Compounds > cypellocarpin c
Page last updated: 2024-11-12

cypellocarpin c

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Description

cypellocarpin C: isolated from Eucalyptus cypellocarpa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
EucalyptusgenusA genus of trees of the Myrtaceae family, native to Australia, that yields gums, oils, and resins which are used as flavoring agents, astringents, and aromatics.[MeSH]MyrtaceaeThe myrtle plant family of the order Myrtales. It includes several aromatic medicinal plants such as EUCALYPTUS.[MeSH]

Cross-References

ID SourceID
PubMed CID10625791
CHEMBL ID247486
MeSH IDM0376038

Synonyms (8)

Synonym
camaldulenside
CHEMBL247486
cypellocarpin c
cypellocarpa c
ncgc00385100-01![(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(5-hydroxy-2-methyl-4-oxochromen-7-yl)oxyoxan-2-yl]methyl (4r)-4-(2-hydroxypropan-2-yl)cyclohexene-1-carboxylate
294856-66-9
[(2r,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(5-hydroxy-2-methyl-4-oxochromen-7-yl)oxyoxan-2-yl]methyl (4r)-4-(2-hydroxypropan-2-yl)cyclohexene-1-carboxylate
AKOS040762842
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (32)

Assay IDTitleYearJournalArticle
AID305381Apparent permeability from apical to basolateral side of human Caco-2 cells at 50 uM in presence of iodoacetamide2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305382Apparent permeability from basolateral to apical side of human Caco-2 cells at 50 uM in presence of iodoacetamide2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305375Apparent permeability from basolateral to apical side of human Caco-2 cells at 30 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305376Apparent permeability from basolateral to apical side of human Caco-2 cells at 50 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305387Drug level in Caco-2 cells assessed as intracellular accumulation at 50 uM after 150 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305379Ratio of permeability from basolateral to apical side over apical to basolateral side of human Caco-2 cells at 50 uM2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305391Drug level in Caco-2 cells assessed as total recovery rate at 50 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305388Drug level in Caco-2 cells assessed as intracellular accumulation at 50 uM after 180 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305384Drug level in Caco-2 cells assessed as intracellular accumulation at 50 uM after 60 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305389Drug level in Caco-2 cells assessed as total recovery rate at 50 uM after 30 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305374Apparent permeability from apical to basolateral side of human Caco-2 cells at 100 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305394Drug level in Caco-2 cells assessed as total recovery rate at 50 uM after 180 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID469284Cytotoxicity against african green monkey Vero cells after 3 days by MTT assay2009Journal of natural products, Sep, Volume: 72, Issue:9
Eucalmaidins A-E, (+)-oleuropeic acid derivatives from the fresh leaves of Eucalyptus maideni.
AID305386Drug level in Caco-2 cells assessed as intracellular accumulation at 50 uM after 120 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305383Drug level in Caco-2 cells assessed as intracellular accumulation at 50 uM after 30 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305372Apparent permeability from apical to basolateral side of human Caco-2 cells at 30 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305392Drug level in Caco-2 cells assessed as total recovery rate at 50 uM after 120 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID377266Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 500 molar ratio relative to TPA2000Journal of natural products, Sep, Volume: 63, Issue:9
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
AID377267Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells at 100 molar ratio relative to TPA2000Journal of natural products, Sep, Volume: 63, Issue:9
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
AID469283Antiviral activity against HSV1 infected in african green monkey Vero cells assessed as inhibition of virus-induced cytopathic effect after 3 days by crystal violet staining2009Journal of natural products, Sep, Volume: 72, Issue:9
Eucalmaidins A-E, (+)-oleuropeic acid derivatives from the fresh leaves of Eucalyptus maideni.
AID305380Ratio of permeability from basolateral to apical side over apical to basolateral side of human Caco-2 cells at 100 uM2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305390Drug level in Caco-2 cells assessed as total recovery rate at 50 uM after 60 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305395Apparent permeability from apical to basolateral side of human Caco-2 cells at 50 uM in presence of verapamil2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID377510Antitumor activity against (+/-)-(E)-4-methyl-2-[(E)-hydroxyimino]-6-methoxy-5-nitro-3-hexenamide/TPA-induced carcinogenesis in mouse assessed as reduction in number of tumor bearing mouse at 50 molar ratio/TPA after 10 weeks relative to control2000Journal of natural products, Sep, Volume: 63, Issue:9
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
AID377265Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio relative to TPA2000Journal of natural products, Sep, Volume: 63, Issue:9
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
AID377268Inhibition of 12-O-tetradecanoylphorbol-13-acetate induced EBV-early antigen activation in human Raji cells at 10 molar ratio relative to TPA2000Journal of natural products, Sep, Volume: 63, Issue:9
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
AID305385Drug level in Caco-2 cells assessed as intracellular accumulation at 50 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305373Apparent permeability from apical to basolateral side of human Caco-2 cells at 50 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305378Ratio of permeability from basolateral to apical side over apical to basolateral side of human Caco-2 cells at 30 uM2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID377511Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio/TPA2000Journal of natural products, Sep, Volume: 63, Issue:9
Cypellocarpins A-C, phenol glycosides esterified with oleuropeic acid, from Eucalyptus cypellocarpa.
AID305377Apparent permeability from basolateral to apical side of human Caco-2 cells at 100 uM after 90 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
AID305393Drug level in Caco-2 cells assessed as total recovery rate at 50 uM after 150 mins2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Intestinal permeability of antivirus constituents from the fruits of Eucalyptus globulus Labill. in Caco-2 Cell Model.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.03 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phloroglucinol
Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.		2.0310benzenetriol;
phenolic donor		algal metabolite
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.7230D-glucopyranoseepitope;
mouse metabolite
oleuropeic acid
oleuropeic acid: structure in first source		210
macrocarpal a
macrocarpal A: structure in first source		2.4420
macrocarpal b
macrocarpal B: structure in first source		2.4420sesquiterpenoid
gamma-sitosterol
clionasterol : A member of the class of phytosterols that is poriferast-5-ene carrying a beta-hydroxy substituent at position 3.		2.03103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols		marine metabolite;
plant metabolite
glycosides
[no description available]		210
sesquiterpenes
[no description available]		2.0310
cytellin
cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982		2.0310
quercetin
[no description available]		2.05107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
quercitrin
[no description available]		2.0510alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite
stigmasterol
stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.		2.03103beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
phytosterols;
stigmastane sterol		plant metabolite
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.05102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Papilloma, Squamous Cell
[description not available]		0210
Cancer of Skin
[description not available]		0210
Papilloma
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)		0210
Skin Neoplasms
Tumors or cancer of the SKIN.		0210