Page last updated: 2024-12-08
3,2'-dihydroxyflavone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
3,2'-dihydroxyflavone: antimicrobial; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 455313 |
CHEMBL ID | 1224243 |
SCHEMBL ID | 290080 |
MeSH ID | M0518165 |
Synonyms (24)
Synonym |
---|
3,2'-dihydroxy flavone |
CHEMBL1224243 |
3-hydroxy-2-(2-hydroxyphenyl)-4h-1-benzopyran-4-one |
3-hydroxy-2-(2-hydroxyphenyl)chromen-4-one |
3,2'-dhf |
2'3-dioh-flavone |
3,2'-dihydroxyflavone |
3-hydroxy-2-(2-hydroxyphenyl)-4h-chromen-4-one |
4h-1-benzopyran-4-one, 3-hydroxy-2-(2-hydroxyphenyl)- |
inchi=1/c15h10o4/c16-11-7-3-1-5-9(11)15-14(18)13(17)10-6-2-4-8-12(10)19-15/h1-8,16,18 |
ST055982 |
FT-0635965 |
6068-76-4 |
SCHEMBL290080 |
2',3-dihydroxyflavone |
AKOS024282371 |
VECGDSZOFMYGAF-UHFFFAOYSA-N |
2'-hydroxyflavonol |
DTXSID90332408 |
mfcd00017674 |
CS-0039378 |
CS-15712 |
D72655 |
3,2-dihydroxyflavone |
Research Excerpts
Bioavailability
Excerpt | Reference | Relevance |
---|---|---|
" Hence, our data support that the synthetic 4'-dimethylamino-7,8-dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent antidepressant effects." | ( A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. Chan, CB; France, S; He, K; Huang, J; Jang, SW; Jia, Y; Liu, X; Luo, HR; Phun, LH; Pradoldej, S; Xiao, G; Ye, K, 2010) | 0.36 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (10)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID502292 | Antioxidant activity assessed as DDPH radical scavenging activity | 2010 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18 | Relationships between structures of hydroxyflavones and their antioxidative effects. |
AID1190605 | Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
AID605243 | Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23 | A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect. |
AID1190604 | Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
AID1190610 | Antimicrobial activity against Candida tropicalis ATCC 750 assessed as inhibition of microbial growth incubated for 72 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
AID1190609 | Antimicrobial activity against Candida albicans ATCC 10231 assessed as inhibition of microbial growth incubated for 72 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
AID1366134 | Cytotoxicity against human SK-MEL-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay | 2017 | Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21 | 3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells. |
AID1190608 | Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
AID1190607 | Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
AID1190606 | Antimicrobial activity against Escherichia coli ATCC 10536 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method | 2015 | Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4 | Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (7)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (14.29) | 29.6817 |
2010's | 5 (71.43) | 24.3611 |
2020's | 1 (14.29) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.54
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.54) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |