difenoconazole profile

Difenoconazole is a triazole fungicide widely used in agriculture to control a broad spectrum of fungal diseases on various crops. It is a systemic fungicide, meaning it is absorbed by the plant and translocated throughout the plant, providing protection against fungal infections. Difenoconazole is synthesized through a multi-step process involving reactions with various chemical intermediates. The compound is known for its effectiveness against powdery mildew, rust, and leaf spot diseases. Its mode of action involves inhibiting the biosynthesis of ergosterol, an essential component of fungal cell membranes. The disruption of ergosterol biosynthesis leads to fungal cell death. Difenoconazole is studied extensively to understand its efficacy, environmental fate, and potential risks to human health and ecosystems. Research focuses on its effects on non-target organisms, its persistence in the environment, and its potential for resistance development in fungal populations.'

difenoconazole : A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	86173
CHEMBL ID	466426
CHEBI ID	81760
SCHEMBL ID	22125
MeSH ID	M0296438

Synonym
NCGC00163894-01
score ec 250
cga 169374
plover
1h-1,2,4-triazole, 1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-
dividend
dividend (fungicide)
difenoconazole [iso]
score
1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1h-1,2,4-triazole
119446-68-3
1-({2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl}methyl)-1h-1,2,4-triazole
difenoconazole
NCGC00163894-02
1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole
FT-0652542
chebi:81760 ,
CHEMBL466426
difenoconazol
A804285
NCGC00163894-03
C18459
1h-1,2,4-triazole,1-((2-(2-chloro-4(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-
unii-d9612xch4p
bardos neu
d9612xch4p ,
hsdb 8370
NCGC00255010-01
dtxcid2012372
dtxsid4032372 ,
cas-119446-68-3
tox21_301110
AKOS015907773
spectro
difenconazole
plandom
cga-169374
cis,trans-3-chloro-4-(4-methyl-2-(1h-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-yl)phenyl 4-chlorophenyl ether
SCHEMBL22125
BQYJATMQXGBDHF-UHFFFAOYSA-N
1-((2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl)methyl)-1h-1,2,4-triazole #
J-004130
1h-1,2,4-triazole, 1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-
difenoconazol, pestanal(r), analytical standard
difenoconazole 10 microg/ml in cyclohexane
difenoconazole 10 microg/ml in acetonitrile
difenoconazole 100 microg/ml in cyclohexane
mmv688943
BCP21450
Q3027717
F21399
mfcd00144119
AS-13948
AMY22441
CS-0012864
difenoconazole 1000 microg/ml in acetone
SR-05000022490-1
HY-B0850
sr-05000022490
difenoconazole 1000 microg/ml in toluene
EN300-7392201
Z3234897102

Research Excerpts

Overview

Difenoconazole is a commonly used triazole fungicide that consists of four stereoisomers with different bioactivity. It can inhibit demethylation during ergosterol synthesis. The fungicide is widely used worldwide and has been frequently detected in agricultural soils.

Excerpt	Reference	Relevance
"Difenoconazole is a commonly used triazole fungicide that consists of four stereoisomers [(2S,4S)-, (2S,4R)-, (2R,4R)-, and (2R,4S)-isomers] with different bioactivity. "	( Stereoselective effects of fungicide difenoconazole and its four stereoisomers on gut barrier, microbiota, and glucolipid metabolism in male mice. Bao, Z; Chen, J; Jin, Y; Qian, M; Wang, J; Yang, G; Zhang, H, 2022)	2.44
"Difenoconazole is a typical triazole fungicide that can inhibit demethylation during ergosterol synthesis. "	( Ecological risk assessment for difenoconazole in aquatic ecosystems using a web-based interspecies correlation estimation (ICE)-species sensitivity distribution (SSD) model. Dong, F; Pan, X; Shen, C; Wu, X; Xu, J; Zheng, Y, 2022)	2.45
"Difenoconazole (DCZ) is a triazole fungicide that negatively affects aquatic organisms and humans. "	( Exposure to difenoconazole induces reproductive toxicity in zebrafish by interfering with gamete maturation and reproductive behavior. Chen, X; Duan, M; Wang, C; Xu, H; Xu, Y; Yang, Y; Zhang, J; Zhao, W; Zheng, J, 2022)	2.54
"Difenoconazole is a chemical entity containing two chiral centers and having four stereoisomers: (2"	( A Cheminformatics Study Regarding the Human Health Risks Assessment of the Stereoisomers of Difenoconazole. Isvoran, A; Ostafe, V; Roman, DL; Voiculescu, DI, 2022)	2.38
"Difenoconazole is a commonly used triazole fungicide in agricultural production. "	( Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp. Chen, H; Chu, M; Dong, J; Feng, H; Li, X; Pan, E; Qiang, J; Wu, X; Xu, B, 2023)	2.56
"Difenoconazole (DFZ) is a broad-spectrum fungicide widely applied in wheat production. "	( Transcriptomic and physiological properties reveal the tolerance mechanism to difenoconazole toxicity in wheat (Triticum aestivum L.). Geng, R; Kong, X; Li, J; Li, L; Liu, R; Zhang, Z, 2023)	2.58
"Difenoconazole is a widely used but difficult-to-degrade fungicide that can directly affect aquatic ecosystems. "	( Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole. Chen, H; Dong, J; Feng, H; Li, X; Pan, E; Qiang, J; Wu, X; Xu, B; Yang, H; Zhang, J, 2023)	2.57
"Difenoconazole is a triazole fungicide that is widely used worldwide and has been frequently detected in agricultural soils, but its ecotoxicological effect on soil bacterial community remains unknown. "	( Exposure to fungicide difenoconazole reduces the soil bacterial community diversity and the co-occurrence network complexity. Chen, S; Fang, H; Mei, J; Song, J; Yu, Y; Zhang, H; Zhang, Q; Zhang, Z, 2021)	2.38
"Difenoconazole is a widely used triazole fungicide that has been frequently detected in the environment, but comprehensive study about its environmental fate and toxicity of potential transformation products (TPs) is still lacking. "	( Degradation of difenoconazole in water and soil: Kinetics, degradation pathways, transformation products identification and ecotoxicity assessment. Almvik, M; Clarke, JL; Dong, F; Holten, R; Liu, X; Man, Y; Stenrød, M; Wu, C; Wu, X; Xu, J; Yuan, S; Zheng, Y, 2021)	2.42
"Difenoconazole (DFZ) is a broad-spectrum triazole fungicide, that is extensively used in agriculture. "	( Insights into the effects of difenoconazole on the livers in male mice at the biochemical and transcriptomic levels. Jin, C; Jin, Y; Li, Y; Qian, M; Wang, J; Weng, Y; Yang, G; Zhang, H, 2022)	2.46
"Difenoconazole (DFZ) is a widely used triazole fungicide which has been detected in some estuaries and embayments. "	( Reproductive effects of life-cycle exposure to difenoconazole on female marine medaka (Oryzias melastigma). Chen, M; Dong, X; Guo, J; Li, H; Wang, C; Yang, Z; Zhang, L; Zuo, Z, 2017)	2.15
"Difenoconazole (DFZ) is a triazole fungicide which has been detected in the aquatic environment, including estuaries and embayments. "	( Exposure to difenoconazole inhibits reproductive ability in male marine medaka (Oryzias melastigma). Chen, M; Dong, X; Wang, C; Yang, Z; Zhang, L; Zuo, Z, 2018)	2.3
"Difenoconazole is a universal chiral fungicide which is widely used in apples. "	( Enantioselective Behavior of Chiral Difenoconazole in Apple and Field Soil. Chang, W; Nie, J; Yan, Z, 2019)	2.23
"Difenoconazole is a widely used triazole fungicide, its extensive application may potentially cause toxic effects on non-target organisms. "	( Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Chai, T; Li, X; Mu, X; Pang, S; Wang, C; Wang, K; Yang, Y; Zhang, J; Zhu, L, 2015)	2.08
"Difenoconazole is a widely used triazole fungicide and has been reported to have negative impacts on zebrafish embryos. "	( The developmental effect of difenoconazole on zebrafish embryos: A mechanism research. Chai, T; Huang, Y; Li, X; Li, Y; Mu, X; Shen, G; Wang, C; Wang, K; Zhu, L, 2016)	2.17
"Difenoconazole (DFZ) is a triazole fungicide that inhibits the biosynthesis of sterols in cell membranes and is widely used in agriculture for effectively treating fungal infections. "	( Influence of difenoconazole on lipid metabolism in marine medaka (Oryzias melastigma). Chen, M; Dong, X; Li, Y; Wang, C; Zhang, L; Zuo, Z, 2016)	2.25

Actions

Excerpt	Reference	Relevance
"Difenoconazole was found to increase MDA levels while decreasing the activities of CAT, SOD, and GSH-PX, according to biochemical indicators."	( Crosstalk of oxidative stress, inflammation, apoptosis, and autophagy under reactive oxygen stress involved in difenoconazole-induced kidney damage in carp. Chen, H; Chu, M; Dong, J; Feng, H; Li, X; Pan, E; Qiang, J; Wu, X; Xu, B, 2023)	1.84

Toxicity

Difenoconazole concentration at the NOEC (no observed effect concentration) level indicated a synergetic toxic interaction with abamectin. ECOSAR prediction and laboratory tests showed that the acute toxicities of four novel TPs on Brachydanio rerio, Daphnia magna and Selenastrum capricornutum are substantially lower than that of difenconazole.

Excerpt	Reference	Relevance
"To investigate the safe use of 10% difenoconazole in planting Gentiana scabra."	( [Study on safe use of 10% difenoconazole in GAP of Gentiana scabra]. Chen, F; Liu, HK; Liu, HT; Xue, J; Zhang, BG; Zheng, YL, 2008)	0.92
" scabra collecting in different time were determined by GC with ECD detection, and the half life of difenoconazole in the plant was calculated, and then the safe use method of 10% difenoconazole was formulated."	( [Study on safe use of 10% difenoconazole in GAP of Gentiana scabra]. Chen, F; Liu, HK; Liu, HT; Xue, J; Zhang, BG; Zheng, YL, 2008)	0.86
" Okra samples harvested after the estimated PHIs were found safe for human consumption."	( Residue analysis of fipronil and difenoconazole in okra by liquid chromatography tandem mass spectrometry and their food safety evaluation. Ahammed Shabeer, TP; Banerjee, K; Hingmire, S; Oulkar, DP; Utture, SC, 2015)	0.7
" Here, the dissipation and residual levels of three fungicides (pyraclostrobin, myclobutanil, and difenoconazole) were studied for strawberry under greenhouse conditions using high-performance liquid chromatography (HPLC)-tandem mass spectrometry after Quick, Easy, Cheap, Effective, Rugged, and Safe extraction."	( Degradation of three fungicides following application on strawberry and a risk assessment of their toxicity under greenhouse conditions. Cang, T; Sun, C; Wang, Q; Wang, X; Wang, Z; Yu, R; Zhao, X, 2015)	0.63
"Two simple sample pretreatment for the determination of difenoconazole in cowpea was developed including micellar extraction combined with ionic liquid based vortex-assisted liquid-liquid microextraction (ME-IL-VALLME) prior to high performance liquid chromatography (HPLC), and modified quick, easy, cheap, effective, rugged, and safe method (QuEChERS) coupled with HPLC-MS/MS."	( Comparison of micellar extraction combined with ionic liquid based vortex-assisted liquid-liquid microextraction and modified quick, easy, cheap, effective, rugged, and safe method for the determination of difenoconazole in cowpea. Bian, Y; Chen, X; Liu, F; Sun, P; Teng, P, 2017)	0.89
" Score however, was not toxic to the springtails."	( Impact of temperature on the toxicity of Kraft 36 EC® (a.s. abamectin) and Score 250 EC® (a.s. difenoconazole) to soil organisms under realistic environmental exposure scenarios. Athayde, DB; Daam, MA; Duarte-Neto, PJ; Espíndola, ELG; Guerra, GDS; Pitombeira de Figueirêdo, L; van Gestel, CAM, 2020)	0.78
" TEB and DIF mixture showed additive effect on the acute toxicity to adult zebrafish, the combined toxicity on liver was less than the additive effect of individual TEB and DIF, and TEB and DIF mixture also reduced the toxic effects on gonad and intestinal microflora."	( Histology and multi-omic profiling reveal the mixture toxicity of tebuconazole and difenoconazole in adult zebrafish. Chen, L; Jiang, J; Liu, X; Wang, L; Wu, S; Zhao, X, 2021)	0.85
" ECOSAR prediction and laboratory tests showed that the acute toxicities of four novel TPs on Brachydanio rerio, Daphnia magna and Selenastrum capricornutum are substantially lower than that of difenoconazole, while all the TPs except for TP277C were predicted chronically very toxic to fish, which may pose a potential threat to aquatic ecosystems."	( Degradation of difenoconazole in water and soil: Kinetics, degradation pathways, transformation products identification and ecotoxicity assessment. Almvik, M; Clarke, JL; Dong, F; Holten, R; Liu, X; Man, Y; Stenrød, M; Wu, C; Wu, X; Xu, J; Yuan, S; Zheng, Y, 2021)	1.16
" A difenoconazole concentration at the NOEC (no observed effect concentration) level indicated a synergetic toxic interaction with abamectin."	( Acute toxicity of the insecticide abamectin and the fungicide difenoconazole (individually and in mixture) to the tropical stingless bee Melipona scutellaris. Brigante, J; Costa, JO; Daam, MA; Espíndola, ELG, 2021)	1.48
" The present study expanded our understanding of the toxic effects of difenoconazole on organisms and its possible threat to the aquatic environment."	( Mechanisms regarding respiratory toxicity triggered by accumulation of ROS in carp exposed to difenoconazole. Chen, H; Dong, J; Feng, H; Li, X; Pan, E; Qiang, J; Wu, X; Xu, B; Yang, H; Zhang, J, 2023)	1.36

Compound-Compound Interactions

Excerpt	Reference	Relevance
"Two simple sample pretreatment for the determination of difenoconazole in cowpea was developed including micellar extraction combined with ionic liquid based vortex-assisted liquid-liquid microextraction (ME-IL-VALLME) prior to high performance liquid chromatography (HPLC), and modified quick, easy, cheap, effective, rugged, and safe method (QuEChERS) coupled with HPLC-MS/MS."	( Comparison of micellar extraction combined with ionic liquid based vortex-assisted liquid-liquid microextraction and modified quick, easy, cheap, effective, rugged, and safe method for the determination of difenoconazole in cowpea. Bian, Y; Chen, X; Liu, F; Sun, P; Teng, P, 2017)	0.89

Bioavailability

Excerpt	Reference	Relevance
"The aim of this study was to assess the bioavailability of epoxiconazole (EPO) and difenoconazole (DIF) in rice plants by evaluating their uptake, translocation, and accumulation."	( Bioavailability evaluation of epoxiconazole and difenoconazole in rice and the influence of dissolved organic matter in reducing uptake and translocation. Chen, Y; Liu, X; Mao, L; Zhang, L; Zheng, Y; Zhou, Y; Zhu, L, 2023)	1.39
"Passive sampling technology is widely used to evaluate the bioavailability of pollutants."	( Bioavailability assessment of difenoconazole to earthworms (Eisenia fetida) in soil by oleic acid-embedded cellulose acetate membrane. Chen, Y; Feng, X; Liu, X; Mao, L; Zhang, L; Zheng, Y; Zhu, L, 2023)	1.2

Dosage Studied

Difenoconazole and azoxystrobin should be stable in bananas and soil, but both decreased to safe concentrations by the minimum harvest time after spraying the mixture.

Excerpt	Relevance	Reference
" It was also found to be the most effective compound with higher antifungal activity against Rhizoctonia solani and Botrytis cinerea at the dosage of 100 μg mL(-1)."	( Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1. Feng, L; He, H; He, J; Li, J; Liao, X; Long, Q; Ren, Y; Sun, Q; Tao, R; Wan, J; Wang, F, 2012)	0.38
" To investigate the effect of difenoconazole on cholesterol content and related mechanism, adult zebrafish were exposed to environmental related dosage (0."	( Sex specific response in cholesterol level in zebrafish (Danio rerio) after long-term exposure of difenoconazole. Chai, T; Li, X; Mu, X; Pang, S; Wang, C; Wang, K; Yang, Y; Zhang, J; Zhu, L, 2015)	0.92
" Mesocosms filled with Brazilian natural soil (lattosolo) were dosed with water (control), Kraft (10."	( Impact of temperature on the toxicity of Kraft 36 EC® (a.s. abamectin) and Score 250 EC® (a.s. difenoconazole) to soil organisms under realistic environmental exposure scenarios. Athayde, DB; Daam, MA; Duarte-Neto, PJ; Espíndola, ELG; Guerra, GDS; Pitombeira de Figueirêdo, L; van Gestel, CAM, 2020)	0.78
" The initial deposition amount of difenoconazole under the same application dosage showed the following order: fruits < cultivated soils < lower stems < upper stems < lower leaves < upper leaves, open field < greenhouse, and Changjiang < Cixi < Hefei < Langfang, respectively, which increased with increasing application dosage."	( Deposition and dissipation of difenoconazole in pepper and soil and its reduced application to control pepper anthracnose. Fang, H; Li, T; Mei, J; Qiu, M; Shen, H; Song, J; Wu, Z; Xu, L; Zheng, Z, 2023)	1.48

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Role	Description
environmental contaminant	Any minor or unwanted substance introduced into the environment that can have undesired effects.
xenobiotic	A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor	An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC 1.14.13.70 (sterol 14alpha-demethylase).
antifungal agrochemical	Any substance used in acriculture, horticulture, forestry, etc. for its fungicidal properties.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
dioxolane
triazoles	An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.
cyclic ketal	A ketal in the molecule of which the ketal carbon and one or both oxygen atoms thereon are members of a ring.
conazole fungicide	Any conazole antifungal agent that has been used as a fungicide.
triazole fungicide	Any triazole antifungal agent that has been used as a fungicide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
hypoxia-inducible factor 1 alpha subunit	Homo sapiens (human)	Potency	7.7606	3.1890	29.8841	59.4836	AID1224846
RAR-related orphan receptor gamma	Mus musculus (house mouse)	Potency	16.2921	0.0060	38.0041	19,952.5996	AID1159521; AID1159523
SMAD family member 2	Homo sapiens (human)	Potency	48.9662	0.1737	34.3047	61.8120	AID1346924
SMAD family member 3	Homo sapiens (human)	Potency	48.9662	0.1737	34.3047	61.8120	AID1346924
GLI family zinc finger 3	Homo sapiens (human)	Potency	3.3729	0.0007	14.5928	83.7951	AID1259369; AID1259392
AR protein	Homo sapiens (human)	Potency	18.3078	0.0002	21.2231	8,912.5098	AID1259243; AID1259247; AID588515; AID588516; AID743035; AID743042; AID743054; AID743063
estrogen receptor 2 (ER beta)	Homo sapiens (human)	Potency	27.3060	0.0006	57.9133	22,387.1992	AID1259378
progesterone receptor	Homo sapiens (human)	Potency	19.0110	0.0004	17.9460	75.1148	AID1346784; AID1346795
glucocorticoid receptor [Homo sapiens]	Homo sapiens (human)	Potency	43.5026	0.0002	14.3764	60.0339	AID588533; AID720691; AID720692; AID720719
retinoid X nuclear receptor alpha	Homo sapiens (human)	Potency	22.4797	0.0008	17.5051	59.3239	AID1159527; AID1159531; AID588544; AID588546
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	8.6282	0.0015	30.6073	15,848.9004	AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
farnesoid X nuclear receptor	Homo sapiens (human)	Potency	49.8047	0.3758	27.4851	61.6524	AID588526; AID743217
pregnane X nuclear receptor	Homo sapiens (human)	Potency	61.1306	0.0054	28.0263	1,258.9301	AID1346982
estrogen nuclear receptor alpha	Homo sapiens (human)	Potency	25.5652	0.0002	29.3054	16,493.5996	AID1259244; AID1259248; AID1259383; AID588513; AID588514; AID743069; AID743075; AID743078; AID743079; AID743080; AID743091
peroxisome proliferator-activated receptor delta	Homo sapiens (human)	Potency	40.2945	0.0010	24.5048	61.6448	AID588534; AID743215
peroxisome proliferator activated receptor gamma	Homo sapiens (human)	Potency	26.0215	0.0010	19.4141	70.9645	AID588536; AID743140; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptor	Homo sapiens (human)	Potency	54.3668	0.0237	23.2282	63.5986	AID588543; AID743222; AID743223
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	Homo sapiens (human)	Potency	30.6379	0.0017	23.8393	78.1014	AID743083
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	64.8601	0.0016	28.0151	77.1139	AID1259385; AID1259395
activating transcription factor 6	Homo sapiens (human)	Potency	61.6448	0.1434	27.6121	59.8106	AID1159519
Histone H2A.x	Cricetulus griseus (Chinese hamster)	Potency	126.7930	0.0391	47.5451	146.8240	AID1224845
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	16.0362	0.0003	23.4451	159.6830	AID743065; AID743066; AID743067
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	6.4324	0.0006	27.2152	1,122.0200	AID651741; AID743202; AID743219
Voltage-dependent calcium channel gamma-2 subunit	Mus musculus (house mouse)	Potency	10.8707	0.0015	57.7890	15,848.9004	AID1259244
Cellular tumor antigen p53	Homo sapiens (human)	Potency	63.5690	0.0023	19.5956	74.0614	AID651631; AID720552
Glutamate receptor 2	Rattus norvegicus (Norway rat)	Potency	10.8707	0.0015	51.7393	15,848.9004	AID1259244
ATPase family AAA domain-containing protein 5	Homo sapiens (human)	Potency	4.8558	0.0119	17.9420	71.5630	AID651632
Ataxin-2	Homo sapiens (human)	Potency	4.8558	0.0119	12.2221	68.7989	AID651632
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle G2/M phase transition	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
ER overload response	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
in utero embryonic development	Cellular tumor antigen p53	Homo sapiens (human)
somitogenesis	Cellular tumor antigen p53	Homo sapiens (human)
release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
T cell proliferation involved in immune response	Cellular tumor antigen p53	Homo sapiens (human)
B cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
T cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
response to ischemia	Cellular tumor antigen p53	Homo sapiens (human)
nucleotide-excision repair	Cellular tumor antigen p53	Homo sapiens (human)
double-strand break repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
protein import into nucleus	Cellular tumor antigen p53	Homo sapiens (human)
autophagy	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
Ras protein signal transduction	Cellular tumor antigen p53	Homo sapiens (human)
gastrulation	Cellular tumor antigen p53	Homo sapiens (human)
neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
protein localization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA replication	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
determination of adult lifespan	Cellular tumor antigen p53	Homo sapiens (human)
mRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
rRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
response to salt stress	Cellular tumor antigen p53	Homo sapiens (human)
response to inorganic substance	Cellular tumor antigen p53	Homo sapiens (human)
response to X-ray	Cellular tumor antigen p53	Homo sapiens (human)
response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of gene expression	Cellular tumor antigen p53	Homo sapiens (human)
cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
viral process	Cellular tumor antigen p53	Homo sapiens (human)
glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
cerebellum development	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell growth	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
mitotic G1 DNA damage checkpoint signaling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of telomere maintenance via telomerase	Cellular tumor antigen p53	Homo sapiens (human)
T cell differentiation in thymus	Cellular tumor antigen p53	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
regulation of tissue remodeling	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV	Cellular tumor antigen p53	Homo sapiens (human)
multicellular organism growth	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of mitochondrial membrane permeability	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
entrainment of circadian clock by photoperiod	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial DNA repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
transcription initiation-coupled chromatin remodeling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of proteolysis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
response to antibiotic	Cellular tumor antigen p53	Homo sapiens (human)
fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
circadian behavior	Cellular tumor antigen p53	Homo sapiens (human)
bone marrow development	Cellular tumor antigen p53	Homo sapiens (human)
embryonic organ development	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Cellular tumor antigen p53	Homo sapiens (human)
protein stabilization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of helicase activity	Cellular tumor antigen p53	Homo sapiens (human)
protein tetramerization	Cellular tumor antigen p53	Homo sapiens (human)
chromosome organization	Cellular tumor antigen p53	Homo sapiens (human)
neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic stem cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
type II interferon-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
cardiac septum morphogenesis	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of programmed necrotic cell death	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Cellular tumor antigen p53	Homo sapiens (human)
thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
necroptotic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to xenobiotic stimulus	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to ionizing radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV-C	Cellular tumor antigen p53	Homo sapiens (human)
stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to actinomycin D	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
replicative senescence	Cellular tumor antigen p53	Homo sapiens (human)
oxidative stress-induced premature senescence	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
oligodendrocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of execution phase of apoptosis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of G1 to G0 transition	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of miRNA processing	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of pentose-phosphate shunt	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
regulation of fibroblast apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
cell population proliferation	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of B cell proliferation	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
nuclear DNA replication	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
signal transduction in response to DNA damage	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
isotype switching	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of DNA replication	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of isotype switching to IgG isotypes	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
DNA clamp unloading	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
regulation of mitotic cell cycle phase transition	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
positive regulation of cell cycle G2/M phase transition	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
negative regulation of receptor internalization	Ataxin-2	Homo sapiens (human)
regulation of translation	Ataxin-2	Homo sapiens (human)
RNA metabolic process	Ataxin-2	Homo sapiens (human)
P-body assembly	Ataxin-2	Homo sapiens (human)
stress granule assembly	Ataxin-2	Homo sapiens (human)
RNA transport	Ataxin-2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
core promoter sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
TFIID-class transcription factor complex binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
protease binding	Cellular tumor antigen p53	Homo sapiens (human)
p53 binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity	Cellular tumor antigen p53	Homo sapiens (human)
mRNA 3'-UTR binding	Cellular tumor antigen p53	Homo sapiens (human)
copper ion binding	Cellular tumor antigen p53	Homo sapiens (human)
protein binding	Cellular tumor antigen p53	Homo sapiens (human)
zinc ion binding	Cellular tumor antigen p53	Homo sapiens (human)
enzyme binding	Cellular tumor antigen p53	Homo sapiens (human)
receptor tyrosine kinase binding	Cellular tumor antigen p53	Homo sapiens (human)
ubiquitin protein ligase binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase regulator activity	Cellular tumor antigen p53	Homo sapiens (human)
ATP-dependent DNA/DNA annealing activity	Cellular tumor antigen p53	Homo sapiens (human)
identical protein binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase binding	Cellular tumor antigen p53	Homo sapiens (human)
protein heterodimerization activity	Cellular tumor antigen p53	Homo sapiens (human)
protein-folding chaperone binding	Cellular tumor antigen p53	Homo sapiens (human)
protein phosphatase 2A binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Cellular tumor antigen p53	Homo sapiens (human)
14-3-3 protein binding	Cellular tumor antigen p53	Homo sapiens (human)
MDM2/MDM4 family protein binding	Cellular tumor antigen p53	Homo sapiens (human)
disordered domain specific binding	Cellular tumor antigen p53	Homo sapiens (human)
general transcription initiation factor binding	Cellular tumor antigen p53	Homo sapiens (human)
molecular function activator activity	Cellular tumor antigen p53	Homo sapiens (human)
promoter-specific chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
protein binding	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
ATP binding	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
ATP hydrolysis activity	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
DNA clamp unloader activity	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
DNA binding	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
RNA binding	Ataxin-2	Homo sapiens (human)
epidermal growth factor receptor binding	Ataxin-2	Homo sapiens (human)
protein binding	Ataxin-2	Homo sapiens (human)
mRNA binding	Ataxin-2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nuclear body	Cellular tumor antigen p53	Homo sapiens (human)
nucleus	Cellular tumor antigen p53	Homo sapiens (human)
nucleoplasm	Cellular tumor antigen p53	Homo sapiens (human)
replication fork	Cellular tumor antigen p53	Homo sapiens (human)
nucleolus	Cellular tumor antigen p53	Homo sapiens (human)
cytoplasm	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrion	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial matrix	Cellular tumor antigen p53	Homo sapiens (human)
endoplasmic reticulum	Cellular tumor antigen p53	Homo sapiens (human)
centrosome	Cellular tumor antigen p53	Homo sapiens (human)
cytosol	Cellular tumor antigen p53	Homo sapiens (human)
nuclear matrix	Cellular tumor antigen p53	Homo sapiens (human)
PML body	Cellular tumor antigen p53	Homo sapiens (human)
transcription repressor complex	Cellular tumor antigen p53	Homo sapiens (human)
site of double-strand break	Cellular tumor antigen p53	Homo sapiens (human)
germ cell nucleus	Cellular tumor antigen p53	Homo sapiens (human)
chromatin	Cellular tumor antigen p53	Homo sapiens (human)
transcription regulator complex	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex	Cellular tumor antigen p53	Homo sapiens (human)
plasma membrane	Glutamate receptor 2	Rattus norvegicus (Norway rat)
Elg1 RFC-like complex	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
nucleus	ATPase family AAA domain-containing protein 5	Homo sapiens (human)
cytoplasm	Ataxin-2	Homo sapiens (human)
Golgi apparatus	Ataxin-2	Homo sapiens (human)
trans-Golgi network	Ataxin-2	Homo sapiens (human)
cytosol	Ataxin-2	Homo sapiens (human)
cytoplasmic stress granule	Ataxin-2	Homo sapiens (human)
membrane	Ataxin-2	Homo sapiens (human)
perinuclear region of cytoplasm	Ataxin-2	Homo sapiens (human)
ribonucleoprotein complex	Ataxin-2	Homo sapiens (human)
cytoplasmic stress granule	Ataxin-2	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (87)

Assay ID	Title	Year	Journal	Article
AID1112460	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN14 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID644737	Antifungal activity against Alternaria solani assessed as inhibition of mycelium growth at 100 ug/ml after 48 hrs	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1.
AID1080653	Fungicidal activity against Alternaria solani assessed as growth inhibition at 1 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112442	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN32 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112443	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN31 expressing C3 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112461	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN13 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112415	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS07 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112417	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS05 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112416	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS06 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID644736	Antifungal activity against Botryotinia fuckeliana assessed as inhibition of mycelium growth at 100 ug/ml after 48 hrs	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1.
AID352273	Fungicidal activity against Cercospora arachidicola assessed as inhibition of mycelium growth at 50 mg/L after 72 hrs	2009	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11	Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates.
AID1112454	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN20 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112411	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS11 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID352272	Fungicidal activity against Alternaria solani assessed as inhibition of mycelium growth at 50 mg/L after 72 hrs	2009	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11	Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates.
AID1112429	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH07 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112426	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH12 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112467	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN07 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112455	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN19 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID644735	Antifungal activity against Rhizoctonia solani assessed as inhibition of mycelium growth at 100 ug/ml after 48 hrs	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1.
AID1112469	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN05 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID352274	Fungicidal activity against Physalospora pyricola assessed as inhibition of mycelium growth at 50 mg/L after 72 hrs	2009	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11	Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates.
AID1112456	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN18 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112424	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate AH14 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112419	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate JS03 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112421	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate JS01 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112457	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN17 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112459	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN15 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112412	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate JS10 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112425	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate AH13 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112472	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN02 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112445	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN29 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112444	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN30 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112435	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH01 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID352275	Fungicidal activity against Cladosporium cucumerinum assessed as inhibition of mycelium growth at 50 mg/L after 72 hrs	2009	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11	Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates.
AID1112436	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate SD06 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112448	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN26 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112423	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH15 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112471	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN03 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080655	Fungicidal activity against Alternaria solani assessed as growth inhibition at 50 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112474	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH09 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112466	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN08 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080645	Fungicidal activity against Fusarium oxysporum assessed as growth inhibition at 1 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112414	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate JS08 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112418	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS04 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112470	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN04 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080658	Fungicidal activity against Fusarium graminearum assessed as growth inhibition at 50 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112450	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN24 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID644738	Antifungal activity against Alternaria alternata Keissler assessed as inhibition of mycelium growth at 100 ug/ml after 48 hrs	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1.
AID1112468	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN06 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112462	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN12 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080651	Fungicidal activity against Mycosphaerella arachidis assessed as growth inhibition at 1 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112420	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate JS02 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112439	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate SD03 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080647	Fungicidal activity against Fusarium oxysporum assessed as growth inhibition at 50 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112413	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS09 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112453	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN21 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080652	Fungicidal activity against Mycosphaerella arachidis assessed as growth inhibition at 50 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112410	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate JS12 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112431	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH05 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112465	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN09 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112475	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH08 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112441	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate SD01 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112463	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN11 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112458	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN16 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID644734	Antifungal activity against Gibberella zeae assessed as inhibition of mycelium growth at 100 ug/ml after 48 hrs	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1.
AID1112434	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate AH02 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112447	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN27 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112473	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN01 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112452	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN22 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID352271	Fungicidal activity against Gibberella zeae assessed as inhibition of mycelium growth at 50 mg/L after 72 hrs	2009	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 19, Issue:11	Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates.
AID1112440	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate SD02 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080656	Fungicidal activity against Fusarium graminearum assessed as growth inhibition at 1 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112427	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH11 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112432	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH04 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112437	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate SD05 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112449	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN25 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112430	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate AH06 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112428	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate AH10 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID644739	Antifungal activity against Colletotrichum orbiculare assessed as inhibition of mycelium growth at 100 ug/ml after 48 hrs	2012	Bioorganic & medicinal chemistry, Mar-01, Volume: 20, Issue:5	Design, synthesis and biological evaluation of novel 2-methylpyrimidine-4-ylamine derivatives as inhibitors of Escherichia coli pyruvate dehydrogenase complex E1.
AID1112464	Antifungal activity against sithiofam-resistant Gaeumannomyces graminis var. tritici isolate HN10 expressing C1 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112451	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN23 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080650	Fungicidal activity against Botryosphaeria berengeriana assessed as growth inhibition at 50 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112422	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH16 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112438	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate SD04 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1112446	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate HN28 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
AID1080648	Fungicidal activity against Botryosphaeria berengeriana assessed as growth inhibition at 1 ug/mL	2009	Journal of agricultural and food chemistry, Jun-10, Volume: 57, Issue:11	Synthesis and fungicidal evaluation of 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives.
AID1112433	Antifungal activity against sithiofam-sensitive Gaeumannomyces graminis var. tritici isolate AH03 expressing C2 genetic cluster assessed as reduction in fungal colony diameter after 4 days	2012	Pest management science, Aug, Volume: 68, Issue:8	Sensitivity to silthiofam, tebuconazole and difenoconazole of Gaeumannomyces graminis var. tritici isolates from China.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (0.67)	18.2507
2000's	9 (6.00)	29.6817
2010's	71 (47.33)	24.3611
2020's	69 (46.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (0.66%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	151 (99.34%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
acetone methyl ketone : A ketone of formula RC(=O)CH3 (R =/= H).	2.08	1	0	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent
benzene [no description available]	2.6	1	0	aromatic annulene; benzenes; volatile organic compound	carcinogenic agent; environmental contaminant; non-polar solvent
carbamates [no description available]	3.33	6	0	amino-acid anion
glycine [no description available]	2.69	2	0	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
indoleacetic acid indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.	2.05	1	0	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.07	1	0	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
carbofuran Carbofuran: A cholinesterase inhibitor that is used as a systemic insecticide, an acaricide, and nematocide. (From Merck Index, 11th ed)	2.08	1	0	1-benzofurans; carbamate ester	acaricide; agrochemical; avicide; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; nematicide
chlorpyrifos Chlorpyrifos: An organothiophosphate cholinesterase inhibitor that is used as an insecticide and as an acaricide.. chlorpyrifos : An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.	7.78	3	0	chloropyridine; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; insecticide; xenobiotic
cypermethrin cypermethrin : A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.. zeta-cypermethrin : A diastereoisomeric mixture comprising the isomeric pair (1R)-cis-(alphaS)- and (1S)-trans-(alphaR)-cypermethrin together with the isomeric pair (1S)-cis-(alphaS)- and (1S)-trans-(alphaS)-cypermethrin where the ratio between the isomeric pairs lies in the range 45:55 to 55:45.	2.31	1	0	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound	agrochemical; molluscicide; pyrethroid ester acaricide; pyrethroid ester insecticide
diazinon Diazinon: A cholinesterase inhibitor that is used as an organothiophosphorus insecticide.. diazinon : A member of the class of pyrimidines that is pyrimidine carrying an isopropyl group at position 2, a methyl group at position 6 and a (diethoxyphosphorothioyl)oxy group at position 4.	2.05	1	0	organic thiophosphate; pyrimidines	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; environmental contaminant; nematicide; xenobiotic
endosulfan Endosulfan: A polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61). endosulfan : A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.	2.5	2	0	cyclic sulfite ester; cyclodiene organochlorine insecticide	acaricide; agrochemical; GABA-gated chloride channel antagonist; persistent organic pollutant
fipronil fipronil: has low mammalian toxicity; structure given in first source. fipronil : A racemate comprising equimolar amounts of (R)- and (S)-fipronil.. 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile : A member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively.	7.11	1	0	(trifluoromethyl)benzenes; dichlorobenzene; nitrile; primary amino compound; pyrazoles; sulfoxide
liquid crystal polymer bromuconazole: a fungicide; structure in first source. bromuconazole : A member of the class of oxolanes carrying 1,2,4-triazol-ylmethyl and 2,4-dichlorophenyl substituents at position 2 as well as a bromo substituent at position 4. A foliar applied conazole fungicide for a range of crops including cereals, fruit, vegetables and vines.	2.07	1	0	conazole fungicide; dichlorobenzene; organobromine compound; oxolanes; triazole fungicide; triazoles	antifungal agrochemical; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
iodoquinol Iodoquinol: One of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.. iodoquinol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by iodine. It is considered the drug of choice for treating asymptomatic or moderate forms of amoebiasis.	2.25	1	0	monohydroxyquinoline; organoiodine compound	antiamoebic agent; antibacterial agent; antiprotozoal drug; antiseptic drug
thiram Thiram: A dithiocarbamate chemical, used commercially in the rubber processing industry and as a fungicide. In vivo studies indicate that it inactivates the enzyme GLUTATHIONE REDUCTASE. It has mutagenic activity and may induce chromosomal aberrations.. thiram : An organic disulfide that results from the formal oxidative dimerisation of N,N-dimethyldithiocarbamic acid. It is widely used as a fungicidal seed treatment.	7.08	1	0	organic disulfide	antibacterial drug; antifungal agrochemical; antiseptic drug
thyroxine Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.. thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions.	2.11	1	0	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone
systhane systhane: structure in first source. 2-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile : A nitrile that is hexanenitrile substituted at the 2-position by p-chlorophenyl and (1,2,4-triazol-1-yl)methyl groups.	2.49	2	0	monochlorobenzenes; nitrile; triazoles
4-butyrolactone 4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.	2.52	2	0	butan-4-olide	metabolite; neurotoxin
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.31	1	0	pyrrole; secondary amine
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.07	1	0	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
cyclohexane Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.	2.08	1	0	cycloalkane; volatile organic compound	non-polar solvent
thiazoles [no description available]	2.15	1	0	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
linuron Linuron: A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed). linuron : A member of the class of phenylureas that is N-methyl urea substituted by a methoxy group at position 1 and a 3,4-dichlorophenyl group at position 3.	7.21	1	0	dichlorobenzene; phenylureas	agrochemical; environmental contaminant; herbicide; xenobiotic
tetrachloroisophthalonitrile tetrachloroisophthalonitrile: structure. chlorothalonil : A dinitrile that is benzene-1,3-dicarbonitrile substituted by four chloro groups. A non-systemic fungicide first introduced in the 1960s, it is used to control a range of diseases in a wide variety of crops.	2.87	3	0	aromatic fungicide; dinitrile; tetrachlorobenzene	antifungal agrochemical
isoprocarb [no description available]	7.07	1	0	carbamate ester	agrochemical; carbamate insecticide; EC 3.1.1.7 (acetylcholinesterase) inhibitor
terbutylazine terbutylazine : A diamino-1,3,5-triazine that is N-tert-butyl-N'-methyl-1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6.	2.07	1	0	chloro-1,3,5-triazine; diamino-1,3,5-triazine	environmental contaminant; herbicide; xenobiotic
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	7.41	1	0	copper group element atom; elemental silver	Escherichia coli metabolite
phenmedipham phenmedipham: minor descriptor (72-84); on-line search CARBAMATES (72-84); Index Medicus search HERBICIDES, CARBAMATE (75-84), CARBAMATES (72-75). phenmedipham : A carbamate ester that is (3-methylphenyl)carbamic acid in which the hydrogen of the hydroxy group has been replaced by a 3-[(methoxycarbonyl)amino]phenyl group.	2.01	1	0	carbamate ester	environmental contaminant; herbicide; xenobiotic
ozone Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).. ozone : An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.	7.84	3	0	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer
carbendazim carbendazim: carcinogen when combined with sodium nitrite; principle metabolite of thiophanate methyl & benomyl; structure. carbendazim : A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.	7.52	2	0	benzimidazole fungicide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	antifungal agrochemical; antinematodal drug; metabolite; microtubule-destabilising agent
terbufos [no description available]	2.13	1	0	organic thiophosphate; organosulfur compound; organothiophosphate insecticide	agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; nematicide
chlortoluron chlorotoluron : A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by two methyl groups while the other is substituted by a 3-chloro-4-methylphenyl group. A herbicide that is non-toxic to honeybees but moderately toxic to mammals, birds, earthworms and most aquatic organisms.	2.01	1	0	monochlorobenzenes; phenylureas	agrochemical; environmental contaminant; herbicide; xenobiotic
fenitrothion Fenitrothion: An organothiophosphate cholinesterase inhibitor that is used as an insecticide.. fenitrothion : An organic thiophosphate that is O,O-dimethyl O-phenyl phosphorothioate substituted by a methyl group at position 3 and a nitro group at position 4.	2.08	1	0	C-nitro compound; organic thiophosphate	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; insecticide
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	3.08	4	0	benzenes; phenyl acetates
triazophos triazophos: structure	2.31	1	0	organic thiophosphate; organothiophosphate insecticide	acaricide; agrochemical; EC 3.1.1.7 (acetylcholinesterase) inhibitor; nematicide
procymidone procymidone : An azabicycloalkane that is 1,5-dimethyl-3-azabicyclo[3.1.0]hexane-2,4-dione in which the amino hydrogen is replaced by a 3,5-dichlorophenyl group. A fungicide widely used in horticulture as a seed dressing, pre-harvest spray or post-harvest dip for the control of various diseases.	2.08	1	0
isoproturon isoproturon : A member of the class of phenylureas that is 1,1-dimethylurea substituted by a p-cumenyl group at position 3. A selective, systemic herbicide used to control annual grasses and broadleaf weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life; there have also been concerns about its endocrine-disrupting properties.	2.01	1	0	3-(3,4-substituted-phenyl)-1,1-dimethylurea	agrochemical; environmental contaminant; herbicide; xenobiotic
diflubenzuron Diflubenzuron: An insect growth regulator which interferes with the formation of the insect cuticle. It is effective in the control of mosquitoes and flies.. diflubenzuron : A benzoylurea insecticide that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 4-chlorophenyl group, and a hydrogen attached to the other nitrogen is replaced bgy a 2,6-difluorobenzoyl group.	7.21	1	0	benzoylurea insecticide; monochlorobenzenes	insect sterilant
enilconazole enilconazole: RN given refers to parent cpd. enilconazole : A racemate comprising equimolar amounts of (R)- and (S)-enilconazole. A fungicide used to control a wide range of fungi including Tilletia and Helminthosporium spp. on fruit, vegetables and ornamentals. In veterinary medicine, it is used topically for the treatment of fungal skin infections in cattle, dogs, and horses; it is also used by inhalation for the treatment of aspergillosis in ostriches.. 1-[2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a 2-(allyloxy)-2-(2,4-dichlorophenyl)ethyl group.	2.11	1	0	dichlorobenzene; ether; imidazoles
pendimethalin pendimethalin : A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.	7.44	2	0	C-nitro compound; secondary amino compound; substituted aniline	agrochemical; environmental contaminant; herbicide
triadimefon 1-(4-chlorophenoxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one : A member of the class of triazoles that is 1-hydroxy-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-one in which the hydroxyl hydrogen is replaced by a 4-chlorophenyl group.	2.08	1	0	aromatic ether; hemiaminal ether; ketone; monochlorobenzenes; triazoles
permethrin hemoglobin Atlanta-Coventry: Leu replaced by Pro at beta75 and Leu deleted at beta141	2.01	1	0	cyclopropanecarboxylate ester; cyclopropanes	agrochemical; ectoparasiticide; pyrethroid ester acaricide; pyrethroid ester insecticide; scabicide
decamethrin decamethrin: pyrethroid insecticide; RN given refers to cpd without isomeric designation; structure	1.99	1	0	aromatic ether; cyclopropanecarboxylate ester; nitrile; organobromine compound	agrochemical; antifeedant; calcium channel agonist; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; pyrethroid ester insecticide
propiconazole Orbit: Bony cavity that holds the eyeball and its associated tissues and appendages.	4.01	12	0	conazole fungicide; cyclic ketal; dichlorobenzene; triazole fungicide; triazoles	antifungal agrochemical; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor; environmental contaminant; xenobiotic
florisil Florisil: hard, porous, granular substance used in vitamin analysis, chromatography, & antibiotic processing	2.08	1	0
hexaconazole 2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol : A member of the class of triazoles that is 1-hexyl-1H-1,2,4-triazole in which the hydrogens at position 2 of the hexyl chain are replaced by hydroxy and 2,4-dichlorophenyl groups.. hexaconazole : A racemate comprising equimolar amounts of (R)- and (S)-hexaconazole. An agricultural fungicide introduced in the 1980s, it is not approved for use within the European Union.	7.75	3	0	dichlorobenzene; tertiary alcohol; triazoles	chelator
triazoles Triazoles: Heterocyclic compounds containing a five-membered ring with two carbon atoms and three nitrogen atoms with the molecular formula C2H3N3.. triazoles : An azole in which the five-membered heterocyclic aromatic skeleton contains three N atoms and two C atoms.	7.75	134	1	1,2,3-triazole
triasulfuron triasulfuron : An N-sulfonylurea that is N-[o-(2-chloroethoxy)phenyl]sulfonylurea in which one of the hydrogens attached to the non-sulfonylated nitrogen has been replaced by a 4-methoxy-6-methyl-1,3,5-triazin-2-yl group. A herbicide used to control broad-leaved weeds in cereals, its use within the EU has been banned after September 2017 on the grounds of potential groundwater contamination and risks to aquatic life.	2.01	1	0	1,3,5-triazines; aromatic ether; N-sulfonylurea; organochlorine compound	agrochemical; herbicide
prochloraz Mirage: a feldspathic porcelain that can be etched & bonded to the tooth. prochloraz : A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.	1.99	1	0	amide fungicide; aromatic ether; conazole fungicide; imidazole fungicide; imidazoles; trichlorobenzene; ureas	antifungal agrochemical; EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor; environmental contaminant; xenobiotic
tetraconazole tetraconazole : A racemate comprising equal amounts of (R)- and (S)-tetraconazole. A fungicide used to control a range of fungal infections including powdery mildew, rusts, bunt, loose smut and scab.. 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]1,2,4-triazole : A member of the class of triazoles that is 1,2,4-triazole substituted at position 1 by a 2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl group.	7.46	2	0	dichlorobenzene; ether; organofluorine compound; triazoles
tetramethrin tetramethrin: structure	2.01	1	0	cyclopropanecarboxylate ester; maleimides; phthalimide insecticide	pyrethroid ester insecticide
tebuconazole Lynx: A genus in the family FELIDAE comprising felines with long legs, ear tufts, and a short tail.. 1-(4-chlorophenyl)-4,4-dimethyl-3-(1H-1,2,4-triazol-1-ylmethyl)pentan-3-ol : A tertiary alcohol that is pentan-3-ol substituted by a 4-chlorophenyl, methyl, methyl, and a 1H-1,2,4-triazol-1-ylmethyl at positions 1, 4, 4 and 3 respectively.. tebuconazole : A racemate composed of equimolar amounts of (R)- and (S)-tebuconazole. A fungicide effective against various smut and bunt diseases in cereals and other field crops.	3.81	10	0	monochlorobenzenes; tertiary alcohol; triazoles
4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile fenbuconazole: fenbuconazole is a formulant in the fungicide Enable; structure in first source. fenbuconazole : A racemate comprising equimolar amounts of (R)- and (S)-fenbuconazole. A fungicide used to control a range of diseases including powdery mildew, black rot and scab.. 4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile : A member of the class of triazoles that is 1-chloro-4-(3-phenylpropyl)benzene substituted at position 3 of the propyl moiety by cyano and 1,2,4-triazol-1-ylmethyl groups.	2.07	1	0	monochlorobenzenes; nitrile; triazoles
cyprodinil cyprodinil: structure in first source. cyprodinil : A member of the class of aminopyrimidine that is N-phenylpyrimidin-2-amine carrying additional cyclopropyl and methyl substituents at positions 4 and 6 respectively. A broad spectrum fungicide used to control a range of pathogens including Tapesia yallundae, Botrytis spp., Alternaria spp. and Rhynchospium secalis. Whilst it is a recognised irritant no serious human health concerns have been identified. It is moderately toxic to birds as well as most aquatic organisms and earthworms, but it is not considered toxic to honeybees.	2.5	2	0	aminopyrimidine; anilinopyrimidine fungicide; cyclopropanes; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; environmental contaminant; xenobiotic
fludioxonil fludioxonil: structure in first source. fludioxonil : A member of the class of benzodioxoles that is 2,2-difluoro-1,3-benzodioxole substituted at position 4 by a 3-cyanopyrrol-4-yl group. A fungicide seed treatment for control of a range of diseases including Fusarium, Rhizoctonia and Alternaria.	2.31	1	0	benzodioxoles; nitrile; organofluorine compound; pyrroles	androgen antagonist; antifungal agrochemical; estrogen receptor agonist
pyrimethanil pyrimethanil: structure in first source. pyrimethanil : A member of the class of aminopyrimidines that is N-phenylpyrimidin-2-amine carrying two additional methyl substituents at positions 4 and 6. A fungicide used to control grey mould on fruit, vegetables and ornamentals as well as leaf scab on pome fruit. Also commonly employed to control Botrytis cinerea throughout the winemaking process in grapes, must, fermenting must and wine.	2.08	1	0	aminopyrimidine; anilinopyrimidine fungicide; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; environmental contaminant; xenobiotic
bitertanol bitertanol: a triazole fungicide; structure given in first source. bitertanol : A diastereoisomeric mixture composed of the enantiomeric pair (1R,2S)- and (1S,2R)-bitertanol in a 4:1 ratio with the enantiomeric pair (1R,2R)- and (1S,2S)-bitertanol. A fungicide used to control a range of diseases including scab, powder mildew, rusts and blackspot. It is moderately toxic to most animal and insect species but is non-toxic to honeybees.. 1-(biphenyl-4-yloxy)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)butan-2-ol : A member of the class of triazoles that is 3,3-dimethyl-1-(1,2,4-triazol-1-yl)butane-1,2-diol substituted at position O-1 by a biphenyl-4-yl group.	2.25	1	0	aromatic ether; biphenyls; secondary alcohol; triazoles
triflumizol triflumizol: structure given in first source. triflumizole : A carboxamidine resulting from the formal condensation of the amino group of 4-chloro-2-(trifluoromethyl)aniline with the oxygen of the acetyl group of N-(propoxyacetyl)imidazole. A sterol demethylation inhibitor, it is used as a fungicide for the control of powdery mildew, scab and other diseases on a variety of crops.	2.02	1	0
flutriafol flutriafol: fungicide; structure in first source. flutriafol : A racemate comprising an equimolar mixture of (R)- and (S)-flutriafol. A systemic fungicide, it is used to control fungal diseases in cereal crops.. 1-(2-fluorophenyl)-1-(4-fluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanol : A tertiary alcohol that is ethanol in which one of the hydrogens at position 1 is replaced by an p-fluorophenyl group, the other hydrogen at position 1 is replaced by a p-fluorophenyl group, and one of the hydrogens at position 2 is replaced by a 1H-1,2,4-triazol-1-yl group.	2.51	2	0	monofluorobenzenes; tertiary alcohol; triazoles
hexafluoron hexafluoron: insect growth regulator against mosquito larva; the active agent in Sonet, a Russian product, is hexaflumuron. hexaflumuron : An N-acylurea that is urea in which a hydrogen attached to one of the nitrogens is replaced by a 2,6-difluorobenzoyl group, while a hycrogen attached to the other nitorgen is replaced by a 3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl group.	2.07	1	0	aromatic ether; benzoylurea insecticide; dichlorobenzene; N-acylurea; organochlorine insecticide; organofluorine insecticide
cyfluthrin cyfluthrin: effective against mosquitoes. cyfluthrin : A carboxylic ester obtained by formal condensation between 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic acid and (4-fluoro-3-phenoxyphenyl)(hydroxy)acetonitrile.	2.08	1	0	aromatic ether; cyclopropanecarboxylate ester; nitrile; organochlorine compound; organofluorine compound	agrochemical; pyrethroid ester insecticide
thiamethoxam Thiamethoxam: A nitro-oxazine and thiazole derivative that is used as a broad spectrum neonicotinoid insecticide.. thiamethoxam : An oxadiazane that is tetrahydro-N-nitro-4H-1,3,5-oxadiazin-4-imine bearing (2-chloro-1,3-thiazol-5-yl)methyl and methyl substituents at positions 3 and 5 respectively.	7.15	1	0	1,3-thiazoles; 2-nitroguanidine derivative; organochlorine compound; oxadiazane	antifeedant; carcinogenic agent; environmental contaminant; neonicotinoid insectide; xenobiotic
thiacloprid thiacloprid: structure in first source. (Z)-thiacloprid : The (Z)-stereoisomer of thiacloprid.. thiacloprid : A nitrile that is cyanamide in which the hydrogens are replaced by a 1,3-thiazolidin-2-ylidene group which in turn is substituted by a (6-chloropyridin-3-yl)methyl group at the ring nitrogen.	2.05	1	0	monochloropyridine; nitrile; thiazolidines	environmental contaminant; neonicotinoid insectide; xenobiotic
lignin Lignin: The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed). lignin : A polyphenylpropanoid derived from three monolignol monomers: trans-p-coumaryl alcohol, coniferol and trans-sinapyl alcohol. There is extensive cross-linking and no defined primary structure.	2.6	1	0
spirodiclofen spirodiclofen: an acaricide	7.52	2	0	dichlorobenzene; gamma-lactone; organochlorine acaricide; oxaspiro compound
n-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide: structure in first source. fenhexamid : An aromatic amide resulting from the formal condensation of the carboxy group of 1-methylcyclohexanecarboxylic acid with the amino group of 4-amino-2,3-dichlorophenol.	2.08	1	0	anilide fungicide; aromatic amide; dichlorobenzene; monocarboxylic acid amide; phenols	antifungal agrochemical; EC 1.14.13.72 (methylsterol monooxygenase) inhibitor; sterol biosynthesis inhibitor
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.41	1	0	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
oleic acid Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.	7.6	1	0	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent
glycosides [no description available]	2.08	1	0
nabam mancozeb: complex of zinc & maneb, containing 20% manganese & 2.5% zinc. mancozeb : A mixture composed from maneb and zineb, which is used as a broad-spectrum contact fungicide.. ethylenebis(dithiocarbamic acid) : A dithiocarbamic acid resulting from the formal addition of a molecule of carbon disulfide to each amino group of ethylenediamine.	2.96	3	0	dithiocarbamic acids
zineb Zineb: An agricultural fungicide of the dithiocarbamate class. It has relatively low toxicity and there is little evidence of human injury from exposure.. zineb : A polymeric complex of zinc with the ethylene bis(dithiocarbamate) anionic ligand. Formerly used as an agricultural fungicide for the control of downy mildews and rusts, its use is no longer permitted in the US or the EU.	2.96	3	0	dithiocarbamate salt; macromolecule; zinc coordination entity	antifungal agrochemical
maneb Maneb: Manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat.. maneb : A polymeric complex of manganese with the ethylene bis(dithiocarbamate) anionic ligand. An agrochemical fungicide, it is used to control a variety of diseases including blight, leaf spot, rust, downy mildew and scab.	2.96	3	0
thiophanate Thiophanate: Nematocide used in livestock; also has fungicidal properties.. thiophanate : A member of the class of thioureas that is the diethyl ester of (1,2-phenylenedicarbamothioyl)biscarbamic acid. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould.	2.08	1	0	benzimidazole precursor fungicide; carbamate ester; carbamate fungicide; thioureas	antifungal drug
azoxystrobin azoxystrobin: a methoxyacrylate analog; a strobilurin fungicide; structure given in first source. azoxystrobin : An aryloxypyrimidine having a 4,6-diphenoxypyrimidine skeleton in which one of the phenyl rings is cyano-substituted at C-2 and the other carries a 2-methoxy-1-(methoxycarbonyl)vinyl substituent, also at C-2. An inhibitor of mitochondrial respiration by blocking electron transfer between cytochromes b and c1, it is used widely as a fungicide in agriculture.	4.24	15	0	aryloxypyrimidine; enoate ester; enol ether; methoxyacrylate strobilurin antifungal agent; methyl ester; nitrile	antifungal agrochemical; environmental contaminant; mitochondrial cytochrome-bc1 complex inhibitor; quinone outside inhibitor; xenobiotic
nitenpyram nitenpyram: a nitromethylene neonicotinoid insecticide; structure in first source. (E)-nitenpyram : A nitenpyram in which the double bond has E configuration.. nitenpyram : A C-nitro compound consisting of 2-nitroethene-1,1-diamine where one of the nitrogens bears ethyl and (6-chloro-3-pyridinyl)methyl while the other nitrogen carries a methyl group.	7.41	1	0	chloropyridyl insecticide; nitenpyram
epoxiconazole epoxiconazole : A racemate composed of equimolar amounts of (2S,3R)- and (2R,3S)-epoxiconazole. A broad-spectrum fungicide for control of diseases caused by Ascomycetes, Basidiomycetes and Deuteromycetes. Epoxiconazole is moderately toxic to birds, honeybees, earthworms and most aquatic organisms.. 1-{[3-(2-chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl}-1H-1,2,4-triazole : An epoxide that is oxirane substituted by a 2-chlorophenyl, 4-fluorophenyl and a 1H-1,2,4-triazol-1-ylmethyl groups.	7.57	2	0	epoxide; monochlorobenzenes; monofluorobenzenes; triazoles
quercetin [no description available]	2.17	1	0	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
pyrachlostrobin pyraclostrobin : A carbamate ester that is the methyl ester of [2-({[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy}methyl)phenyl]methoxycarbamic acid. A fungicide used to control major plant pathogens including Septoria tritici, Puccinia spp. and Pyrenophora teres.	3.08	4	0	aromatic ether; carbamate ester; carbanilate fungicide; methoxycarbanilate strobilurin antifungal agent; monochlorobenzenes; pyrazoles	antifungal agrochemical; environmental contaminant; mitochondrial cytochrome-bc1 complex inhibitor; xenobiotic
prothioconazole prothioconazole: a fungicide. prothioconazole : A racemate comprising equal amounts of (R)- and (S)-prothioconazole. A fungicide for use both as a seed treatment and foliar spray to treat a variety of diseases in cereals.. 2-[2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl]-1,2-dihydro-1,2,4-triazole-3-thione : A member of the class of triazoles that is 1,2,4-triazole-3-thione substituted at position 2 by a 2-(1-chlorocyclopropyl)-3-(2-chlorophenyl)-2-hydroxypropyl group.	2.17	1	0	cyclopropanes; monochlorobenzenes; tertiary alcohol; thiocarbonyl compound; triazoles
js399-19 phenamacril: an effective agent against several fungi species belonging to the Fusarium genus	2.31	1	0
chlorantranilipole chlorantranilipole: anthranilic diamide insecticide.that disrupts mating in codling moth (Lepidoptera: Tortricidae). chlorantraniliprole : A carboxamide resulting from the formal condensation of the carboxylic acid group of 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid with the primary amino group of 2-amino-5-chloro-N,3-dimethylbenzamide. The first of the anthranilic diamide insecticides, it is a ryanodine receptor activator and is used to protect a wide variety of crops, including corn, cotton, grapes, rice and potatoes.	2.6	1	0	monochlorobenzenes; organobromine compound; pyrazole insecticide; pyrazoles; pyridines; secondary carboxamide	ryanodine receptor agonist
dextrothyroxine [no description available]	3.71	8	0
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.41	1	0
fluxapyroxad fluxapyroxad: carboxamide; succinate dehydrogenase inhibitor. fluxapyroxad : An aromatic amide obtained by formal condensation of the carboxy group of 3-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid with the amino group of 3',4',5'-trifluorobiphenyl-2-amine. Used to control a number of cereal fungal pathogens including those belonging to the Ascomycetes, Basidiomycetes and Zygomycetes families.	2.61	2	0	anilide fungicide; aromatic amide; biphenyls; pyrazoles; trifluorobenzene	antifungal agrochemical; EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor
cellulose DEAE-Cellulose: Cellulose derivative used in chromatography, as ion-exchange material, and for various industrial applications.	7.31	1	0	glycoside
phentin acetate phentin acetate: see also triphenyltin hydroxide.; structure. fentin acetate : An organotin compound that is the O-acetyl derivative of triphenyltin hydroxide. A fungicide used to control blights on potatoes, leaf spot diseases on sugar beet and anthracnose on beans.	2.01	1	0	acetate ester; organotin compound	antifungal agrochemical
chitosan [no description available]	3.22	3	0
trifloxystrobin trifloxystrobin : The methyl ester of (2E)-(methoxyimino)[2-({[(E)-{1-[3-(trifluoromethyl)phenyl]ethylidene}amino]oxy}methyl)phenyl]acetic acid. A foliar applied fungicide for cereals which is particularly active against Ascomycetes, Deuteromycetes and Oomycetes	8.08	4	0
pyrethrins [no description available]	2.96	4	0
imidacloprid imidacloprid: systemic & contact insecticide exhibiting low mammalian toxicity; structure given in first source; it is one of the neonicotinoid insecticides, which acts as an antagonist by binding to postsynaptic nicotinic receptors in the insect central nervous system. imidacloprid : An imidazolidine that is N-nitroimidazolidin-2-imine bearing a (6-chloro-3-pyridinyl)methyl substituent at position 1.	2.83	3	0	imidacloprid; imidazolidines; monochloropyridine	environmental contaminant; genotoxin; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
clothianidin clothianidin: structure in first source. clothianidin : An N-nitro compound consisting of 2-nitroguanidine having a (2-chloro-1,3-thiazol-5-yl)methyl group at position 1 and a methyl group at position 3.	2.15	1	0	1,3-thiazoles; 2-nitroguanidine derivative; clothianidin; organochlorine compound	environmental contaminant; neonicotinoid insectide; nicotinic acetylcholine receptor agonist; xenobiotic
acetylcellulose acetylcellulose: coating compound. cellulose acetate : A glucan derivative obtained through the esterification of cellulose by acetic anhydride or acetic acid, resulting in the substitution of some of the hydroxy groups of cellulose by acetyl groups. It is used in a variety of applications including base material for photographic film, clothing, membrane filters, coatings, food packaging, and as a frame material for eyeglasses.	2.6	1	0

Condition	Relationship Strength	Studies
Cardiac Toxicity [description not available]	2.41	1
Innate Inflammatory Response [description not available]	2.9	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.9	2
Cardiotoxicity Damage to the HEART or its function secondary to exposure to toxic substances such as drugs used in CHEMOTHERAPY; IMMUNOTHERAPY; or RADIATION.	7.41	1
Abnormality, Heart [description not available]	4.21	9
Heart Defects, Congenital Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.	4.21	9
Hives [description not available]	7.6	1
Urticaria A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.	2.6	1
Disease Resistance The capacity of an organism to defend itself against pathological processes or the agents of those processes. This most often involves innate immunity whereby the organism responds to pathogens in a generic way. The term disease resistance is used most frequently when referring to plants.	2.6	1
Chromoblastomycosis Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. The extremity may become swollen and, at its distal portion, covered with various nodular, tumorous, verrucous lesions that resemble cauliflower. In rare instances, the disease may begin on the hand or wrist and involve the entire upper extremity. (Arnold, Odom, and James, Andrew's Diseases of the Skin, 8th ed, p362)	2.25	1
Acute Liver Injury, Drug-Induced [description not available]	2.61	2
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.61	2
Liver Steatosis [description not available]	2.31	1
Hepatocellular Carcinoma [description not available]	2.31	1
Cancer of Liver [description not available]	2.31	1
Fatty Liver Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.	2.31	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	2.31	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.31	1
Cancer of Prostate [description not available]	2.01	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.01	1

difenoconazole

Description

Cross-References

Synonyms (62)

Research Excerpts

Overview

Actions

Toxicity

Compound-Compound Interactions

Bioavailability

Dosage Studied

Roles (4)

Drug Classes (6)

Protein Targets (28)

Potency Measurements

Biological Processes (141)

Molecular Functions (40)

Ceullar Components (27)

Bioassays (87)

Research

Studies (150)

Market Indicators

Research Demand Index: 47.82

Study Types

difenoconazole

Description

Cross-References

Synonyms (62)

Research Excerpts

Overview

Actions

Toxicity

Compound-Compound Interactions

Bioavailability

Dosage Studied

Roles (4)

Drug Classes (6)

Protein Targets (28)

Potency Measurements

Biological Processes (141)

Molecular Functions (40)

Ceullar Components (27)

Bioassays (87)

Research

Studies (150)

Market Indicators

Research Demand Index: 47.82

Study Types

Related Drugs (92)

Related Conditions (20)