An EC 4.6.* (P-O lyase) inhibitor that interferes with the action of enzyme adenylate cyclase (EC 4.6.1.1).
ChEBI ID: 90365
| Member | Definition | Class |
|---|---|---|
| dideoxyadenosine | A purine 2',3'-dideoxyribonucleoside in which the nucleobase component is specified as adenine. | 2',3'-dideoxyadenosine |
| sq 22536 | A nucleoside analogue that is adenine in which the nitrogen at position 9 has been substituted by a tetrahydrofuran-2-yl group. It is an adenylate cyclase inhibitor. | 9-(tetrahydrofuryl)adenine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 110 (26.38) | 18.7374 |
| 1990's | 146 (35.01) | 18.2507 |
| 2000's | 104 (24.94) | 29.6817 |
| 2010's | 39 (9.35) | 24.3611 |
| 2020's | 18 (4.32) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (0.22%) | 5.53% |
| Reviews | 7 (1.57%) | 6.00% |
| Case Studies | 1 (0.22%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 436 (97.98%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 17.7828 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 30.0480 | 6 | 6 |
| arylsulfatase A | Homo sapiens (human) | Potency | 2.6855 | 1 | 1 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 29.0810 | 1 | 1 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 1.0691 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 0.3981 | 2 | 2 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 3.9811 | 1 | 1 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 54.3672 | 2 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 27.3335 | 2 | 2 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 12.0828 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 0.0580 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 27.8345 | 1 | 1 |
| IDH1 | Homo sapiens (human) | Potency | 1.8356 | 1 | 1 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 0.0008 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 1.5355 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 31.2308 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 57.0158 | 2 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 37.6858 | 1 | 1 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 24.0353 | 1 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 3.4290 | 2 | 6 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 4.1527 | 2 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 27.8345 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine deaminase | Bos taurus (cattle) | Ki | 120.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 2.4000 | 1 | 1 |
| Adenosine receptor A2b | Rattus norvegicus (Norway rat) | Ki | 2.4000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | Ki | 21.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | Ki | 21.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | Ki | 21.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | IC50 | 28.2000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | Ki | 21.2000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Adenosine deaminase | Bos taurus (cattle) | Km | 45.0000 | 1 | 1 |
| Deoxycytidine kinase | Homo sapiens (human) | Km | 220.0000 | 1 | 1 |
| Phosphatidylinositol 4-kinase alpha | Homo sapiens (human) | Km | 261.8000 | 1 | 1 |
| Phosphatidylinositol 4-kinase beta | Homo sapiens (human) | Km | 261.8000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-alpha | Homo sapiens (human) | Km | 261.8000 | 1 | 1 |
| Phosphatidylinositol 4-kinase type 2-beta | Homo sapiens (human) | Km | 261.8000 | 1 | 1 |
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | ED50 | 6.4000 | 1 | 1 |