Page last updated: 2024-12-10

isobavachalcone

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Description

isobavachalcone: RN given for (E)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5281255
CHEMBL ID253467
CHEBI ID28106
SCHEMBL ID600137
MeSH IDM0443034

Synonyms (49)

Synonym
HY-13065
(2e)-1-[2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
20784-50-3
C08648
isobavachalcone
(e)-1-[2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl]-3-(4-hydroxyphenyl)prop-2-en-1-one
4-hydroxyisocordoim
1-[2,4-dihydroxy-3-(3-methyl-but-2-enyl)-phenyl]-3-(4-hydroxy-phenyl)-propenone
2',4,4'-trihydroxy-3'-(3-methyl-2-butenyl)chalcone
corylifolinin
LMPK12120039
4-hydroxyisocordoin
isobacachalcone
chebi:28106 ,
CHEMBL253467
54676-49-2
2-propen-1-one, 1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-
unii-zwo2sc993a
zwo2sc993a ,
CS-0430
AKOS015912636
S5456
(e)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
SCHEMBL600137
bdbm50441633
J-501822
DUWPGRAKHMEPCM-IZZDOVSWSA-N
2-propen-1-one,1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-, (2e)-
AC-34001
AS-74506
isobavachalcone, >=98% (hpce)
(e)-1-(2,4-dihydroxy-3-(3-methylbut-2-enyl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
corylifolinin;isobacachalcone
(e)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
(e)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)-phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one
Q27103503
2-propen-1-one, 1-(2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl)-3-(4-hydroxyphenyl)-, (2e)-
(2e)-1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
isobavachalcone [inci]
2-propen-1-one, 1-(2,4-dihydroxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-, (2e)-
chalcone, 2',4,4'-trihydroxy-3'-(3-methyl-2-butenyl)-
CCG-267747
2-propen-1-one, 1-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)phenyl]-3-(4-hydroxyphenyl)-, (2e)-
1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
A879426
2',4',4-trihydroxy-3'-[3''-methylbut-3''-enyl]chalcone
corylifolinin(isobavachalcone)
DTXSID601317123
(2e)-1-(2,4-dihydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one

Research Excerpts

Overview

Isobavachalcone (IBC) is a natural chalcone compound widely distributed in traditional Chinese medicine Psoralea corylifolia L., and Tibetan medicine Abelmoschus manihot (L.) Medik. It is a flavonoid found in various foods and natural products. Studies have investigated its diverse effects, including its neuroprotective and anticancer effects.

ExcerptReferenceRelevance
"Isobavachalcone (IBC) is a natural chalcone compound widely distributed in traditional Chinese medicine Psoralea corylifolia L., and Tibetan medicine Abelmoschus manihot (L.) Medik. "( Investigation of the mechanism of Isobavachalcone in treating rheumatoid arthritis through a combination strategy of network pharmacology and experimental verification.
Du, Q; Geng, S; Sun, J; Wang, S; Zhang, Y, 2022
)
2.44
"Isobavachalcone (IBC) is a natural compound isolated from Fructus psoraleae. "( A novel target TAX1BP1 and P38/Nrf2 pathway independently involved in the anti-neuroinflammatory effect of isobavachalcone.
He, W; Li, Y; Li, Z; Luan, H; Tian, G; Wang, Q; Yang, M, 2020
)
2.21
"Isobavachalcone (IBC) is a flavonoid found in various foods and natural products, and studies have investigated its diverse effects, including its neuroprotective and anticancer effects."( Isobavachalcone attenuates myotube atrophy induced by TNF-α through muscle atrophy F-box signaling and the nuclear factor erythroid 2-related factor 2 cascade.
Choi, SY; Ha, TY; Hur, J; Jang, Y; Kim, M, 2019
)
2.68
"Isobavachalcone (IBC) is a prenylated chalcone and belongs to the class of flavonoids, which is an active component isolated from Psoralea corylifolia L. "( Structural elucidation of in vivo metabolites of isobavachalcone in rat by LC-ESI-MS(n) and LC-NMR.
Bai, L; Li, X; Su, S; Tang, Y; Wang, Y; Xia, B; Xu, P; Xue, M, 2015
)
2.11
"Isobavachalcone is a main component of Chinese herb medicine Psoralea corylifolia, which function includes immunoregulation, anti-oxidation and the regulation of β-amyloid (Aβ42) deposited in hippocampus in Alzheimer's patients."( Isobavachalcone Attenuates MPTP-Induced Parkinson's Disease in Mice by Inhibition of Microglial Activation through NF-κB Pathway.
Fu, W; Jing, H; Wang, M; Wang, S; Xu, D; Zhang, C, 2017
)
2.62

Effects

ExcerptReferenceRelevance
"Isobavachalcone (IBC) has been shown to induce apoptosis and differentiation of acute myeloid leukemia (AML) cells. "( Isobavachalcone inhibits acute myeloid leukemia: Potential role for ROS-dependent mitochondrial apoptosis and differentiation.
He, H; Jiang, M; Li, L; Li, P; Liu, G; Lu, Q; Ma, H; Qi, H; Wang, C, 2021
)
3.51

Pharmacokinetics

ExcerptReferenceRelevance
" This method was suitable for pharmacokinetic studies after oral administration of 80 mg/kg IBC in rats."( Determination of isobavachalcone in rat plasma by LC-MS/MS and its application to a pharmacokinetic study.
Huo, Q; Li, HM; Ma, T; Nie, LJ; Wu, CZ; Zhang, YX, 2015
)
0.76
" The developed method was applied to evaluating the pharmacokinetic study of 13 bioactive compounds after oral administration of Psoraleae Fructus in rat of different genders."( Simultaneous characterization of multiple Psoraleae Fructus bioactive compounds in rat plasma by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry for application in sex-related differences in pharmacokinetics.
Cheng, LY; Song, L; Wu, YL; Yang, L; Yu, YL; Zhang, Y; Zhou, K; Zhou, ZX, 2020
)
0.56
" Pharmacokinetic studies have shown that IBC has low bioavailability, but can penetrate the blood-brain barrier and is widely distributed in the brain."( Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms.
Meng, X; Wang, S; Xing, N, 2022
)
2.16
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (3)

RoleDescription
antibacterial agentA substance (or active part thereof) that kills or slows the growth of bacteria.
platelet aggregation inhibitorA drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (2)

ClassDescription
chalconesA ketone that is 1,3-diphenylpropenone (benzylideneacetophenone), ArCH=CH(=O)Ar, and its derivatives formed by substitution.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (5)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cytochrome P450 3A4Homo sapiens (human)IC50 (µMol)27.30000.00011.753610.0000AID775571
Replicase polyprotein 1aSevere acute respiratory syndrome-related coronavirusKi7.00000.00753.23929.1100AID1803390
Cytochrome P450 2D6Homo sapiens (human)IC50 (µMol)27.30000.00002.015110.0000AID775571
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)IC50 (µMol)27.30000.00053.49849.7600AID775571
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)IC50 (µMol)0.13000.00050.742710.0000AID1872610
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (57)

Processvia Protein(s)Taxonomy
lipid hydroxylationCytochrome P450 3A4Homo sapiens (human)
lipid metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid catabolic processCytochrome P450 3A4Homo sapiens (human)
xenobiotic metabolic processCytochrome P450 3A4Homo sapiens (human)
steroid metabolic processCytochrome P450 3A4Homo sapiens (human)
cholesterol metabolic processCytochrome P450 3A4Homo sapiens (human)
androgen metabolic processCytochrome P450 3A4Homo sapiens (human)
estrogen metabolic processCytochrome P450 3A4Homo sapiens (human)
alkaloid catabolic processCytochrome P450 3A4Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 3A4Homo sapiens (human)
calcitriol biosynthetic process from calciolCytochrome P450 3A4Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D metabolic processCytochrome P450 3A4Homo sapiens (human)
vitamin D catabolic processCytochrome P450 3A4Homo sapiens (human)
retinol metabolic processCytochrome P450 3A4Homo sapiens (human)
retinoic acid metabolic processCytochrome P450 3A4Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 3A4Homo sapiens (human)
aflatoxin metabolic processCytochrome P450 3A4Homo sapiens (human)
oxidative demethylationCytochrome P450 3A4Homo sapiens (human)
symbiont-mediated perturbation of host ubiquitin-like protein modificationReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
xenobiotic metabolic processCytochrome P450 2D6Homo sapiens (human)
steroid metabolic processCytochrome P450 2D6Homo sapiens (human)
cholesterol metabolic processCytochrome P450 2D6Homo sapiens (human)
estrogen metabolic processCytochrome P450 2D6Homo sapiens (human)
coumarin metabolic processCytochrome P450 2D6Homo sapiens (human)
alkaloid metabolic processCytochrome P450 2D6Homo sapiens (human)
alkaloid catabolic processCytochrome P450 2D6Homo sapiens (human)
monoterpenoid metabolic processCytochrome P450 2D6Homo sapiens (human)
isoquinoline alkaloid metabolic processCytochrome P450 2D6Homo sapiens (human)
xenobiotic catabolic processCytochrome P450 2D6Homo sapiens (human)
retinol metabolic processCytochrome P450 2D6Homo sapiens (human)
long-chain fatty acid biosynthetic processCytochrome P450 2D6Homo sapiens (human)
negative regulation of bindingCytochrome P450 2D6Homo sapiens (human)
oxidative demethylationCytochrome P450 2D6Homo sapiens (human)
negative regulation of cellular organofluorine metabolic processCytochrome P450 2D6Homo sapiens (human)
arachidonic acid metabolic processCytochrome P450 2D6Homo sapiens (human)
positive regulation of JUN kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of signal transductionTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
actin cytoskeleton organizationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of endocytosisTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of vascular endothelial growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulum unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of intracellular protein transportTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cellular response to unfolded proteinTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylationTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
platelet-derived growth factor receptor-beta signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor recyclingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of MAP kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of insulin receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of type I interferon-mediated signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
growth hormone receptor signaling pathway via JAK-STATTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of protein tyrosine kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of ERK1 and ERK2 cascadeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
regulation of hepatocyte growth factor receptor signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of IRE1-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
negative regulation of PERK-mediated unfolded protein responseTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
positive regulation of receptor catabolic processTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
UDP biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
'de novo' UMP biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
pyrimidine ribonucleotide biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
'de novo' pyrimidine nucleobase biosynthetic processDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (41)

Processvia Protein(s)Taxonomy
monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
steroid bindingCytochrome P450 3A4Homo sapiens (human)
iron ion bindingCytochrome P450 3A4Homo sapiens (human)
protein bindingCytochrome P450 3A4Homo sapiens (human)
steroid hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
retinoic acid 4-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
oxidoreductase activityCytochrome P450 3A4Homo sapiens (human)
oxygen bindingCytochrome P450 3A4Homo sapiens (human)
enzyme bindingCytochrome P450 3A4Homo sapiens (human)
heme bindingCytochrome P450 3A4Homo sapiens (human)
vitamin D3 25-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
caffeine oxidase activityCytochrome P450 3A4Homo sapiens (human)
quinine 3-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
testosterone 6-beta-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 3A4Homo sapiens (human)
aromatase activityCytochrome P450 3A4Homo sapiens (human)
vitamin D 24-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 16-alpha-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
estrogen 2-hydroxylase activityCytochrome P450 3A4Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activityCytochrome P450 3A4Homo sapiens (human)
RNA-dependent RNA polymerase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activityReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
monooxygenase activityCytochrome P450 2D6Homo sapiens (human)
iron ion bindingCytochrome P450 2D6Homo sapiens (human)
oxidoreductase activityCytochrome P450 2D6Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygenCytochrome P450 2D6Homo sapiens (human)
heme bindingCytochrome P450 2D6Homo sapiens (human)
anandamide 8,9 epoxidase activityCytochrome P450 2D6Homo sapiens (human)
anandamide 11,12 epoxidase activityCytochrome P450 2D6Homo sapiens (human)
anandamide 14,15 epoxidase activityCytochrome P450 2D6Homo sapiens (human)
RNA bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
insulin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
zinc ion bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
enzyme bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
receptor tyrosine kinase bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cadherin bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
ephrin receptor bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein phosphatase 2A bindingTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
non-membrane spanning protein tyrosine phosphatase activityTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
dihydroorotase activityDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
protein bindingDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
dihydroorotate dehydrogenase (quinone) activityDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
dihydroorotate dehydrogenase activityDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (17)

