Compounds > cirsimarin
Page last updated: 2024-09-26

cirsimarin

Description

cirsimarin: a flavone glycoside from Microtea debilis; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Microteagenus[no description available]Microteaceae[no description available]

Cross-References

ID SourceID
PubMed CID159460
CHEMBL ID517637
CHEBI ID192417
SCHEMBL ID2016369
MeSH IDM0280270

Synonyms (25)

Synonym
4h-1-benzopyran-4-one, 2-(4-(beta-d-glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-
cirsitakaoside
cirsimarin
2-(4-(beta-d-glucopyranosyloxy)phenyl)-5-hydroxy-6,7-dimethoxy-4h-1-benzopyran-4-one
bdbm50250467
CHEMBL517637 ,
13020-19-4
CHEBI:192417
5-hydroxy-6,7-dimethoxy-2-[4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]chromen-4-one
SCHEMBL2016369
DTXSID80926633
4-(5-hydroxy-6,7-dimethoxy-4-oxo-4h-1-benzopyran-2-yl)phenyl hexopyranoside
HY-N7272
CS-0111105
Q63399214
MS-28836
STARBLD0000899
E80544
AKOS040732824
5,4'-dihydroxy-6,7-dimethoxyflavone 4'-o-beta-d-glucoside
72U3YNK7DV
cirsimaretin
2-[4-(beta-d-glucopyranosyloxy)phenyl]-5-hydroxy-6,7-dimethoxy-4h-1-benzopyran-4-one
4h-1-benzopyran-4-one, 2-[4-(beta-d-glucopyranosyloxy)phenyl]-5-hydroxy-6,7-dimethoxy-
cirsimaritin 4'-glucoside

Drug Classes (2)

ClassDescription
glycosideA glycosyl compound resulting from the attachment of a glycosyl group to a non-acyl group RO-, RS-, RSe-, etc. The bond between the glycosyl group and the non-acyl group is called a glycosidic bond. By extension, the terms N-glycosides and C-glycosides are used as class names for glycosylamines and for compounds having a glycosyl group attached to a hydrocarbyl group respectively. These terms are misnomers and should not be used. The preferred terms are glycosylamines and C-glycosyl compounds, respectively.
flavonoidsAny organic molecular entity whose stucture is based on derivatives of a phenyl-substituted 1-phenylpropane possessing a C15 or C16 skeleton, or such a structure which is condensed with a C6-C3 lignan precursors. The term is a 'superclass' comprising all members of the classes of flavonoid, isoflavonoid, neoflavonoid, chalcones, dihydrochalcones, aurones, pterocarpan, coumestans, rotenoid, flavonolignan, homoflavonoid and flavonoid oligomers. Originally restricted to natural products, the term is also applied to synthetic compounds related to them.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Xanthine dehydrogenase/oxidaseHomo sapiens (human)IC50 (µMol)100.00000.00132.81389.8200AID399340
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (27)

Processvia Protein(s)Taxonomy
allantoin metabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of protein phosphorylationXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of endothelial cell proliferationXanthine dehydrogenase/oxidaseHomo sapiens (human)
guanine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
inosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
deoxyinosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
adenosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
deoxyadenosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
deoxyguanosine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
AMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
IMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
activation of cysteine-type endopeptidase activity involved in apoptotic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
lactationXanthine dehydrogenase/oxidaseHomo sapiens (human)
hypoxanthine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
xanthine catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of gene expressionXanthine dehydrogenase/oxidaseHomo sapiens (human)
iron-sulfur cluster assemblyXanthine dehydrogenase/oxidaseHomo sapiens (human)
amide catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of endothelial cell differentiationXanthine dehydrogenase/oxidaseHomo sapiens (human)
GMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
dGMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
dAMP catabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionXanthine dehydrogenase/oxidaseHomo sapiens (human)
positive regulation of p38MAPK cascadeXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of vascular endothelial growth factor signaling pathwayXanthine dehydrogenase/oxidaseHomo sapiens (human)
positive regulation of reactive oxygen species metabolic processXanthine dehydrogenase/oxidaseHomo sapiens (human)
negative regulation of vasculogenesisXanthine dehydrogenase/oxidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (11)

Processvia Protein(s)Taxonomy
xanthine dehydrogenase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
xanthine oxidase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
iron ion bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
protein bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
protein homodimerization activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
molybdopterin cofactor bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
flavin adenine dinucleotide bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
2 iron, 2 sulfur cluster bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
hypoxanthine dehydrogenase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
hypoxanthine oxidase activityXanthine dehydrogenase/oxidaseHomo sapiens (human)
FAD bindingXanthine dehydrogenase/oxidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Processvia Protein(s)Taxonomy
cytosolXanthine dehydrogenase/oxidaseHomo sapiens (human)
extracellular spaceXanthine dehydrogenase/oxidaseHomo sapiens (human)
peroxisomeXanthine dehydrogenase/oxidaseHomo sapiens (human)
cytosolXanthine dehydrogenase/oxidaseHomo sapiens (human)
sarcoplasmic reticulumXanthine dehydrogenase/oxidaseHomo sapiens (human)
extracellular spaceXanthine dehydrogenase/oxidaseHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID399341Antioxidant activity assessed as superoxide-scavenging activity by nitrite method1998Journal of natural products, Jan, Volume: 61, Issue:1
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
AID403920Displacement of [3H]DPCPX from adenosine A1 receptor in rat forebrain membrane in presence of GTP1997Journal of natural products, Jun, Volume: 60, Issue:6
Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis.
AID403919Displacement of [3H]DPCPX from adenosine A1 receptor in rat forebrain membrane1997Journal of natural products, Jun, Volume: 60, Issue:6
Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis.
AID338974Inhibition of cow milk xanthine oxidase at 50 ug/mL
AID403918Displacement of [3H]DPCPX from adenosine A1 receptor in rat forebrain membrane assessed as fraction of receptor bound radioligand at 100 ug/mL1997Journal of natural products, Jun, Volume: 60, Issue:6
Adenosine-1 active ligands: cirsimarin, a flavone glycoside from Microtea debilis.
AID399340Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry1998Journal of natural products, Jan, Volume: 61, Issue:1
Structure-activity relationship and classification of flavonoids as inhibitors of xanthine oxidase and superoxide scavengers.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's4 (40.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's2 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
flavone[no description available]medium10flavonesmetabolite;
nematicide
quercetin pentaacetate[no description available]medium10
sakuranetin[no description available]medium10(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
flavonoid phytoalexin;
monomethoxyflavanone		antimycobacterial drug;
plant metabolite
prunin protein, prunus[no description available]medium10(2S)-flavan-4-one;
4'-hydroxyflavanones;
dihydroxyflavanone;
flavanone 7-O-beta-D-glucoside;
monosaccharide derivative		antibacterial agent;
antilipemic drug;
hypoglycemic agent;
metabolite
daidzin[no description available]medium107-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative		plant metabolite
homoorientin[no description available]medium10flavone C-glycoside;
tetrahydroxyflavone		antineoplastic agent;
radical scavenger
liquiritigenin[no description available]medium104',7-dihydroxyflavanonehormone agonist;
plant metabolite
astilbin[no description available]medium103'-hydroxyflavanones;
4'-hydroxyflavanones;
alpha-L-rhamnoside;
flavanone glycoside;
monosaccharide derivative;
tetrahydroxyflavanone		anti-inflammatory agent;
plant metabolite;
radical scavenger
aromadedrin[no description available]medium104'-hydroxyflavanones;
dihydroflavonols;
secondary alpha-hydroxy ketone;
tetrahydroxyflavanone		metabolite
swertisin[no description available]medium10dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone;
monosaccharide derivative;
polyphenol		adenosine A1 receptor antagonist;
anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite
cirsiliol[no description available]medium10dimethoxyflavone;
trihydroxyflavone		plant metabolite
isosakuranetin[no description available]medium10(2S)-flavan-4-one;
4'-methoxyflavanones;
dihydroxyflavanone;
monomethoxyflavanone		plant metabolite
cirsilineol[no description available]medium10dihydroxyflavone;
trimethoxyflavone		antineoplastic agent;
plant metabolite
pectolinarin[no description available]medium10dimethoxyflavone;
disaccharide derivative;
glycosyloxyflavone;
monohydroxyflavanone;
rutinoside		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
plant metabolite
irisflorentin[no description available]medium104'-methoxyisoflavones
scutellarin[no description available]medium10glucosiduronic acid;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antineoplastic agent;
proteasome inhibitor
cirsimaritin[no description available]medium30dihydroxyflavone;
dimethoxyflavone
phellamurin[no description available]medium104'-hydroxyflavanones;
beta-D-glucoside;
dihydroflavonols;
flavanone glycoside;
monosaccharide derivative;
trihydroxyflavanone		metabolite
taxifolin[no description available]medium10taxifolinmetabolite
eriodictyol[no description available]medium103'-hydroxyflavanones;
tetrahydroxyflavanone
5,6,7-trimethoxyflavone[no description available]medium10trimethoxyflavoneanti-HSV-1 agent;
plant metabolite
likviriton[no description available]medium10beta-D-glucoside;
flavanone glycoside;
monohydroxyflavanone;
monosaccharide derivative		anti-inflammatory agent;
anticoronaviral agent;
plant metabolite
quercetin 3-o-glucuronide[no description available]medium10beta-D-glucosiduronic acid;
quercetin O-glycoside		antidepressant;
antioxidant;
metabolite
formononetin[no description available]medium104'-methoxyisoflavones;
7-hydroxyisoflavones		phytoestrogen;
plant metabolite
vitexin[no description available]medium20C-glycosyl compound;
trihydroxyflavone		antineoplastic agent;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
plant metabolite;
platelet aggregation inhibitor
acacetin[no description available]medium10dihydroxyflavone;
monomethoxyflavone		anticonvulsant;
plant metabolite
luteolin-7-glucoside[no description available]medium10beta-D-glucoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antioxidant;
plant metabolite
chrysoeriol[no description available]medium10monomethoxyflavone;
trihydroxyflavone		antineoplastic agent;
antioxidant;
metabolite
quercetin 3-o-methyl ether[no description available]medium10monomethoxyflavone;
tetrahydroxyflavone		antimicrobial agent;
metabolite
apigetrin[no description available]medium10beta-D-glucoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative		antibacterial agent;
metabolite;
non-steroidal anti-inflammatory drug
genistein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
genistin[no description available]medium107-hydroxyisoflavones 7-O-beta-D-glucoside
amentoflavone[no description available]medium10biflavonoid;
hydroxyflavone;
ring assembly		angiogenesis inhibitor;
antiviral agent;
cathepsin B inhibitor;
P450 inhibitor;
plant metabolite
baicalein[no description available]medium20trihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
diosmin[no description available]medium10dihydroxyflavanone;
disaccharide derivative;
glycosyloxyflavone;
monomethoxyflavone;
rutinoside		anti-inflammatory agent;
antioxidant
hyperoside[no description available]medium20beta-D-galactoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		hepatoprotective agent;
