Page last updated: 2024-10-24

polysaccharide digestion

Definition

Target type: biologicalprocess

The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism. [GOC:go_curators]

Polysaccharide digestion is a complex process that begins in the mouth and continues in the small intestine. It involves the breakdown of large, complex carbohydrates into smaller, simpler sugars that can be absorbed by the body.

The process starts with the mechanical breakdown of food by chewing. This increases the surface area of the food, making it easier for enzymes to work on it. Salivary amylase, an enzyme found in saliva, begins the chemical digestion of starch, a type of polysaccharide, by breaking it down into smaller polysaccharides called dextrins.

Once the food reaches the stomach, salivary amylase is inactivated by the acidic environment. However, the stomach's churning action continues to break down food particles.

The majority of polysaccharide digestion takes place in the small intestine. Here, pancreatic amylase, an enzyme secreted by the pancreas, continues the breakdown of starch into smaller polysaccharides and disaccharides (sugars composed of two simple sugars).

The small intestine also contains enzymes called disaccharidases that break down disaccharides into monosaccharides (simple sugars). These enzymes include lactase (which breaks down lactose), sucrase (which breaks down sucrose), and maltase (which breaks down maltose).

The resulting monosaccharides, such as glucose, fructose, and galactose, are then absorbed into the bloodstream through the lining of the small intestine. They are transported to the liver, where they are used for energy or stored as glycogen.

Fiber, a type of polysaccharide that is not digested by humans, passes through the digestive system undigested. It provides bulk and helps regulate bowel movements.

In summary, polysaccharide digestion involves the following steps:

1. Mechanical breakdown by chewing
2. Chemical breakdown by salivary amylase in the mouth
3. Further breakdown by pancreatic amylase and disaccharidases in the small intestine
4. Absorption of monosaccharides into the bloodstream
5. Transport to the liver for energy use or storage'
"

Proteins (8)

ProteinDefinitionTaxonomy
Acidic mammalian chitinaseAn acidic mammalian chitinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZP6]Homo sapiens (human)
Chitotriosidase-1A chitotriosidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13231]Homo sapiens (human)
Sucrase-isomaltase, intestinalA sucrase-isomaltase, intestinal that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14410]Homo sapiens (human)
Pancreatic alpha-amylaseAn alpha-amylase 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04746]Homo sapiens (human)
Acidic mammalian chitinaseAn acidic mammalian chitinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BZP6]Homo sapiens (human)
Chitotriosidase-1A chitotriosidase-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13231]Homo sapiens (human)
Sucrase-isomaltase, intestinalA sucrase-isomaltase, intestinal that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14410]Homo sapiens (human)
Pancreatic alpha-amylaseAn alpha-amylase 2A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04746]Homo sapiens (human)

Compounds (40)

CompoundDefinitionClassesRoles
acetazolamideAcetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)monocarboxylic acid amide;
sulfonamide;
thiadiazoles
anticonvulsant;
diuretic;
EC 4.2.1.1 (carbonic anhydrase) inhibitor
theophyllinedimethylxanthineadenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent
caffeinepurine alkaloid;
trimethylxanthine
adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic
kinetincytokinin : A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots.

kinetin : A member of the class of 6-aminopurines that is adenine carrying a (furan-2-ylmethyl) substituent at the exocyclic amino group.

Kinetin: A furanyl adenine found in PLANTS and FUNGI. It has plant growth regulation effects.
6-aminopurines;
furans
cytokinin;
geroprotector
pentoxifyllineoxopurine
2,4-thiazolidinedione1,3-thiazolidine-2,4-dione : A thiazolidenedione carrying oxo substituents at positions 2 and 4.

thiazolidine-2,4-dione: structure in first source
thiazolidenedione
methyl acetoacetatemethyl acetoacetate: structureoxo carboxylic acid
diethyl malonatediethyl malonate: isomer of diethylmalonic acid; one of most used compounds in drug synthesis, don't confuse with ethylmalonic aciddicarboxylic acid
8-chlorotheophyllineorganochlorine compound;
purines
central nervous system stimulant
1-deoxynojirimycin1-deoxy-nojirimycin: structure in first source

duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid
anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
acarbosetetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
miglustatmiglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group.

miglustat: a glucosylceramide synthase inhibitor
piperidines;
tertiary amino compound
anti-HIV agent;
EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor
(-)-catechin(-)-catechin : The (-)-enantiomer of catechin.catechinmetabolite
terphenyllinterphenyllin : A para-terphenyl that is 1,1':4',1''-terphenyl substituted by methoxy groups at positions 3' and 6' and hydroxy groups at positions 2', 4 and 4''. It has been isolated from Aspergillus taichungensis.

terphenyllin: novel p-terphenyl metabolite from Aspergillus candidus
dimethoxybenzene;
para-terphenyl;
phenols
Aspergillus metabolite;
mycotoxin
allosamidinallosamidin: Anti-Asthmatic
1,4-dideoxy-1,4-iminoarabinitol1,4-dideoxy-1,4-iminoarabinitol: RN given refers to (2S-(2alpha,3beta,4alpha))-isomer; structure given in first source
valiolaminevaliolamine: isolated from Streptomyces hygroscopicus; RN from CA Index; RN not in Chemline 2/85
migalastatmigalastat: a potent inhibitor of glycolipid biosynthesispiperidines
3-hydroxyterphenyllin3-hydroxyterphenyllin : A para-terphenyl that is the 3-hydroxy derivative of terphenyllin. It has been isolated from Aspergillus taichungensis.

3-hydroxyterphenyllin: metabolite of Aspergillus candidus; structure
catechols;
dimethoxybenzene;
para-terphenyl
Aspergillus metabolite
valienaminevalienamine: intermediate formed by microbial degradation of validamycins; structure given in first source
miglitolpiperidines
validaminevalidamine : An amino cyclitol consisting of 1D-chiro-inositol lacking the 6-hydroxy group and having those at positions 1 and 5 replaced by amino and hydroxymethyl groups respectively.

validamine: RN given from CA Index Guide; RN not in Chemline 11/84; structure given in first source
amino cyclitol
argadinargadin: a chitinase inhibitor, produced by Clonostachys sp. FO-7314; structure in first source
argifinargifin: possible lead insecticide; isolated from Gliocladium; structure in first source
2-(Benzotriazol-1-yl)-1-(4-bromophenyl)ethanonearomatic ketoneanticoronaviral agent
trisindolinetrisindoline: an antibiotic indole trimer, produced by Vibrio separated from the marine sponge Hyrtios altum; structure given in first source
cholecystokinin (27-33), tert-butyloxycarbonyl-nle(28,31)-cholecystokinin (27-33), tert-butyloxycarbonyl-Nle(28,31)-: cholecystokinin agonist
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
baicaleintrihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
mangostinalpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.

mangostin: xanthone from rind of Garcinia mangostana Linn. fruit
aromatic ether;
phenols;
xanthones
antimicrobial agent;
antineoplastic agent;
antioxidant;
plant metabolite
7,8-dihydroxy-4-methylcoumarin7,8-dihydroxy-4-methylcoumarin: possess strong antioxidant and radical scavenging activities; structure in first sourcehydroxycoumarin
gamma-mangostingamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity.phenols;
xanthones
antineoplastic agent;
plant metabolite;
protein kinase inhibitor
beta-Mangostinxanthones
9-Hydroxycalabaxanthonexanthones
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin
l-altro-1-deoxynojirimycinL-altro-1-deoxynojirimycin: structure in first source
sch 725680Sch 725680: an aazaphilone from Aspergillus sp.; structure in first source
aspernolide aaspernolide A: structure in first source
aspulvinone E4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one : A member of the class of butenolides that is furan-2(5H)-one substituted by 4-hydroxyphenyl, hydroxy and 4-hydroxybenzylidene groups at positions 3, 4 and 5, respectively.

aspulvinone E : A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts a Z-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity.
4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one;
aspulvinone
antiviral agent;
Aspergillus metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
marine metabolite
pinophilin bpinophilin B: from cultures of a fungus (Penicillium pinophilum Hedgcok) derived from a seaweed; structure in first source