Assay ID | Title | Year | Journal | Article |
AID301246 | Oral bioavailability in Beagle dog at 3 mg/kg | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301236 | Cmax in Sprague-Dawley rat at 10 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID309983 | AUC (0 to 24 hrs) in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
| Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist. |
AID301240 | Half life in Beagle dog at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301241 | Half life in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301237 | Cmax in Beagle dog at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301244 | AUC in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1437830 | Half life in rat microsomes | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID301238 | Cmax in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301229 | Half life in Sprague-Dawley rat at 3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1437825 | Agonist activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID309982 | Half life in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
| Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist. |
AID301234 | Tmax in Beagle dog at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID309980 | Tmax in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
| Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist. |
AID301230 | Half life in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1437824 | Intrinsic activity at recombinant human IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level at 10 uM after 1 hr incubation by HTRF method relative to iloprost | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID301242 | AUC in Sprague-Dawley rat at 10 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301243 | AUC in Beagle dog at 3 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301232 | AUC in Beagle dog at 1 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301245 | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1437829 | Half life in human microsomes | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID301235 | Tmax in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID301233 | Tmax in Sprague-Dawley rat at 10 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1437826 | Agonist activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID1437828 | Agonist activity at IP receptor in human primary platelets assessed as inhibition of ADP-induced platelet aggregation | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID301231 | AUC in Sprague-Dawley rat at 3 mg/kg, iv | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID309981 | Cmax in cynomolgus monkey at 1 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Dec-15, Volume: 15, Issue:24
| Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist. |
AID1437827 | Intrinsic activity at recombinant human DP1 receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method relative to prostaglandin D2 | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID1437823 | Agonist activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level after 1 hr incubation by HTRF method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID1437822 | Intrinsic activity at recombinant rat IP receptor expressed in CHO-K1 cells assessed as increase in intracellular cAMP level at 10 uM after 1 hr incubation by HTRF method relative to iloprost | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID301239 | Half life in Sprague-Dawley rat at 10 mg/kg, po | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1437853 | Agonist activity at IP receptor in PAH patient-derived primary pulmonary arterial smooth muscle cells assessed as induction of cAMP levels after 1 hr by HTRF method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Discovery of 2-(((1r,4r)-4-(((4-Chlorophenyl)(phenyl)carbamoyl)oxy)methyl)cyclohexyl)methoxy)acetate (Ralinepag): An Orally Active Prostacyclin Receptor Agonist for the Treatment of Pulmonary Arterial Hypertension. |
AID301228 | Inhibition of ADP-induced platelet aggregation in human platelet rich plasma | 2007 | Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
| Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists. |
AID1346308 | Human EP2 receptor (Prostanoid receptors) | 2007 | The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
| 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. |
AID1346331 | Rat IP receptor (Prostanoid receptors) | 2007 | The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
| 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. |
AID1346350 | Human IP receptor (Prostanoid receptors) | 2007 | The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
| 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. |
AID1346427 | Human EP4 receptor (Prostanoid receptors) | 2007 | The Journal of pharmacology and experimental therapeutics, Sep, Volume: 322, Issue:3
| 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |