| Assay ID | Title | Year | Journal | Article |
|---|
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | | | |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID715781 | Induction of cell differentiation in human U937 cells assessed as increase of CD88 expression at 50 uM after 72 hrs by FACS flow cytometer analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID315168 | Induction of apoptosis in human U937 cells at 250 uM after 24 hrs | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID315170 | Reversal of induction of apoptosis in human U937 cells at 250 uM in presence of 10 mM NAC added every 8 hrs for 24 hrs | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID1701173 | Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by fluorescence polarization assay | 2021 | Bioorganic & medicinal chemistry, 01-01, Volume: 29 | Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. |
| AID33221 | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 10 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID715769 | Induction of apoptosis in human Jurkat cells assessed as activation of caspase-3-mediated PARP cleavage at 250 uM after 24 hrs by colorimetric assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID1349249 | Cytotoxicity against human A549 cells assessed as reduction in cell viability up to 120 ug/ml after 24 hrs by microscopic analysis | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Regioselective IBX-Mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activities. |
| AID195230 | Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 20 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID1349251 | Cytotoxicity against human A549 cells assessed as reduction in cell viability up to 120 ug/ml after 24 hrs by MTT assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Regioselective IBX-Mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activities. |
| AID715792 | Induction of apoptosis in human U937 cells assessed as PARP cleavage at 250 uM after 24 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID541338 | Inhibition of alpha-glucosidase using para-nitrophenyl substrate | 2010 | Journal of medicinal chemistry, Dec-09, Volume: 53, Issue:23
| Hydroxycoumarin derivatives: novel and potent α-glucosidase inhibitors. |
| AID715788 | Induction of apoptosis in human U937 cells assessed as increase of caspase-9 cleavage at 250 uM by Western blot analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID320334 | Protective effect against doxorubicin-induced oxidative stress in human MCF7 cells assessed as reduction of ROS level at 25 uM | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin. |
| AID715789 | Induction of apoptosis in human U937 cells assessed as increase of caspase-9 cleavage at 250 uM after 12 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715803 | Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID34798 | Compound was tested for inhibitory concentration against rat lens aldose reductase (uncompetitive inhibition type) | 1986 | Journal of medicinal chemistry, Jun, Volume: 29, Issue:6
| Synthesis and rat lens aldose reductase inhibitory activity of some benzopyran-2-ones. |
| AID33223 | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 30 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID715776 | Pro-oxidant activity in 0.1 M potassium phosphate buffer at pH 7.4 assessed as increase of oxidation potential by cyclic voltammetry analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715794 | Induction of apoptosis in human U937 cells assessed as activation of caspase-3 at 250 uM after 24 hrs by colorimetric assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID315165 | Growth inhibition of human U937 cells by [3H]thymidine incorporation assay | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID715786 | Induction of apoptosis in human U937 cells assessed as increase of caspase-8 cleavage at 250 uM after 12 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715784 | Induction of cell differentiation in human U937 cells assessed as increase of CD11b and CD14 expression at 50 uM after 72 hrs by FACS flow cytometer analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715764 | Induction of DNA damage in human U937 cells | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID320331 | Antioxidant activity in human MCF7 cells by FRAP test | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin. |
| AID977602 | Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID195231 | Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 30 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID1349250 | Cytotoxicity against human A549 cells assessed as reduction in cell viability up to 120 ug/ml after 24 hrs by tryphan blue exclusion assay | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Regioselective IBX-Mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activities. |
| AID1349252 | Antiviral activity against Influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in A549 cells assessed as reduction in viral titer after 24 to 48 hrs by hemagglutination test | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Regioselective IBX-Mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activities. |
