Page last updated: 2024-10-24

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

Definition

Target type: molecularfunction

Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP. [EC:2.7.1.140, GOC:pz]

Myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase (IP7K) is an enzyme that catalyzes the phosphorylation of inositol hexakisphosphate (IP6) to inositol heptakisphosphate (IP7). Specifically, IP7K adds a phosphate group to the 5-hydroxyl group of IP6, resulting in the formation of IP7. This reaction is crucial for various cellular processes, including:

- **Signal transduction:** IP7 acts as a second messenger, participating in various signaling pathways. For example, IP7 is involved in the regulation of calcium signaling, membrane trafficking, and cytoskeletal organization.

- **Gene expression:** IP7 influences gene expression by modulating the activity of transcription factors and other regulatory proteins.

- **Cellular growth and proliferation:** IP7 plays a role in regulating cell growth and proliferation by influencing the activity of key regulatory proteins involved in these processes.

- **Cellular stress response:** IP7 participates in the cellular response to various stresses, including oxidative stress, DNA damage, and nutrient deprivation.

In summary, IP7K, through the generation of IP7, plays a crucial role in a wide range of cellular processes, underscoring its importance in maintaining normal cellular function.'
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Proteins (1)

ProteinDefinitionTaxonomy
Inositol polyphosphate multikinaseAn inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5]Homo sapiens (human)

Compounds (15)

CompoundDefinitionClassesRoles
3',4'-dihydroxyflavone3',4'-dihydroxyflavone: inhibitors of arachidonic acid peroxidation
4',6-dihydroxyflavone4',6-dihydroxyflavone : A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 4' and 6.dihydroxyflavone
naringenin(S)-naringenin : The (S)-enantiomer of naringenin.(2S)-flavan-4-one;
naringenin
expectorant;
plant metabolite
eriodictyoleriodictyol : A tetrahydroxyflavanone that is flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' respectively.

eriodictyol: structure
3'-hydroxyflavanones;
tetrahydroxyflavanone
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
acacetin5,7-dihydroxy-4'-methoxyflavone : A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.dihydroxyflavone;
monomethoxyflavone
anticonvulsant;
plant metabolite
apigeninChamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.trihydroxyflavoneantineoplastic agent;
metabolite
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
kaempferol7-hydroxyflavonol;
flavonols;
tetrahydroxyflavone
antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
diosmetin3'-hydroxyflavonoid;
monomethoxyflavone;
trihydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
bone density conservation agent;
cardioprotective agent;
plant metabolite;
tropomyosin-related kinase B receptor agonist;
vasodilator agent
genkwaningenkwanin : A monomethoxyflavone that is apigenin in which the hydroxy group at position 7 is methylated.

genkwanin: structure
dihydroxyflavone;
monomethoxyflavone
metabolite
3-methylquercetinisorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.7-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone
anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
rhamnetinrhamnetin : A monomethoxyflavone that is quercetin methylated at position 7.

rhamnetin: aglycone of xanthorhamnin; from Rhamnus
monomethoxyflavone;
tetrahydroxyflavone
anti-inflammatory agent;
antioxidant;
metabolite
4',7-dihydroxyflavone4',7-dihydroxyflavone : A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7.

4',7-dihydroxyflavone: inducer of nod gene
dihydroxyflavonemetabolite