Page last updated: 2024-11-05

pyrithione zinc

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Pyrithione zinc is a synthetic compound that is commonly used as an antifungal and antimicrobial agent. It is a white to yellowish-white powder that is insoluble in water but soluble in organic solvents. Pyrithione zinc is typically synthesized by reacting zinc salts with pyrithione, which can be obtained from various sources, including coal tar. The compound has been shown to be effective against a broad spectrum of fungi and bacteria, including Malassezia globosa, a common cause of dandruff. It works by inhibiting the growth of these microorganisms by interfering with their metabolic processes. Pyrithione zinc is a key ingredient in many anti-dandruff shampoos, soaps, and creams. Its effectiveness in treating dandruff has led to extensive research into its mechanism of action and its potential for other therapeutic applications. Research is also being conducted to explore its potential as an anti-cancer agent, as it has been shown to inhibit the growth of some cancer cells in vitro.'

Cross-References

ID SourceID
PubMed CID26041
MeSH IDM0055920

Synonyms (603)

Synonym
(t-4)-bis(1-hydroxy-2(1h)-pyridinethionato-o,s)zinc
bis(2-pyridinethiol-1-oxide)zinc
bis(2-pyridylthio)zinc 1,1'-dioxide
pyrithion-zink
zinc, bis(1-hydroxy-2(1h)-pyridinethionato)-
zinc 1-hydroxy-2-pyridinethione
om-1563
2-pyridinethiol-1-oxide, zinc salt
zinc 1-hydroxypyridine-2-thione
bis(1-hydroxy-2-(1h)-pyridinethionato)zinc
NCGC00091933-01
einecs 236-671-3
nsc 290409
head and shoulders conditioner
biocut zp
tomicide z 50
caswell no. 923
zinci pyrithionum
niccanon skt
zinc pt
hokucide zpt
evafine p 50
zinc bis(2-pyridylthio)-n-oxide
epa pesticide chemical code 088002
ccris 4894
bc-j
finecide zpt
tomicide zpt 50
fsb 8332
ai3-62421
bis(n-oxopyridine-2-thionato)zinc (ii)
2-mercaptopyridine 1-oxide zinc salt
hsdb 4498
zinc pyridine-2-thiol 1-oxide
zinc 2-pyridinethiol-1-oxide
zinc bis(2-thioxopyridin-1(2h)-olate)
NCGC00183121-01
zincopan
pyrithionum zincicum
unii-r953o2rhz5
pyrithione zincique
ec 236-671-3
piritionato cincico
cas-13463-41-7
tox21_303205
dtxsid7026314 ,
NCGC00257089-01
dtxcid90820451
tox21_113399
tox21_202180
NCGC00259729-01
tox21_111182
Q-201649
mfcd00067336
zinc pyrithione powder
F16428
zinc;1-oxidopyridin-1-ium-2-thiolate
bis(1-oxidopyridin-2-ylthio)zinc
2-mercaptopyridine-1-oxide zinc salt
jm5b01461, compound 171
bdbm429354
bis((1-oxidopyridin-2-yl)thio)zinc
1698050-37-1
mercaptopyridine n-oxide zinc salt
shampoo
AKOS040732194
p.o.v. classic dandruff
dr. scalp active
head and shoulders royal oils deep moisture masque
xtracare 2 in 1 hair cleanse and conditiongreen apple
head and shoulders styling pomade
alevai stem cell anti-dandruff
equate dry scalp 2 in 1 dandruff sh and condanti-dandruff
equaline dandruffclassic clean
personal caredry scalp
axearmor antidandruff 2 in 1
walgreens dandruff plus conditioner 2 in 1
head and shouldersitchy scalp
x folate
pyritione zinc
head and shoulders deep moisture
bye-bye cradle cap
head and shouldersdry scalp care
pyrithizone zinc
topcare beauty pure sport dandruff
head and shoulders men advanced series bourbon 2in1
esikavital with active z 2-in-1 dandruff control
dg bodysimply clean
head and shoulders 2in1 men advanced series charcoal
head and shoulders deep moisture 2in1
pert plus 2 in 1 shampoo and conditionerdry scalp care
walgreens dandruff plus conditioner 2 in 1 dry scalp
head and shoulders 2in1 men advanced series swagger old spice
head and shoulders royal oils nighttime scalp tonic
pyrithione zincique (inn-french)
head and shoulders dry scalp care
divine dandrene 1%
pyrithionr zinc
flakes cedar mint anti dandruff
neutrogena daily control tgel 2 in 1 dandruff plus conditioner
gkhair anti-dandruff
zinc-pyrion
dovedermacare scalp pure daily care anti-dandruff
head and shoulders clinical scalp calming treatment
fresh mint dandruff
medaclear
suaverevitalizing mint and eucalyptus antidandruff
balmers cooling zone 31
head and shoulders grooming
head and shoulders shea butter hair and scalp conditioner
xtracare anti-dandruff hair cleanse
head and shoulders clinical dandruff defense dry scalp rescue
marcs dry scalp care dandruff
keracare dry and itchy scalp anti-dandruff
suavemen 2 in 1 pure power antidandruff
nioxin scalp recovery moisturizing conditioner
pert plus 2 in 1
affirmcare scalp therapyanti-dandruff exfoliating masque
head and shoulders deep moisture scalp and hair mask
halsa pyrithione zinc dandruff
zenotri scalp shampoo.
2 in 1 dandruff
lancell huitomo hair loss prevention hair grower clean formula
head and shouldermen old spice
classic control antidandruff
daylogic 2 in 1 dandruff
xtracare anti-dandruff hair cleansecocoa and shea butter
clearmen 2 in 1 complete care antidandruff
affirmcare scalp therapy
sulfur 8 oil moisturizer anti-dandruff
head and shoulders tea tree oil 2in1
xtracare anti-dandruff conditionercoconut and shea butter
fruitopia
head and shoulders hair and scalp conditionerclassic clean
revagain hair and scalp revitalizing
hairq
dandruff conditionerdry scalp recovery
head and shouldersbreakage prevention
head and shoulders tea tree oil daily
zinc, bis(1-hydroxy-2(1h)-pyridinethionato-o,s)-, (t-4)-
jason dandruff relief treatment 2 in 1
as i amdry and itchy scalp care co wash
design essentials peppermint-aloe therapeutics
head and shoulders styling gel
head and shoulders headstrong daily dandruff
head and shouldersmenthol fresh
safeway carenormal to oily hair
pyrithione zinc 0.22%
head and shoulders2 in 1 smooth and silky
dovedermacare scalp dryness and itch relief anti-dandruff conditioner
epochava puhi moni
dovedermacare scalp coconut hydration anti-dandruff conditioner
simply bodycare dandruff
head and shoulders 2 in 1 instant moisturization
clean apple
head and shoulders clinical moisturizing scalp
vanicream z-bar
at one with naturedry and itchy scalp
head and shouldersbreakege prevention
head and shoulders lemon oil 2in1
my black is beautiful scalp care calming scalp and hair
head and shoulders apple cider vinegar 2in1
2 in 1
head and shoulders ginger 2in1
clearcomplete care antidandruff
head and shoulders scalp x
clearcomplete scalp care antidandruff conditioner
cyzonebe sexy
head and shoulders deep moisture hair and scalp conditioner
equate green apple 2 in 1 dandruff
matrix biolage scalpsync antidandruff
xtracare anti-dandruff hair cleansemint and eucalyptus
nioxin scalp recovery anti-dandruff system
walgreens dandruff itchy dry scalp defense
head and shoulders 2in1
nioxin scalp recovery soothing serum
zn-pyrion
head and shoulders headstrong daily dandruff 2in1
royal oils by head and shoulders moisture renewal scalp balancing conditioner
dermaharmony seborrheic dermatitis
advance techniques keep clear2-in-1 anti-dandruff
equateeveryday clean
suaveinvigorating ocean minerals and aloe vera antidandruff
classic clean 2 in 1for normal hair
rite aid dandruff2 in 1 classic clean
head and shoulders supreme scalp moisturizer with hemp seed
equate everyday clean dandruffanti-dandruff
luckyclassic
control dandruff therapy
dry scalp dandruff
piritionato cincico (inn-spanish)
head and shoulders dual sachetssmooth and silky
2 in 1 antidandruff
itchy scalp
members mark gentle dandruff
1-hydroxy-2-pyridinethione, zinc salt
modesa 2 in 1 dandruff almond oil dry scalp
simply clean dandruff
walgreens dandruff conditioner 2 in 1 itchy scalp
dandruff detox
topcaregentle dandruff everyday clean
clearmen deep clean hydration antidandruff
pyrithione zinc 1%
head and shoulders deep scalp cleanse 2in1
walgreens dandruff plus conditioner 2 in 1 dry scalpanti-dandruff
mane n tail daily control anti-dandruff
head and shoulders deep moisture daily
topcaregentle dandruff green apple
cvs pharmacydandruff
australian goldmetro 365 medicated 2 in 1 anti-dandruff
mane n tail daily control 2 in 1 anti dandruff shampoo conditioner
dg body2 in 1 classic
bis(2-pyridinethiol 1-oxide)zinc
equate everyday clean 2 in 1 dandruffanti-dandruff
safewaydandruff dry scalp
suaveprofessionals men 2 in 1 classic clean antidandruff
sereve professional scalp
head remedy dandruff conditioner
walgreens dandruff plus conditioner 2 in 1anti-dandruff
dermaharmony pyrithione zinc
suaveprofessionals men antidandruff
sulfur 8 fresh anti-dandruff moisturizing
topcaregentle dandruff dry scalp
bis(2-pyridylthio)zinc, 1,1'-dioxide
equate everyday clean gentle dandruff
topcare everyday clean dandruff
2in1dandruff and conditioner
shills acne purifying peel off black mask
dovedermacare scalp dryness and itch relief anti-dandruff
zincon medicated dandruff
head and shoulders 2in1 dry scalp care with almond and coconut oil
topcare2 in 1 dandruff green apple
modesa 2 in 1 dandruff
axe2 in 1 armor antidandruff 2 in 1
advanced seborrheic dermatitis therapy
pert plus 2 in 1anti-dandruff
biokera
vanicream
msm hair signature
australian goldmetro 365 medicated leave-in treatment step 3
pert plus for men daily dandruff
marcs everyday care dandruffanti-dandruff
dermaharmony unscented bar
wecare anti-dandruff
head and shoulderssmooth and silky 2in1
dry scalp care
hairjoy msm hair
head and shoulders conditionersmooth and silky
equate mens bold scent 2 in 1 dandruff sh and cond
clearmen cool sport mint antidandruff
head and shouldersdry scalp care 2in1
royal dandruff
head and shoulders coconut daily
head and shoulders 2in1classic clean
head and shoulders shea butter
anti-dandruff juniper and eucalyptus
equate soft and smooth 2 in 1 dandruff sh and cond
hebdandruff
dandruff therapy shampoo
dial for men dandruff control hair and body wash
head and shoulders supreme detox and hydrate conditioner
zolidyne
safewaydandruff
the original mane n tail daily control 2 in 1 anti dandruff
usepa/opp pesticide code: 088002
smooth and glossy
safeway caredandruff
crawford dandruff
head and shoulders clinical itch relief scalp mist
equate everyday clean 2 in 1 dandruff sh and condanti-dandruff
axefreeze antidandruff
head and shoulders scalp restore
sulfur 8 fresh anti-dandruff oil moisturizing
affirmcare scalp therapyhydrating anti-dandruff conditioner
dandruff 2 in 1 shampoo and conditionerdry scalp recovery
head and shoulders deep scalp hydration daily
american crew anti-dandruff plus sebum control
sulfur 8 kids anti-dandruff
head and shoulders men advanced series lavender mint 2in1
head and shoulders deep scalp hydration 2in1
head and shoulders 2in1 men advanced series full and thick
marcs 2 in 1 everyday care dandruffanti-dandruff
as i amdry and itchy scalp care
loreal paris men expert antidandruff conditioner and
xtracare anti-dandruff hair cleansefor sensitive hair
the original mane n tail daily control anti dandruff
royal oils by head and shoulders moisturizing hair and scalp co-wash
treatment
blue cap
clearmen 2 in 1 dry scalp hydration antidandruff
2-pyridinethiol n-oxide zinc salt
head and shoulders apple fresh
equate everyday clean 2 in 1 dandruff
xtracare anti-dandruff hair cleansecoconut and shea butter
p.o.v. 2 in 1 dry scalp dandruff
hyvee care dry scalp dandruff
xtracare anti-dandruff hair cleansefor normal hair
bis(2-pyridylthio)zinc, n,n'-dioxide
xtracare anti-dandruff conditionermint and eucalyptus
head and shoulders white charcoal daily hair and scalp conditioner
head remedy
cyzonebe sexy bs tech zinc pyrithione and silicones
head and shouldersgreen apple
suavemen 2 in 1 dandruff
dual senses scalp regulation antidandruff shampoo
esikamen maximum strength
marcs 2 in 1 everyday care dandruff
head and shoulders supreme nourish and smooth
suavemen deep clean mint refresh antidandruff
australian gold defense zoneanti-dandruff step 2
elementz
3590-23-6
divine dandrene 2%
personal care pyrithione zinc dandruff
moisturizing dandruff1% pyrithione zinc
head and shoulders dual sachetsclassic clean
head and shoulders bare minimal ingredients soothing hydration
shampoo plus conditioner
pyrithione (base)
everyday clean
head and shoulders supreme detoxifying pre-wash mask
damoae therapy
head and shoulders scalp x for men
suavenourishing coconut and shea butter antidandruff conditioner
dermaharmony zinc therapy
shopko beauty green apple 2 in 1 dandruff
dermaharmony 1% pyrithione zinc
dandruff shampoodry scalp recovery
head and shoulders hair and scalp conditionergreen apple
selsun blue itchy dry scalp
being well bodydry scalp care
head and shoulderssmooth and silky
safeyway carenormal to oily hair
australian gold defense zone
nioxin scalp recovery
advance techniques keep clearanti-dandruff treatment
bioxsine series
axefeeze antidandruff
suaverevitalizing mint and eucalyptus antidandruff conditioner
nioxin scalp recoverymedicating cleanser
clearcomplete care nourishing antidandruff
art of sport anti dandruff compete
anti-dandruff shampoo
suavenourishing coconut and shea butter antidandruff
equate soft and smooth 2 in 1 dandruff sh and condanti-dandruff
happy cappy
basic essentials dandruff (clean and conditioner)2 in 1 everyday clean
luckydry hair
lbelhomme antidandruff
equate everyday clean dandruff
head and shoulders men advanced series sage and mint 2in1
axesignature daily dandruff defense anti-dandruff
dg body2 in 1 dry scalp care
dandruff 2 in 1 shampoo and conditionershiny smooth
dandruff shampoo and conditionerwith cucumber and lemongrass extracts
revox
clearmen citrus fresh hydration antidandruff
hyvee care classic clean dandruff
free and clear
essentials scalp control anti-dandruff 2 in 1 shampoo plus conditioner
clearmen clean and refresh antidandruff
natural 17 anti-dandruff
art of sport anti dandruff victory
dovedermacare scalp pure daily care 2 in 1 anti-dandruff
leader dandruff everyday clean
shopko beauty classic spice 2 in 1 dandruff
royal dandruff dry scalp
marcs everyday care dandruff
head and shoulders molding clay
urban wash dandruff
head and shoulders supreme nourish and smooth conditioner
alberto vo5 2 in 1 dandruff
modesa 2 in 1 dandruff green apple
head and shoulders royal oils frizz tamer
equate 2 in 1 dry scalp dandruff
modesa dandruff everyday clean
pert plus 2 in 1 shampoo and conditioneranti-dandruff
nioxin scalp recovery medicating cleanser
shelo nabel anti caspa
control dandruff-free beard wash
antidandruff
head and shoulders royal oils daily moisture scalp
sulfur 8 five star anti-dandruff hair groom
esikamen effective control
panrosa fresh clean pyrithione zinc dandruff
head and shoulders deep scalp cleanse daily
halsa pyrithione zinc dandruff-dry scalp care
being well body2in1 dandruff and conditioner
head and shoulders calming lavender daily
dovemen plus care anti dandruff
head and shoulders refreshing relief
dry scalp
head and shouldersvolume boost hair and scalp conditioner
equalinedry scalp 2 in 1
head and shoulders supreme clarify and volumize scalp and hair conditioner
head and shoulders bare minimal ingredients
head and shoulders aloe vera 2in1
head and shoulders men advanced series sandalwood 2in1
equate everyday clean 2in1 dandruff
dermazinc
medecean seborrhea
zenotri follicle shampoo.
dovedermacare scalp invigorating mint 2 in 1 anti-dandruff
head and shoulders dual pack green apple
equate beauty color safe dandruff
alevai stem cell anti-dandruff conditioner
clearmen strong and full antidandruff
topcare 2 in 1 everyday clean dandruff
anti-dandruff shampoo and conditionerhowl
dry scalp caredandruff md
antidandruff shampoo
j1002901jason dandruff relief 2in1treatment
head and shoulders royal oils instant soothe scalp
xtracare 2 in 1 hair cleanse and conditioncoconut water
pert plus dandruff plus
head and shoulders dual pack
om 1563
equate dry scalp dandruff
walgreens dandruff itchy dry scalp defenseanti-dandruff
apex crown anti dandruff
equate mens ultra sport 2 in 1 dandruff sh and condanti-dandruff
dandrene anti-dandruff conditioner
equate everyday clean 2 in 1 dandruff sh and cond
topcare2 in 1 dandruff dry scalp
vancide zp dispersion
esikamen multi-action 2-in-1
topcare 2 in 1 dry scalp dandruff
head and shoulders supreme hydrating scalp serum
every man jack 2-in-1 anti-dandruff
shopko beauty everyday clean dandruff
head and shoulders old spice
esika men 2 en 1 antidandruff multi-action
maxxam dermacare pre-shampoo scalp treatment
kerastase paris symbiose antidandruff
daylogic dry scalp dandruff
rebirth hair
head and shouldersvolume boost
moisturizing dandruff
pyrithionum zincicum (inn-latin)
equate green apple 2 in 1 dandruffanti-dandruff
classic control
head and shouldershair loss prevention
as i amdry and itchy scalp care conditioner
head and shoulders calming lavender
equaline dandruffdry scalp 2 in 1
zinc pyridine-2-thione-n-oxide
mojelim dr
pyrthione zinc
equate dry scalp 2 in 1 dandruff sh and cond
redken 5th avenue nyc scalp relief dandruff control
daylogic 2in1 dandruff classic clean
leader dandruff everyday cleananti-dandruff
shikatri class
d11ax12
equate classic spice 2 in 1 dandruff
equate dry scalp 2 in 1 dandruffanti-dandruff
head and shoulders dry scalp carehair and scalp conditioner
head and shoulders 2in1 men advanced series pure sport old spice
head and shoulders scalp x conditioner
sulfur 8 aqua blue
alevai-anti dandruff scalp serum
first aid beauty anti-dandruff
vitale sensitive scalp daily scalp healer
dandrene
topcare2 in 1 dandruff everyday clean
head and shoulders dual packsmooth and silky
head and shoulders cleansing cucumber
head and shoulders 3 in 1 men
piritiona cincica
zinc soap
spai-sonsalkaline dry-dandruff
head and shoulders 2 in soft and manageable
walgreens dandruff conditioner 2 in 1 itchy scalpanti-dandruff
lifecell womens
classic clean
dandruff 2 in 1 shampoo and conditionerdaily clean for normal hair
marcs dry scalp care dandruffanti-dandruff
j1002902 jason dandruff relief 2in1 treatment
pyrithione zine
royal oils by head and shoulders moisture boost scalp care
head and shouldersclassic clean
p.o.v. dry scalp dandruff
everyday clean dandruff
head and shoulders classic clean with vitamin e
topcare dry scalp gentle dandruff
royal dandruff dry scalp care
zinc therapy
clearcomplete scalp care antidandruff
head and shoulders complete scalp care 2in1
p.o.v. classic 2 in 1 dandruff
nioxin scalp recoverysoothing serum
ocean breeze 2 in 1 dandruffsea mineral scent
clear2 in 1 scalp comfort antidandruff
zinc 1-hydroxy-2-pyridine-thione
alevai-stem cell anti dandruff
blue cap cream
salon designs everyday clean dandruff
equate beauty color safe dandruff conditioner
clearmen 2 in 1 clean and refresh antidandruff
head and shoulders texturizing putty
glovers clinical care seborrheic dermatitis antidandruff
esika men dandruffmaximum strength
head and shoulders apple cider vinegar
advanced herbal carefor thinning-damaged hair
head and shoulders supreme color protect conditioner
my black is beautiful scalp care cooling scalp serum
dovedermacare scalp coconut hydration anti-dandruff
daylogic refresh dandruff
sebastian purist antidandruff
daylogic 2 in 1 dandruffclassic scent
pyrithione zinc shampoo
daylogic dandruff classic clean
dg body2 in 1 green apple
aloe coal 01
equaline dandruffrefresh
xtracare anti-dandruff conditioner
epoch ava puhi moni anti-dandruff
hair and scalp anti-dandruff
head and shoulders moisturizing avocado oil
head and shoulders supreme detox and hydrate
alevai-stem cell anti-dandruff conditioner
australian gold defense zoneanti-dandruff leave-in treatment
head and shoulders coconut
royal oils by head and shoulders sulfate free scalp care
safewaydandruff classic clean
personal caredaily clean
head and shoulders men old spice pure sport
essentials scalp control deep clean with invigorating mint anti-dandruff shampoo
lucky2in1 classic
pyrithions zinc
daylogic 2in1 dandruff dry scalp care
xtracare 2 in 1 hair cleanse and condition
royal oils by head and shoulders moisture boost 2in1
dandruff shampoodaily clean for normal hair
head and shoulders supreme soothe and strengthen
vegetability natural
head and shoulders men advanced series sandalwood
p.o.v. timeless spice 2 in 1 dandruff
equalineclassic clean 2 in 1
head and shoulders supreme soothe and strengthen conditioner
blade howlanti-dandruff
head and shoulders coconut kit
lifecell mens
equate mens bold scent 2 in 1 dandruff sh and condanti-dandruff
equalineclassic clean
loreal paris ever pure dandruff scalp care and detox
dermaharmony face and body
rite aid dandruff2 in 1 dry scalp care
head and shoulders supreme color protect
head and shoulders coconut 2in1
head and shoulders calming lavenderdaily hair and scalp conditioner
eternal spirit beauty hair pro anti-dandruff
mizani scalp care antidandruff
basic essentials dandruffeveryday clean
dermaharmony tea tree bar
dg body2 in 1 simply clean
affirmcare scalp therapyhydrating anti-dandruff
mizani scalp care conditioner antidandruff conditioner
dandruff conditionerdaily clean for normal hair
head and shoulders renewing cleanse
head and shoulders men advanced series swagger old spice
clearmen ocean mineral antidandruff
selex dna
head and shouldersitchy scalp 2in1
head and shoulder
shiny and sleek
basic essentials dandruffdry scalp
head and shoulders 2in1 men eucalyptus and neem
cremo anti-dandruff fresh blend
axeantidandruff styling
ballvic sebo
dandruff 2 in 1
halsa anti dandruffmoisturizes and restores
equate dry scalp 2 in 1 dandruff
chevance
head and shouldersrenewing clean
aloe coal 02 conditioner
hyvee care classic clean 2 in 1 dandruff
head and shoulders coconutdaily hair and scalp conditioner
oily hair dandruffzerran international
equate mens ultra sport 2 in 1 dandruff sh and cond
head and shoulders classic clean dandruff
head and shouldersgreen apple 2in1
head and shoulders 2 in renewing cleanse
head and shoulders royal oils moisture boost
p.o.v. green apple 2 in 1 dandruff
head and shoulders supreme clarify and volumize
american crew
urban wash everday clean dandruff
oread blue anti-dandruff
head and shoulders charcoal daily
dovedermacare scalp invigorating mint anti-dandruff
sulfur 8 light moisturizer anti-dandruff
balancing
leudine anti-dandruff
bis(pyridine-2-thiolato-kappas 1(oxide-kappao))zinc
satinique anti dandruff
control anti-dandruff
dermaharmony pyrithione zincwith shea butter
just for men control gx anti-dandruff
four season
head and shoulders hair and scalp conditioner
global keratin-anti-dandruff

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
zinc coordination entity
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (81)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency5.01190.004023.8416100.0000AID485290
Chain A, HADH2 proteinHomo sapiens (human)Potency8.55390.025120.237639.8107AID886; AID893
Chain B, HADH2 proteinHomo sapiens (human)Potency8.55390.025120.237639.8107AID886; AID893
Chain A, CruzipainTrypanosoma cruziPotency1.29250.002014.677939.8107AID1476; AID1478
LuciferasePhotinus pyralis (common eastern firefly)Potency0.36970.007215.758889.3584AID1224835; AID624030
interleukin 8Homo sapiens (human)Potency66.82420.047349.480674.9780AID651758
15-lipoxygenase, partialHomo sapiens (human)Potency0.19950.012610.691788.5700AID887
pregnane X receptorRattus norvegicus (Norway rat)Potency39.81070.025127.9203501.1870AID651751
phosphopantetheinyl transferaseBacillus subtilisPotency44.66840.141337.9142100.0000AID1490
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency0.93493.189029.884159.4836AID1224846; AID1224894
RAR-related orphan receptor gammaMus musculus (house mouse)Potency0.03450.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency6.81470.173734.304761.8120AID1346924
GLS proteinHomo sapiens (human)Potency12.58930.35487.935539.8107AID624170
SMAD family member 3Homo sapiens (human)Potency6.81470.173734.304761.8120AID1346924
TDP1 proteinHomo sapiens (human)Potency0.09370.000811.382244.6684AID686978; AID686979
GLI family zinc finger 3Homo sapiens (human)Potency0.03880.000714.592883.7951AID1259368; AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency2.04140.000221.22318,912.5098AID1259243; AID1259247; AID588515; AID588516; AID743035; AID743036; AID743042; AID743053; AID743054; AID743063
caspase 7, apoptosis-related cysteine proteaseHomo sapiens (human)Potency0.90070.013326.981070.7614AID1346978
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency1.25890.011212.4002100.0000AID1030
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency3.16230.00137.762544.6684AID2120
thyroid stimulating hormone receptorHomo sapiens (human)Potency6.30960.001318.074339.8107AID926; AID938
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency0.63910.000657.913322,387.1992AID1259377; AID1259378
hypothetical protein, conservedTrypanosoma bruceiPotency31.62280.223911.245135.4813AID624173
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency0.12630.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency1.92630.000417.946075.1148AID1346784; AID1346795
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency3.54810.01237.983543.2770AID1346984
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency24.22130.000214.376460.0339AID588532; AID588533; AID720691; AID720692; AID720719
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency0.02260.003041.611522,387.1992AID1159552; AID1159553; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency1.07920.000817.505159.3239AID1159527; AID1159531; AID588544; AID588546
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency0.51580.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptorHomo sapiens (human)Potency4.87300.375827.485161.6524AID588526; AID588527; AID743217; AID743220; AID743239
pregnane X nuclear receptorHomo sapiens (human)Potency0.61900.005428.02631,258.9301AID1346982; AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency5.71120.000229.305416,493.5996AID1259244; AID1259248; AID1259383; AID588513; AID588514; AID743069; AID743075; AID743077; AID743078; AID743079; AID743080; AID743091
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency1.25110.001024.504861.6448AID588534; AID588535; AID743212; AID743215; AID743227
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency4.19090.001019.414170.9645AID588537; AID743094; AID743140; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency9.93410.023723.228263.5986AID588541; AID588543; AID743222; AID743223; AID743241
caspase-3Homo sapiens (human)Potency0.90070.013326.981070.7614AID1346978
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency6.30960.035520.977089.1251AID504332
aryl hydrocarbon receptorHomo sapiens (human)Potency1.99110.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency0.09490.001723.839378.1014AID743083
thyroid stimulating hormone receptorHomo sapiens (human)Potency69.28770.001628.015177.1139AID1259385; AID1259395
activating transcription factor 6Homo sapiens (human)Potency22.45930.143427.612159.8106AID1159516; AID1159519
thyrotropin-releasing hormone receptorHomo sapiens (human)Potency1.99140.154917.870243.6557AID1346877; AID1346891
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_aHomo sapiens (human)Potency0.032719.739145.978464.9432AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency0.18600.057821.109761.2679AID1159528
nuclear receptor subfamily 1, group I, member 2Rattus norvegicus (Norway rat)Potency6.30960.10009.191631.6228AID1346983
Histone H2A.xCricetulus griseus (Chinese hamster)Potency8.74780.039147.5451146.8240AID1224845; AID1224896
Caspase-7Cricetulus griseus (Chinese hamster)Potency0.00980.006723.496068.5896AID1346980
cellular tumor antigen p53 isoform aHomo sapiens (human)Potency2.51190.316212.443531.6228AID902
polyunsaturated fatty acid lipoxygenase ALOX12Homo sapiens (human)Potency14.12541.000012.232631.6228AID1452
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency10.00000.001815.663839.8107AID894
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.11870.354828.065989.1251AID504847
thyroid hormone receptor beta isoform aHomo sapiens (human)Potency15.64980.010039.53711,122.0200AID588545; AID588547
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency4.79570.01789.637444.6684AID588834
caspase-3Cricetulus griseus (Chinese hamster)Potency0.00980.006723.496068.5896AID1346980
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency0.12910.000323.4451159.6830AID743065; AID743066; AID743067
histone deacetylase 9 isoform 3Homo sapiens (human)Potency3.50950.037617.082361.1927AID1259364; AID1259388
heat shock protein beta-1Homo sapiens (human)Potency6.57410.042027.378961.6448AID743210; AID743228
huntingtin isoform 2Homo sapiens (human)Potency0.89130.000618.41981,122.0200AID1688
mitogen-activated protein kinase 1Homo sapiens (human)Potency12.58930.039816.784239.8107AID995
nuclear factor NF-kappa-B p105 subunit isoform 1Homo sapiens (human)Potency39.81074.466824.832944.6684AID651749
histone-lysine N-methyltransferase 2A isoform 2 precursorHomo sapiens (human)Potency89.12510.010323.856763.0957AID2662
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency1.62590.000627.21521,122.0200AID651741; AID743202; AID743219
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency0.07130.00798.23321,122.0200AID2546; AID2551
gemininHomo sapiens (human)Potency0.71980.004611.374133.4983AID624296; AID624297
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency8.37210.005612.367736.1254AID624032; AID624044
survival motor neuron protein isoform dHomo sapiens (human)Potency2.51190.125912.234435.4813AID1458
lethal factor (plasmid)Bacillus anthracis str. A2012Potency0.39810.020010.786931.6228AID912
lamin isoform A-delta10Homo sapiens (human)Potency0.10000.891312.067628.1838AID1487
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency15.84890.316212.765731.6228AID881
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency0.09120.001557.789015,848.9004AID1259244
Cellular tumor antigen p53Homo sapiens (human)Potency11.75820.002319.595674.0614AID651631; AID651743; AID720552
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency0.09120.001551.739315,848.9004AID1259244
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency15.84890.00638.235039.8107AID881
Nuclear receptor ROR-gammaHomo sapiens (human)Potency1.88340.026622.448266.8242AID651802
ATPase family AAA domain-containing protein 5Homo sapiens (human)Potency1.32050.011917.942071.5630AID651632; AID720516
Ataxin-2Homo sapiens (human)Potency1.49400.011912.222168.7989AID651632
ATP-dependent phosphofructokinaseTrypanosoma brucei brucei TREU927Potency1.25890.060110.745337.9330AID492961
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusKi0.17000.00753.23929.1100AID1804126
Replicase polyprotein 1abHuman coronavirus 229EKi0.17000.00000.73329.1100AID1804126
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirusKi0.17000.00753.00839.1100AID1804126
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (172)

Processvia Protein(s)Taxonomy
lipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
phospholipid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
apoptotic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell population proliferationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of macrophage derived foam cell differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell migrationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
prostate gland developmentPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
regulation of epithelial cell differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of chemokine productionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of peroxisome proliferator activated receptor signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
positive regulation of keratinocyte differentiationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell cyclePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of growthPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
hepoxilin biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
endocannabinoid signaling pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cannabinoid biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipoxin A4 biosynthetic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleic acid metabolic processPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipid oxidationPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipoxygenase pathwayPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
symbiont-mediated perturbation of host ubiquitin-like protein modificationReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
symbiont-mediated perturbation of host ubiquitin-like protein modificationReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
cell population proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of B cell proliferationATPase family AAA domain-containing protein 5Homo sapiens (human)
nuclear DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
signal transduction in response to DNA damageATPase family AAA domain-containing protein 5Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
isotype switchingATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of DNA replicationATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of isotype switching to IgG isotypesATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloadingATPase family AAA domain-containing protein 5Homo sapiens (human)
regulation of mitotic cell cycle phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorATPase family AAA domain-containing protein 5Homo sapiens (human)
positive regulation of cell cycle G2/M phase transitionATPase family AAA domain-containing protein 5Homo sapiens (human)
negative regulation of receptor internalizationAtaxin-2Homo sapiens (human)
regulation of translationAtaxin-2Homo sapiens (human)
RNA metabolic processAtaxin-2Homo sapiens (human)
P-body assemblyAtaxin-2Homo sapiens (human)
stress granule assemblyAtaxin-2Homo sapiens (human)
RNA transportAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (59)

