| Assay ID | Title | Year | Journal | Article |
|---|
| AID401846 | Antitumor activity against human A549/ATCC cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID381380 | Inhibition of HIV1 reverse transcriptase assessed as enzyme residual activity at 0.12 mM | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID1170405 | Growth inhibition of p53 null,pRb+ human PC3 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1224752 | Delta TM value showing the stabilisation of CAMK2B produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID449703 | NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1224757 | Delta TM value showing the stabilisation of CDK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170409 | Growth inhibition of p53+, pRb+ human NCI-H460 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401847 | Antitumor activity against human EKVX cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1265403 | Thermodynamic aqueous solubility of the compound in stimulated intestinal fluid | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID325835 | Inhibition of CDK | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170390 | Binding affinity to human CDK9/cyclinT1 | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401898 | Antitumor activity against human T47D cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401874 | Antitumor activity against human UACC62 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID460277 | Antiparasitic activity against Plasmodium falciparum K1 | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation. |
| AID401609 | Antitumor activity against human MOLT4 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID449706 | NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compound showed > 50% inhibition/induction, expressed as a percentage of the number of assays in which the compound was tested. | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID401880 | Antitumor activity against human SKOV3 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1170406 | Growth inhibition of p53His273 mut, pRb+ human MiaPaCa cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1224751 | Delta TM value showing the stabilisation of CAMK2A produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401890 | Antitumor activity against human DU145 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1265389 | Induction of P-glycoprotein in human LS180 cells assessed as accumulation of intracellular rhodamine-123 at 1 uM after 48 hrs by fluorescence assay relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID1224774 | Delta TM value showing the stabilisation of p38beta produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401872 | Antitumor activity against human SK-MEL-5 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224788 | Delta TM value showing the stabilisation of PIM3 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401888 | Antitumor activity against human UO31 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224783 | Delta TM value showing the stabilisation of PAK6 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170411 | Growth inhibition of p53 null, pRb null human NCI-H358 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1224800 | Delta TM value showing the stabilisation of MST4 (2) produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170387 | Binding affinity to human CDK2/cyclinA using GST-pRB152 as substrate by chemiluminescence assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401851 | Antitumor activity against human NCI-H23 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401881 | Antitumor activity against human 786-O cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224799 | Delta TM value showing the stabilisation of NDR1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170386 | Binding affinity to human CDK4/cyclinD1 using GST-pRB152 as substrate by chemiluminescence assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1277181 | Inhibition of CDK4/Cyclin D (unknown origin) expressed in baculovirus infected insect Sf9 cells using human pRB as substrate in presence of [gamma-32P]ATP | 2016 | European journal of medicinal chemistry, Jan-27, Volume: 108 | Synthesis, biological evaluation and molecular modeling of a novel series of 7-azaindole based tri-heterocyclic compounds as potent CDK2/Cyclin E inhibitors. |
| AID401882 | Antitumor activity against human A498 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID628233 | Cytotoxicity against rat L6 cells | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID1224777 | Delta TM value showing the stabilisation of MST4(1) produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID381379 | Inhibition of p56 LCK activity at 0.7 mM | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID401860 | Antitumor activity against human KM12 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401610 | Antitumor activity against human RPMI8226 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401875 | Antitumor activity against human IGROV1 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401605 | Cytotoxicity against human CEM cells at 0.4 ug/disk by disk diffusion soft agar colony formation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401886 | Antitumor activity against human SN12C cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID378670 | Inhibition of CDK4 | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1
| A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. |
| AID401863 | Antitumor activity against human SF295 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID381386 | Cytotoxicity against rat L6 cells | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID1900950 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as reduction in bacterial counts at 2X MIC within 0.5 hrs by time-kill kinetic assay | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID381375 | Antibacterial activity against Bacillus megaterium at 50 ug by agar diffusion assay | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID1224786 | Delta TM value showing the stabilisation of PIM1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401865 | Antitumor activity against human SNB19 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224784 | Delta TM value showing the stabilisation of PCTK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401871 | Antitumor activity against human SK-MEL-28 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID460284 | Selectivity ratio of IC50 for rat L6 cells to IC50 for Plasmodium falciparum K1 | 2010 | Bioorganic & medicinal chemistry, Feb-15, Volume: 18, Issue:4
| Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation. |
| AID1265400 | Thermodynamic aqueous solubility of the compound in water | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID401894 | Antitumor activity against human Hs 578T cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224796 | Delta TM value showing the stabilisation of LOK produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401859 | Antitumor activity against human HT-29 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401884 | Antitumor activity against human Caki1 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1170413 | Growth inhibition of mouse BNL-SVA.8 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1265394 | Induction of P-glycoprotein in human LS180 cells assessed as accumulation of intracellular rhodamine-123 at 250 nM after 48 hrs by fluorescence assay relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID431535 | Inhibition of human CDK4/ Cyclin D1 catalytic subunit expressed in Sf9 insect cells assessed as GST-RB152 fusion protein phosphorylation-associated depletion in ATP level by luminescence assay | 2009 | Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
| Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1. |
| AID401607 | Antitumor activity against human HL-60(TB) cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID628228 | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of ring-stage parasite growth after 48 hrs | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID401889 | Antitumor activity against human PC3 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224806 | Delta TM value showing the stabilisation of VRK3 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401855 | Antitumor activity against human COLO205 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224761 | Delta TM value showing the stabilisation of CLK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401611 | Antitumor activity against human SR cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224764 | Delta TM value showing the stabilisation of CK1G1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1900980 | Cmax in rat plasma at 3 mg/kg, iv | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID1224775 | Delta TM value showing the stabilisation of ERK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224770 | Delta TM value showing the stabilisation of JAK1~B produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401601 | Cytotoxicity against mouse C38 cells at 0.4 ug/disk by disk diffusion soft agar colony formation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1900954 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as inhibition of bacterial regrowth at 2X MIC after 24 hrs by time-kill kinetic assay | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID1224755 | Delta TM value showing the stabilisation of CAMK4 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401858 | Antitumor activity against human HCT15 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401600 | Cytotoxicity against mouse L1210 cells at 0.4 ug/disk by disk diffusion soft agar colony formation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1900948 | Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 4330 after 16 to 18 hrs by microbroth dilution method | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID401861 | Antitumor activity against human SW620 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401892 | Antitumor activity against ADF-resistant human MCF7 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224798 | Delta TM value showing the stabilisation of DRAK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401850 | Antitumor activity against human NCI-H226 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224779 | Delta TM value showing the stabilisation of NEK6 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID449705 | NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1170388 | Binding affinity to human CDK2/cyclinE | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401877 | Antitumor activity against human OVCAR4 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID365672 | Inhibition of human CDK2/GST-cyclin A expressed in Sf9 cells assessed as histone phosphorylation | 2008 | Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
| Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. |
| AID1224789 | Delta TM value showing the stabilisation of PLK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401873 | Antitumor activity against human UACC257 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1265398 | Induction of P-glycoprotein expression in human LS180 cells at 1 uM by Western blot analysis relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID1224756 | Delta TM value showing the stabilisation of CAMKK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224787 | Delta TM value showing the stabilisation of PIM2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224768 | Delta TM value showing the stabilisation of DMPK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224758 | Delta TM value showing the stabilisation of CDK6 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401896 | Antitumor activity against human MDA-N cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401897 | Antitumor activity against human BT549 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224795 | Delta TM value showing the stabilisation of SLK produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401895 | Antitumor activity against human MDA-MB-435 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID449704 | NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay | 2008 | Proceedings of the National Academy of Sciences of the United States of America, Jul-01, Volume: 105, Issue:26
| In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. |
