An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of kexin (EC 3.4.21.61).
ChEBI ID: 189665
Member | Definition | Class |
---|---|---|
PF-06446846 | A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9. | PF-06446846 |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 7 (77.78) | 24.3611 |
2020's | 2 (22.22) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 2 (22.22%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 7 (77.78%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
40S ribosomal protein S10 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S11 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S12 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S13 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S14 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S15 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S15a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S16 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S17 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S18 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S19 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S2 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S20 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S21 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S23 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S24 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S25 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S26 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S27 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S28 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S29 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S3 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S30 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S3a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S4, X isoform | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S4, Y isoform 1 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S5 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S6 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S7 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S8 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein S9 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
40S ribosomal protein SA | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S acidic ribosomal protein P0 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S acidic ribosomal protein P1 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L10 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L10a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L11 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L12 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L13 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L13a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L14 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L15 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L17 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L18 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L18a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L19 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L21 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L22 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L23 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L23a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L24 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L26 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L27 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L27a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L28 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L29 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L3 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L30 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L31 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L32 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L34 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L35 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L35a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L36 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L36a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L37 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L37a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L38 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L39 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L4 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L41 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L5 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L6 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L7 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L7a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L8 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
60S ribosomal protein L9 | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |
Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 8.5000 | 1 | 1 |
Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | Ki | 18.1000 | 1 | 1 |
Proprotein convertase subtilisin/kexin type 9 | Homo sapiens (human) | IC50 | 0.7500 | 1 | 1 |
Ubiquitin-40S ribosomal protein S27a | Homo sapiens (human) | IC50 | 2.1250 | 4 | 4 |