myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP. [EC:2.7.1.140, GOC:pz]

Myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase (IP7K) is an enzyme that catalyzes the phosphorylation of inositol hexakisphosphate (IP6) to inositol heptakisphosphate (IP7). Specifically, IP7K adds a phosphate group to the 5-hydroxyl group of IP6, resulting in the formation of IP7. This reaction is crucial for various cellular processes, including:

- **Signal transduction:** IP7 acts as a second messenger, participating in various signaling pathways. For example, IP7 is involved in the regulation of calcium signaling, membrane trafficking, and cytoskeletal organization.

- **Gene expression:** IP7 influences gene expression by modulating the activity of transcription factors and other regulatory proteins.

- **Cellular growth and proliferation:** IP7 plays a role in regulating cell growth and proliferation by influencing the activity of key regulatory proteins involved in these processes.

- **Cellular stress response:** IP7 participates in the cellular response to various stresses, including oxidative stress, DNA damage, and nutrient deprivation.

In summary, IP7K, through the generation of IP7, plays a crucial role in a wide range of cellular processes, underscoring its importance in maintaining normal cellular function.'
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Proteins (1)

Compounds (15)