| AID1224790 | Delta TM value showing the stabilisation of PLK4 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401868 | Antitumor activity against human LOXIMVI cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID381378 | Inhibition of HIV1 recombinant reverse transcriptase | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID325558 | Inhibition of tyrosine kinase | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224749 | Delta TM value showing the stabilisation of CAMK1D produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401891 | Antitumor activity against human MCF7 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401876 | Antitumor activity against human OVCAR-3 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID381385 | Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID1224792 | Delta TM value showing the stabilisation of RIOK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224772 | Delta TM value showing the stabilisation of MAP2K6 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224794 | Delta TM value showing the stabilisation of RSK2b produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401848 | Antitumor activity against human HOP62 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224803 | Delta TM value showing the stabilisation of PBK produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID381381 | Antitrypanosomal activity against Trypanosoma brucei subsp. rhodesiense | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID401602 | Cytotoxicity against mouse CFU-GM cells at 0.4 ug/disk by disk diffusion soft agar colony formation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1170404 | Growth inhibition of p53+, pRb+ human LS 174T cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID378672 | Inhibition of CDK6 | 2006 | Journal of natural products, Jan, Volume: 69, Issue:1
| A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. |
| AID381382 | Antiviral activity against HAV cytHB1.1 in FRhK4 cells assessed as effect on cytopathogenic effect at 0.038 ug/mL after 21 days by immunofluorescence analysis | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID1224750 | Delta TM value showing the stabilisation of CAMK1G produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224802 | Delta TM value showing the stabilisation of TNIK produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224762 | Delta TM value showing the stabilisation of CLK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401879 | Antitumor activity against human OVCAR8 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401885 | Antitumor activity against human RXF393 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224759 | Delta TM value showing the stabilisation of CDKL1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401862 | Antitumor activity against human SF268 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224769 | Delta TM value showing the stabilisation of GSK3B produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224776 | Delta TM value showing the stabilisation of ERK3 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224807 | Delta TM value showing the stabilisation of YSK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1265396 | Cytotoxicity against HGF cells assessed as cell viability after 48 hrs by MTT assay | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID1265401 | Thermodynamic aqueous solubility of the compound in phosphate buffer saline | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID381383 | Antiviral activity against HAV 7 in FRhK4 cells assessed as effect on cytopathogenic effect at 0.038 ug/mL after 21 days by immunofluorescence analysis | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID1224748 | Delta TM value showing the stabilisation of AMPKA2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170389 | Binding affinity to human CDK1/cyclinB1 | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1224782 | Delta TM value showing the stabilisation of PAK5 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224766 | Delta TM value showing the stabilisation of CK1G3 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID628226 | Antimalarial activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID401606 | Antitumor activity against human CCRF-CEM cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1170410 | Growth inhibition of p53 null, pRb+ human NCI-H1299 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1224785 | Delta TM value showing the stabilisation of PDK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID381384 | Antiplasmodial activity against chloroquine, pyrimethamine-resistant Plasmodium falciparum K1 | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID401608 | Antitumor activity against human K562 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224767 | Delta TM value showing the stabilisation of DAPK3 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1170408 | Growth inhibition of p53 null, pRb+ human Calu1 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401857 | Antitumor activity against human HCT116 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1170412 | Growth inhibition of mouse BNL-CL2 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401854 | Antitumor activity against human NCI-H522 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224754 | Delta TM value showing the stabilisation of CAMK2G produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID325556 | Inhibition of Cdk/cyclin D1 | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401856 | Antitumor activity against human HCC2998 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID325557 | Inhibition of Cdk6/cyclin D1 | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224771 | Delta TM value showing the stabilisation of MEK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401878 | Antitumor activity against human OVCAR5 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224753 | Delta TM value showing the stabilisation of CAMK2D produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224793 | Delta TM value showing the stabilisation of RSK2a produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401887 | Antitumor activity against human TK10 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1900981 | Cmax in rat plasma at 15 mg/kg, IG | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID1224780 | Delta TM value showing the stabilisation of OSR1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224781 | Delta TM value showing the stabilisation of PAK4 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID628230 | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of schizonts growth after 48 hrs | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID1900952 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as reduction in bacterial counts at 1 to 4X MIC within 24 hrs by time-kill kinetic assay | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID1265402 | Thermodynamic aqueous solubility of the compound in stimulated gastric fluid | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID401853 | Antitumor activity against human NCI-H460 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1900949 | Stability in plasma (unknown origin) | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID1265404 | Inhibition of CDK4 (unknown origin) | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID1900951 | Bactericidal activity against methicillin-resistant Staphylococcus aureus ATCC 4330 assessed as reduction in bacterial counts at 4X MIC by time-kill kinetic assay | 2022 | European journal of medicinal chemistry, Feb-15, Volume: 230 | Fascaplysin derivatives binding to DNA via unique cationic five-ring coplanar backbone showed potent antimicrobial/antibiofilm activity against MRSA in vitro and in vivo. |
| AID1224791 | Delta TM value showing the stabilisation of PRKACA produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID365673 | Inhibition of human CDK4/GST-cyclin D1 expressed in Sf9 cells assessed as retinoblastoma GST-RB152 phosphorylation | 2008 | Bioorganic & medicinal chemistry, Aug-15, Volume: 16, Issue:16
| Design, synthesis and biological evaluation of new tryptamine and tetrahydro-beta-carboline-based selective inhibitors of CDK4. |
| AID1265393 | Induction of P-glycoprotein in human LS180 cells assessed as accumulation of intracellular rhodamine-123 at 62.5 nM after 48 hrs by fluorescence assay relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID1224805 | Delta TM value showing the stabilisation of VRK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401893 | Antitumor activity against human MDA-MB-231 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401864 | Antitumor activity against human SF539 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID628234 | Ratio of MIC for rat L6 cells to MIC for chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID1170377 | Displacement of ethidium bromide from closed circular plasmid DNA (unknown origin) by fluorescence quenching assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID1265395 | Induction of P-glycoprotein in human LS180 cells assessed as accumulation of intracellular rhodamine-123 at 500 nM after 48 hrs by fluorescence assay relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID628229 | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of trophozoites growth after 48 hrs | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID401852 | Antitumor activity against human NCI-H322M cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224804 | Delta TM value showing the stabilisation of VRK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224763 | Delta TM value showing the stabilisation of CLK3 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID381374 | Antibacterial activity against Escherichia coli at 50 ug by agar diffusion assay | 2000 | Journal of natural products, Jun, Volume: 63, Issue:6
| A new bioactive sesterterpene and antiplasmodial alkaloids from the marine sponge hyrtios cf. erecta. |
| AID431536 | Inhibition of human CDK2/ Cyclin A catalytic subunit expressed in Sf9 insect cells assessed as histone H1 phosphorylation-associated depletion in ATP level by luminescence assay | 2009 | Bioorganic & medicinal chemistry, Aug-15, Volume: 17, Issue:16
| Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1. |
| AID401603 | Cytotoxicity against human H116 cells at 0.4 ug/disk by disk diffusion soft agar colony formation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401870 | Antitumor activity against human M14 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224778 | Delta TM value showing the stabilisation of NEK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401866 | Antitumor activity against human SNB75 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224797 | Delta TM value showing the stabilisation of MPSK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID628227 | Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes after 48 hrs | 2011 | Bioorganic & medicinal chemistry, Nov-15, Volume: 19, Issue:22
| 3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian. |
| AID1265392 | Induction of P-glycoprotein in human LS180 cells assessed as accumulation of intracellular rhodamine-123 at 125 nM after 48 hrs by fluorescence assay relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID401867 | Antitumor activity against human U251 cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1170407 | Growth inhibition of p53+, pRb+ human A549 cells after 48 hrs by MTT assay | 2014 | Journal of medicinal chemistry, Nov-26, Volume: 57, Issue:22
| Biphenyl-4-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-methylamide (CA224), a nonplanar analogue of fascaplysin, inhibits Cdk4 and tubulin polymerization: evaluation of in vitro and in vivo anticancer activity. |
| AID401869 | Antitumor activity against human MALME-3M cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID401883 | Antitumor activity against human ACHN cells | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224773 | Delta TM value showing the stabilisation of ASK1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID401604 | Cytotoxicity against human H125 cells at 0.4 ug/disk by disk diffusion soft agar colony formation assay | 2004 | Journal of natural products, May, Volume: 67, Issue:5
| Comparison of fascaplysin and related alkaloids: a study of structures, cytotoxicities, and sources. |
| AID1224765 | Delta TM value showing the stabilisation of CK1G2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1265397 | Cytotoxicity against human LS180 cells assessed as cell viability at 10 uM after 48 hrs by MTT assay relative to control | 2016 | European journal of medicinal chemistry, Jan-01, Volume: 107 | Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. |
| AID1224760 | Delta TM value showing the stabilisation of CHEK2 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| AID1224801 | Delta TM value showing the stabilisation of MST1 produced by compound binding | 2007 | Proceedings of the National Academy of Sciences of the United States of America, Dec-18, Volume: 104, Issue:51
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |