quercetin and Leishmaniasis

quercetin has been researched along with Leishmaniasis* in 2 studies

Other Studies

2 other study(ies) available for quercetin and Leishmaniasis

Article	Year
Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction. Journal of natural products, 2015, Apr-24, Volume: 78, Issue:4 Leishmaniasis is an important neglected disease caused by protozoa of the genus Leishmania that affects more than 12 million people worldwide. Leishmaniasis treatment requires the administration of toxic and poorly tolerated drugs, and parasite resistance greatly reduces the efficacy of conventional medications. Apigenin (1), a naturally occurring plant flavone, has a wide range of reported biological effects. In this study, antileishmanial activity of 1 in vitro was investigated, and its mechanism of action against Leishmania amazonensis promastigotes was described. Treatment with 1 for 24 h resulted in concentration-dependent inhibition of cellular proliferation (IC50 = 23.7 μM) and increased reactive oxygen species (ROS) generation. Glutathione and N-acetyl-l-cysteine protected L. amazonensis from the effects of 1 and reduced ROS levels after the treatment. By contrast, oxidized glutathione did not reduce the levels of ROS caused by 1 by not preventing the proliferation inhibition. Apigenin 1 also induced an extensive swelling in parasite mitochondria, leading to an alteration of the mitochondrial membrane potential, rupture of the trans-Golgi network, and cytoplasmic vacuolization. These results demonstrate the leishmanicidal effect of 1 and suggest the involvement of ROS leading to mitochondrial collapse as part of the mechanism of action. Topics: Acetylcysteine; Antiprotozoal Agents; Apigenin; Glutathione; Humans; Leishmania; Leishmaniasis; Mitochondria; Molecular Structure; Reactive Oxygen Species	2015
Antileishmaniasis activity of flavonoids from Consolida oliveriana. Journal of natural products, 2009, Volume: 72, Issue:6 A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim). Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Female; Flavonoids; Galactosides; Kaempferols; Leishmania; Leishmaniasis; Meglumine; Meglumine Antimoniate; Molecular Structure; Organometallic Compounds; Ranunculaceae; Rats; Rats, Inbred Strains; Turkey	2009

Article

Year

Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction.

Journal of natural products, 2015, Apr-24, Volume: 78, Issue:4

Leishmaniasis is an important neglected disease caused by protozoa of the genus Leishmania that affects more than 12 million people worldwide. Leishmaniasis treatment requires the administration of toxic and poorly tolerated drugs, and parasite resistance greatly reduces the efficacy of conventional medications. Apigenin (1), a naturally occurring plant flavone, has a wide range of reported biological effects. In this study, antileishmanial activity of 1 in vitro was investigated, and its mechanism of action against Leishmania amazonensis promastigotes was described. Treatment with 1 for 24 h resulted in concentration-dependent inhibition of cellular proliferation (IC50 = 23.7 μM) and increased reactive oxygen species (ROS) generation. Glutathione and N-acetyl-l-cysteine protected L. amazonensis from the effects of 1 and reduced ROS levels after the treatment. By contrast, oxidized glutathione did not reduce the levels of ROS caused by 1 by not preventing the proliferation inhibition. Apigenin 1 also induced an extensive swelling in parasite mitochondria, leading to an alteration of the mitochondrial membrane potential, rupture of the trans-Golgi network, and cytoplasmic vacuolization. These results demonstrate the leishmanicidal effect of 1 and suggest the involvement of ROS leading to mitochondrial collapse as part of the mechanism of action.

Topics: Acetylcysteine; Antiprotozoal Agents; Apigenin; Glutathione; Humans; Leishmania; Leishmaniasis; Mitochondria; Molecular Structure; Reactive Oxygen Species

2015

Antileishmaniasis activity of flavonoids from Consolida oliveriana.

Journal of natural products, 2009, Volume: 72, Issue:6

A set of flavonoids from Consolida oliveriana, kaempferol (1), quercetin (2), trifolin (3), and acetyl hyperoside (5) and their O-acetyl derivatives (1a, 2a, 3a), and octa-O-acetylhyperoside (4) showed leishmanicidal activity against promastigote as well as amastigote forms of Leishmania spp. The cellular proliferation, metabolic, and ultrastructural studies showed that the acetylated compounds 2a, 3a, and 4 were highly active against Leishmania (V.) peruviana, while 2a as well as 4 were effective against Leishmania (V.) braziliensis. These compounds were not cytotoxic and are effective at similar concentrations up to or lower than the reference drugs (pentostam and glucantim).

Topics: Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Female; Flavonoids; Galactosides; Kaempferols; Leishmania; Leishmaniasis; Meglumine; Meglumine Antimoniate; Molecular Structure; Organometallic Compounds; Ranunculaceae; Rats; Rats, Inbred Strains; Turkey

2009