Processvia Protein(s)Taxonomy
cytoplasmCytochrome P450 3A4Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 3A4Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 3A4Homo sapiens (human)
double membrane vesicle viral factory outer membraneReplicase polyprotein 1aSevere acute respiratory syndrome-related coronavirus
mitochondrionCytochrome P450 2D6Homo sapiens (human)
endoplasmic reticulumCytochrome P450 2D6Homo sapiens (human)
endoplasmic reticulum membraneCytochrome P450 2D6Homo sapiens (human)
cytoplasmCytochrome P450 2D6Homo sapiens (human)
intracellular membrane-bounded organelleCytochrome P450 2D6Homo sapiens (human)
plasma membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial matrixTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytosolTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
mitochondrial cristaTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endosome lumenTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
sorting endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmic side of endoplasmic reticulum membraneTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
protein-containing complexTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
endoplasmic reticulumTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
cytoplasmTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
early endosomeTyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)
nucleoplasmDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
mitochondrionDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
mitochondrial inner membraneDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
cytosolDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
mitochondrial inner membraneDihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (143)

Assay IDTitleYearJournalArticle
AID1803390SARS-CoV PLpro Inhibition Assay from Article 10.3109/14756366.2012.753591: \\Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.\\2014Journal of enzyme inhibition and medicinal chemistry, Feb, Volume: 29, Issue:1
Phenolic phytochemical displaying SARS-CoV papain-like protease inhibition from the seeds of Psoralea corylifolia.
AID476726Cytotoxicity against BHK cells after 48 hrs by MTT assay2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs.
AID523118Antimicrobial activity against tetracycline-resistant Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523265Antimicrobial activity against Enterobacter cloacae Ec1194 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID639977Cytotoxicity against African green monkey Vero cells assessed as inhibition of cell growth after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID1693052Inhibition of porcine pancreatic lipase type 22021Bioorganic & medicinal chemistry, 01-01, Volume: 29Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors.
AID1180340Antioxidant activity assessed as AAPH-induced peroxyl radical scavenging activity at 10 uM by oxygen radical absorbance assay relative to trolox2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Anti-osteoporotic and antioxidant activities of chemical constituents of the aerial parts of Ducrosia ismaelis.
AID1717788Inhibition of SARS-CoV N-terminal 6His-tagged TEV-fused papain-like protease expressed in Escherichia coli BL21(DE3) cells using Z-RLRGG-AMC as substrate by fluorescence method2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
AID1180339Antioxidant activity assessed as AAPH-induced peroxyl radical scavenging activity by oxygen radical absorbance assay2014Bioorganic & medicinal chemistry letters, Aug-01, Volume: 24, Issue:15
Anti-osteoporotic and antioxidant activities of chemical constituents of the aerial parts of Ducrosia ismaelis.
AID523259Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID388001Antibacterial activity against Bacillus cereus ATCC 11778 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID523260Antimicrobial activity against Pseudomonas aeruginosa PA124 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID376639Cytotoxicity against mouse RAW264.7 cells by MTT assay2006Journal of natural products, Apr, Volume: 69, Issue:4
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
AID775566Inhibition of TCPTP (unknown origin) at 100 uM2013Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
AID523258Antimicrobial activity against Pseudomonas aeruginosa PAO1 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID640015Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 7 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID388002Antibacterial activity against Escherichia coli ATCC 25922 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID640019Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 3 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID388003Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID476728Antiprotozoal activity against Bodo caudatus hrs by MTT assay2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs.
AID523117Antimicrobial activity against Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523255Antimicrobial activity against Klebsiella pneumoniae KP55 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1872627Cytotoxicity against human PC3 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay2022European journal of medicinal chemistry, Mar-15, Volume: 232Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives.
AID640014Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 8 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID640009Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 13 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID523256Antimicrobial activity against Klebsiella pneumoniae KP63 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1516837Antifungal activity against Candida albicans2019Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19
Recent advances in natural antifungal flavonoids and their derivatives.
AID523126Antimicrobial activity against Enterobacter aerogenes EA289 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1225513Increase in SIRT1 (unknown origin) deacetylation activity at 10 uM2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
AID341720Inhibition of FGFR2 at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID523112Antimicrobial activity against Escherichia coli ATCC 8739 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523113Antimicrobial activity against Escherichia coli ATCC 8739 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1737255Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells2020European journal of medicinal chemistry, May-01, Volume: 193Development of a novel nitric oxide (NO) production inhibitor with potential therapeutic effect on chronic inflammation.
AID476725Antiprotozoal activity against Bodo caudatus after 48 hrs by MTT assay2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs.
AID523115Antimicrobial activity against Escherichia coli AG100 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523123Antimicrobial activity against Enterobacter aerogenes ATCC 13048 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1484047Antiproliferative activity against human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID523254Antimicrobial activity against Klebsiella pneumoniae KP55 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1453615Growth inhibition of human SW480 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1516835Antifungal activity against Cryptococcus neoformans2019Bioorganic & medicinal chemistry letters, 10-01, Volume: 29, Issue:19
Recent advances in natural antifungal flavonoids and their derivatives.
AID775567Mixed type inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis2013Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
AID1484040Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production at 10 uM after 24 hrs by Griess assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID1453625Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated for 15 mins followed by substrate addition relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID1453623Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 10 uM after 30 mins relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID378959Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 10 molar ratio relative to TPA2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID523249Antimicrobial activity against Enterobacter aerogenes EA3 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1872628Cytotoxicity against human OVCAR-8 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay2022European journal of medicinal chemistry, Mar-15, Volume: 232Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives.
AID523124Antimicrobial activity against Enterobacter aerogenes EA-CM64 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523264Antimicrobial activity against Enterobacter cloacae Ec1194 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID357965Inhibition of aromatase from human placental microsomes2001Journal of natural products, Oct, Volume: 64, Issue:10
Aromatase inhibitors from Broussonetia papyrifera.
AID523114Antimicrobial activity against Escherichia coli AG100 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523130Antimicrobial activity against Enterobacter aerogenes EA298 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID639978Cytotoxicity against african green monkey Vero cells assessed as cell death after 72 hrs by MTT assay2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID1484046Antiproliferative activity against human A549 cells at 10 uM after 24 hrs by MTS assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID1717789Mixed inhibition of SARS-CoV N-terminal 6His-tagged TEV-fused papain-like protease expressed in Escherichia coli BL21(DE3) cells using Z-RLRGG-AMC as substrate by Lineweaver-Burk plot analysis2020Journal of medicinal chemistry, 11-25, Volume: 63, Issue:22
Chinese Therapeutic Strategy for Fighting COVID-19 and Potential Small-Molecule Inhibitors against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
AID523111Antimicrobial activity against Escherichia coli ATCC 10536 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine beta-naphthylamide2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID334635Toxicity in Salmonella Typhimurium T98 at 300 ug/plate after 72 hrs by Ames assay in presence of Ames S-9 fraction
AID388004Antibacterial activity against Staphylococcus aureus ATCC 25923 after 24 hrs by microdilution broth method2008Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22
Structure-activity relationship of antibacterial chalcones.
AID341705Inhibition of c-Src at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID341707Inhibition of FGFR1 at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID640012Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 10 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID523132Antimicrobial activity against Enterobacter aerogenes EA27 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID378963Inhibition of tumor promotion in mouse assessed as papilloma bearing mouse after 10 weeks2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID640013Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 9 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID376640Selectivity index, ratio of CC50 for mouse RAW264.7 cells to IC50 for nitric oxide production in mouse RAW264.7 cells2006Journal of natural products, Apr, Volume: 69, Issue:4
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
AID640023Selectivity index, Ratio of CC50 for african green monkey Vero cells to IC50 for african green monkey Vero cells2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID640016Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 6 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID775565Inhibition of VHR (unknown origin) at 100 uM2013Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
AID1484039Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM after 6 hrs by ARE-driven luciferase reporter gene assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID640008Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 14 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID523125Antimicrobial activity against Enterobacter aerogenes EA-CM64 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523119Antimicrobial activity against tetracycline-resistant Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID476724Antiprotozoal activity against Bodo caudatus at 0.6 mg/ml after 24 hrs by MTT assay2010Bioorganic & medicinal chemistry, Apr-01, Volume: 18, Issue:7
