Compounds > viscolin
Page last updated: 2024-11-12

viscolin

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Description

viscolin: from Viscum coloratum; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ViscumgenusA plant genus in the family VISCACEAE, order Santalales, subclass Rosidae, class Magnoliopsida. Species of this genus contain cytotoxic LECTINS. The common name of MISTLETOE is used for many species of this and the LORANTHACEAE families.[MeSH]SantalaceaeA plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. They are parasites that form connections (haustoria) to their hosts to obtain water and nutrients. The one-seeded fruit may be surrounded by a brightly colored nut-like structure.[MeSH]

Cross-References

ID SourceID
PubMed CID16079989
CHEMBL ID221098
MeSH IDM0502215

Synonyms (6)

Synonym
viscolin
CHEMBL221098
912957-28-9
4-[3-(4-hydroxy-3-methoxyphenyl)propyl]-2,3,5-trimethoxyphenol
DTXSID10582044
4-(3-(4-hydroxy-3-methoxyphenyl)propyl)-2,3,5-trimethoxyphenol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (72)

Assay IDTitleYearJournalArticle
AID641218Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640137Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as decrease in number of inflammatory cells at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641281Down regulation of iNOS protein expression in LPS-stimulated mouse RAW264.7 cells at 20 uM after 24 hrs by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277127Inhibition of PKA at 25 uM by ELISA2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641274Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production at 20 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277112Inhibition of fMLP-induced calcium mobilisation in human peripheral leukocytes at 5 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641290Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced serum NO level at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641270Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 20 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277119Inhibition of PMA plus ionomycin-induced IFN-gamma production in human CD8+ leukocytes measured as mean channel fluorescence at 25 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID277125Cytotoxicity against microglial cells at 10 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641219Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 5 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277124Cytotoxicity against microglial cells at 5 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID640219Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as effect on shape of collagen fiber at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640118Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced serum TNFalpha level at 4 mg/kg, ip2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640223Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as reduction in iNOS immunoreactive cells at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277122Inhibition of PMA plus LPS-induced TNFalpha production in mouse BV2 cells measured as mean channel fluorescence at 25 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID277106Inhibition of PMA-induced ROS production in human PMN2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641215Antioxidant activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide anion generation2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640117Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced serum TNFalpha level at 2 mg/kg, ip2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641275Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277128Inhibition of PKC at 25 uM by ELISA2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID277129Inhibition of fMLP-induced calcium mobilisation in human peripheral leukocytes at 25 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID277110Inhibition of PKA in human peripheral leucocytes at 5 uM by ELISA2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641280Down regulation of COX-2 protein expression in LPS-stimulated mouse RAW264.7 cells at 20 uM after 24 hrs by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277121Inhibition of PMA plus LPS-induced TNFalpha production in mouse BV2 cells measured as mean channel fluorescence at 5 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID277111Inhibition of PKC in human peripheral leucocytes at 5 uM by ELISA2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641286Antiinflammatory activity in ICR mouse assessed as inhibition of carrageenan-induced hind paw edema at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277120Inhibition of PMA plus ionomycin-induced IFN-gamma production in human CD8+ leukocytes measured as mean channel fluorescence at 5 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641277Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production at 20 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641272Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production at 5 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640131Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in GPx activity at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640136Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced inflammatory response at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640130Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in GPx activity at 4 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640121Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in CAT activity at 2 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277109Inhibition of fMLP-induced ROS production in human mononuclear leukocytes2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641276Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production at 10 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641271Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640129Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in GPx activity at 2 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640133Down regulation of iNOS protein expression in carrageenan-stimulated ICR mouse at 8 mg/kg, ip measured after 5 hrs by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641278Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of COX-2 protein expression after 24 hrs by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641273Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNFalpha production at 10 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640225Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as decrease in cellular infiltration to intercellular spaces at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640220Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as decrease in intercellular spaces at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641217Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640126Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in SOD activity at 4 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640224Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as reduction in COX2 immunoreactive cells at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277113Inhibition of NOS-dependent nitric oxide production in mouse BV2 cells2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID277107Inhibition of fMLP-induced ROS production in human PMN2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641279Antiinflammatory activity in LPS-stimulated mouse RAW264.7 cells assessed as inhibition of iNOS protein expression after 24 hrs by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641283Inhibition of p38 phosphorylation in LPS-stimulated mouse RAW264.7 cells at 5 to 20 uM after 30 mins by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640138Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as vascular localization of inflammatory cells at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640127Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in SOD activity at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641285Antiinflammatory activity in ICR mouse assessed as inhibition of carrageenan-induced hind paw edema at 8 mg/kg, ip measured after 4 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640125Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in SOD activity at 2 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641282Inhibition of Erk1/2 phosphorylation in LPS-stimulated mouse RAW264.7 cells at 5 to 20 uM after 30 mins by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277108Inhibition of PMA-induced ROS production in human mononuclear leukocytes2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID640119Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced serum TNFalpha level at 8 mg/kg, ip2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640122Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in CAT activity at 4 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277123DPPH radical scavenging activity2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641216Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277117Inhibition of PMA plus ionomycin-induced IL2 production in human CD4+ Th cells measured as mean channel fluorescence at 25 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641292Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced serum TNFalpha level at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641288Antiinflammatory activity in ICR mouse assessed as decrease in carrageenan-induced MDA level at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640132Down regulation of COX-2 protein expression in carrageenan-stimulated ICR mouse at 8 mg/kg, ip measured after 5 hrs by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID641284Inhibition of JNK phosphorylation in LPS-stimulated mouse RAW264.7 cells at 5 to 20 uM after 30 mins by Western blot analysis2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID640221Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as effect on connective tissue damage at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277118Inhibition of PMA plus ionomycin-induced IL2 production in human CD4+ Th cells measured as mean channel fluorescence at 5 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID640222Antiinflammatory activity in carrageenan-stimulated ICR mouse assessed as decrease in neutrophil number at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277114Inhibition of NADPH oxidase-dependent nitric oxide production in mouse BV2 cells2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID640123Antioxidant activity in carrageenan-stimulated ICR mouse assessed as increase in CAT activity at 8 mg/kg, ip measured after 5 hrs2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
AID277126Cytotoxicity against microglial cells at 25 uM2006Bioorganic & medicinal chemistry letters, Dec-15, Volume: 16, Issue:24
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent.
AID641269Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM administered 1 hr before LPS challenge measured after 24 hrs by Griess method2012European journal of medicinal chemistry, Feb, Volume: 48A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.80

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.80 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index29.35 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (19.80)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
diphenyleneiodonium
diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor. dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.		2.0310organic cation
indomethacin
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.		2.0710aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
rolipram
[no description available]		2.0610pyrrolidin-2-onesantidepressant;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor
propane
Propane: A three carbon alkane with the formula H3CCH2CH3.		8.5680alkane;
gas molecular entity		food propellant
ng-nitroarginine methyl ester
NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.		2.0310alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid
[no description available]		2.0310chromanol;
monocarboxylic acid;
phenols		antioxidant;
ferroptosis inhibitor;
neuroprotective agent;
radical scavenger;
Wnt signalling inhibitor
formylmethionyl-leucyl-phenylalanine methyl ester
[no description available]		2.0310peptide
n-formylmethionine leucyl-phenylalanine
N-Formylmethionine Leucyl-Phenylalanine: A formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.. N-formyl-L-methionyl-L-leucyl-L-phenylalanine : A tripeptide composed of L-Met, L-Leu and L-Phe in a linear sequence with a formyl group at the amino terminus. It acts as a potent inducer of leucocyte chemotaxis and macrophage activator as well as a ligand for the FPR receptor.		2.4320tripeptide
chalcone
trans-chalcone : The trans-isomer of chalcone.		2.0710chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		7.0610
quercetin
[no description available]		2.03107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.0710prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
ConditionIndicatedRelationship StrengthStudiesTrials
Anasarca
[description not available]		02.0710
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.0710
Neointima
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.		07.1310
Hyperplasia
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.		07.1310
Innate Inflammatory Response
[description not available]		02.0610
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.0610
Bronchial Hyperreactivity
Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.		02.0610
Atherogenesis
[description not available]		02.0610
Atherosclerosis
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.		02.0610