NADH binding

Definition

Target type: molecularfunction

Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]

NADH binding is a molecular function associated with proteins that bind to nicotinamide adenine dinucleotide (NADH), a crucial cofactor in cellular metabolism. NADH is a reduced form of NAD+, and its binding to proteins is often involved in redox reactions, where electrons are transferred between molecules. NADH binding typically occurs at specific sites within a protein's structure, often within a deep cleft or pocket. The binding of NADH to these sites can induce conformational changes in the protein, which can alter its activity or its interactions with other molecules. The binding affinity between NADH and its binding site is influenced by factors such as the protein's amino acid sequence, the surrounding environment, and the presence of other molecules that may compete for binding. The functional implications of NADH binding are diverse and depend on the specific protein involved. For example, NADH binding can trigger enzyme activity, facilitate electron transfer, regulate protein stability, or mediate protein-protein interactions. Overall, NADH binding is a fundamental molecular process that plays a vital role in a wide range of cellular functions.'
"

Proteins (3)

Compounds (18)