An agonist that binds to and activates prostacyclin receptors
ChEBI ID: 90845
| Member | Definition | Class |
|---|---|---|
| mre 269 | A member of the class of pyrazines that is {4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetic acid carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. The active metabolite of selexipag, an orphan drug used for the treatment of pulmonary arterial hypertension. | ACT-333679 |
| selexipag | A member of the class of pyrazines that is N-(methanesulfonyl)-2-{4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetamide carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. An orphan drug used for the treatment of pulmonary arterial hypertension. It is a prodrug for ACT-333679 (the free carboxylic acid). | selexipag |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (2.78) | 29.6817 |
| 2010's | 88 (61.11) | 24.3611 |
| 2020's | 52 (36.11) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 42 (23.20%) | 5.53% |
| Reviews | 31 (17.13%) | 6.00% |
| Case Studies | 18 (9.94%) | 4.05% |
| Observational | 5 (2.76%) | 0.25% |
| Other | 85 (46.96%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 16.9330 | 1 | 1 |
| G | Vesicular stomatitis virus | Potency | 23.9185 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 23.9185 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 23.9185 | 1 | 1 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Prostacyclin receptor | Homo sapiens (human) | IC50 | 0.1750 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Prostacyclin receptor | Homo sapiens (human) | EC50 | 0.0140 | 1 | 2 |
| Prostacyclin receptor | Rattus norvegicus (Norway rat) | EC50 | 0.2000 | 1 | 1 |
| Prostaglandin D2 receptor | Homo sapiens (human) | EC50 | 0.1270 | 1 | 2 |