| Assay ID | Title | Year | Journal | Article |
|---|
| AID452853 | Antioxidant activity assessed as hydrogen peroxide scavenging activity by peroxyoxalate chemiluminescent method | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1849993 | Inhibition of synthetic AcPHF6 peptide aggregation in pH 7.4 phosphate buffer assessed as reduction in fluorescence intensity at 10 uM and measured every minute over 2 hrs by ThT fluorescence assay relative to control | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers. |
| AID767303 | Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate assessed as change in enzyme activity at 5 uM after 20 mins by scintillation counting analysis in presence of 33P-ATP relative to negative control | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID452849 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 20 mins | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID611431 | Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis at 20 uM | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. |
| AID452847 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 20 mins | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1173709 | Cytotoxicity against human MeT-5A cells after 16 hrs by luciferase reporter gene assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID452852 | Antioxidant activity assessed as hydroxyl radical scavenging activity at 100 uM | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1173706 | Inhibition of HDAC2 (unknown origin) after 15 mins by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID1173707 | Inhibition of HDAC6 (unknown origin) after 15 mins by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID1173704 | Inhibition of HDAC in human HeLa cell extract after 15 mins by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID452851 | Antioxidant activity assessed as superoxide anion radical scavenging activity at 10 uM | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1849995 | Displacement of ThT from AcPHF6 in pH 7.4 phosphate buffer at 1:1 compound:ThT ratio | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers. |
| AID452848 | Antioxidant activity assessed as DPPH radical scavenging activity at 50 uM after 60 mins | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID452856 | Inhibition of soybean 5-lipoxygenase at 100 uM by UV-absorbance based enzyme assay | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1173712 | Modulation of sirtuin 2 (unknown origin) by thermal shift assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID1173708 | Inhibition of HDAC in human MeT-5A cells assessed as hisone H3 acetylation after 16 hrs by BRET assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID611430 | Inhibition of HCV genotype 1b J4 N-terminal His-tagged NS5Bdelta21 polymerase expressed in Escherichia coli C41(DE3) assessed as amount of double-stranded RNA synthesis | 2011 | Journal of medicinal chemistry, Aug-11, Volume: 54, Issue:15
| Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase. |
| AID1173711 | Cytotoxicity against human HepG2 cells assessed as cell viability at 15 uM after 72 hrs by Celltitre-glo assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID767306 | Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate assessed as change in enzyme activity at 0.005 uM after 20 mins by scintillation counting analysis in presence of 33P-ATP relative to negative control | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID452850 | Antioxidant activity assessed as DPPH radical scavenging activity at 100 uM after 60 mins | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1173710 | Cytotoxicity against human MCF7 cells assessed as cell viability at 15 uM after 72 hrs by Celltitre-glo assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID767307 | Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate after 20 mins by scintillation counting analysis in presence of 33P-ATP | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID1849994 | Displacement of ThT from AcPHF6 in pH 7.4 phosphate buffer assessed as reduction in fluorescence intensity relative to control | 2022 | European journal of medicinal chemistry, Mar-05, Volume: 231 | Exploring the structure-activity relationship of benzylidene-2,3-dihydro-1H-inden-1-one compared to benzofuran-3(2H)-one derivatives as inhibitors of tau amyloid fibers. |
| AID767308 | Inhibition of CDK5/p25 (unknown origin) after 30 mins by SDS-PAGE analysis | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID767302 | Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate assessed as change in enzyme activity at 50 uM after 20 mins by scintillation counting analysis in presence of 33P-ATP relative to negative control | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID767304 | Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate assessed as change in enzyme activity at 0.5 uM after 20 mins by scintillation counting analysis in presence of 33P-ATP relative to negative control | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID767305 | Inhibition of CDK5/p25 (unknown origin)-mediated incorporation of gamma33P into substrate assessed as change in enzyme activity at 0.05 uM after 20 mins by scintillation counting analysis in presence of 33P-ATP relative to negative control | 2013 | Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
| Potential neuroprotective flavonoid-based inhibitors of CDK5/p25 from Rhus parviflora. |
| AID1173703 | Inhibition of HDAC in human HeLa cell extract at 100 uM after 15 mins by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID452854 | Antioxidant activity assessed as inhibition of AAPH-induced lipid peroxidation at 10 uM by uV spectrophotometry | 2009 | Bioorganic & medicinal chemistry, Dec-01, Volume: 17, Issue:23
| Natural and synthetic 2'-hydroxy-chalcones and aurones: synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity. |
| AID1173705 | Inhibition of HDAC1 (unknown origin) after 15 mins by fluorescence assay | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| AID1173713 | Inhibition of RAR-beta (unknown origin) assessed as change in DNA methylation | 2014 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 24, Issue:23
| Aurones as histone deacetylase inhibitors: identification of key features. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |