Target type: molecularfunction
Binding to a translation elongation factor, any polypeptide factor involved in the peptide elongation in ribosome-mediated translation. [GOC:dph]
Translation elongation factor binding is a molecular function that describes the interaction between proteins and translation elongation factors (EFs). These EFs are essential components of the ribosome, the molecular machinery responsible for protein synthesis. EFs play crucial roles in various stages of translation, including the delivery of aminoacyl-tRNAs to the ribosome, the translocation of the ribosome along the mRNA, and the regulation of the rate and fidelity of protein synthesis.
Translation elongation factor binding involves the specific recognition and interaction of an EF with its target protein or molecule on the ribosome. This interaction is mediated by a combination of electrostatic interactions, hydrogen bonds, and hydrophobic interactions. The binding event often involves the formation of a complex between the EF and its target, which is then stabilized by additional interactions with other components of the ribosome.
The molecular function of translation elongation factor binding is crucial for the proper functioning of the ribosome and the accurate and efficient synthesis of proteins. It is an essential process that is tightly regulated by a variety of cellular factors, including the availability of EFs, the concentration of amino acids, and the presence of specific mRNA sequences.
Mutations or dysregulation of translation elongation factor binding can lead to various cellular defects, including impaired protein synthesis, misfolded proteins, and altered cellular function. This can have significant implications for cell growth, development, and disease pathogenesis.'
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Protein | Definition | Taxonomy |
---|---|---|
Heat shock factor protein 1 | A heat shock factor protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q00613] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
zm 336372 | N-(5-(3-dimethylaminobenzamido)-2-methylphenyl)-4-hydroxybenzamide: an inhibitor of c-Raf; activates Raf-1; structure in first source | benzamides | |
celastrol | monocarboxylic acid; pentacyclic triterpenoid | anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite | |
quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
chir-265 | aromatic ether | ||
az-628 | AZ-628: a multikinase inhibitor; structure in first source | benzamides | |
GDC-0879 | indanes; ketoxime; primary alcohol; pyrazoles; pyridines | antineoplastic agent; B-Raf inhibitor | |
plx4032 | aromatic ketone; difluorobenzene; monochlorobenzenes; pyrrolopyridine; sulfonamide | antineoplastic agent; B-Raf inhibitor | |
dabrafenib | 1,3-thiazoles; aminopyrimidine; organofluorine compound; sulfonamide | anticoronaviral agent; antineoplastic agent; B-Raf inhibitor | |
tak-632 | TAK-632 : A member of the class of benzothiazoles that is 1,3-benzothiazole substituted by (cyclopropanecarbonyl)amino, 4-fluoro-3-{2-[3-(trifluoromethyl)phenyl]acetamido}phenoxy, and cyano groups at positions 2, 6 and 7, respectively. It is a potent pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF(V600E), BRAF(WT), respectively. | (trifluoromethyl)benzenes; aromatic ether; benzothiazoles; cyclopropylcarboxamide; monofluorobenzenes; nitrile; secondary carboxamide | antineoplastic agent; apoptosis inducer; B-Raf inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; necroptosis inhibitor |
dinaciclib | pyrazolopyrimidine | ||
n2-(1h-indazole-5-yl)-n6-methyl-3-nitropyridine-2,6-diamine | KRIBB11 : A member of the class of indazoles that is 1H-indazole substituted by a [6-(methylamino)-3-nitropyridin-2-yl]amino group at position 5. It is an inhibitor of heat shock factor 1 (IC50 = 1.2muM) and suppresses tumour growth in mouse xenograft models. N2-(1H-indazole-5-yl)-N6-methyl-3-nitropyridine-2,6-diamine: a heat shock factor 1 antagonist; structure in first source |