interneuron migration
Definition
Target type: biologicalprocess
The orderly movement of an interneuron from one site to another. [GO_REF:0000091, GOC:ah, GOC:TermGenie, PMID:18622031]
Interneuron migration is a complex and precisely regulated process that involves the movement of interneurons, a type of neuron that connects other neurons, from their birthplace in the developing brain to their final destination. This migration is essential for establishing the intricate circuitry of the brain and is critical for proper brain function.
Interneuron migration occurs during embryonic development and is guided by a variety of cues, including chemical gradients, cell-cell interactions, and the extracellular matrix. These cues provide directional information to migrating interneurons, ensuring that they reach their correct location in the brain.
One important cue for interneuron migration is the presence of chemoattractant and chemorepellent molecules, which create gradients that guide migrating neurons towards or away from specific destinations. These gradients can be established by the surrounding cells or by the extracellular matrix.
Another important cue is the interaction between migrating interneurons and other cells, such as radial glial cells, which act as scaffolds for migrating neurons. These interactions provide structural support and guidance to migrating neurons, ensuring that they move along specific pathways.
The extracellular matrix also plays a crucial role in interneuron migration by providing a physical substrate for migration and by presenting additional cues, such as adhesion molecules that can influence the direction and speed of migration.
The process of interneuron migration is highly regulated and is disrupted in a number of neurodevelopmental disorders, such as autism spectrum disorder and epilepsy. These disorders can result in aberrant brain wiring and can lead to cognitive and behavioral impairments.
In summary, interneuron migration is a fundamental process in brain development, involving precise guidance of these neurons from their birthplace to their final location in the brain. This migration is essential for establishing the intricate circuitry of the brain and is critical for proper brain function. It is guided by a combination of chemical gradients, cell-cell interactions, and the extracellular matrix, and its disruption can lead to neurodevelopmental disorders.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| C-C chemokine receptor type 4 | A C-C chemokine receptor type 4 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P51679] | Homo sapiens (human) |
Compounds (8)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| amiodarone | amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. | 1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound | cardiovascular drug |
| clotrimazole | conazole antifungal drug; imidazole antifungal drug; imidazoles; monochlorobenzenes | antiinfective agent; environmental contaminant; xenobiotic | |
| disulfiram | organic disulfide; organosulfur acaricide | angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor | |
| itraconazole | piperazines | ||
| tak 779 | |||
| quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
| ucb 35625 | UCB 35625: J-113863 is the (trans)-isomer; structure in first source | ||
| amd 070 | mavorixafor: a derivative of AMD3100; a CXCR4 blocker | aminoquinoline |