plant metabolite
3-methylquercetin[no description available]medium207-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone		anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite
orientin[no description available]medium103'-hydroxyflavonoid;
C-glycosyl compound;
tetrahydroxyflavone		antioxidant;
metabolite
robinetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		plant metabolite
sciadopitysin[no description available]medium10biflavonoid;
hydroxyflavone;
methoxyflavone;
ring assembly		bone density conservation agent;
platelet aggregation inhibitor
scutellarein[no description available]medium10tetrahydroxyflavonemetabolite
wogonin[no description available]medium10dihydroxyflavone;
monomethoxyflavone		angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite
daidzein[no description available]medium107-hydroxyisoflavonesantineoplastic agent;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
phytoestrogen;
plant metabolite
iridin[no description available]medium104'-methoxyisoflavones;
7-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
monosaccharide derivative		plant metabolite
tectoridin[no description available]medium107-hydroxyisoflavones 7-O-beta-D-glucoside;
hydroxyisoflavone;
methoxyisoflavone;
monosaccharide derivative		plant metabolite
tectorigenin[no description available]medium107-hydroxyisoflavones;
methoxyisoflavone		anti-inflammatory agent;
plant metabolite
kaempferol-3-o-galactoside[no description available]medium10beta-D-galactoside;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		antifungal agent;
plant metabolite
rhoifolin[no description available]medium10dihydroxyflavone;
glycosyloxyflavone;
neohesperidoside		metabolite
veronicastroside[no description available]medium20disaccharide derivative;
glycosyloxyflavone;
neohesperidoside;
trihydroxyflavone		antibacterial agent;
metabolite
quercimeritrin[no description available]medium10beta-D-glucoside;
flavonols;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antioxidant;
metabolite
linarin[no description available]medium20
fustin[no description available]medium10
juglanin[no description available]medium10flavonoids;
glycoside
5,7-dihydroxy-4',6-dimethoxyflavone[no description available]medium10dihydroxyflavone;
dimethoxyflavone		plant metabolite
sophoricoside[no description available]medium10acrovestone;
isoflavonoid
tilianin[no description available]medium10
4',5,7-trihydroxy-3,6-dimethoxyflavone[no description available]medium10
irigenin[no description available]medium104'-methoxyisoflavones;
hydroxyisoflavone		plant metabolite
narcissin flavonol[no description available]medium10disaccharide derivative;
glycosyloxyflavone;
monomethoxyflavone;
trihydroxyflavone
lespenefril[no description available]medium10alpha-L-rhamnoside;
dihydroxyflavone;
glycosyloxyflavone;
monosaccharide derivative;
polyphenol		anti-inflammatory agent;
antidepressant;
antineoplastic agent;
apoptosis inducer;
bone density conservation agent;
hypoglycemic agent;
immunomodulator;
plant metabolite
avicularin[no description available]medium10alpha-L-arabinofuranoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		hepatoprotective agent;
plant metabolite
kaempferol 7-o-glucoside[no description available]medium10beta-D-glucoside;
flavonols;
kaempferol O-glucoside;
monosaccharide derivative;
trihydroxyflavone		metabolite;
plant metabolite;
radical scavenger
Diosmetin 7-O-beta-D-glucopyranoside[no description available]medium10flavonoids;
glycoside
apigenin[no description available]medium20trihydroxyflavoneantineoplastic agent;
metabolite
quercitrin[no description available]medium20alpha-L-rhamnoside;
monosaccharide derivative;
quercetin O-glycoside;
tetrahydroxyflavone		antileishmanial agent;
antioxidant;
EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor;
EC 1.1.1.21 (aldehyde reductase) inhibitor;
EC 1.14.18.1 (tyrosinase) inhibitor;
plant metabolite
rutin[no description available]medium20disaccharide derivative;
quercetin O-glucoside;
rutinoside;
tetrahydroxyflavone		antioxidant;
metabolite
kaempferol[no description available]medium207-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
myricetin[no description available]medium207-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
kaempferol-3-o-rutinoside[no description available]medium20disaccharide derivative;
kaempferol O-glucoside;
rutinoside;
trihydroxyflavone		metabolite;
plant metabolite;
radical scavenger
taxifolin[no description available]medium103'-hydroxyflavanones;
4'-hydroxyflavanones;
dihydroflavonols;
pentahydroxyflavanone;
secondary alpha-hydroxy ketone
catechin[no description available]medium10catechinantioxidant;
plant metabolite
3-hydroxyflavone[no description available]medium10flavonols;
monohydroxyflavone
tangeretin[no description available]medium10pentamethoxyflavoneantineoplastic agent;
plant metabolite
epicatechin[no description available]medium10catechin;
polyphenol		antioxidant
gallocatechol[no description available]medium10catechin;
flavan-3,3',4',5,5',7-hexol		antioxidant;
food component;
plant metabolite
nobiletin[no description available]medium10methoxyflavoneantineoplastic agent;
plant metabolite
4'-hydroxyflavanone[no description available]medium104'-hydroxyflavanones;
monohydroxyflavanone
naringenin[no description available]medium10(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
quercetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
luteolin[no description available]medium103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
chrysin[no description available]medium107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
fisetin[no description available]medium103'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
galangin[no description available]medium107-hydroxyflavonol;
trihydroxyflavone		antimicrobial agent;
EC 3.1.1.3 (triacylglycerol lipase) inhibitor;
plant metabolite
morin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
ombuine[no description available]medium10dimethoxyflavone;
flavonols;
trihydroxyflavone		anti-inflammatory agent;
plant metabolite
tiliroside[no description available]medium10cinnamate ester;
glycosyloxyflavone;
monosaccharide derivative;
trihydroxyflavone		plant metabolite
allopurinol[no description available]medium10nucleobase analogue;
organic heterobicyclic compound		antimetabolite;
EC 1.17.3.2 (xanthine oxidase) inhibitor;
gout suppressant;
radical scavenger
glycosides[no description available]medium90
1,3-dipropyl-8-cyclopentylxanthine[no description available]medium10oxopurineadenosine A1 receptor antagonist;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
adenosine-5'-(n-ethylcarboxamide)[no description available]medium10adenosines;
monocarboxylic acid amide		adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
adenosine[no description available]medium10adenosines;
purines D-ribonucleoside		analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent
tomatine[no description available]low00alkaloid antibiotic;
glycoalkaloid;
glycoside;
steroid alkaloid;
tetrasaccharide derivative		antifungal agent;
immunological adjuvant;
phytotoxin
sucrose octaacetate[no description available]low00glycoside
phenyl beta-d-glucopyranoside[no description available]low00glycoside
thiocolchicoside[no description available]low00glycoside
plumieride[no description available]low00glycoside
chrysomycin a[no description available]low00glycoside
convicine[no description available]low00glycoside
gentiopicroside[no description available]low00glycoside
picein[no description available]low00glycoside
populin[no description available]low00glycoside
skimmin[no description available]low00coumarins;
glycoside
arctiin[no description available]low00glycoside;
lignan
dodecyl-beta-d-maltoside[no description available]low00disaccharide derivative;
glycoside		detergent
gastrodin[no description available]low00glycoside
phenylglucuronide[no description available]low00glycoside
nepitrin[no description available]low00flavonoids;
glycoside
4-methylumbelliferylcellobioside[no description available]low00coumarins;
glycoside
bungeiside c[no description available]low00glycoside
4-(rhamnosyloxy)phenylacetonitrile[no description available]low00glycoside
lac dye[no description available]low00disaccharide derivative;
glycoside;
monoazo compound		dye
leiocarposide[no description available]low00glycoside
rhodioloside[no description available]low00glycoside
sweroside[no description available]low00glycoside
aloenin[no description available]low00glycoside
tracheloside[no description available]low00glycoside;
lignan		metabolite
tribenoside[no description available]low00glycoside
beta-indol-3-yl-glucoside[no description available]low00glycoside;
indoles
7-hydroxy-5-methyl-2-(2-oxopropyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one[no description available]low00glycoside
levanbiose[no description available]low00glycoside
ranunculin[no description available]low00glycoside
swertiamarin[no description available]low00glycoside
Rhododendrin[no description available]low00glycoside
tremulacin[no description available]low00glycoside
acarbose[no description available]low00amino cyclitol;
glycoside
isopropyl-beta-galactopyranoside[no description available]low00glycoside
acarviosine[no description available]low00amino cyclitol;
glycoside
hidrosmin[no description available]low00flavonoids;
glycoside
glucovanillin[no description available]low00glycoside
resveratrol-4'-o-glucuronide[no description available]low00glycoside;
stilbenoid
chartreusin[no description available]low00benzochromenone;
glycoside
isorhapontin[no description available]low00glycoside;
stilbenoid
acteoside[no description available]low00catechols;
cinnamate ester;
disaccharide derivative;
glycoside;
polyphenol		anti-inflammatory agent;
antibacterial agent;
antileishmanial agent;
neuroprotective agent;
plant metabolite
josamycin[no description available]low00acetate ester;
aldehyde;
disaccharide derivative;
glycoside;
macrolide antibiotic;
tertiary alcohol;
tertiary amino compound		antibacterial drug;
metabolite
rutin[no description available]low00flavonoids;
glycoside
desoxyrhaponticin[no description available]low00glycoside;
stilbenoid
kaempferol 3-o-neohesperidoside[no description available]low00flavonoids;
glycoside
neoisoliquiritin[no description available]low00flavonoids;
glycoside
4-[4-(4-hydroxy-3-methoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]-2-methoxyphenyl hexopyranoside[no description available]low00glycoside;
lignan
Diosmetin rutinoside[no description available]low00flavonoids;
glycoside
simmondsin[no description available]low00glycoside
icarrin[no description available]low00flavonoids;
glycoside
vitexin rhamnoside[no description available]low00flavonoids;
glycoside
epimedin b[no description available]low00flavonoids;
glycoside
epimedin c[no description available]low00flavonoids;
glycoside
hesperidin[no description available]low00flavonoids;
glycoside
marein[no description available]low00flavonoids;
glycoside
isoliquiritin apioside[no description available]low00flavonoids;
glycoside
mulberroside a[no description available]low00glycoside;
stilbenoid
2''-galloylhyperin[no description available]low00flavonoids;
glycoside
sergliflozin etabonate[no description available]low00glycoside
7-monohydroxyethylrutoside[no description available]low00flavonoids;
glycoside
remogliflozin etabonate[no description available]low00glycoside
ginsenoside rb1[no description available]low00ginsenoside;
glycoside;
tetracyclic triterpenoid		anti-inflammatory drug;
anti-obesity agent;
apoptosis inhibitor;
neuroprotective agent;
plant metabolite;
radical scavenger
ginsenoside rg3[no description available]low00ginsenoside;
glycoside;
tetracyclic triterpenoid		angiogenesis modulating agent;
antineoplastic agent;
apoptosis inducer;
plant metabolite
goniothalesdiol[no description available]low00glycoside
sagittatoside b[no description available]low00flavonoids;
glycoside
pumiloside[no description available]low00glycoside
ipragliflozin[no description available]low00glycoside
kelampayoside a[no description available]low00glycosidemetabolite
4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid o-glucoside[no description available]low00glycoside
garcimangosone d[no description available]low00glycoside
Asebotin[no description available]low00flavonoids;
glycoside
Phenylethyl beta-D-glucopyranoside[no description available]low00glycoside
3-hydroxy-3-methyl-5-oxo-5-[[3,4,5-trihydroxy-6-[[6-methoxy-2-oxo-3-[(2-oxo-1-benzopyran-7-yl)oxy]-1-benzopyran-7-yl]oxy]-2-oxanyl]methoxy]pentanoic acid[no description available]low00coumarins;
glycoside
asperulosidic acid[no description available]low00glycoside;
iridoid monoterpenoid
verproside[no description available]low00glycosidemetabolite
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 6-O-(6-deoxyhexopyranosyl)hexopyranoside[no description available]low00flavonoids;
glycoside
helicide[no description available]low00glycoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-3-yl 2-O-hexopyranosylhexopyranoside[no description available]low00flavonoids;
glycoside
Shanzhiside methyl ester[no description available]low00glycoside;
iridoid monoterpenoid
3'',4''-Diacetylafzelin[no description available]low00flavonoids;
glycoside
2-[1-[1-hydroxy-10,13-dimethyl-3-[3,4,5-trihydroxy-6-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethyl]-4,5-dimethyl-2,3-dihydropyran-6-one[no description available]low00glycoside;
withanolide
cellulose[no description available]low00glycoside
salirepin[no description available]low00glycoside
didymin[no description available]low00flavonoids;
glycoside
ethyl cellulose[no description available]low00glycoside
salicortin[no description available]low00glycoside
bacillithiol[no description available]low00glycoside;
monosaccharide derivative;
thiol		antioxidant;
bacterial metabolite;
cofactor
multiflorin a[no description available]low00flavonoids;
glycoside
typhaneoside[no description available]low00flavonoids;
glycoside
vanilloloside[no description available]low00glycosidemetabolite
jadomycin b[no description available]low00glycoside;
jadomycin;
organic heteropentacyclic compound		antibacterial agent;
antineoplastic agent;
apoptosis inducer;
Aurora kinase inhibitor;
bacterial metabolite
(20R)-ginsenoside Rg3[no description available]low00ginsenoside;
glycoside;
tetracyclic triterpenoid		antioxidant;
plant metabolite
5-hydroxytryptophol glucuronide[no description available]low00glycoside
coumermycin[no description available]low00aromatic amide;
coumarins;
glycoside;
heteroarenecarboxylate ester;
pyrroles		antimicrobial agent;
antineoplastic agent;
bacterial metabolite;
DNA synthesis inhibitor;
Hsp90 inhibitor;
topoisomerase IV inhibitor
ascorbic acid 2-o-glucoside[no description available]low00glycoside
opt 80[no description available]low00carboxylic ester;
glycoside;
macrolide antibiotic;
organochlorine compound;
phenols		antibacterial drug;
bacterial metabolite;
EC 2.7.7.6 (RNA polymerase) inhibitor
pravastatin[no description available]low00glycoside;
lignan
dehydrotomatine[no description available]low00alkaloid antibiotic;
glycoside;
steroid alkaloid;
tetrasaccharide derivative		antifungal agent;
phytotoxin;
plant metabolite
vicine[no description available]low00glycoside
dimefline[no description available]low00ether;
flavonoids
hesperetin[no description available]low00ether;
flavonoids
4'-methoxyflavone[no description available]low00ether;
flavonoids
5,7,4'-trimethylapigenin[no description available]low00ether;
flavonoids
5-Methoxyflavone[no description available]low00ether;
flavonoids
cellulose sulfate[no description available]low00ether;
flavonoids
5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone[no description available]low00ether;
flavonoids
2'-methoxyflavone[no description available]low00ether;
flavonoids
6-methoxyflavone[no description available]low00ether;
flavonoids
3,3',4',5,6,7,8-heptamethoxyflavone[no description available]low00ether;
flavonoids
sideritoflavone[no description available]low00ether;
flavonoids
3'-demethylnobiletin[no description available]low00ether;
flavonoids
3',4',5'-trimethoxyflavone[no description available]low00ether;
flavonoids
5-demethylnobiletin[no description available]low00ether;
flavonoids
5-Hydroxy-7-methoxy-6-methylflavone[no description available]low00ether;
flavonoids
5,7-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one[no description available]low00ether;
flavonoids
7-methoxyflavone[no description available]low00ether;
flavonoids
negletein[no description available]low00ether;
flavonoids
5-hydroxy-6,7-dimethoxyflavone[no description available]low00ether;
flavonoids
zapotin[no description available]low00ether;
flavonoids
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one[no description available]low00ether;
flavonoids
6-methoxy-2-(3-methoxyphenyl)-1-benzopyran-4-one[no description available]low00ether;
flavonoids
3,7-dimethoxyflavone[no description available]low00ether;
flavonoids
6-methoxy-2-(4-methoxyphenyl)-1-benzopyran-4-one[no description available]low00ether;
flavonoids
N-(2-ethylphenyl)-2-[[2-(4-methoxyphenyl)-4-oxo-1-benzopyran-6-yl]oxy]acetamide[no description available]low00ether;
flavonoids
6,3',4'-Trimethoxyflavanone[no description available]low00ether;
flavonoids
demethoxysudachitin[no description available]low00ether;
flavonoids
2-[[2-(4-methoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]-4-methylpentanoic acid[no description available]low00ether;
flavonoids
5,7-dihydroxy-2-(4-hydroxyphenyl)-6-[3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]-8-(3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)-4H-chromen-4-one[no description available]low00C-glycosyl compound;
flavonoids
2-[[2-(3,4-dimethoxyphenyl)-6-methyl-1-benzopyran-4-ylidene]amino]butanoic acid[no description available]low00ether;
flavonoids
6-(5,6-Dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid[no description available]low00flavonoids;
glucosiduronic acid
alpinetin[no description available]low00ether;
flavonoids
isovitexin[no description available]low00C-glycosyl compound;
flavonoids
7-methoxy-2-(4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one[no description available]low00ether;
flavonoids
hydroxygenkwanin[no description available]low00ether;
flavonoids
Kumatakenin[no description available]low00ether;
flavonoids
apigenin-7-o-beta-d-glucuronide[no description available]low00flavonoids;
glucosiduronic acid
artemetin[no description available]low00ether;
flavonoids
apigenin-7-o-glucuronide[no description available]low00flavonoids;
glucosiduronic acid
ternatin (flavonoid)[no description available]low00ether;
flavonoids
1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]hexitol[no description available]low00C-glycosyl compound;
flavonoids
5,7-dihydroxy-2-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]-1-benzopyran-4-one[no description available]low00C-glycosyl compound;
flavonoids
pinostrobin[no description available]low00ether;
flavonoids
calycopterin[no description available]low00ether;
flavonoids
5-Hydroxyauranetin[no description available]low00ether;
flavonoids
sudachitin[no description available]low00ether;
flavonoids
4'-hydroxy-5,6,7,8,3'-pentamethoxyflavone[no description available]low00ether;
flavonoids
ConditionIndicatedRelationship StrengthStudiesTrials
Abnormalities, Autosome0low10
Abnormalities, Chromosomal0low10
Abnormalities, Chromosome0low10
Acute Kidney Failure0low10
Acute Kidney Injury0low10
Acute Kidney Insufficiency0low10
Acute Renal Failure0low10
Acute Renal Injury0low10
Acute Renal Insufficiency0low10
Autosome Abnormalities0low10
Body Weight0low10
Breast Cancer0low10
Breast Carcinoma0low10
Breast Neoplasms0low10
Breast Tumors0low10
Cancer of Breast0low10
Cancer of the Breast0low10
Chromosomal Aberrations0low10
Chromosome Aberrations0low10
Chromosome Abnormalities0low10
Cytogenetic Aberrations0low10
Cytogenetic Abnormalities0low10
Disease Models, Animal0low10
Human Mammary Carcinoma0low10
Inflammation0low10
Innate Inflammatory Response0low10
Kidney Failure, Acute0low10
Kidney Insufficiency, Acute0low10
Malignant Neoplasm of Breast0low10
Malignant Tumor of Breast0low10
Mammary Cancer0low10
Mammary Carcinoma, Human0low10
Mammary Neoplasm, Human0low10
Mammary Neoplasms, Human0low10
Neoplasms, Breast0low10
Renal Failure, Acute0low10
Renal Insufficiency, Acute0low10
Stomatitis, Vesicular0low10
Tumors, Breast0low10
Vesicular Stomatitis0low10