| Assay ID | Title | Year | Journal | Article |
|---|
| AID1796579 | MAO A and MAO B Activity Measurements from Article 10.1021/jm0310885: \\Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues.\\ | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID1796508 | Cholinesterase Inhibition Assay from Article 10.1021/jm020120c: \\Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease.\\ | 2002 | Journal of medicinal chemistry, Nov-21, Volume: 45, Issue:24
| Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. |
| AID1657010 | Inhibition of equine serum butyrylcholinesterase using butyrylthiocholine as substrate preincubated for 60 mins followed by substrate addition by Ellman's method | 2020 | Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11
| Acetylene Group, Friend or Foe in Medicinal Chemistry. |
| AID1412306 | Inhibition of equine serum BuChE using S-butyrylthiocholine iodide as substrate pretreated for 10 mins followed by substrate addition and measured after 10 mins by Ellman's method | | | |
| AID1412307 | Selectivity index, ratio of IC50 for electric eel AChE to IC50 for equine serum BuChE | | | |
| AID1057004 | Inhibition of human recombinant MAO-A using p-tyramine as substrate assessed as formation of H2O2 at 100 uM preincubated for 15 mins under dark condition followed by substrate addition measured after 20 mins by fluorescence assay relative to control | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
| Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids. |
| AID125561 | Binding affinity towards monoamine oxidase A activity was measured using a kynuramine assay | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID1557446 | Invivo inhibition of MAO-B in po dosed rabbit brain relative to control | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. |
| AID1656476 | In-vivo inhibition of MAO B in rat brain at 26 mg/kg, po relative to control | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3
| Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
| AID1557443 | Invivo inhibition of AChE in po dosed rabbit brain relative to control | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. |
| AID126545 | Compound was evaluated for A 450 decay towards monoamine oxidase B enzyme; ND = not determined | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID126669 | Compound was evaluated for A 450 rise towards monoamine oxidase B enzyme; ND = not determined | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID126671 | Compound was evaluated for inactivation for monoamine oxidase B; ND = not determined | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID125567 | Compound was evaluated for A 450 decay towards monoamine oxidase A enzyme; ND = not determined | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID314095 | Inhibition of MAOB | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Multi-target-directed ligands to combat neurodegenerative diseases. |
| AID1657008 | Inhibition of human MAO-B | 2020 | Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11
| Acetylene Group, Friend or Foe in Medicinal Chemistry. |
| AID759445 | Inhibition of equine serum BuChE using butylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
| Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1412302 | Inhibition of human recombinant MAOA using kynuramine as substrate preincubated for 10 mins followed by substrate addition at 10 secs intervals measured after 20 mins by fluorescence assay | | | |
| AID706469 | Inhibition of human recombinant MAOA assessed as H2O2 production by Amplex Red reagent-based assay | 2012 | Journal of medicinal chemistry, Oct-11, Volume: 55, Issue:19
| Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease. |
| AID126542 | Binding affinity towards monoamine oxidase B activity was measured using a benzylamine assay | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID314091 | Inhibition of human AchE | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Multi-target-directed ligands to combat neurodegenerative diseases. |
| AID710228 | Cytotoxicity against rat H9c2 cells assessed as cell viability in absence of H2O2 | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
| Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID314094 | Inhibition of MAOA | 2008 | Journal of medicinal chemistry, Feb-14, Volume: 51, Issue:3
| Multi-target-directed ligands to combat neurodegenerative diseases. |
| AID1587206 | Inhibition of apoptosis in human SK-N-SH cells assessed as increase in cleaved caspase-3 by Western blot analysis | 2019 | European journal of medicinal chemistry, May-01, Volume: 169 | Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease. |
| AID126056 | Inhibitory concentration towards monoamine oxidase A in rat brain was measured | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID1412305 | Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 10 mins followed by substrate addition and measured after 10 mins by Ellman's method | | | |
| AID1657007 | Inhibition of human MAO-A | 2020 | Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11
| Acetylene Group, Friend or Foe in Medicinal Chemistry. |
| AID1525504 | Inhibition of AChE in human erythrocytes preincubated for 60 mins followed by substrate addition by Ellman's method | 2019 | Journal of medicinal chemistry, 10-24, Volume: 62, Issue:20
| Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms. |
| AID1057002 | Inhibition of human recombinant MAO-B using benzylamine as substrate preincubated for 15 mins under dark condition followed by substrate addition measured after 20 mins by fluorescence assay | 2013 | Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
| Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids. |
| AID1412303 | Inhibition of human recombinant MAOB using kynuramine as substrate preincubated for 10 mins followed by substrate addition at 10 secs intervals measured after 20 mins by fluorescence assay | | | |
| AID1656475 | In-vivo inhibition of MAO A in rat brain at 26 mg/kg, po relative to control | 2020 | Bioorganic & medicinal chemistry letters, 02-01, Volume: 30, Issue:3
| Propargylamine-derived multi-target directed ligands for Alzheimer's disease therapy. |
| AID710238 | Inhibition of bovine AChE after 120 mins by Ellman's method | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
| Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1545324 | In vivo inhibition of MAO-B in Sprague-Dawley rat at 26 mg/kg, po administered for 2 weeks by radioassay method relative to control | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID759444 | Inhibition of human recombinant MAOA using p-tyramine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluorescence plate reader analysis | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
| Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1557445 | Invivo inhibition of MAO-B in po dosed rat brain relative to control | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. |
| AID125571 | Compound was evaluated for inactivation for monoamine oxidase A; ND = not determined | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID710236 | Selectivity ratio of IC50 for equine BuChE to IC50 for bovine AChE | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
| Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1545325 | In vivo inhibition of MAO-A in Sprague-Dawley rat at 26 mg/kg, po administered for 2 weeks by radioassay method relative to control | 2019 | Bioorganic & medicinal chemistry, 03-15, Volume: 27, Issue:6
| Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
| AID710237 | Inhibition of equine BuChE after 120 mins by Ellman's method | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
| Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID125569 | Compound was evaluated for A 450 rise towards monoamine oxidase A enzyme; ND = not determined | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID710226 | Prevention of apoptosis in rat H9c2 cells assessed as protection against oxidative stress-induced cytotoxicity at 100 nM pM by Alamar blue assay | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
| Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID1412304 | Selectivity index, ratio of IC50 for human recombinant MAOA to IC50 for human recombinant MAOB | | | |
| AID759443 | Inhibition of human recombinant MAOB using benzylamine as substrate incubated for 15 mins prior to substrate addition measured after 20 mins by fluorescence plate reader analysis | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
| Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1657009 | Inhibition of human acetylcholinesterase using acetylthiocholine iodide as substrate preincubated for 60 mins followed by substrate addition by Ellman's method | 2020 | Journal of medicinal chemistry, 06-11, Volume: 63, Issue:11
| Acetylene Group, Friend or Foe in Medicinal Chemistry. |
| AID706470 | Inhibition of human recombinant MAOB assessed as H2O2 production by Amplex Red reagent-based assay | 2012 | Journal of medicinal chemistry, Oct-11, Volume: 55, Issue:19
| Multitarget-directed benzylideneindanone derivatives: anti-β-amyloid (Aβ) aggregation, antioxidant, metal chelation, and monoamine oxidase B (MAO-B) inhibition properties against Alzheimer's disease. |
| AID1557442 | Invivo inhibition of AChE in po dosed rat brain relative to control | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. |
| AID1557441 | Invivo inhibition of AChE in po dosed mouse brain relative to control | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. |
| AID759446 | Inhibition of electric eel AChE using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition measured every 1 min by Ellman's method | 2013 | Journal of medicinal chemistry, Jul-25, Volume: 56, Issue:14
| Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. |
| AID1525505 | Inhibition of MAO-A in rat brain using [14C]-5-hydroxytryptamine creatinine disulfate as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins by liquid scintillation counting method | 2019 | Journal of medicinal chemistry, 10-24, Volume: 62, Issue:20
| Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms. |
| AID710227 | Prevention of apoptosis in rat H9c2 cells assessed as reduction in fall of mitochondrial membrane potential at 100 nM after 1 hr | 2012 | Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23
| Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
| AID127007 | Inhibitory concentration towards monoamine oxidase B in rat brain was measured | 2004 | Journal of medicinal chemistry, Mar-25, Volume: 47, Issue:7
| Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. |
| AID1557444 | Invivo inhibition of MAO-B in po dosed mouse brain relative to control | 2019 | MedChemComm, Dec-01, Volume: 10, Issue:12
| Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands. |
| AID1525506 | Inhibition of MAO-B in rat brain using [14C]-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after 30 mins by liquid scintillation counting method | 2019 | Journal of medicinal chemistry, 10-24, Volume: 62, Issue:20
| Rational Design of Multitarget-Directed Ligands: Strategies and Emerging Paradigms. |
| AID1600694 | Inhibition of rat brain MAO-B using [14C]-phenylethylamine as substrate preincubated for 60 mins followed by substrate addition and measured after 20 mins by liquid scintillation counting method | 2019 | Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19
| Rasagiline derivatives combined with histamine H |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |