| Assay ID | Title | Year | Journal | Article |
|---|
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID597814 | Toxicity in human H22 tumor-nearing ICR mouse assessed as spleen index at 10 mg/kg, ip for 7 days measured on day 9 relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597812 | Toxicity in human H22 tumor-nearing ICR mouse assessed as white blood cell count at 10 mg/kg, ip for 7 days measured on day 9 relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597813 | Toxicity in human H22 tumor-nearing ICR mouse assessed as thymus index at 10 mg/kg, ip for 7 days measured on day 9 relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID1384568 | Inhibition of GSTO1-1 (unknown origin) by 4-NPG substrate based assay | 2018 | Journal of medicinal chemistry, 09-13, Volume: 61, Issue:17
| Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. |
| AID597753 | Antitumor activity against human PANC1 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597751 | Antitumor activity against human PC3 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597748 | Antitumor activity against human MCF7 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597810 | Cytotoxicity against human PBMC assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597811 | Antitumor activity against mouse H22 tumor-nearing ICR mouse assessed as inhibition of tumor growth at 10 mg/kg, ip for 7 days measured on day 9 | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597808 | Antitumor activity against human U266 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597807 | Antitumor activity against human RPMI8226 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597750 | Antitumor activity against human SKOV3 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID296681 | Cytotoxicity against human HepG2 cells after 72 hrs by MTT colorimetric method | 2007 | Journal of medicinal chemistry, 08-09, Volume: 50, Issue:16
| First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. |
| AID296685 | Cytotoxicity against human A549 cells after 72 hrs by MTT colorimetric method | 2007 | Journal of medicinal chemistry, 08-09, Volume: 50, Issue:16
| First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. |
| AID597809 | Cytotoxicity against human HEK293 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597815 | Toxicity in human H22 tumor-nearing ICR mouse assessed as body weight at 10 mg/kg, ip for 7 days measured on day 9 relative to control | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597752 | Antitumor activity against human HepG2 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID402362 | Activity at human estrogen receptor expressed in transgenic Arabidopsis plant at >100 uM by pER8-GFP reporter assay | 2005 | Journal of natural products, Jul, Volume: 68, Issue:7
| The transgenic Arabidopsis plant system, pER8-GFP, as a powerful tool in searching for natural product estrogen-agonists/antagonists. |
| AID597749 | Antitumor activity against human MDA-MB-231 cells assessed as cell proliferation after 24 hrs by MTT assay | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID597817 | Toxicity in human H22 tumor-nearing ICR mouse assessed as decrease in ratio of granulocytic and erythroid cell system at 10 mg/kg, ip for 7 days measured on day 9 | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID296684 | Cytotoxicity against human MCF7 cells after 72 hrs by MTT colorimetric method | 2007 | Journal of medicinal chemistry, 08-09, Volume: 50, Issue:16
| First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. |
| AID296682 | Cytotoxicity against human Hep3B cells after 72 hrs by MTT colorimetric method | 2007 | Journal of medicinal chemistry, 08-09, Volume: 50, Issue:16
| First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. |
| AID597816 | Toxicity in human H22 tumor-nearing ICR mouse assessed as decrease in total nucleated bone marrow cells at 10 mg/kg, ip for 7 days measured on day 9 | 2011 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 21, Issue:11
| A novel, broad-spectrum antitumor compound containing the 1-hydroxycyclohexa-2,5-dien-4-one group: the disclosure of a new antitumor pharmacophore in protoapigenone 1. |
| AID296683 | Cytotoxicity against human MDA-MB-231 cells after 72 hrs by MTT colorimetric method | 2007 | Journal of medicinal chemistry, 08-09, Volume: 50, Issue:16
| First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |