Roles > EC 3.6.5.2 (small monomeric GTPase) inhibitor
Page last updated: 2024-08-05 15:41:34

EC 3.6.5.2 (small monomeric GTPase) inhibitor

null

ChEBI ID: 144981

Members (2)

MemberDefinitionClass
nsc 23766An aminopyrimidine that is 6-methylpyrimidine-2,4-diamine in which the amino groups at positions 2 and 4 are substituted by 5-(diethylamino)pentan-2-yl and 4-amino-2-methylquinolin-6-yl groups respectively. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).NSC 23766
nsc 23766A hydrochloride resulting from the formal reaction of NSC 23766 with 3 mol eq. of hydrogen chloride. An inhibitor of the signalling G-protein known as RAC1 (Ras-related C3 botulinum toxin substrate 1).NSC 23766 trihydrochloride

Research

Studies (209)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's47 (22.49)29.6817
2010's134 (64.11)24.3611
2020's28 (13.40)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews3 (1.42%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other209 (98.58%)84.16%

Protein Targets (8)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
cytochrome P450 2D6Homo sapiens (human)Potency23.918511
EWS/FLI fusion proteinHomo sapiens (human)Potency27.052222
Histamine H2 receptorCavia porcellus (domestic guinea pig)Potency12.589312
Microtubule-associated protein tauHomo sapiens (human)Potency29.396922
Polyunsaturated fatty acid lipoxygenase ALOX15BHomo sapiens (human)Potency12.589311

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Ras-related C3 botulinum toxin substrate 1Homo sapiens (human)IC5095.000011
Ras-related C3 botulinum toxin substrate 1Mus musculus (house mouse)IC506.300022

Other Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
RAC-alpha serine/threonine-protein kinaseHomo sapiens (human)Activity50.000011