Any compound that inhibits the action of tankyrase.
ChEBI ID: 62887
| Member | Definition | Class |
|---|---|---|
| xav939 | A thiopyranopyrimidine in which a 7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidine skeleton is substituted at C-4 by a hydroxy group and at C-2 by a para-(trifluoromethyl)phenyl group. | XAV939 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (0.54) | 29.6817 |
| 2010's | 141 (76.22) | 24.3611 |
| 2020's | 43 (23.24) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 4 (2.15%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 182 (97.85%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 18.9991 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 21.3174 | 1 | 1 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 24.3667 | 4 | 4 |
| G | Vesicular stomatitis virus | Potency | 18.9991 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 18.9991 | 1 | 1 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 18.9991 | 1 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 18.9991 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Chain A, Tankyrase-1 | Homo sapiens (human) | IC50 | 0.0110 | 1 | 2 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | IC50 | 2.9925 | 15 | 17 |
| Poly [ADP-ribose] polymerase 2 | Homo sapiens (human) | IC50 | 0.5276 | 10 | 11 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | IC50 | 11.3962 | 23 | 24 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | IC50 | 11.3832 | 23 | 24 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| Protein mono-ADP-ribosyltransferase PARP11 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Protein mono-ADP-ribosyltransferase PARP14 | Homo sapiens (human) | IC50 | 5.6001 | 2 | 3 |
| Protein mono-ADP-ribosyltransferase PARP15 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| Protein mono-ADP-ribosyltransferase PARP16 | Homo sapiens (human) | IC50 | 5.0119 | 1 | 1 |
| Protein mono-ADP-ribosyltransferase PARP3 | Homo sapiens (human) | IC50 | 3.8903 | 2 | 3 |
| Protein mono-ADP-ribosyltransferase PARP4 | Homo sapiens (human) | IC50 | 4.5890 | 2 | 3 |
| Protein mono-ADP-ribosyltransferase PARP6 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| Protein Wnt-3a | Homo sapiens (human) | IC50 | 0.0780 | 1 | 1 |
| Protein Wnt-3a | Mus musculus (house mouse) | IC50 | 0.0780 | 1 | 1 |
| Vesicular acetylcholine transporter | Rattus norvegicus (Norway rat) | IC50 | 0.0150 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Axin-2 | Homo sapiens (human) | EC50 | 0.3710 | 1 | 1 |
| Chain A, Tankyrase-2 | Homo sapiens (human) | Kd | 0.0080 | 1 | 1 |
| Poly [ADP-ribose] polymerase 1 | Homo sapiens (human) | Kd | 0.6200 | 1 | 1 |
| Poly [ADP-ribose] polymerase tankyrase-1 | Homo sapiens (human) | Kd | 0.0540 | 2 | 2 |
| Poly [ADP-ribose] polymerase tankyrase-2 | Homo sapiens (human) | Kd | 0.0094 | 3 | 3 |