Page last updated: 2024-10-24

store-operated calcium channel activity

Definition

Target type: molecularfunction

A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]

Store-operated calcium channels (SOCs) are a type of calcium channel that are activated by the depletion of calcium from intracellular stores. This depletion triggers the opening of the channel, allowing calcium ions to flow into the cell from the extracellular space. SOCs play a critical role in a wide range of cellular processes, including:

1. **Cell signaling:** Calcium is a ubiquitous second messenger that regulates many cellular functions, including gene expression, enzyme activity, and cell growth. SOCs are key players in calcium signaling pathways, as they provide a direct link between the depletion of intracellular calcium stores and the influx of extracellular calcium.

2. **Muscle contraction:** In muscle cells, calcium influx through SOCs is essential for muscle contraction. Depletion of calcium from the sarcoplasmic reticulum (SR), the intracellular calcium store in muscle cells, triggers the opening of SOCs, leading to calcium influx and subsequent muscle contraction.

3. **Exocytosis:** The process of exocytosis, in which cellular vesicles fuse with the plasma membrane and release their contents into the extracellular space, is also regulated by calcium. SOCs contribute to calcium-dependent exocytosis by providing the calcium influx necessary for vesicle fusion.

4. **Immune cell activation:** In immune cells, SOCs play a key role in the activation of immune responses. Calcium influx through SOCs activates signaling pathways that lead to the production of inflammatory cytokines and the activation of immune cells.

5. **Cell growth and differentiation:** SOCs are also involved in cell growth and differentiation. Calcium influx through SOCs can activate signaling pathways that promote cell proliferation and differentiation.

The molecular mechanism of SOC activation involves a complex interplay between several proteins, including stromal interaction molecule 1 (STIM1), Orai1, and TRPC1.

1. **STIM1:** STIM1 is a calcium sensor protein that resides in the ER membrane. When calcium levels in the ER decrease, STIM1 undergoes conformational changes that cause it to cluster at ER-plasma membrane junctions.

2. **Orai1:** Orai1 is a transmembrane protein that forms the pore of the SOC. STIM1 clusters bind to and activate Orai1, leading to the opening of the calcium channel.

3. **TRPC1:** TRPC1 is another calcium channel that can be activated by STIM1. However, the exact mechanism of TRPC1 activation and its role in SOCs are still being investigated.

In summary, SOCs are essential calcium channels that are activated by the depletion of intracellular calcium stores. They play a crucial role in a wide range of cellular processes, including cell signaling, muscle contraction, exocytosis, immune cell activation, and cell growth and differentiation. The molecular mechanism of SOC activation involves a complex interplay between several proteins, including STIM1, Orai1, and TRPC1.'
"

Proteins (9)

ProteinDefinitionTaxonomy
Short transient receptor potential channel 7A short transient receptor potential cation channel TRPC7 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9HCX4]Homo sapiens (human)
Short transient receptor potential channel 3A short transient receptor potential cation channel TRPC3 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q13507]Homo sapiens (human)
Short transient receptor potential channel 6A short transient receptor potential channel 6 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y210]Homo sapiens (human)
Short transient receptor potential channel 5A short transient receptor potential channel 5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UL62]Homo sapiens (human)
Short transient receptor potential channel 1A short transient receptor potential channel 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48995]Homo sapiens (human)
Stromal interaction molecule 2A stromal interaction molecule 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9P246]Homo sapiens (human)
Protein orai-3A protein orai-3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BRQ5]Homo sapiens (human)
Protein orai-2A protein orai-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96SN7]Homo sapiens (human)
Calcium release-activated calcium channel protein 1A calcium release-activated calcium channel protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q96D31]Homo sapiens (human)

Compounds (22)

CompoundDefinitionClassesRoles
ym 58483
clemizoleclemizole : A member of the class of benzimidazoles that is 1H-benzimidazole substituted by a pyrrolidin-1-ylmethyl and a 4-chlorobenzyl groups at positions 2 and 1 respectively.

clemizole: was heading 1966-94 (see under BENZIMIDAZOLES 1966-90); use BENZIMIDAZOLES to search CLEMIZOLE 1966-94; a histamine H1- blocker used to treat allergies
benzimidazoles;
monochlorobenzenes;
pyrrolidines
histamine antagonist
diphenhydramineantitussive : An agent that suppresses cough. Antitussives have a central or a peripheral action on the cough reflex, or a combination of both. Compare with expectorants, which are considered to increase the volume of secretions in the respiratory tract, so facilitating their removal by ciliary action and coughing, and mucolytics, which decrease the viscosity of mucus, facilitating its removal by ciliary action and expectoration.

diphenhydramine : An ether that is the benzhydryl ether of 2-(dimethylamino)ethanol. It is a H1-receptor antagonist used as a antipruritic and antitussive drug.

Diphenhydramine: A histamine H1 antagonist used as an antiemetic, antitussive, for dermatoses and pruritus, for hypersensitivity reactions, as a hypnotic, an antiparkinson, and as an ingredient in common cold preparations. It has some undesired antimuscarinic and sedative effects.
ether;
tertiary amino compound
anti-allergic agent;
antidyskinesia agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
antitussive;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
oneirogen;
sedative
econazole1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 4-chlorobenzyl group.

econazole : A racemate composed of equimolar amounts of (R)- and (S)-econazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections.

Econazole: An imidazole derivative that is commonly used as a topical antifungal agent.
dichlorobenzene;
ether;
imidazoles;
monochlorobenzenes
miconazole1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.

miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.

Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
dichlorobenzene;
ether;
imidazoles
benzohydroldiphenylmethanol : A secondary alcohol that is diphenylmethane which carries a hydroxy group at position 1.benzyl alcohols;
secondary alcohol
bacterial xenobiotic metabolite;
human urinary metabolite;
human xenobiotic metabolite;
rat metabolite
diphenylborinic aciddiphenylborinic acid: structure given in first source
mibefradilMibefradil: A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.tetralinsT-type calcium channel blocker
methaneboronic acid
N-butyl-1H-benzimidazol-2-aminebenzimidazoles
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigeninChamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.trihydroxyflavoneantineoplastic agent;
metabolite
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone
antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
galangin5,7-dihydroxyflavonol: antimicrobial from the twigs of Populus nigra x Populus deltoides; structure in first source

galangin : A 7-hydroxyflavonol with additional hydroxy groups at positions 3 and 5 respectively; a growth inhibitor of breast tumor cells.
7-hydroxyflavonol;
trihydroxyflavone
antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
4-[3-(4-fluorophenyl)-2-methyl-7-oxo-1H-pyrazolo[1,5-a]pyrimidin-5-yl]-1-piperidinecarboxylic acid ethyl esterpyrazoles;
ring assembly
englerin acinnamate ester;
glycolate ester;
guaiane sesquiterpenoid
antineoplastic agent;
metabolite
gsk-5498a2,6-difluoro-N-(1-(2-fluoro-6-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide: structure in first source

GSK-5498A : A member of the class of pyrazoles that is 1H-pyrazole substituted by 2-fluoro-6-(trifluoromethyl)benzyl and (2,6-difluorobenzoyl)amino groups at positions 1 and 3, respectively. It is a inhibitor of Ca(2+) release-activated Ca(2+) (CRAC) channel and inhibits the release of mast cell mediators and T-cell cytokines in human and rat preparations.
(trifluoromethyl)benzenes;
difluorobenzene;
pyrazoles;
secondary carboxamide
calcium channel blocker
teriflunomide(trifluoromethyl)benzenes;
aromatic amide;
enamide;
enol;
nitrile;
secondary carboxamide
drug metabolite;
EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor;
hepatotoxic agent;
non-steroidal anti-inflammatory drug;
tyrosine kinase inhibitor
ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1h-pyrazole-4-carboxylateethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate: structure in first source
gsk-7975a2,6-difluoro-N-(1-(4-hydroxy-2-(trifluoromethyl)benzyl)-1H-pyrazol-3-yl)benzamide: structure in first source