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ChEBI ID: 38924
| Member | Definition | Role |
|---|---|---|
| methiothepin | A dibenzothiepine that is 10,11-dihydrodibenzo[b,f]thiepine bearing additional methylthio and 4-methylpiperazin-1-yl substituents at positions 8 and 10 respectively. Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively). | methiothepin |
| monatepil | Monatepil | |
| octoclothepine | clorotepine | |
| tropatepine | tropatepine | |
| zotepine | zotepine |
| Timeframe | Studies, Drugs in This Class (%) | All Drugs % |
|---|---|---|
| pre-1990 | 197 (27.82) | 18.7374 |
| 1990's | 257 (36.30) | 18.2507 |
| 2000's | 138 (19.49) | 29.6817 |
| 2010's | 89 (12.57) | 24.3611 |
| 2020's | 27 (3.81) | 2.80 |
| Publication Type | Studies, Drugs in This Class (%) | All Drugs (%) |
|---|---|---|
| Trials | 36 (4.75%) | 5.53% |
| Reviews | 30 (3.96%) | 6.00% |
| Case Studies | 30 (3.96%) | 4.05% |
| Observational | 1 (0.13%) | 0.25% |
| Other | 661 (87.20%) | 84.16% |