of L-xylitol as a source of energy and building blocks for cellular components. It involves a series of enzymatic reactions that convert L-xylitol into essential metabolites, contributing to the overall metabolic balance of the organism.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Sorbitol dehydrogenase | A sorbitol dehydrogenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00796] | Homo sapiens (human) |
Compounds (14)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| coumarin | 2H-chromen-2-one: coumarin derivative | coumarins | fluorescent dye; human metabolite; plant metabolite |
| herniarin | herniarin : A member of the class of coumarins that is coumarin substituted by a methoxy group at position 7. herniarin: methoxy analog of umbelliferone; structure | coumarins | fluorochrome |
| 3-hydroxy-1-benzopyran-2-one | 3-hydroxycoumarin: Photoprotective from sea urchin gametes and embryonic cells; structure in first source hydroxycoumarin : Any coumarin carrying at least one hydroxy substituent. | hydroxycoumarin | |
| isoscopoletin | isoscopoletin : A hydroxycoumarin that is esculetin in which the hydroxy group at position 7 is replaced by a methoxy group. It is the major primary metabolite of scoparone. | aromatic ether; hydroxycoumarin | plant metabolite |
| cp-166,572 | |||
| epalrestat | epalrestat : A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy. | monocarboxylic acid; thiazolidines | EC 1.1.1.21 (aldehyde reductase) inhibitor |
| quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
| scopoletin | hydroxycoumarin | plant growth regulator; plant metabolite | |
| hymecromone | Hymecromone: A coumarin derivative possessing properties as a spasmolytic, choleretic and light-protective agent. It is also used in ANALYTICAL CHEMISTRY TECHNIQUES for the determination of NITRIC ACID. | hydroxycoumarin | antineoplastic agent; hyaluronic acid synthesis inhibitor |
| esculetin | esculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. esculetin: used in filters for absorption of ultraviolet light; structure | hydroxycoumarin | antioxidant; plant metabolite; ultraviolet filter |
| 7-hydroxycoumarin | 7-oxycoumarin: derivatives have anti-oxidant properties umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7. | hydroxycoumarin | fluorescent probe; food component; plant metabolite |
| 4-methylesculetin | 4-methylesculetin: has antiinflammatory activity 6,7-dihydroxy-4-methylcoumarin : A hydroxycoumarin that is 4-methylcuomarin which is substituted by hydroxy groups at positions 3 and 4. A hyaluronan synthesis inhibitor. It has also been used as a fluorescent sensor to monitor the consumption of a boronic acid in Suzuki coupling reactions; fluorescence is readily detectable by the naked eye using a standard 365 nm UV lamp. | hydroxycoumarin | anti-inflammatory agent; antioxidant; hyaluronan synthesis inhibitor |
| 7-hydroxycoumarin-4-acetic acid | 7-hydroxycoumarin-4-acetic acid: pH-indicator dye; structure in first source | ||
| 4-hydroxycoumarin | 2-hydroxychromone: structure | hydroxycoumarin |