Page last updated: 2024-12-08
garcinia biflavonoid 2
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
Garcinia biflavonoid 2: biflavone of Garcinia kola seeds [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Related Flora
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Garcinia | genus | A plant genus of the family CLUSIACEAE. Members contain XANTHONES.[MeSH] | Clusiaceae | The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH] |
| Garcinia kola | species | A plant species of the family CLUSIACEAE. The common name of 'Bitter Kola' is sometimes also used to refer to COLA.[MeSH] | Clusiaceae | The mangosteen plant family (sometimes classified as Guttiferae; also known as Hypericaceae) of the order THEALES, subclass Dilleniidae, class Magnoliopsida. It includes trees and shrubs with resinous, sticky sap, usually with broad-ended, oblong, leathery leaves with a strong, central vein, flowers with many stamens.[MeSH] |
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 161259 |
| CHEMBL ID | 508885 |
| MeSH ID | M0155089 |
Synonyms (15)
| Synonym |
|---|
| CHEMBL508885 |
| (2r,3r)-8-[(2s,3r)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-3-yl]-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydrochromen-4-one |
| wii418ygax , |
| garcinia biflavonoid 2 |
| (3,8'-bi-4h-1-benzopyran)-4,4'-dione, 2'-(3,4-dihydroxyphenyl)-2,2',3,3'-tetrahydro-3',5,5',7,7'-pentahydroxy-2-(4-hydroxyphenyl)-, (2s-(2alpha,3beta(2's*,3's*)))- |
| unii-wii418ygax |
| 18913-18-3 |
| gb2 garcinia |
| DTXSID70172309 |
| gb 2 (garcinia) |
| (3,8'-bi-4h-1-benzopyran)-4,4'-dione, 2'-(3,4-dihydroxyphenyl)-2,2',3,3'-tetrahydro-3',5,5',7,7'-pentahydroxy-2-(4-hydroxyphenyl)-, (2s,2'r,3r,3'r)- |
| 5,7,4',3'',5'',7'',3''',4'''-octahydroxy(3-8'')biflavanone |
| (3,8'-bi-4h-1-benzopyran)-4,4'-dione, 2'-(3,4-dihydroxyphenyl)-2,2',3,3'-tetrahydro-3',5,5',7,7'-pentahydroxy-2-(4-hydroxyphenyl)-, (2s-(2.alpha.,3.beta.(2's*,3's*)))- |
| 3,8''-biflavanone, 3'',3''',4',4''',5,5'',7,7''-octahydroxy- |
| Q27292661 |
Research Excerpts
Toxicity
| Excerpt | Reference | Relevance |
|---|---|---|
| " The ability of butylated hydroxyanisole (BHA) to attenuate the toxic effect of 2-AAF was also examined." | ( Chemoprevention of 2-acetylaminofluorene-induced hepatotoxicity and lipid peroxidation in rats by kolaviron--a Garcinia kola seed extract. Agboola, AO; Emerole, GO; Farombi, EO; Nwankwo, JO; Tahnteng, JG, 2000) | 0.31 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (12)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID376708 | Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 0.32 nmol after 48 hrs relative to TPA | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID376705 | Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 32 nmol after 48 hrs relative to TPA | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID376712 | Cytotoxicity against human Raji cells assessed as cell viability at 0.32 nmol by trypan blue staining | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID376710 | Cytotoxicity against human Raji cells assessed as cell viability at 16 nmol by trypan blue staining | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID1696174 | Bactericidal activity against Streptococcus sobrinus 6715 assessed as reduction in bacterial growth incubated for 48 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID376706 | Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 16 nmol after 48 hrs relative to TPA | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID1696172 | Bactericidal activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in bacterial growth incubated for 48 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID376707 | Antitumor-promoting activity assessed as TPA-induced EBV-early antigen activation in human Raji cells at 3.2 nmol after 48 hrs relative to TPA | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID376711 | Cytotoxicity against human Raji cells assessed as cell viability at 3.2 nmol by trypan blue staining | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID1696171 | Antibacterial activity against Porphyromonas gingivalis ATCC 33277 assessed as reduction in bacterial growth incubated for 24 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| AID376709 | Cytotoxicity against human Raji cells assessed as cell viability at 32 nmol by trypan blue staining | 1999 | Journal of natural products, Dec, Volume: 62, Issue:12 | A new biflavonoid from Calophyllum panciflorum with antitumor-promoting activity. |
| AID1696173 | Antibacterial activity against Streptococcus sobrinus 6715 assessed as reduction in bacterial growth incubated for 24 hrs by INT dye based broth dilution method | 2020 | Journal of natural products, 07-24, Volume: 83, Issue:7 | Garcinoic Acids and a Benzophenone Derivative from the Seeds of |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.72
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.72) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||