Page last updated: 2024-12-11

Norartocarpetin

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Cross-References

ID SourceID
PubMed CID5481970
CHEMBL ID463145
CHEBI ID174716
SCHEMBL ID1546435

Synonyms (26)

Synonym
2-(2,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
CHEBI:174716
520-30-9
norartocarpetin
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-chromen-4-one
2-(2,4-dihydroxy-phenyl)-5,7-dihydroxy-1-benzopyran-4-one
bdbm50269559
norartocarpetin, 5
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4h-chromen-4-one
CHEMBL463145 ,
LMPK12110941
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4h-1-benzopyran-4-one
unii-l2y5rsy4bm
4h-1-benzopyran-4-one, 2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-
l2y5rsy4bm ,
AKOS015906501
SCHEMBL1546435
5,7,2',4'-tetrahydroxyflavone
DTXSID00199963
2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4h-1-benzopyran-4-one, 9ci
Q15425765
MS-24075
CS-0608332
HY-N10503
2-(2,4-bis(oxidanyl)phenyl)-5,7-bis(oxidanyl)chromen-4-one
2',4',5,7-tetrahydroxyflavone
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
flavonesA member of the class of flavonoid with a 2-aryl-1-benzopyran-4-one (2-arylchromen-4-one) skeleton and its substituted derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (11)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Phosphotyrosine protein phosphatase Mycobacterium tuberculosisIC50 (µMol)1.20111.20005.04898.5114AID1402907
Polyphenol oxidase 2Agaricus bisporusIC50 (µMol)167.06670.03403.987110.0000AID1799721; AID730305
Polyphenol oxidase 2Agaricus bisporusKi0.00060.00063.28838.8900AID1799721
Pancreatic triacylglycerol lipaseSus scrofa (pig)IC50 (µMol)70.00000.00401.10246.5000AID1204217
TyrosinaseHomo sapiens (human)IC50 (µMol)0.02300.02304.459310.0000AID1504875
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)5.18000.00053.49849.7600AID1402909
Prostaglandin G/H synthase 1Homo sapiens (human)IC50 (µMol)14.00000.00021.557410.0000AID332217
Prostaglandin G/H synthase 2Homo sapiens (human)IC50 (µMol)100.00000.00010.995010.0000AID332218
Beta-secretase 1Homo sapiens (human)IC50 (µMol)60.60000.00061.619410.0000AID593981
Beta-secretase 1Homo sapiens (human)Ki82.60000.00031.35248.0000AID593982
Low molecular weight protein-tyrosine phosphatase AMycobacterium tuberculosis H37RvIC50 (µMol)11.97002.74005.39678.8000AID1402908
Tyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)IC50 (µMol)30.29001.10004.69009.5400AID1402911
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (148)

Processvia Protein(s)Taxonomy
melanin biosynthetic process from tyrosineTyrosinaseHomo sapiens (human)
eye pigment biosynthetic processTyrosinaseHomo sapiens (human)
visual perceptionTyrosinaseHomo sapiens (human)
cell population proliferationTyrosinaseHomo sapiens (human)
response to UVTyrosinaseHomo sapiens (human)
response to blue lightTyrosinaseHomo sapiens (human)
response to vitamin DTyrosinaseHomo sapiens (human)
melanin biosynthetic processTyrosinaseHomo sapiens (human)
thymus developmentTyrosinaseHomo sapiens (human)
response to cAMPTyrosinaseHomo sapiens (human)
pigmentationTyrosinaseHomo sapiens (human)
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
prostaglandin biosynthetic processProstaglandin G/H synthase 1Homo sapiens (human)
response to oxidative stressProstaglandin G/H synthase 1Homo sapiens (human)
regulation of blood pressureProstaglandin G/H synthase 1Homo sapiens (human)
cyclooxygenase pathwayProstaglandin G/H synthase 1Homo sapiens (human)
regulation of cell population proliferationProstaglandin G/H synthase 1Homo sapiens (human)
cellular oxidant detoxificationProstaglandin G/H synthase 1Homo sapiens (human)
prostaglandin biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
angiogenesisProstaglandin G/H synthase 2Homo sapiens (human)
response to oxidative stressProstaglandin G/H synthase 2Homo sapiens (human)
embryo implantationProstaglandin G/H synthase 2Homo sapiens (human)
learningProstaglandin G/H synthase 2Homo sapiens (human)
memoryProstaglandin G/H synthase 2Homo sapiens (human)
regulation of blood pressureProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of cell population proliferationProstaglandin G/H synthase 2Homo sapiens (human)
response to xenobiotic stimulusProstaglandin G/H synthase 2Homo sapiens (human)
response to nematodeProstaglandin G/H synthase 2Homo sapiens (human)
response to fructoseProstaglandin G/H synthase 2Homo sapiens (human)
response to manganese ionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of vascular endothelial growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
cyclooxygenase pathwayProstaglandin G/H synthase 2Homo sapiens (human)
bone mineralizationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of prostaglandin biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of fever generationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of synaptic plasticityProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of synaptic transmission, dopaminergicProstaglandin G/H synthase 2Homo sapiens (human)
prostaglandin secretionProstaglandin G/H synthase 2Homo sapiens (human)
response to estradiolProstaglandin G/H synthase 2Homo sapiens (human)
response to lipopolysaccharideProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of peptidyl-serine phosphorylationProstaglandin G/H synthase 2Homo sapiens (human)
response to vitamin DProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to heatProstaglandin G/H synthase 2Homo sapiens (human)
response to tumor necrosis factorProstaglandin G/H synthase 2Homo sapiens (human)
maintenance of blood-brain barrierProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of protein import into nucleusProstaglandin G/H synthase 2Homo sapiens (human)
hair cycleProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of apoptotic processProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of nitric oxide biosynthetic processProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of cell cycleProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of vasoconstrictionProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of smooth muscle contractionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of smooth muscle contractionProstaglandin G/H synthase 2Homo sapiens (human)
decidualizationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of smooth muscle cell proliferationProstaglandin G/H synthase 2Homo sapiens (human)
regulation of inflammatory responseProstaglandin G/H synthase 2Homo sapiens (human)
brown fat cell differentiationProstaglandin G/H synthase 2Homo sapiens (human)
response to glucocorticoidProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of calcium ion transportProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of synaptic transmission, glutamatergicProstaglandin G/H synthase 2Homo sapiens (human)
response to fatty acidProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to mechanical stimulusProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to lead ionProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to ATPProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to hypoxiaProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to non-ionic osmotic stressProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to fluid shear stressProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of transforming growth factor beta productionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of cell migration involved in sprouting angiogenesisProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of fibroblast growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of brown fat cell differentiationProstaglandin G/H synthase 2Homo sapiens (human)
positive regulation of platelet-derived growth factor productionProstaglandin G/H synthase 2Homo sapiens (human)
cellular oxidant detoxificationProstaglandin G/H synthase 2Homo sapiens (human)
regulation of neuroinflammatory responseProstaglandin G/H synthase 2Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stressProstaglandin G/H synthase 2Homo sapiens (human)
cellular response to homocysteineProstaglandin G/H synthase 2Homo sapiens (human)
response to angiotensinProstaglandin G/H synthase 2Homo sapiens (human)
proteolysisBeta-secretase 1Homo sapiens (human)
membrane protein ectodomain proteolysisBeta-secretase 1Homo sapiens (human)
response to lead ionBeta-secretase 1Homo sapiens (human)
protein processingBeta-secretase 1Homo sapiens (human)
amyloid-beta formationBeta-secretase 1Homo sapiens (human)
amyloid precursor protein catabolic processBeta-secretase 1Homo sapiens (human)
positive regulation of neuron apoptotic processBeta-secretase 1Homo sapiens (human)
amyloid-beta metabolic processBeta-secretase 1Homo sapiens (human)
detection of mechanical stimulus involved in sensory perception of painBeta-secretase 1Homo sapiens (human)
prepulse inhibitionBeta-secretase 1Homo sapiens (human)
cellular response to copper ionBeta-secretase 1Homo sapiens (human)
cellular response to manganese ionBeta-secretase 1Homo sapiens (human)
presynaptic modulation of chemical synaptic transmissionBeta-secretase 1Homo sapiens (human)
signaling receptor ligand precursor processingBeta-secretase 1Homo sapiens (human)
cellular response to amyloid-betaBeta-secretase 1Homo sapiens (human)
amyloid fibril formationBeta-secretase 1Homo sapiens (human)
symbiont-mediated suppression of host apoptosisLow molecular weight protein-tyrosine phosphatase AMycobacterium tuberculosis H37Rv
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
regulation of epidermal growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
tissue regenerationTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
cellular response to epidermal growth factor stimulusTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
negative regulation of ERBB signaling pathwayTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
negative regulation of platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
lipid metabolic processTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
autophagyTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of autophagyTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of gene expressionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of gene expressionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
T cell differentiationTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
lipopolysaccharide-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of type I interferon productionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
response to lipopolysaccharideTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of interleukin-6 productionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of interleukin-8 productionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of tumor necrosis factor productionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of type II interferon productionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
regulation of natural killer cell proliferationTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of toll-like receptor 3 signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of toll-like receptor 4 signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
phosphoanandamide dephosphorylationTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
regulation of innate immune responseTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
regulation of B cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of T cell receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of T cell activationTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathwayTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
cellular response to muramyl dipeptideTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of NLRP3 inflammasome complex assemblyTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
regulation of non-canonical NF-kappaB signal transductionTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
positive regulation of protein K63-linked ubiquitinationTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
negative regulation of p38MAPK cascadeTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (32)

Processvia Protein(s)Taxonomy
tyrosinase activityTyrosinaseHomo sapiens (human)
copper ion bindingTyrosinaseHomo sapiens (human)
protein bindingTyrosinaseHomo sapiens (human)
identical protein bindingTyrosinaseHomo sapiens (human)
protein homodimerization activityTyrosinaseHomo sapiens (human)
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peroxidase activityProstaglandin G/H synthase 1Homo sapiens (human)
prostaglandin-endoperoxide synthase activityProstaglandin G/H synthase 1Homo sapiens (human)
protein bindingProstaglandin G/H synthase 1Homo sapiens (human)
heme bindingProstaglandin G/H synthase 1Homo sapiens (human)
metal ion bindingProstaglandin G/H synthase 1Homo sapiens (human)
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenProstaglandin G/H synthase 1Homo sapiens (human)
peroxidase activityProstaglandin G/H synthase 2Homo sapiens (human)
prostaglandin-endoperoxide synthase activityProstaglandin G/H synthase 2Homo sapiens (human)
protein bindingProstaglandin G/H synthase 2Homo sapiens (human)
enzyme bindingProstaglandin G/H synthase 2Homo sapiens (human)
heme bindingProstaglandin G/H synthase 2Homo sapiens (human)
protein homodimerization activityProstaglandin G/H synthase 2Homo sapiens (human)
metal ion bindingProstaglandin G/H synthase 2Homo sapiens (human)
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenProstaglandin G/H synthase 2Homo sapiens (human)
amyloid-beta bindingBeta-secretase 1Homo sapiens (human)
endopeptidase activityBeta-secretase 1Homo sapiens (human)
aspartic-type endopeptidase activityBeta-secretase 1Homo sapiens (human)
protein bindingBeta-secretase 1Homo sapiens (human)
peptidase activityBeta-secretase 1Homo sapiens (human)
beta-aspartyl-peptidase activityBeta-secretase 1Homo sapiens (human)
enzyme bindingBeta-secretase 1Homo sapiens (human)
protein serine/threonine kinase bindingBeta-secretase 1Homo sapiens (human)
protein tyrosine phosphatase activityLow molecular weight protein-tyrosine phosphatase AMycobacterium tuberculosis H37Rv
phosphoprotein phosphatase activityTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
SH3 domain bindingTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
phosphatase activityTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
SH3 domain bindingTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
kinase bindingTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
ubiquitin protein ligase bindingTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (47)

Processvia Protein(s)Taxonomy
cytoplasmTyrosinaseHomo sapiens (human)
lysosomeTyrosinaseHomo sapiens (human)
Golgi-associated vesicleTyrosinaseHomo sapiens (human)
melanosome membraneTyrosinaseHomo sapiens (human)
melanosomeTyrosinaseHomo sapiens (human)
intracellular membrane-bounded organelleTyrosinaseHomo sapiens (human)
perinuclear region of cytoplasmTyrosinaseHomo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
photoreceptor outer segmentProstaglandin G/H synthase 1Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 1Homo sapiens (human)
endoplasmic reticulum membraneProstaglandin G/H synthase 1Homo sapiens (human)
Golgi apparatusProstaglandin G/H synthase 1Homo sapiens (human)
intracellular membrane-bounded organelleProstaglandin G/H synthase 1Homo sapiens (human)
extracellular exosomeProstaglandin G/H synthase 1Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 1Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 1Homo sapiens (human)
nuclear inner membraneProstaglandin G/H synthase 2Homo sapiens (human)
nuclear outer membraneProstaglandin G/H synthase 2Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulumProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulum lumenProstaglandin G/H synthase 2Homo sapiens (human)
endoplasmic reticulum membraneProstaglandin G/H synthase 2Homo sapiens (human)
caveolaProstaglandin G/H synthase 2Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 2Homo sapiens (human)
protein-containing complexProstaglandin G/H synthase 2Homo sapiens (human)
neuron projectionProstaglandin G/H synthase 2Homo sapiens (human)
cytoplasmProstaglandin G/H synthase 2Homo sapiens (human)
lysosomeBeta-secretase 1Homo sapiens (human)
endosomeBeta-secretase 1Homo sapiens (human)
early endosomeBeta-secretase 1Homo sapiens (human)
late endosomeBeta-secretase 1Homo sapiens (human)
multivesicular bodyBeta-secretase 1Homo sapiens (human)
endoplasmic reticulum lumenBeta-secretase 1Homo sapiens (human)
Golgi apparatusBeta-secretase 1Homo sapiens (human)
trans-Golgi networkBeta-secretase 1Homo sapiens (human)
plasma membraneBeta-secretase 1Homo sapiens (human)
synaptic vesicleBeta-secretase 1Homo sapiens (human)
cell surfaceBeta-secretase 1Homo sapiens (human)
endosome membraneBeta-secretase 1Homo sapiens (human)
membraneBeta-secretase 1Homo sapiens (human)
axonBeta-secretase 1Homo sapiens (human)
dendriteBeta-secretase 1Homo sapiens (human)
neuronal cell bodyBeta-secretase 1Homo sapiens (human)
membrane raftBeta-secretase 1Homo sapiens (human)
recycling endosomeBeta-secretase 1Homo sapiens (human)
Golgi-associated vesicle lumenBeta-secretase 1Homo sapiens (human)
hippocampal mossy fiber to CA3 synapseBeta-secretase 1Homo sapiens (human)
endosomeBeta-secretase 1Homo sapiens (human)
plasma membraneBeta-secretase 1Homo sapiens (human)
trans-Golgi networkBeta-secretase 1Homo sapiens (human)
cytosolLow molecular weight protein-tyrosine phosphatase AMycobacterium tuberculosis H37Rv
podosomeTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
nucleoplasmTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
focal adhesionTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
cell projectionTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 12Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
cytoplasmic side of plasma membraneTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
perinuclear region of cytoplasmTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
nucleusTyrosine-protein phosphatase non-receptor type 22Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (24)

Assay IDTitleYearJournalArticle
AID1204217Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol preincubated for 15 mins followed by substrate addition measured after 15 mins2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.
AID1402907Inhibition of Mycobacterium tuberculosis PtpB using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1402912Selectivity index, ratio of IC50 for LYP (unknown origin) to IC50 for Mycobacterium tuberculosis PtpB2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID448783Noncompetitive inhibition of Clostridium welchii neuraminidase by Dixon plot2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition.
AID593982Noncompetitive inhibition of human recombinant BACE-1 by Dixon plot analysis2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1).
AID1607865Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production2019European journal of medicinal chemistry, Oct-01, Volume: 179Human disorders associated with inflammation and the evolving role of natural products to overcome.
AID1204216Inhibition of porcine pancreatic lipase using p-nitrophenylbutyrate as substrate assessed as formation of p-nitrophenol at 100 uM preincubated for 15 mins followed by substrate addition measured after 15 mins relative to control2015Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11
Pancreatic lipase inhibitory constituents from Morus alba leaves and optimization for extraction conditions.
AID593981Inhibition of human recombinant BACE-1 expressed in HEK293 cells assessed as inhibition of amyloid precursor protein cleavage into amyloid beta after 60 mins using Rh-EVNLDAEFK-Quencher as a substrate by FRET assay2011Bioorganic & medicinal chemistry letters, May-15, Volume: 21, Issue:10
Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1).
AID730305Inhibition of mushroom tyrosinase assessed as reduction in diphenolase activity using L-DOPA substrate pre-incubated for 20 mins at 30 degC2013Bioorganic & medicinal chemistry, Apr-01, Volume: 21, Issue:7
Design and synthesis of 3,5-diaryl-4,5-dihydro-1H-pyrazoles as new tyrosinase inhibitors.
AID1402910Selectivity index, ratio of IC50 for human PTP1B to IC50 for Mycobacterium tuberculosis PtpB2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1402911Inhibition of LYP (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1402908Inhibition of Mycobacterium tuberculosis PtpA using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1504875Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measured for 7 mins by spectrophotometric analysis2017Journal of natural products, 12-22, Volume: 80, Issue:12
Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities.
AID448782Inhibition of Clostridium welchii neuraminidase2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
Structural characteristics of flavanones and flavones from Cudrania tricuspidata for neuraminidase inhibition.
AID1402914Selectivity index, ratio of IC50 for PTP-PEST (unknown origin) to IC50 for Mycobacterium tuberculosis PtpB2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1402906Selectivity index, ratio of IC50 for Mycobacterium tuberculosis PtpA to IC50 for Mycobacterium tuberculosis PtpB2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID332217Inhibition of COX12002Journal of natural products, Feb, Volume: 65, Issue:2
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
AID1402909Inhibition of human PTP1B using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1656446Inhibition of rat neutrophils beta-glucuronidase at 100 uM relative to control2020European journal of medicinal chemistry, Feb-01, Volume: 187Therapeutic significance of β-glucuronidase activity and its inhibitors: A review.
AID332219Inhibition of DMBA-induced preneoplastic lesions in mouse mammary gland organ culture at 10 ug/mL2002Journal of natural products, Feb, Volume: 65, Issue:2
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
AID1402913Inhibition of PTP-PEST (unknown origin) using p-nitrophenyl phosphate as substrate preincubated for 10 mins followed by substrate addition measured every minute for 10 mins by UV-VIS spectrophotometric analysis2018European journal of medicinal chemistry, Jan-20, Volume: 144Naturally occurring Diels-Alder-type adducts from Morus nigra as potent inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B.
AID1504877Potency index, ratio of kojic acid IC50 to compound IC50 for tyrosinase (unknown origin)2017Journal of natural products, 12-22, Volume: 80, Issue:12
Artocarmins G-M, Prenylated 4-Chromenones from the Stems of Artocarpus rigida and Their Tyrosinase Inhibitory Activities.
AID332218Inhibition of COX22002Journal of natural products, Feb, Volume: 65, Issue:2
Constituents of the bark and twigs of Artocarpus dadah with cyclooxygenase inhibitory activity.
AID1799721Tyrosinase Assay from Article 10.1080/14756360701810207: \\Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.\\2008Journal of enzyme inhibition and medicinal chemistry, Dec, Volume: 23, Issue:6
Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's6 (60.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.40 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.80 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]