Total synthesis, antiprotozoal and cytotoxicity activities of rhuschalcone VI and analogs.
AID1453619Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM after 24 hrs by Griess reagent based assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID523134Antimicrobial activity against Enterobacter aerogenes EA3 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1484045Antiproliferative activity against human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID523127Antimicrobial activity against Enterobacter aerogenes EA289 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1463920Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated for 6 hrs by ARE-driven luciferase reporter gene assay relative to untreated control2017Bioorganic & medicinal chemistry, 10-15, Volume: 25, Issue:20
Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl
AID523129Antimicrobial activity against Enterobacter aerogenes EA294 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1400536Activation of Nrf2 in mouse Heap1c1c7 cells assessed as induction of NAD(P)H:quinone reductase activity at 50 uM relative to control2018Bioorganic & medicinal chemistry, 10-01, Volume: 26, Issue:18
Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults.
AID341706Inhibition of c-Met at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID775571Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate2013Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21
Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
AID523253Antimicrobial activity against Klebsiella pneumoniae ATCC 11296 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523121Antimicrobial activity against tetracycline-resistant Escherichia coli AG102 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID354588Antiplatelet activity against rabbit platelet assessed as inhibition of collagen-induced platelet aggregation preincubated for 3 mins by turbidimetric method1996Journal of natural products, Jul, Volume: 59, Issue:7
Antiplatelet flavonoids from seeds of Psoralea corylifolia.
AID523110Antimicrobial activity against Escherichia coli ATCC 10536 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID640018Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 4 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID378961Inhibition of TPA-induced EBV-early antigen activation in human Raji cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1453621Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human SW480 cells at 10 uM by luciferase reporter gene assay2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID523131Antimicrobial activity against Enterobacter aerogenes EA298 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1484037Inhibition of recombinant human PTP1B using pNPP as substrate at 10 uM after 30 mins relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID357254Antifungal activity against Candida albicans ATCC 900282002Journal of natural products, Dec, Volume: 65, Issue:12
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
AID523120Antimicrobial activity against tetracycline-resistant Escherichia coli AG102 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523128Antimicrobial activity against Enterobacter aerogenes EA294 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID640022Antibacterial activity against methicillin-sensitive Staphylococcus aureus ATCC 25923 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID640017Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 5 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID1872610Inhibition of human DHODH2022European journal of medicinal chemistry, Mar-15, Volume: 232Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives.
AID1484042Inhibition of LPS-induced NF-kappaB (unknown origin) transactivation expressed in human SW480 cells at 10 uM administered 1 hr after LPS stimulation measured after 6 hrs by luciferase reporter gene assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID640021Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 1 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID1453614Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID354590Antiplatelet activity against rabbit platelet assessed as inhibition of platelet-activating factor-induced platelet aggregation preincubated for 3 mins by turbidimetric method1996Journal of natural products, Jul, Volume: 59, Issue:7
Antiplatelet flavonoids from seeds of Psoralea corylifolia.
AID378960Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID640011Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 11 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID378964Inhibition of tumor promotion in mouse assessed as papilloma bearing mouse after 20 weeks2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID310849Antifungal activity against Cryptococcus neoformans2007European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
A review of anti-infective and anti-inflammatory chalcones.
AID1225511Cytotoxicity against human A549 cells after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
AID1453616Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to control2017Bioorganic & medicinal chemistry, 07-15, Volume: 25, Issue:14
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
AID422533Cytotoxicity against NHEM cells assessed as cell viability 24 hrs by WST-8 assay2009Journal of natural products, Jan, Volume: 72, Issue:1
Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
AID422532Inhibition of melanin synthesis in NHEM after 24 hrs by liquid scintillation2009Journal of natural products, Jan, Volume: 72, Issue:1
Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
AID523122Antimicrobial activity against Enterobacter aerogenes ATCC 13048 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID378956Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 1000 molar ratio relative to TPA2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID354589Antiplatelet activity against rabbit platelet assessed as inhibition of arachidonic acid-induced platelet aggregation preincubated for 3 mins by turbidimetric method1996Journal of natural products, Jul, Volume: 59, Issue:7
