EC 3.4.24.35 (gelatinase B) inhibitor

An EC 3.4.24.* (metalloendopeptidase) inhibitor that interferes with the action of gelatinase B (EC 3.4.24.35).

ChEBI ID: 79088

Members (3)

Member	Definition	Class
isoginkgetin	A biflavonoid resulting from the formal oxidative dimerisation between position 8 of one molecule of 5,7-dihydroxy-4'-methoxyflavone and the 3' position of another. Found in the leaves of Ginkgo biloba, it is a potent inhibitor of matrix metalloproteinase 9 (MMP-9).	isoginkgetin
MMP-9-IN-1	A secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor.	MMP-9-IN-1
prinomastat	A hydroxamic acid that is (3S)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide in which the hydrogen attached to the thiomorpholine nitrogen has been replaced by a [4-(pyridin-4-yloxy)phenyl]sulfonyl group. It is a selective inhibitor with of matrix metalloproteinases (MMPs) 2, 3, 9, 13, and 14.	prinomastat

Research

Studies (130)

Timeframe	Studies, Drugs with This Role(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	11 (8.46)	18.2507
2000's	68 (52.31)	29.6817
2010's	30 (23.08)	24.3611
2020's	21 (16.15)	2.80

Study Types

Publication Type	Studies, Drugs with this Role (%)	All Drugs (%)
Trials	5 (3.70%)	5.53%
Reviews	17 (12.59%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	113 (83.70%)	84.16%

Protein Targets (46)

Potency Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
67.9K protein	Vaccinia virus	Potency	21.4215	2	2
apical membrane antigen 1, AMA1	Plasmodium falciparum 3D7	Potency	15.8489	1	1
cellular tumor antigen p53 isoform a	Homo sapiens (human)	Potency	22.1060	2	2
Chain A, Beta-lactamase	Escherichia coli K-12	Potency	1.5849	1	1
Chain A, HADH2 protein	Homo sapiens (human)	Potency	31.6228	1	1
Chain B, HADH2 protein	Homo sapiens (human)	Potency	31.6228	1	1
cytochrome P450 3A4 isoform 1	Homo sapiens (human)	Potency	3.9811	2	2
GABA theta subunit	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit alpha-5	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit beta-1	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit beta-2	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit beta-3	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit delta	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit epsilon	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit gamma-3	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
Gamma-aminobutyric acid receptor subunit pi	Rattus norvegicus (Norway rat)	Potency	3.9811	1	1
hemoglobin subunit beta	Homo sapiens (human)	Potency	25.7877	2	2
Integrin alpha-IIb	Homo sapiens (human)	Potency	12.5893	1	1
Integrin beta-3	Homo sapiens (human)	Potency	12.5893	1	1
lamin isoform A-delta10	Homo sapiens (human)	Potency	19.9526	1	1
Microtubule-associated protein tau	Homo sapiens (human)	Potency	17.7828	1	1
TDP1 protein	Homo sapiens (human)	Potency	20.2550	2	2
USP1 protein, partial	Homo sapiens (human)	Potency	50.1187	1	1

Inhibition Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
72 kDa type IV collagenase	Homo sapiens (human)	IC50	0.0005	7	7
72 kDa type IV collagenase	Homo sapiens (human)	Ki	0.0001	4	4
Amyloid-beta precursor protein	Homo sapiens (human)	IC50	10.1000	1	1
Beta-secretase 1	Homo sapiens (human)	IC50	3.0100	1	1
Collagenase 3	Homo sapiens (human)	IC50	0.0008	5	5
Collagenase 3	Homo sapiens (human)	Ki	0.0000	2	2
corticotropin releasing factor-binding protein	Homo sapiens (human)	IC50	47.1000	1	1
corticotropin-releasing hormone receptor 2	Homo sapiens (human)	IC50	47.1000	1	1
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens (human)	IC50	8.3110	2	2
Interstitial collagenase	Homo sapiens (human)	IC50	0.0209	7	7
Interstitial collagenase	Homo sapiens (human)	Ki	0.0082	3	3
Matrilysin	Homo sapiens (human)	IC50	0.0723	3	3
Matrilysin	Homo sapiens (human)	Ki	0.0540	1	1
Matrix metalloproteinase-14	Homo sapiens (human)	IC50	0.0003	1	1
Matrix metalloproteinase-9	Homo sapiens (human)	IC50	0.0007	6	6
Melatonin receptor type 1A	Gallus gallus (chicken)	IC50	0.0049	1	1
Melatonin receptor type 1B	Gallus gallus (chicken)	IC50	0.0049	1	1
Melatonin receptor type 1C	Gallus gallus (chicken)	IC50	0.0049	1	1
Neutrophil collagenase	Homo sapiens (human)	IC50	0.0005	2	2
Stromelysin-1	Homo sapiens (human)	IC50	0.0022	5	5
Stromelysin-1	Homo sapiens (human)	Ki	0.0003	2	2

Activation Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
corticotropin releasing factor-binding protein	Homo sapiens (human)	EC50	53.0000	1	1
corticotropin-releasing hormone receptor 2	Homo sapiens (human)	EC50	53.0000	1	1
Matrix metalloproteinase-9	Homo sapiens (human)	Kd	2.1000	1	1

Other Measurements

Protein	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Drugs
72 kDa type IV collagenase	Homo sapiens (human)	Activity	0.0003	1	1
Collagenase 3	Homo sapiens (human)	Activity	0.0005	1	1
Interstitial collagenase	Homo sapiens (human)	Activity	0.0235	1	1