Target type: biologicalprocess
The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside. [GOC:go_curators]
Sucrose metabolism is a fundamental process in plant biology, involving the synthesis, transport, and breakdown of sucrose, a disaccharide composed of glucose and fructose. This process is crucial for plant growth, development, and energy storage.
**Sucrose Synthesis:**
* **Photosynthesis:** The primary source of sucrose is photosynthesis, where sunlight energy is used to convert carbon dioxide and water into glucose.
* **Sucrose Phosphate Synthase (SPS):** This enzyme catalyzes the first committed step in sucrose biosynthesis, combining UDP-glucose and fructose-6-phosphate to form sucrose-6-phosphate.
* **Sucrose Phosphate Phosphatase (SPP):** This enzyme removes the phosphate group from sucrose-6-phosphate, generating free sucrose.
**Sucrose Transport:**
* **Phloem:** Sucrose is transported throughout the plant via the phloem, a vascular tissue responsible for long-distance transport of sugars and other nutrients.
* **Sucrose Transporters:** Specific membrane proteins, called sucrose transporters, facilitate the movement of sucrose across cell membranes, both into and out of the phloem.
**Sucrose Breakdown:**
* **Invertase:** This enzyme hydrolyzes sucrose into glucose and fructose, which can then be used for energy production or as building blocks for other carbohydrates.
* **Cellular Respiration:** Glucose and fructose are metabolized through cellular respiration, releasing energy (ATP) that fuels cellular processes.
**Regulation of Sucrose Metabolism:**
* **Hormones:** Plant hormones, such as auxin, gibberellin, and cytokinin, play important roles in regulating sucrose metabolism.
* **Environmental Factors:** Factors like light intensity, temperature, and nutrient availability influence the rate of sucrose synthesis, transport, and breakdown.
**Significance:**
* **Plant Growth and Development:** Sucrose provides the primary source of carbon for plant growth and development, including leaf expansion, stem elongation, and root growth.
* **Energy Storage:** Excess sucrose is stored as starch in various plant organs, serving as a readily available energy reserve.
* **Crop Yield:** Sucrose metabolism directly impacts crop yield, as it determines the availability of sugars for seed development and other reproductive processes.
**Overall, sucrose metabolism is a complex and tightly regulated process essential for plant survival and productivity. It involves coordinated synthesis, transport, and breakdown of sucrose, driven by a network of enzymes, transporters, and regulatory factors.**'
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Protein | Definition | Taxonomy |
---|---|---|
Lysosomal alpha-glucosidase | A lysosomal alpha-glucosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P10253] | Homo sapiens (human) |
Compound | Definition | Classes | Roles |
---|---|---|---|
n-methyldeoxynojirimycin | N-methyl-1-deoxynojirimycin : A hydroxypiperidine that is duvoglustat in which the amino hydrogen is replaced by a methyl group. It is an inhibitor of alpha-glucosidase, an agonist of the glucose sensor SGLT3 and exhibits anti-HIV activity. | ||
2,4-thiazolidinedione | 1,3-thiazolidine-2,4-dione : A thiazolidenedione carrying oxo substituents at positions 2 and 4. thiazolidine-2,4-dione: structure in first source | thiazolidenedione | |
methyl acetoacetate | methyl acetoacetate: structure | oxo carboxylic acid | |
diethyl malonate | diethyl malonate: isomer of diethylmalonic acid; one of most used compounds in drug synthesis, don't confuse with ethylmalonic acid | dicarboxylic acid | |
orcinol | orcinol : A 5-alkylresorcinol in which the alkyl group is specified as methyl. orcinol: used as reagent for pentoses, lignin, beet sugar, saccharoses, arabinose & diastase; RN given refers to parent cpd; structure | 5-alkylresorcinol; dihydroxytoluene | Aspergillus metabolite |
1-deoxynojirimycin | 1-deoxy-nojirimycin: structure in first source duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration. | 2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid | anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite |
acarbose | tetrasaccharide derivative | EC 3.2.1.1 (alpha-amylase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; geroprotector; hypoglycemic agent | |
miglustat | miglustat : A hydroxypiperidine that is deoxynojirimycin in which the amino hydrogen is replaced by a butyl group. miglustat: a glucosylceramide synthase inhibitor | piperidines; tertiary amino compound | anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor |
orsellinic acid | o-orsellinic acid : A dihydroxybenzoic acid that is 2,4-dihydroxybenzoic acid in which the hydrogen at position 6 is replaced by a methyl group. orsellinic acid: from the Sonoran desert endophytic fungus Chaetomium globosum; structure in first source | dihydroxybenzoic acid; resorcinols | fungal metabolite; marine metabolite; metabolite |
(-)-catechin | (-)-catechin : The (-)-enantiomer of catechin. | catechin | metabolite |
mor-14 | N-methyldeoxynojirimycin: glucosidase inhibitor | hydroxypiperidine; piperidine alkaloid; tertiary amino compound | anti-HIV agent; cardioprotective agent; EC 3.2.1.20 (alpha-glucosidase) inhibitor; plant metabolite |
terphenyllin | terphenyllin : A para-terphenyl that is 1,1':4',1''-terphenyl substituted by methoxy groups at positions 3' and 6' and hydroxy groups at positions 2', 4 and 4''. It has been isolated from Aspergillus taichungensis. terphenyllin: novel p-terphenyl metabolite from Aspergillus candidus | dimethoxybenzene; para-terphenyl; phenols | Aspergillus metabolite; mycotoxin |
homonojirimycin | homonojirimycin: inhibits alpha-glucosidase; RN given for (2R-(2alpha,3alpha,4beta,5alpha,6beta))-isomer; structure in first source | ||
valiolamine | valiolamine: isolated from Streptomyces hygroscopicus; RN from CA Index; RN not in Chemline 2/85 | ||
migalastat | migalastat: a potent inhibitor of glycolipid biosynthesis | piperidines | |
3-hydroxyterphenyllin | 3-hydroxyterphenyllin : A para-terphenyl that is the 3-hydroxy derivative of terphenyllin. It has been isolated from Aspergillus taichungensis. 3-hydroxyterphenyllin: metabolite of Aspergillus candidus; structure | catechols; dimethoxybenzene; para-terphenyl | Aspergillus metabolite |
miglitol | piperidines | ||
ao 128 | AO 128: alpha-glucosidase inhibitor; structure given in first source | organic molecular entity | |
acarbose | amino cyclitol; glycoside | ||
2,5-dideoxy-2,5-imino-d-glucitol | 2,5-dideoxy-2,5-imino-D-glucitol: structure in first source | ||
2-(Benzotriazol-1-yl)-1-(4-bromophenyl)ethanone | aromatic ketone | anticoronaviral agent | |
trisindoline | trisindoline: an antibiotic indole trimer, produced by Vibrio separated from the marine sponge Hyrtios altum; structure given in first source | ||
quercetin | 7-hydroxyflavonol; pentahydroxyflavone | antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger | |
baicalein | trihydroxyflavone | angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger | |
mangostin | alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities. mangostin: xanthone from rind of Garcinia mangostana Linn. fruit | aromatic ether; phenols; xanthones | antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite |
7,8-dihydroxy-4-methylcoumarin | 7,8-dihydroxy-4-methylcoumarin: possess strong antioxidant and radical scavenging activities; structure in first source | hydroxycoumarin | |
gamma-mangostin | gamma-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3, 6 and 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antitumour activity. | phenols; xanthones | antineoplastic agent; plant metabolite; protein kinase inhibitor |
beta-Mangostin | xanthones | ||
9-Hydroxycalabaxanthone | xanthones | ||
n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | |||
3-o-methylfunicone | 3-O-methylfunicone: derived from Penicillium pinophilum; structure in first source | ||
l-altro-1-deoxynojirimycin | L-altro-1-deoxynojirimycin: structure in first source | ||
sch 725680 | Sch 725680: an aazaphilone from Aspergillus sp.; structure in first source | ||
5-[[4-(4-acetylphenyl)-1-piperazinyl]sulfonyl]-1,3-dihydroindol-2-one | aromatic ketone | ||
aspernolide a | aspernolide A: structure in first source | ||
5-[[4-(4-acetylphenyl)-1-piperazinyl]sulfonyl]-3,3-dichloro-1H-indol-2-one | aromatic ketone | ||
aspulvinone E | 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one : A member of the class of butenolides that is furan-2(5H)-one substituted by 4-hydroxyphenyl, hydroxy and 4-hydroxybenzylidene groups at positions 3, 4 and 5, respectively. aspulvinone E : A 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one in which the double bond adopts a Z-configuration. It is a marine metabolite isolated from the fungus Aspergillus terreus and exhibits antiviral activity. | 4-hydroxy-5-(4-hydroxybenzylidene)-3-(4-hydroxyphenyl)furan-2(5H)-one; aspulvinone | antiviral agent; Aspergillus metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; marine metabolite |
pinophilin b | pinophilin B: from cultures of a fungus (Penicillium pinophilum Hedgcok) derived from a seaweed; structure in first source |