Roles > EC 3.4.21.61 (kexin) inhibitor
Page last updated: 2024-08-05 15:50:45

EC 3.4.21.61 (kexin) inhibitor

An EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of kexin (EC 3.4.21.61).

ChEBI ID: 189665

Members (1)

MemberDefinitionClass
PF-06446846A triazolopyridine that is 3H-[1,2,3]triazolo[4,5-b]pyridine substituted by a 4-{(3-chloropyridin-2-yl)[(3R)-piperidin-3-yl]carbamoyl}phenyl group at position 3. It is a potent inhibitor of PCSK9.PF-06446846

Research

Studies (9)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (77.78)24.3611
2020's2 (22.22)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (22.22%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (77.78%)84.16%

Protein Targets (84)

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
40S ribosomal protein S10Homo sapiens (human)IC502.125044
40S ribosomal protein S11Homo sapiens (human)IC502.125044
40S ribosomal protein S12Homo sapiens (human)IC502.125044
40S ribosomal protein S13Homo sapiens (human)IC502.125044
40S ribosomal protein S14Homo sapiens (human)IC502.125044
40S ribosomal protein S15Homo sapiens (human)IC502.125044
40S ribosomal protein S15aHomo sapiens (human)IC502.125044
40S ribosomal protein S16Homo sapiens (human)IC502.125044
40S ribosomal protein S17Homo sapiens (human)IC502.125044
40S ribosomal protein S18Homo sapiens (human)IC502.125044
40S ribosomal protein S19Homo sapiens (human)IC502.125044
40S ribosomal protein S2Homo sapiens (human)IC502.125044
40S ribosomal protein S20Homo sapiens (human)IC502.125044
40S ribosomal protein S21Homo sapiens (human)IC502.125044
40S ribosomal protein S23Homo sapiens (human)IC502.125044
40S ribosomal protein S24Homo sapiens (human)IC502.125044
40S ribosomal protein S25Homo sapiens (human)IC502.125044
40S ribosomal protein S26Homo sapiens (human)IC502.125044
40S ribosomal protein S27Homo sapiens (human)IC502.125044
40S ribosomal protein S28Homo sapiens (human)IC502.125044
40S ribosomal protein S29Homo sapiens (human)IC502.125044
40S ribosomal protein S3Homo sapiens (human)IC502.125044
40S ribosomal protein S30Homo sapiens (human)IC502.125044
40S ribosomal protein S3aHomo sapiens (human)IC502.125044
40S ribosomal protein S4, X isoformHomo sapiens (human)IC502.125044
40S ribosomal protein S4, Y isoform 1Homo sapiens (human)IC502.125044
40S ribosomal protein S5Homo sapiens (human)IC502.125044
40S ribosomal protein S6Homo sapiens (human)IC502.125044
40S ribosomal protein S7Homo sapiens (human)IC502.125044
40S ribosomal protein S8Homo sapiens (human)IC502.125044
40S ribosomal protein S9Homo sapiens (human)IC502.125044
40S ribosomal protein SAHomo sapiens (human)IC502.125044
60S acidic ribosomal protein P0Homo sapiens (human)IC502.125044
60S acidic ribosomal protein P1Homo sapiens (human)IC502.125044
60S ribosomal protein L10Homo sapiens (human)IC502.125044
60S ribosomal protein L10aHomo sapiens (human)IC502.125044
60S ribosomal protein L11Homo sapiens (human)IC502.125044
60S ribosomal protein L12Homo sapiens (human)IC502.125044
60S ribosomal protein L13Homo sapiens (human)IC502.125044
60S ribosomal protein L13aHomo sapiens (human)IC502.125044
60S ribosomal protein L14Homo sapiens (human)IC502.125044
60S ribosomal protein L15Homo sapiens (human)IC502.125044
60S ribosomal protein L17Homo sapiens (human)IC502.125044
60S ribosomal protein L18Homo sapiens (human)IC502.125044
60S ribosomal protein L18aHomo sapiens (human)IC502.125044
60S ribosomal protein L19Homo sapiens (human)IC502.125044
60S ribosomal protein L21Homo sapiens (human)IC502.125044
60S ribosomal protein L22Homo sapiens (human)IC502.125044
60S ribosomal protein L23Homo sapiens (human)IC502.125044
60S ribosomal protein L23aHomo sapiens (human)IC502.125044
60S ribosomal protein L24Homo sapiens (human)IC502.125044
60S ribosomal protein L26Homo sapiens (human)IC502.125044
60S ribosomal protein L27Homo sapiens (human)IC502.125044
60S ribosomal protein L27aHomo sapiens (human)IC502.125044
60S ribosomal protein L28Homo sapiens (human)IC502.125044
60S ribosomal protein L29Homo sapiens (human)IC502.125044
60S ribosomal protein L3Homo sapiens (human)IC502.125044
60S ribosomal protein L30Homo sapiens (human)IC502.125044
60S ribosomal protein L31Homo sapiens (human)IC502.125044
60S ribosomal protein L32Homo sapiens (human)IC502.125044
60S ribosomal protein L34Homo sapiens (human)IC502.125044
60S ribosomal protein L35Homo sapiens (human)IC502.125044
60S ribosomal protein L35aHomo sapiens (human)IC502.125044
60S ribosomal protein L36Homo sapiens (human)IC502.125044
60S ribosomal protein L36aHomo sapiens (human)IC502.125044
60S ribosomal protein L37Homo sapiens (human)IC502.125044
60S ribosomal protein L37aHomo sapiens (human)IC502.125044
60S ribosomal protein L38Homo sapiens (human)IC502.125044
60S ribosomal protein L39Homo sapiens (human)IC502.125044
60S ribosomal protein L4Homo sapiens (human)IC502.125044
60S ribosomal protein L41Homo sapiens (human)IC502.125044
60S ribosomal protein L5Homo sapiens (human)IC502.125044
60S ribosomal protein L6Homo sapiens (human)IC502.125044
60S ribosomal protein L7Homo sapiens (human)IC502.125044
60S ribosomal protein L7aHomo sapiens (human)IC502.125044
60S ribosomal protein L8Homo sapiens (human)IC502.125044
60S ribosomal protein L9Homo sapiens (human)IC502.125044
Cytochrome P450 1A2Homo sapiens (human)IC5030.000011
Cytochrome P450 2C9 Homo sapiens (human)IC5030.000011
Cytochrome P450 2D6Homo sapiens (human)IC5030.000011
Cytochrome P450 3A4Homo sapiens (human)IC5030.000011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)IC508.500011
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)Ki18.100011
Proprotein convertase subtilisin/kexin type 9Homo sapiens (human)IC500.750011
Ubiquitin-40S ribosomal protein S27aHomo sapiens (human)IC502.125044
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