Processvia Protein(s)Taxonomy
iron ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
calcium ion bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
protein bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
lipid bindingPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleate 13S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonate 8(S)-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
arachidonate 15-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
linoleate 9S-lipoxygenase activityPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
RNA-dependent RNA polymerase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
3'-5'-RNA exonuclease activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
RNA-dependent RNA polymerase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
mRNA 5'-cap (guanine-N7-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
mRNA (nucleoside-2'-O-)-methyltransferase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
5'-3' RNA helicase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activityReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
ATP hydrolysis activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA clamp unloader activityATPase family AAA domain-containing protein 5Homo sapiens (human)
DNA bindingATPase family AAA domain-containing protein 5Homo sapiens (human)
RNA bindingAtaxin-2Homo sapiens (human)
epidermal growth factor receptor bindingAtaxin-2Homo sapiens (human)
protein bindingAtaxin-2Homo sapiens (human)
mRNA bindingAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (32)

Processvia Protein(s)Taxonomy
nucleusPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytosolPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
cytoskeletonPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
plasma membranePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
adherens junctionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
focal adhesionPolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
membranePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
extracellular exosomePolyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
double membrane vesicle viral factory outer membraneReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
double membrane vesicle viral factory outer membraneReplicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
Elg1 RFC-like complexATPase family AAA domain-containing protein 5Homo sapiens (human)
nucleusATPase family AAA domain-containing protein 5Homo sapiens (human)
cytoplasmAtaxin-2Homo sapiens (human)
Golgi apparatusAtaxin-2Homo sapiens (human)
trans-Golgi networkAtaxin-2Homo sapiens (human)
cytosolAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
membraneAtaxin-2Homo sapiens (human)
perinuclear region of cytoplasmAtaxin-2Homo sapiens (human)
ribonucleoprotein complexAtaxin-2Homo sapiens (human)
cytoplasmic stress granuleAtaxin-2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1804126No assay is provided from Article 10.1021/acs.jmedchem.5b01461: \\An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.\\2016Journal of medicinal chemistry, 07-28, Volume: 59, Issue:14
An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 55.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index55.20 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index163.70 (26.88)
Search Engine Supply Index3.90 (0.95)

This Compound (55.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (23)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Conventional vs. Video-Assisted Laryngoscopy for Perioperative Endotracheal Intubation [NCT05228288]2,600 participants (Anticipated)Interventional2022-03-28Recruiting
Laryngoscopy for Neonatal and Infant aIrway Management wIth Supplemental oxygEn (OPTIMISE): a Multi-center Prospective Randomized Controlled Trial [NCT04295902]250 participants (Actual)Interventional2020-04-01Completed
Comparative Study of King Vision® Standard Blade and King Vision® Channeled for Tracheal Intubation: a Prospective Randomised Study [NCT02344030]44 participants (Actual)Interventional2015-01-31Completed
Comparison of Visualisation of Laryngeal Inlet and Ease of Intubation With Different Laryngoscope Blades. [NCT01352299]120 participants (Actual)Interventional2008-08-31Completed
Phase 2 Study of Evaluation of Videolaryngoscopes in Difficult Airway (SWIVITII) [NCT02088801]480 participants (Actual)Interventional2014-02-28Completed
Comparison of Direct and Indirect Laryngoscopy Using C-MAC PM® With Macintosh Blade and D-Blade® in Simulated Difficult Airway [NCT03403946]48 participants (Actual)Interventional2011-12-01Completed
A Prospective, Multicenter, Randomized and Single Bind Trial. Influence of Laryngoscope Blade Material on Postoperative PHARYNGEAL AND LARYNGEAL Morbidity Following Scheduled OroTracheal Intubation [NCT01118533]712 participants (Actual)Interventional2010-09-30Completed
Comparison of the C-MAC Video Laryngoscope With Conventional Direct Laryngoscopy in Morbidly Obese Patients Using a Photographic Overlay Technique [NCT02167477]0 participants (Actual)Interventional2013-01-31Withdrawn
A Randomized, Controlled, Open-label, 4 Parallel Arms Study to Demonstrate Reductions in Exposure to Selected Harmful and Potentially Harmful Constituents (HPHC) of Cigarette (CIG) Smoke in Healthy Smokers Switching to Different Versions of Tobacco Heatin [NCT05599451]79 participants (Actual)Interventional2022-11-16Completed
Comparison of Performance of Three Laryngoscope Blades: Plastic Single Use, Metallic Single Use and Metallic Reusable Blades. [NCT00876967]Phase 41,040 participants (Anticipated)Interventional2008-01-31Completed
Comparative Evaluation of Two Surgical Blade Designs to Harvest Palatal Connective Tissue Graft by Single Incision Technique: A Randomized Controlled Clinical Trial [NCT04189302]30 participants (Anticipated)Interventional2020-01-31Not yet recruiting
Awake Airway Assessment With Video Laryngoscopes [NCT03999866]18 participants (Actual)Interventional2019-07-01Completed
"Optimal Head and Neck Position for Intubation During Videolaryngoscopy: Comparison Between Sniffing and Neutral Position Using Channelled and Non-channelled Videolaryngoscopes" [NCT02558036]200 participants (Actual)Interventional2015-02-11Completed
Out-of-Hospital Intubation in Emergency Conditions With Either Metal Single Use or Reusable Laryngoscope Blades : Impact on Intubation Difficulties [NCT00644722]Phase 4800 participants (Anticipated)Interventional2008-04-30Completed
Comparison of the Intubation Condition Between Using Two Types of Blade in Patients Receiving Tracheal Intubation Using Videolaryngoscope: Channeled Blade vs. Non-channeled Blade [NCT04948294]118 participants (Actual)Interventional2018-08-22Completed
NoL Index, Heart Rate and Mean Arterial Blood Pressure Responses to Tracheal Intubation Performed With MacIntosh Blade Versus Glidescope [NCT03277872]50 participants (Actual)Interventional2017-09-05Completed
A Prospective Single Blinded Randomised Controlled Trial to Compare Endotracheal Intubation Using C Blade and D Blade of CMAC Videolaryngoscope in Patients Undergoing Elective Cervical Spine Surgery [NCT05561231]68 participants (Actual)Interventional2018-11-01Completed
Comparing the Laryngoscopy View Using Miller and Macintosh Laryngoscopy Blades in Infants Under Two Years of Age [NCT01717872]50 participants (Actual)Interventional2012-10-31Completed
Effect of Cutting Blades for Total Knee Arthroplasty on Implant Migration. A Randomized Controlled Study With Radiostereometric Analysis [NCT01772589]0 participants (Actual)Interventional2015-02-28Withdrawn(stopped due to Comparator sawblade no longer available)
Comparison Of Storz C-Mac® D Blade Videolaryngoscope With McGrath® X3 Blade Videolaryngoscope In Double Lumen Tube Patients [NCT03826706]50 participants (Actual)Interventional2019-02-15Enrolling by invitation
Comparison of 3 Direct Laryngoscopes: Inscope DL Blade Size 3.5 and DL Blade 3.5 Sun-Med GreenLine®/D™ to DL Blade 3 Sun-Med GreenLine®/D™ for Tracheal Intubation in Patients Undergoing Lumbar Spine Surgery, a Prospective Randomized Study [NCT02955511]5 participants (Actual)Interventional2018-01-02Terminated(stopped due to The blade used in the study was modified (changed) by the manufacturer, it does not longer exist.)
Comparison of Intubation Rate of Macintosh Size 2 and 3 Blades in Asian Female: a Randomised Controlled Trial [NCT04566224]90 participants (Actual)Interventional2011-06-01Completed
Comparison of Laryngoscopy View by Classical Miller, Wis-Hipple and C-MAC Straight Size 1 Blades in Young Children [NCT03053583]99 participants (Actual)Interventional2016-04-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

TrialOutcome
NCT01717872 (3) [back to overview]Percent of Glottic Opening With the MAC Blade Lifting the Tongue and the Epiglottis
NCT01717872 (3) [back to overview]Percent of Glottic Opening With the Miller Blade Lifting the Epiglottis and Tongue
NCT01717872 (3) [back to overview]The View of the Larynx (Glottis Opening) as Determined by POGO Score (Percentage of Glottic Opening).
NCT02955511 (5) [back to overview]Glottis Visualization POGO Score
NCT02955511 (5) [back to overview]Glottis Visualization Using Cormack Lehane
NCT02955511 (5) [back to overview]Intubation Attempts
NCT02955511 (5) [back to overview]Intubation Time (Using a Stopwatch)
NCT02955511 (5) [back to overview]Time From the Insertion of the Laryngoscope Blade to Confirm w/ CO2 Waveform

Percent of Glottic Opening With the MAC Blade Lifting the Tongue and the Epiglottis

The MAC blade was inserted under the tongue to view the percent glottic opening and compared with the view with the same blade lifting the epiglottis to view the percent glottic opening. (NCT01717872)
Timeframe: 30 seconds

Interventionpercent of glottic opening (Mean)
MAC Blade Lifting the Tongue84.4
MAC Blade Lifting the Epiglottis67.2

[back to top]

Percent of Glottic Opening With the Miller Blade Lifting the Epiglottis and Tongue

Percent of glottic opening (POGO) with the Miller blade lifting the epiglottis compared with the score with the same blade lifting the tongue (NCT01717872)
Timeframe: 30 seconds

Interventionpercent of glottic opening (Mean)
Miller Blade Lifting the Epiglottis78.4
Miller Blade Lifting the Tongue76

[back to top]

The View of the Larynx (Glottis Opening) as Determined by POGO Score (Percentage of Glottic Opening).

Percent of glottic opening (POGO) with the Miller blade lifting the epiglottis compared with the score with the Macintosh blade lifting the tongue (NCT01717872)
Timeframe: 30 seconds

Interventionpercentage of Glottic opening (Mean)
Macintosh Laryngoscope Blade84
Miller Laryngoscope Blade78

[back to top]

Glottis Visualization POGO Score

The percentage of the glottis visualized (POGO) score It represents the percentage of glottic opening seen; the score ranges from 0% when none of the glottis is seen to 100% when the entire glottis, including the anterior commissure, is seen. (NCT02955511)
Timeframe: During intubation procedure, up to 1 minute

Interventionpercentage of glottic opening (Mean)
Blade MAC Size 375
Blade MAC Size 3.596.6
Inscope Blade Size 3.580

[back to top]

Glottis Visualization Using Cormack Lehane

"Grade Description Approximate frequency Likelihood of difficult intubation~Full view of glottis 68-74% <1%~a Partial view of glottis 21-24% 4.3-13.4%~2b Only posterior extremity of glottis seen or only arytenoid cartilages 3.3-6.5% 65-67.4% 3 Only epiglottis seen, none of glottis seen 1.2-1.6% 80-87.5% 4 Neither glottis nor epiglottis seen very rare~Note:~In the analysis of the data collected for 5 participants, there was no differentiation between 2a and 2b for a grade of 2." (NCT02955511)
Timeframe: During intubation procedure, up to 1 minute

Interventionscore on a scale (Mean)
Blade MAC Size 32
Blade MAC Size 3.51.3
Inscope Blade Size 3.52

[back to top]

Intubation Attempts

"An intubation attempt is defined as the insertion of the laryngoscope blade into a patient's mouth, with the objective of inserting an endotracheal tube into the trachea.~The number of intubation attempts in each participant for successful tracheal intubation measured how many times the anesthesiologist attempted to place the tube into the trachea of each patient." (NCT02955511)
Timeframe: 3 minutes

InterventionIntubation Attempts (Mean)
Blade MAC Size 31
Blade MAC Size 3.51
Inscope Blade Size 3.51

[back to top]

Intubation Time (Using a Stopwatch)

"Intubation Time:~It is the time taken to intubate: from the initial insertion of the laryngoscope blade to the placement of the tracheal tube (approximately 3 minutes).~An intubation attempt:~It is defined as the insertion of the laryngoscope blade into a patient's mouth, with the objective of inserting an endotracheal tube into the trachea." (NCT02955511)
Timeframe: up to 3 minutes

InterventionSeconds (Mean)
Blade MAC Size 338
Blade MAC Size 3.515.3
Inscope Blade Size 3.517

[back to top]

Time From the Insertion of the Laryngoscope Blade to Confirm w/ CO2 Waveform

The time following the initial insertion of the laryngoscope blade into the mouth to confirm w/ CO2 waveform (NCT02955511)
Timeframe: During intubation procedure, up to 3 minutes

InterventionSeconds (Mean)
Blade MAC Size 349
Blade MAC Size 3.536.5
Inscope Blade Size 3.526

[back to top]