Page last updated: 2024-10-24

phosphorus-oxygen lyase activity

Definition

Target type: molecularfunction

Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]

Phosphorus-oxygen lyase activity refers to the enzymatic process that cleaves a phosphorus-oxygen bond. This type of activity is crucial for a variety of biological processes, including:

* **Nucleic acid metabolism:** Enzymes like DNA polymerase and RNA polymerase require phosphorus-oxygen lyases to break down phosphodiester bonds in nucleic acids, enabling DNA replication and transcription.
* **Energy metabolism:** The hydrolysis of phosphate esters, such as ATP, by ATPases involves phosphorus-oxygen lyase activity. This activity is vital for energy production and utilization within cells.
* **Signal transduction:** Phosphatases, enzymes that remove phosphate groups from proteins, utilize phosphorus-oxygen lyase activity. This process regulates protein function and plays a critical role in signaling pathways.
* **Carbohydrate metabolism:** Phosphatases involved in carbohydrate metabolism, such as glucose-6-phosphatase, employ phosphorus-oxygen lyase activity to liberate phosphate groups, contributing to the regulation of glucose levels.

The mechanism of phosphorus-oxygen lyase activity typically involves the formation of a transient intermediate, often a covalent complex between the enzyme and the substrate. This complex facilitates the breaking of the phosphorus-oxygen bond, releasing the products of the reaction. The specific reaction mechanism can vary depending on the enzyme and the substrate involved.

In summary, phosphorus-oxygen lyase activity is an essential enzymatic function involved in a multitude of biological processes, playing a critical role in nucleic acid metabolism, energy production, signal transduction, and carbohydrate metabolism.'
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Proteins (1)

ProteinDefinitionTaxonomy
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1An ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28907]Homo sapiens (human)

Compounds (18)

CompoundDefinitionClassesRoles
taxifolin3'-hydroxyflavanones;
4'-hydroxyflavanones;
dihydroflavonols;
pentahydroxyflavanone;
secondary alpha-hydroxy ketone
catechinhydroxyflavan
delphinidindelphinidin : An anthocyanidin cation consisting of benzopyrylium with hydroxy substituents at the 3-, 5- and 7-positions and a 3,4,5-trihydroxyphenyl group at the 2-position. It is a plant pigment responsible for the colours of the plants of the genera Viola and Delphinium.

delphinidin: RN given refers to parent cpd;
5-hydroxyanthocyanidinantineoplastic agent;
biological pigment;
plant metabolite
cyanidincyanidin cation : An anthocyanidin cation that is flavylium substituted at positions 3, 3', 4', 5 and 7 by hydroxy groups.

cyanidin: RN given refers to parent cpd; structure
5-hydroxyanthocyanidinantioxidant;
metabolite;
neuroprotective agent
malvidinmalvidin : An anthocyanidin cation that is delphinidin carrying methyl substituents at positions 3' and 5'.

malvidin: RN given refers to parent cpd; coloring agent from flowers of Malvaviscus conzatti
5-hydroxyanthocyanidinbiological pigment;
metabolite
pelargonidinpelargonidin : An anthocyanidin cation that is flavylium substituted by a hydroxy groups at positions 3, 5, 7 and 4'.

pelargonidin: influences flower phenotype
5-hydroxyanthocyanidinplant metabolite
cyanidin 3-o-beta-d-glucopyranosidecyanidin 3-O-beta-D-glucoside : An anthocyanin cation that is a cyanidin cation linked to a beta-D-glucosyl moiety at position 3.anthocyanin cation;
beta-D-glucoside;
monosaccharide derivative
metabolite
buclizineluteolinidin: structure in first source5-hydroxyanthocyanidin
peonidinpeonidin : An anthocyanidin cation that is flavylium bearing four hydroxy substituents at positions 3, 4', 5 and 7 as well as a methoxy substituent at position 3'.

peonidin: a COX-2 inhibitor with protein kinase inhibitory and phytogenic antineoplastic activities; RN given for chloride salt
5-hydroxyanthocyanidinantineoplastic agent;
antioxidant;
apoptosis inducer;
metabolite
petunidinpetunidin : An anthocyanidin cation that is flavylium bearing five hydroxy substituents at positions 3, 3', 4', 5 and 7 as well as a methoxy substituent at position 5'.

petunidin: RN given for chloride salt
5-hydroxyanthocyanidinplant metabolite
resveratroltrans-resveratrol : A resveratrol in which the double bond has E configuration.resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
3,3',4,5'-tetrahydroxystilbene3,3',4,5'-tetrahydroxystilbene: demethyl derivative of isorhapontigenin; structure in first source; a Syk kinase inhibitor; found in heartwood of FABACEAE; inhibitor of photosynthesis in spinach chloroplasts; may be inhibitor of plant growth; RN given refers to (E)-isomer

piceatannol : A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.
catechols;
polyphenol;
resorcinols;
stilbenol
antineoplastic agent;
apoptosis inducer;
geroprotector;
hypoglycemic agent;
plant metabolite;
protein kinase inhibitor;
tyrosine kinase inhibitor
ex 5276-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide : A member of the class of carbazoles that is 2,3,4,9-tetrahydro-1H-carbazole which is substituted at position 1 by an aminocarbohyl group and at position 6 by a chlorine.

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide: structure in first source
carbazoles;
monocarboxylic acid amide;
organochlorine compound
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
quercetagetinquercetagetin : A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.

quercetagetin: structure given in first source; inhibits aldose reductase in rat lens
flavonols;
hexahydroxyflavone
antioxidant;
antiviral agent;
plant metabolite
robinetinrobinetin : A pentahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 7, 3, 4' and 5'.

robinetin: structure given in first source
7-hydroxyflavonol;
pentahydroxyflavone
plant metabolite