Page last updated: 2024-12-08

3,2'-dihydroxyflavone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,2'-dihydroxyflavone: antimicrobial; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID455313
CHEMBL ID1224243
SCHEMBL ID290080
MeSH IDM0518165

Synonyms (24)

Synonym
3,2'-dihydroxy flavone
CHEMBL1224243
3-hydroxy-2-(2-hydroxyphenyl)-4h-1-benzopyran-4-one
3-hydroxy-2-(2-hydroxyphenyl)chromen-4-one
3,2'-dhf
2'3-dioh-flavone
3,2'-dihydroxyflavone
3-hydroxy-2-(2-hydroxyphenyl)-4h-chromen-4-one
4h-1-benzopyran-4-one, 3-hydroxy-2-(2-hydroxyphenyl)-
inchi=1/c15h10o4/c16-11-7-3-1-5-9(11)15-14(18)13(17)10-6-2-4-8-12(10)19-15/h1-8,16,18
ST055982
FT-0635965
6068-76-4
SCHEMBL290080
2',3-dihydroxyflavone
AKOS024282371
VECGDSZOFMYGAF-UHFFFAOYSA-N
2'-hydroxyflavonol
DTXSID90332408
mfcd00017674
CS-0039378
CS-15712
D72655
3,2-dihydroxyflavone

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" Hence, our data support that the synthetic 4'-dimethylamino-7,8-dihydroxyflavone and its lead both are orally bioavailable TrkB agonists and possess potent antidepressant effects."( A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
Chan, CB; France, S; He, K; Huang, J; Jang, SW; Jia, Y; Liu, X; Luo, HR; Phun, LH; Pradoldej, S; Xiao, G; Ye, K, 2010
)
0.36
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID502292Antioxidant activity assessed as DDPH radical scavenging activity2010Bioorganic & medicinal chemistry letters, Sep-15, Volume: 20, Issue:18
Relationships between structures of hydroxyflavones and their antioxidative effects.
AID1190605Antimicrobial activity against Staphylococcus aureus ATCC 25923 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
AID605243Agonist activity at TrkB in E17 rat primary cortical neurons assessed as AKT phosphorylation at Ser 473 at 500 nM after 15 mins by ELISA2010Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect.
AID1190604Antimicrobial activity against Bacillus subtilis ATCC 6633 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
AID1190610Antimicrobial activity against Candida tropicalis ATCC 750 assessed as inhibition of microbial growth incubated for 72 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
AID1190609Antimicrobial activity against Candida albicans ATCC 10231 assessed as inhibition of microbial growth incubated for 72 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
AID1366134Cytotoxicity against human SK-MEL-1 cells assessed as reduction in cell viability after 72 hrs by MTT assay2017Bioorganic & medicinal chemistry, 11-01, Volume: 25, Issue:21
3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells.
AID1190608Antimicrobial activity against Klebsiella pneumoniae ATCC 10031 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
AID1190607Antimicrobial activity against Pseudomonas aeruginosa ATCC 10145 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
AID1190606Antimicrobial activity against Escherichia coli ATCC 10536 assessed as inhibition of microbial growth incubated for 24 hrs by broth dilution method2015Bioorganic & medicinal chemistry letters, Feb-15, Volume: 25, Issue:4
Synthesis, antimicrobial activity and molecular docking of novel tetracyclic scaffolds incorporating a flavonoid framework with medium sized oxygen heterocycles.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's5 (71.43)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.54

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.54 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.54)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]