Page last updated: 2024-11-12

mre 269

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid: active form of NS-304 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ACT-333679 : A member of the class of pyrazines that is {4-[(propan-2-yl)(pyrazin-2-yl)amino]butoxy}acetic acid carrying two additional phenyl substituents at positions 5 and 6 on the pyrazine ring. The active metabolite of selexipag, an orphan drug used for the treatment of pulmonary arterial hypertension. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID9931891
CHEMBL ID239226
CHEBI ID90848
SCHEMBL ID676234
MeSH IDM0525440

Synonyms (43)

Synonym
CHEMBL239226 ,
2-{4-[n-(5,6-diphenylpyrazin-2-yl)-n-isopropylamino]butyloxy}acetic acid
S5819
475085-57-5
gtpl5852
act-333679
act 333679
2-[4-[[5,6-di(phenyl)pyrazin-2-yl]-propan-2-ylamino]butoxy]acetic acid
mre 269
mre-269
SCHEMBL676234
BRD-K57391913-001-01-4
CHEBI:90848
{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid
act333679
mre269
OJQMKCBWYCWFPU-UHFFFAOYSA-N ,
e9pc7n0did ,
unii-e9pc7n0did
(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid
J2.120.976G ,
HY-79593
CS-6104
AKOS027307832
2-{4-[(5,6-diphenylpyrazin-2-yl)(propan-2-yl)amino]butoxy}acetic acid
AS-72199
(4-((5,6-diphenylpyrazinyl)(1-methylethyl)amino)butoxy)acetic acid
acetic acid, (4-((5,6-diphenylpyrazinyl)(1-methylethyl)amino)butoxy)-
2-(4-(isopropyl(5,6-diphenylpyrazine-2-yl)amino)butoxy)acetic acid
{4-[(5,6-diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid
BCP16833
2-(4-((5,6-diphenylpyrazin-2-yl)(isopropyl)amino)butoxy)acetic acid
Q27087731
bdbm50235387
EN300-384328
SB19699
2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-ylamino]butoxy]acetic acid
[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid
HMS3748O13
A857157
mre-269(act-333679)
DTXSID801153092
2-[4-[(5,6-diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]acetic acid

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The adverse events in the selexipag group were consistent with the known side effects of prostacyclin, including headache, nausea, jaw pain, and diarrhea."( Clinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertension.
Bruderer, S; Dingemanse, J; Hurst, N; Remenova, T, 2017
)
0.46

Pharmacokinetics

ExcerptReferenceRelevance
" Possible pharmacodynamic and pharmacokinetic interactions between selexipag and warfarin in healthy individuals were investigated."( Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects.
Bruderer, S; Dingemanse, J; Mant, T; Mukai, H; Okubo, K, 2016
)
0.43
"Steady-state levels of selexipag and ACT-333679 after repeated doses of 400 μg selexipag had no influence on the warfarin pharmacodynamic variables."( Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects.
Bruderer, S; Dingemanse, J; Mant, T; Mukai, H; Okubo, K, 2016
)
0.43
" The present study evaluated the possible pharmacokinetic interactions of selexipag with gemfibrozil, a strong CYP2C8 inhibitor, and rifampicin, an inducer of CYP2C8."( Effect of gemfibrozil and rifampicin on the pharmacokinetics of selexipag and its active metabolite in healthy subjects.
Boehler, M; Bruderer, S; Dingemanse, J; Halabi, A; Petersen-Sylla, M; Remeňová, T, 2017
)
0.46

Compound-Compound Interactions

ExcerptReferenceRelevance
" However, due to its low dose and relatively low unbound exposure, selexipag has a low potential for causing drug-drug interactions."( The metabolism and drug-drug interaction potential of the selective prostacyclin receptor agonist selexipag.
Äänismaa, P; de Kanter, R; Delahaye, S; Gnerre, C; Ichikawa, T; Pfeifer, T; Seeland, S; Segrestaa, J; Treiber, A; Yamada, T, 2018
)
0.48

Bioavailability

ExcerptReferenceRelevance
"The aim of this single-center, open-label study was to assess the absolute bioavailability of an oral (tablet) versus intravenous (i."( Absolute oral bioavailability of selexipag, a novel oral prostacyclin IP receptor agonist.
Astruc, B; Dingemanse, J; Hurst, N; Kaufmann, P, 2017
)
0.46
" The absolute oral bioavailability of selexipag (90% CI) was 49."( Absolute oral bioavailability of selexipag, a novel oral prostacyclin IP receptor agonist.
Astruc, B; Dingemanse, J; Hurst, N; Kaufmann, P, 2017
)
0.46
" The bioavailability of selexipag after oral administration is approximately 50%."( Absolute oral bioavailability of selexipag, a novel oral prostacyclin IP receptor agonist.
Astruc, B; Dingemanse, J; Hurst, N; Kaufmann, P, 2017
)
0.46

Dosage Studied

ExcerptRelevanceReference
"9 h, thus permitting oral dosing twice daily."( Selexipag for the treatment of pulmonary arterial hypertension.
Lang, IM; Skoro-Sajer, N, 2014
)
0.4
" Pharmacokinetic properties of ACT-333679 permit twice-daily dosing of selexipag, providing a more convenient treatment compared to prostacyclin or its analogs."( Clinical pharmacology, efficacy, and safety of selexipag for the treatment of pulmonary arterial hypertension.
Bruderer, S; Dingemanse, J; Hurst, N; Remenova, T, 2017
)
0.46
" The dosing flexibility afforded by oral selexipag may facilitate achieving the maximum therapeutic effect with acceptable tolerability in patients with PAH."( Selexipag, a selective prostacyclin receptor agonist in pulmonary arterial hypertension: a pharmacology review.
Honorato Pérez, J, 2017
)
0.46
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (5)

RoleDescription
orphan drugAny drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease.
platelet aggregation inhibitorA drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
prostacyclin receptor agonistAn agonist that binds to and activates prostacyclin receptors
vasodilator agentA drug used to cause dilation of the blood vessels.
drug metabolitenull
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (6)

ClassDescription
aromatic amineAn amino compound in which the amino group is linked directly to an aromatic system.
etherAn organooxygen compound with formula ROR, where R is not hydrogen.
pyrazines
sulfonamideAn amide of a sulfonic acid RS(=O)2NR'2.
tertiary amino compoundA compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
monocarboxylic acidAn oxoacid containing a single carboxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (2)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Prostacyclin receptorHomo sapiens (human)IC50 (µMol)0.28800.00840.07040.2880AID1437828
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Prostacyclin receptorHomo sapiens (human)EC50 (µMol)0.02200.00040.05450.3470AID1437825
Prostaglandin D2 receptorHomo sapiens (human)EC50 (µMol)0.15400.00060.49212.0590AID1437826
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (14)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerProstacyclin receptorHomo sapiens (human)
adenylate cyclase-activating G protein-coupled receptor signaling pathwayProstacyclin receptorHomo sapiens (human)
cell-cell signalingProstacyclin receptorHomo sapiens (human)
negative regulation of platelet-derived growth factor receptor signaling pathwayProstacyclin receptorHomo sapiens (human)
response to lipopolysaccharideProstacyclin receptorHomo sapiens (human)
negative regulation of smooth muscle cell proliferationProstacyclin receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationProstacyclin receptorHomo sapiens (human)
inflammatory responseProstacyclin receptorHomo sapiens (human)
G protein-coupled receptor signaling pathwayProstaglandin D2 receptorHomo sapiens (human)
male sex determinationProstaglandin D2 receptorHomo sapiens (human)
sleepProstaglandin D2 receptorHomo sapiens (human)
mast cell degranulationProstaglandin D2 receptorHomo sapiens (human)
adenosine metabolic processProstaglandin D2 receptorHomo sapiens (human)
cellular response to prostaglandin D stimulusProstaglandin D2 receptorHomo sapiens (human)
positive regulation of cytosolic calcium ion concentrationProstaglandin D2 receptorHomo sapiens (human)
inflammatory responseProstaglandin D2 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
guanyl-nucleotide exchange factor activityProstacyclin receptorHomo sapiens (human)
prostacyclin receptor activityProstacyclin receptorHomo sapiens (human)
prostaglandin J receptor activityProstaglandin D2 receptorHomo sapiens (human)
prostaglandin D receptor activityProstaglandin D2 receptorHomo sapiens (human)
protein bindingProstaglandin D2 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (3)

Processvia Protein(s)Taxonomy
cytosolProstacyclin receptorHomo sapiens (human)
plasma membraneProstacyclin receptorHomo sapiens (human)
plasma membraneProstacyclin receptorHomo sapiens (human)
plasma membraneProstaglandin D2 receptorHomo sapiens (human)
membraneProstaglandin D2 receptorHomo sapiens (human)
plasma membraneProstaglandin D2 receptorHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (37)

Assay IDTitleYearJournalArticle
AID301246Oral bioavailability in Beagle dog at 3 mg/kg2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301236Cmax in Sprague-Dawley rat at 10 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID309983AUC (0 to 24 hrs) in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.
AID301240Half life in Beagle dog at 3 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301241Half life in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301237Cmax in Beagle dog at 3 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301244AUC in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1437830Half life in rat microsomes2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID301238Cmax in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301229Half life in Sprague-Dawley rat at 3 mg/kg, iv2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1437825Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID309982Half life in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.
AID301234Tmax in Beagle dog at 3 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID309980Tmax in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.
AID301230Half life in Beagle dog at 1 mg/kg, iv2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1437824Intrinsic activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level at 10 uM after 1 hr incubation by HTRF method relative to iloprost2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID301242AUC in Sprague-Dawley rat at 10 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301243AUC in Beagle dog at 3 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301232AUC in Beagle dog at 1 mg/kg, iv2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301245Oral bioavailability in Sprague-Dawley rat at 10 mg/kg2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1437829Half life in human microsomes2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID301235Tmax in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID301233Tmax in Sprague-Dawley rat at 10 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1437826Agonist activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID1437828Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID301231AUC in Sprague-Dawley rat at 3 mg/kg, iv2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID309981Cmax in cynomolgus monkey at 1 mg/kg, po2007Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.
AID1437827Intrinsic activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method relative to prostaglandin D22017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID1437823Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID1437822Intrinsic activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level at 10 uM after 1 hr incubation by HTRF method relative to iloprost2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID301239Half life in Sprague-Dawley rat at 10 mg/kg, po2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1437853Agonist activity at IP receptor in PAH patient-derived primary pulmonary arterial smooth muscle cells assessed as induction of cAMP levels after 1 hr by HTRF method2017Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension.
AID301228Inhibition of ADP-induced platelet aggregation in human platelet rich plasma2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.
AID1346308Human EP2 receptor (Prostanoid receptors)2007The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.
AID1346331Rat IP receptor (Prostanoid receptors)2007The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.
AID1346350Human IP receptor (Prostanoid receptors)2007The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.
AID1346427Human EP4 receptor (Prostanoid receptors)2007The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (33)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (12.12)29.6817
2010's27 (81.82)24.3611
2020's2 (6.06)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.95

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.95 (24.57)
Research Supply Index3.78 (2.92)
Research Growth Index5.44 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.95)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials10 (30.30%)5.53%
Reviews3 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other20 (60.61%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]