| Assay ID | Title | Year | Journal | Article |
|---|
| AID1890839 | Antimycobacterial activity against Mycobacterium tuberculosis mc2 6230 assessed as inhibition of mycobacterial growth incubated for 10 to 14 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID732151 | Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID1189850 | Cytotoxicity against human HuH7 cells assessed as inhibition of cell viability after 3 days by CellTiter 96 assay | 2015 | Journal of medicinal chemistry, Jan-22, Volume: 58, Issue:2
| Hydroxamic acids block replication of hepatitis C virus. |
| AID1890838 | Antimycobacterial activity against Mycobacterium marinum ATCC BAA-535/M assessed as inhibition of mycobacterial growth incubated for 10 to 14 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID440465 | Stability in potassium phosphate buffer at pH 7.4 | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Hydroxamates: relationships between structure and plasma stability. |
| AID1890837 | Antimycobacterial activity against Mycobacterium abscessus CIP104536T with rough morphotype assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID1890836 | Antimycobacterial activity against Mycobacterium abscessus CIP104536T with smooth morphotype assessed as inhibition of mycobacterial growth incubated for 3 to 5 days by resazurin microtiter assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID1633989 | Inhibition of HDAC1 in human HuH7 cells assessed as increase in histone H3 K9/K14 acetylation at varying concentrations incubated for 24 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID1633991 | Inhibition of HDAC3 in human HuH7 cells assessed as increase in histone H3 K9/K14acetylation at varying concentrations incubated for 24 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID446324 | Inhibition of human HDAC extracted from human HeLa cells at 10 uM | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. |
| AID1633994 | Cytotoxicity against human HuH7 cells assessed as reduction in cell viability incubated for 3 days by MTT assay | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID1189854 | Therapeutic index, ratio of CC50 for human HuH7 cells to EC50 for HCV genotype 1b infected in human Huh7 cells | 2015 | Journal of medicinal chemistry, Jan-22, Volume: 58, Issue:2
| Hydroxamic acids block replication of hepatitis C virus. |
| AID156319 | Inhibitory activity against PC-3 cell line | 2004 | Bioorganic & medicinal chemistry letters, Feb-09, Volume: 14, Issue:3
| QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids. |
| AID1439830 | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation at 10 uM after 48 hrs in presence of salinomycin by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
| Synthesis and biological activity of salinomycin-hydroxamic acid conjugates. |
| AID1633992 | Inhibition of HDAC6 in human HuH7 cells assessed as increase in alpha-tubulin K40 acetylation at varying concentrations incubated for 24 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID1633995 | Therapeutic index, ratio of CC50 for human HuH7 cells to EC50 for antiviral activity against HCV infected in human HuH7-luc/neo cells assessed as inhibition of DNA replication i | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID1890840 | Cytotoxicity against C57BL/6 mouse BMDM cells assessed as reduction in cell viability measured after 24 hrs by resazurin dye based assay | 2022 | Bioorganic & medicinal chemistry letters, 05-15, Volume: 64 | Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives. |
| AID1439831 | Cytotoxicity against human MDA-MB-231 cells assessed as decrease in cell proliferation after 48 hrs in presence of salinomycin by MTT assay | 2017 | Bioorganic & medicinal chemistry letters, 04-01, Volume: 27, Issue:7
| Synthesis and biological activity of salinomycin-hydroxamic acid conjugates. |
| AID440466 | Metabolic stability in Sprague-Dawley rat plasma at 10 uM by LC-MS/MS analysis | 2009 | Journal of medicinal chemistry, Nov-12, Volume: 52, Issue:21
| Hydroxamates: relationships between structure and plasma stability. |
| AID732152 | Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID7184 | In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1) | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. |
| AID1189851 | Antiviral activity against HCV genotype 1b infected in human Huh7 cells after 3 days by luciferase reporter gene assay | 2015 | Journal of medicinal chemistry, Jan-22, Volume: 58, Issue:2
| Hydroxamic acids block replication of hepatitis C virus. |
| AID446323 | Inhibition of human HDAC extracted from human HeLa cells at 1 uM | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. |
| AID1633990 | Inhibition of HDAC2 in human HuH7 cells assessed as increase in histone H3 K9/K14 acetylation at varying concentrations incubated for 24 hrs by Western blot analysis | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID6809 | In vitro inhibitory activity against RBL-1 5-LO | 1987 | Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
| Hydroxamic acid inhibitors of 5-lipoxygenase. |
| AID446322 | Inhibition of human HDAC extracted from human HeLa cells at 0.1 uM | 2010 | Journal of medicinal chemistry, Jan-28, Volume: 53, Issue:2
| Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. |
| AID7185 | Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1) | 1990 | Journal of medicinal chemistry, Mar, Volume: 33, Issue:3
| Hydroxamic acid inhibitors of 5-lipoxygenase: quantitative structure-activity relationships. |
| AID1633993 | Antiviral activity against HCV infected in human HuH7-luc/neo cells assessed as inhibition of DNA replication incubated for 3 days by luciferase reporter gene assay | 2019 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 29, Issue:16
| Synthesis of N'-propylhydrazide analogs of hydroxamic inhibitors of histone deacetylases (HDACs) and evaluation of their impact on activities of HDACs and replication of hepatitis C virus (HCV). |
| AID732153 | Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| AID732154 | Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfluidic lab-on-a-chip assay | 2013 | Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4
| Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |