Page last updated: 2024-10-24

NADH binding

Definition

Target type: molecularfunction

Binding to the reduced form, NADH, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]

NADH binding is a molecular function associated with proteins that bind to nicotinamide adenine dinucleotide (NADH), a crucial cofactor in cellular metabolism. NADH is a reduced form of NAD+, and its binding to proteins is often involved in redox reactions, where electrons are transferred between molecules. NADH binding typically occurs at specific sites within a protein's structure, often within a deep cleft or pocket. The binding of NADH to these sites can induce conformational changes in the protein, which can alter its activity or its interactions with other molecules. The binding affinity between NADH and its binding site is influenced by factors such as the protein's amino acid sequence, the surrounding environment, and the presence of other molecules that may compete for binding. The functional implications of NADH binding are diverse and depend on the specific protein involved. For example, NADH binding can trigger enzyme activity, facilitate electron transfer, regulate protein stability, or mediate protein-protein interactions. Overall, NADH binding is a fundamental molecular process that plays a vital role in a wide range of cellular functions.'
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Proteins (3)

ProteinDefinitionTaxonomy
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIAn enoyl-[acyl-carrier-protein] reductase [NADH] FabI that is encoded in the genome of Escherichia coli K-12. [PRO:DNx, UniProtKB:P0AEK4]Escherichia coli K-12
Dihydropteridine reductaseA dihydropteridine reductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09417]Homo sapiens (human)
Quinone oxidoreductaseA quinone oxidoreductase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08257]Homo sapiens (human)

Compounds (18)

CompoundDefinitionClassesRoles
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine : A tetrahydropyridine that is 1,2,3,6-tetrahydropyridine substituted by a methyl group at position 1 and a phenyl group at position 4.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A dopaminergic neurotoxic compound which produces irreversible clinical, chemical, and pathological alterations that mimic those found in Parkinson disease.
methylpyridines;
phenylpyridine;
tetrahydropyridine
neurotoxin
triclosanaromatic ether;
dichlorobenzene;
monochlorobenzenes;
phenols
antibacterial agent;
antimalarial;
drug allergen;
EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor;
fungicide;
persistent organic pollutant;
xenobiotic
evernic acidevernic acid: RN given refers to parent cpdcarbonyl compound
4-phenylpyridinephenylpyridine
psoromic acidpsoromic acid: structure in first sourcecarbonyl compound
epigallocatechin gallate(-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.

epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis)
flavans;
gallate ester;
polyphenol
antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
gallocatechol(-)-epigallocatechin : A flavan-3,3',4',5,5',7-hexol having (2R,3R)-configuration.catechin;
flavan-3,3',4',5,5',7-hexol
antioxidant;
food component;
plant metabolite
1-methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine
4-phenyl-1,2,3,6-tetrahydropyridine4-phenyl-1,2,3,6-tetrahydropyridine: RN given refers to parent cpd
xanthorrhizolxanthorrhizol: structure in first sourcesesquiterpenoid
epicatechin gallate(-)-epicatechin-3-O-gallate : A gallate ester obtained by formal condensation of the carboxy group of gallic acid with the (3R)-hydroxy group of epicatechin. A natural product found in Parapiptadenia rigida.

epicatechin gallate: a steroid 5alpha-reductase inhibitor; RN given refers to the (cis)-isomer; structure given in first source; isolated from green tea
catechin;
gallate ester;
polyphenol
EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
metabolite
(+)-usnic acidusnic acid
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
buteinchalcones;
polyphenol
antineoplastic agent;
antioxidant;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
geroprotector;
hypoglycemic agent;
plant metabolite;
radiosensitizing agent;
tyrosine kinase inhibitor
memoquinmemoquin: structure in first source
vulpinic acidvulpinic acid: RN given refers to cpd without isomeric designation; structure given in first source; vulpinic acid refers to (E)-isomerbutenolide
ARS-1620ARS-1620 : A qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals.

ARS-1620: covalent S-IIP G12C inhibitor for targeting of KRAS G12C mutant tumors
quinazolinesantineoplastic agent;
antiviral agent;
inhibitor