Antiplatelet flavonoids from seeds of Psoralea corylifolia.
AID334637Antimutagenic activity in Salmonella Typhimurium T98 assessed as inhibition of 2-aminoanthracene-induced mutation at 600 ug/plate after 72 hrs in presence of Ames S-9 fraction
AID341709Inhibition of KDR at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID341711Inhibition of EGFR at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID1290516Cytotoxicity against human THP1 cells assessed as cell viability after 72 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7
Individual and combined antiparasitic effect of six plant metabolites against Leishmania amazonensis and Trypanosoma cruzi.
AID523251Antimicrobial activity against Enterobacter aerogenes EA5 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1225512Cytotoxicity against human K562 cells after 48 hrs by MTT assay2015Journal of natural products, Apr-24, Volume: 78, Issue:4
Bioactive Metabolites from the Fruits of Psoralea corylifolia.
AID523261Antimicrobial activity against Pseudomonas aeruginosa PA124 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1197164Toxicity against HUVEC incubated for 48 hrs by MTT assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.
AID713897Antimycobacterial activity against Mycobacterium tuberculosis H37Rv2012European journal of medicinal chemistry, Mar, Volume: 49Recent advances in antitubercular natural products.
AID378957Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 500 molar ratio relative to TPA2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID310848Antifungal activity against Candida albicans2007European journal of medicinal chemistry, Feb, Volume: 42, Issue:2
A review of anti-infective and anti-inflammatory chalcones.
AID523257Antimicrobial activity against Klebsiella pneumoniae KP63 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID341713Inhibition of cKit at 10 uM by ELISA2008Journal of medicinal chemistry, Aug-14, Volume: 51, Issue:15
Naturally occurring homoisoflavonoids function as potent protein tyrosine kinase inhibitors by c-Src-based high-throughput screening.
AID523133Antimicrobial activity against Enterobacter aerogenes EA27 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523250Antimicrobial activity against Enterobacter aerogenes EA5 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID523252Antimicrobial activity against Klebsiella pneumoniae ATCC 11296 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID1484034Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate at 10 uM preincubated for 15 mins followed by substrate addition relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID640020Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 2 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID1607865Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production2019European journal of medicinal chemistry, Oct-01, Volume: 179Human disorders associated with inflammation and the evolving role of natural products to overcome.
AID523262Antimicrobial activity against Enterobacter cloacae Ec07769 after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID640010Antibacterial activity against methicillin-resistant Staphylococcus aureus isolate 12 after 24 hrs by broth microdilution method2012Bioorganic & medicinal chemistry letters, Jan-01, Volume: 22, Issue:1
Antibacterial activity of chalcones, hydrazones and oxadiazoles against methicillin-resistant Staphylococcus aureus.
AID334634Toxicity in Salmonella Typhimurium T98 at 600 ug/plate after 72 hrs by Ames assay in presence of Ames S-9 fraction
AID378958Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 100 molar ratio relative to TPA2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID378962Scavenging activity against (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide-induced NO generation in human Chang liver cells2006Journal of natural products, Jan, Volume: 69, Issue:1
Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects.
AID1197163Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay2015European journal of medicinal chemistry, Mar-06, Volume: 92Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs.
AID357255Antifungal activity against Cryptococcus neoformans ATCC 901132002Journal of natural products, Dec, Volume: 65, Issue:12
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
AID376638Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite accumulation after 20 hrs2006Journal of natural products, Apr, Volume: 69, Issue:4
Prenylated flavonoids from the heartwood of Artocarpus communis with inhibitory activity on lipopolysaccharide-induced nitric oxide production.
AID1484048Antiproliferative activity against human SW480 cells at 10 uM after 24 hrs by MTS assay relative to control2017Journal of natural products, 02-24, Volume: 80, Issue:2
Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
AID523263Antimicrobial activity against Enterobacter cloacae Ec07769 after 18 hrs by rapid INT colorimetric assay in presence of efflux pump inhibitor phenylalanine arginine2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
AID357253Inhibition of Saccharomyces cerevisiae fatty acid synthase2002Journal of natural products, Dec, Volume: 65, Issue:12
Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.
AID523116Antimicrobial activity against Escherichia coli AG100A after 18 hrs by rapid INT colorimetric assay2010Antimicrobial agents and chemotherapy, May, Volume: 54, Issue:5
Efflux pumps are involved in the defense of Gram-negative bacteria against the natural products isobavachalcone and diospyrone.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (94)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (1.06)18.2507
2000's13 (13.83)29.6817
2010's50 (53.19)24.3611
2020's30 (31.91)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 28.64

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index28.64 (24.57)
Research Supply Index4.56 (2.92)
Research Growth Index6.02 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (28.64)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews9 (9.47%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other86 (90.53%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]