| AID715765 | Cytotoxicity against human Jurkat at 250 uM after 48 hrs by trypan blue assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID315164 | Cytotoxicity against human U937 cells by trypan blue assay after 48 hrs | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID715773 | Pro-oxidant activity in human U937 cells assessed as DCF-DA oxidation up to 6 hrs by fluorescence assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715787 | Induction of apoptosis in human U937 cells assessed as activation of caspase-3 at 250 uM after 24 hrs by colorimetric assay in presence of caspase-9 inhibitor Z-LEHD-FMK | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID977599 | Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM | 2013 | Molecular pharmacology, Jun, Volume: 83, Issue:6
| Structure-based identification of OATP1B1/3 inhibitors. |
| AID715801 | Cell cycle arrest in human U937 cells assessed as accumulation at sub-G0/G1 phase at 250 uM after 24 hrs using propidium iodide staining by FACS analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID1349248 | Antioxidant activity assessed as DPPH radical scavenging activity incubated for 30 mins under dark condition | 2017 | Journal of natural products, 12-22, Volume: 80, Issue:12
| Regioselective IBX-Mediated Synthesis of Coumarin Derivatives with Antioxidant and Anti-influenza Activities. |
| AID715767 | Cytotoxicity against human PBMC at 250 uM after 48 hrs by trypan blue assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715785 | Induction of apoptosis in human U937 cells assessed as activation of caspase-3 at 250 uM after 24 hrs by colorimetric assay in presence of caspase-8 inhibitor Z-LETD-FMK | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715799 | Induction of apoptosis in human U937 cells assessed as phosphatidylserine expression in plasma membrane at 250 uM after 24 hrs by Annexin V-FITC double staining | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715802 | Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715775 | Induction of free radicals production in RPMI 1640 medium at pH 7.4 by electron spin resonance analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715774 | Induction of free radicals production in carbonate buffer at pH 9 by electron spin resonance analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID320332 | Antioxidant activity in human MCF7 cells assessed as reduction of H2O2 production at 100 uM | 2008 | Bioorganic & medicinal chemistry letters, Feb-01, Volume: 18, Issue:3
| Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin. |
| AID715805 | Induction of apoptosis in human U937 cells assessed as reduction of normal cells at 250 uM after 24 hrs by Annexin V-FITC double staining | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715772 | Pro-oxidant activity in human U937 cells assessed as DCF-DA oxidation at 10 to 250 uM by fluorescence assay | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715790 | Induction of apoptosis in human U937 cells assessed as active 11 kDa fragment of caspase-3 at 250 uM after 24 hrs by Western blot analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID33222 | The compound was evaluated for in Vitro binding of AFB1 to DNA in rat liver microsomes; Pre-incubation time being 20 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID1591995 | Inhibition of alpha-glucosidase (unknown origin) incubated for 20 mins before pNPG substrate addition and measured after 30 mins by UV spectrometry | 2019 | Bioorganic & medicinal chemistry, 06-15, Volume: 27, Issue:12
| α-Glucosidase inhibition activity and in silico study of 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one, a synthetic derivative of flavone. |
| AID715800 | Inhibition of clonogenic activity in human U937 cells assessed as reduction of colony formation in soft agar at 100 to 250 uM after 24 hrs using crystal violet staining | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID715778 | Induction of cell differentiation in human U937 cells assessed as increase of rhC5a-induced response at 50 uM after 72 hrs by FACS flow cytometer analysis | 2012 | Bioorganic & medicinal chemistry, Sep-15, Volume: 20, Issue:18
| Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action. |
| AID195232 | Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 5 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID315169 | Reversal of proapoptotic effect in human U937 cells assessed as inhibition of ladder-like pattern at 250 uM in presence of 10 mM NAC added every 8 hrs for 24 hrs | 2008 | Bioorganic & medicinal chemistry, Mar-01, Volume: 16, Issue:5
| Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells. |
| AID195229 | Influence (5 uM) on transacetylase catalyzed time dependent activation of NADPH cytochrome C reductase at pre-incubation time being 10 mins | 2002 | Bioorganic & medicinal chemistry letters, Sep-16, Volume: 12, Issue:18
| Comparison of the prevention of aflatoxin b(1)-induced genotoxicity by quercetin and quercetin pentaacetate. |
| AID1803437 | CA Inhibition Assay from Article 10.3109/14756366.2013.777334: \\Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX.\\ | 2014 | Journal of enzyme inhibition and medicinal chemistry, Apr, Volume: 29, Issue:2
| Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX. |
| AID1159550 | Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening | 2015 | Nature cell biology, Nov, Volume: 17, Issue:11
| 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |