Page last updated: 2024-12-10
tectoridin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
tectoridin: glycosylated tectorigenin [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
tectoridin : A glycosyloxyisoflavone that is tectorigenin substituted by a beta-D-glucopyranosyl residue at position 7 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5281810 |
| CHEMBL ID | 520214 |
| CHEBI ID | 9428 |
| SCHEMBL ID | 241734 |
| MeSH ID | M0307113 |
Synonyms (37)
| Synonym |
|---|
| 4h-1-benzopyran-4-one, 7-(beta-d-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy- |
| brn 0068384 |
| tectoridin (7ci,8ci) |
| 4',5-dihydro-6-methoxy-7-(o-glucoside)isoflavone |
| 611-40-5 |
| shekanin |
| tectoridin |
| CHEMBL520214 |
| chebi:9428 , |
| 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one |
| 968x515nzh , |
| 4-18-00-03312 (beilstein handbook reference) |
| unii-968x515nzh |
| AKOS015897164 |
| SCHEMBL241734 |
| tectoridin [mi] |
| 4h-1-benzopyran-4-one, 7-(.beta.-d-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy- |
| tectorigenin-7-glucoside |
| tectorigenin 7-o-.beta.-d-glucopyranoside |
| T3724 |
| 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-chromen-4-one |
| 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4-oxo-4h-1-benzopyran-7-yl beta-d-glucopyranoside |
| Q-100704 |
| CNOURESJATUGPN-UDEBZQQRSA-N |
| DTXSID70209982 |
| mfcd01662715 |
| 7-(beta-d-glucopyranosyloxy)-5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-4h-1-benzopyran-4-one |
| 5-hydroxy-3-(4-hydroxyphenyl)-6-methoxy-7-(((2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)oxy)-4h-chromen-4-one |
| HY-N0791 |
| BS-17204 |
| Q10860610 |
| CCG-269367 |
| CS-0009803 |
| S3818 |
| bdbm50540975 |
| A868796 |
| tectorigenin 7-o-beta-d-glucopyranoside |
Research Excerpts
Overview
Tectoridin is a botanical active ingredient with anti-inflammatory properties. It is found in the flowers of Pueraria thomsonii Benth.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Tectoridin is a botanical active ingredient with anti-inflammatory properties." | ( Tectoridin exhibits anti-rheumatoid arthritis activity through the inhibition of the inflammatory response and the MAPK pathway in vivo and in vitro. Han, T; Huang, Q; Li, W; Liu, Y; Niu, X; Song, H; Xiao, X; Yang, Y; Yu, J; Zhang, D, 2022) | 2.89 |
| "Tectoridin is a major isoflavone found in the flowers of Pueraria thomsonii Benth. " | ( Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin. Gao, J; Makino, T; Qu, J; Sun, J; Yuan, D; Zhang, L, 2012) | 2.04 |
Treatment
| Excerpt | Reference | Relevance |
|---|---|---|
| "Tectoridin treatment further suppressed actin ring formation and in vitro bone resorption as determined via F-actin staining and scanning electron microscopy." | ( Tectoridin inhibits osteoclastogenesis and bone loss in a murine model of ovariectomy-induced osteoporosis. Bao, Y; Lv, X; Ma, B; Tang, Y; Wang, G; Wang, J; Wen, X; Zhang, J, 2020) | 2.72 |
Pharmacokinetics
The present method was successfully applied to the pharmacokinetic studies of tectoridin in rats after intravenous administration of three different doses. This study was aimed to analyze the Pharmacokinetic profile of Tectorigenin (the metabolite of tctoridin) after oral administration of I.
| Excerpt | Reference | Relevance |
|---|---|---|
| " The present method was successfully applied to the pharmacokinetic studies of tectoridin in rats after intravenous administration of three different doses." | ( Determination of tectoridin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Chen, Z; Guo, Y; Jiang, X; Liu, T; Ma, G, 2009) | 0.92 |
| " In the present study, we evaluated the plasma pharmacokinetic profile of tectoridin in rats." | ( Pharmacokinetics of conjugated metabolites in rat plasma after oral administration of tectoridin. Gao, J; Makino, T; Qu, J; Sun, J; Yuan, D; Zhang, L, 2012) | 0.83 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " at the same dosage for 10 days to ICR mice bearing sarcoma 180, caused a significant suppression in tumor weight by 44." | ( Anti-angiogenic and anti-tumor activities of isoflavonoids from the rhizomes of Belamcanda chinensis. Jung, SH; Kim, YS; Lee, S; Lee, YS; Lim, SS; Ohuchi, K; Shin, KH, 2003) | 0.32 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Roles (1)
| Role | Description |
|---|---|
| plant metabolite | Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. |
| [role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Drug Classes (4)
| Class | Description |
|---|---|
| hydroxyisoflavone | Member of the class of isoflavones bearing at least one hydroxy group. |
| methoxyisoflavone | Members of the class of isoflavones with at least one methoxy substituent. |
| monosaccharide derivative | A carbohydrate derivative that is formally obtained from a monosaccharide. |
| 7-hydroxyisoflavones 7-O-beta-D-glucoside | A glycosyloxyisoflavone that is any 7-hydroxyisoflavone compound in which the 7-hydroxy group has been converted into its corresponding O-beta-D-glucoside. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Bioassays (7)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID377455 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID338974 | Inhibition of cow milk xanthine oxidase at 50 ug/mL | |||
| AID377457 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 10 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID477213 | Increase in insulin-stimulated [3H]2-deoxy-D-glucose uptake in mouse 3T3L1cells at 1 uM after 3 days by liquid scintillation counting relative to insulin | 2010 | Journal of natural products, Apr-23, Volume: 73, Issue:4 | Homoisoflavonoids from the fibrous roots of Polygonatum odoratum with glucose uptake-stimulatory activity in 3T3-L1 adipocytes. |
| AID1656436 | Inhibition of beta-glucuronidase (unknown origin) | 2020 | European journal of medicinal chemistry, Feb-01, Volume: 187 | Therapeutic significance of β-glucuronidase activity and its inhibitors: A review. |
| AID377456 | Estrogenic activity in human MCF7 cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| AID377458 | Estrogenic activity in human T47D cells assessed as drug level causing stimulation of cell proliferation equivalent to 100 pM estradiol by alamar blue assay | 2005 | Journal of natural products, Mar, Volume: 68, Issue:3 | Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (46)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (8.70) | 18.2507 |
| 2000's | 17 (36.96) | 29.6817 |
| 2010's | 16 (34.78) | 24.3611 |
| 2020's | 9 (19.57) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 24.46
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (24.46) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (2.13%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 46 (97.87%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||