telomeric repeat-containing RNA binding

Definition

Target type: molecularfunction

Binding to long non-coding RNA molecules transcribed from subtelomeric regions in most eukaryotes. Telomeric repeat-containing RNA (TERRA) molecules consist of subtelomeric-derived sequences and G-rich telomeric repeats. [GOC:BHF, GOC:BHF_telomere, GOC:dph, GOC:jbu, PMID:20655916]

Telomeric repeat-containing RNA (TERRA) binding plays a crucial role in maintaining telomere integrity and regulating telomere length. TERRA is a non-coding RNA transcribed from telomeres, and its binding to specific proteins modulates various aspects of telomere function.

One key molecular function is the recruitment of telomere-associated proteins, such as TRF1 and TRF2, to telomeres. These proteins bind to double-stranded telomeric DNA and are essential for the formation of the protective telomere cap structure. TERRA binding to TRF1 can enhance its telomere-binding activity, promoting the formation of a more stable telomere cap.

TERRA also participates in the regulation of telomere length. By binding to telomerase, the enzyme responsible for telomere extension, TERRA can modulate telomerase activity. Some studies suggest that TERRA may act as a negative regulator of telomerase, inhibiting its access to telomeres and limiting telomere elongation. However, other studies indicate that TERRA might have a more complex role in telomere length regulation, potentially promoting telomere extension in certain contexts.

Furthermore, TERRA binding to telomeres can influence the formation of telomere-associated heterochromatin, a condensed chromatin structure that contributes to the silencing of genes located near telomeres. TERRA binding may promote the recruitment of heterochromatin-associated proteins, contributing to the establishment of a repressive chromatin environment at telomeres.

In addition to its role in telomere maintenance, TERRA binding has also been implicated in other cellular processes. For instance, TERRA has been shown to interact with components of the RNA interference machinery, suggesting a potential role in gene regulation.

In conclusion, TERRA binding to specific proteins is a complex molecular process with multifaceted functions. It plays a vital role in telomere maintenance by promoting the recruitment of telomere-associated proteins, regulating telomere length, and influencing the formation of telomere-associated heterochromatin. TERRA binding may also have broader implications for other cellular processes, highlighting its importance in maintaining genomic stability and cellular function.'
"

Proteins (2)

Compounds (49)