Page last updated: 2024-09-27

Alcohol-Induced Peripheral Neuropathy

A condition where damage to the peripheral nervous system (including the peripheral elements of the autonomic nervous system) is associated with chronic ingestion of alcoholic beverages. The disorder may be caused by a direct effect of alcohol, an associated nutritional deficiency, or a combination of factors. Clinical manifestations include variable degrees of weakness; ATROPHY; PARESTHESIAS; pain; loss of reflexes; sensory loss; diaphoresis; and postural hypotension. (From Arch Neurol 1995;52(1):45-51; Adams et al., Principles of Neurology, 6th ed, p1146)

Synonyms(10)

Synonym
Alcohol-Induced Polyneuropathy
Alcoholic Neuropathy
Alcohol-Related Autonomic Polyneuropathy
Polyneuropathy, Alcoholic
Neuropathy, Alcoholic
Alcohol-Related Polyneuropathy
Alcoholic Axonal Neuropathy
Alcohol-Induced Peripheral Neuropathy
Polyneuritis, Alcoholic
Peripheral Neuropathy, Alcohol-Induced

Research Excerpts

Overview

ExcerptReference
"However, features of alcoholic neuropathy is influenced by concomitant thiamine-deficiency state, having so far caused the obscure clinicopathological entity of alcoholic neuropathy."( Hattori, N; Hirayama, M; Iijima, M; Ito, H; Koike, H; Mori, K; Sobue, G; Sugiura, M, 2003)
"Alcoholic neuropathy is characterized by spontaneous burning pain, hyperalgesia (an exaggerated pain in response to painful stimuli) and allodynia (a pain evoked by normally innocuous stimuli)."( Chopra, K; Kuhad, A; Tiwari, V, 2009)
"The mechanism behind alcoholic neuropathy is not well understood, but several explanations have been proposed."( Chopra, K; Tiwari, V, 2012)
"Alcoholic neuropathy is a chronic disorder caused by the excessive consumption of alcohol."( Behl, T; Sharma, PL; Yadav, HN, 2021)

Context

ExcerptReference
"Characteristics of alcoholic neuropathy have been obscured by difficulty in isolating them from features of thiamine-deficiency neuropathy."( Hattori, N; Hirayama, M; Iijima, M; Ito, H; Koike, H; Mori, K; Sobue, G; Sugiura, M, 2003)

Treatment

ExcerptReference
"Benfogamma efficacy in alcoholic polyneuropathy therapy with pain syndrome and other sensor disorders has been studied."( Anisimova, EI; Danilov, AB, 2001)

Research

Studies (60)

TimeframeStudies, This Condition (%)All Conditions %
pre-19908 (13.33)23.3326
1990's0 (0.00)12.5806
2000's30 (50.00)18.1394
2010's20 (33.33)28.8240
2020's2 (3.33)9.53
DrugIndicatedRelationship StrengthStudiesTrials
gamma-aminobutyric acid0medium11
ethylene glycol0low10
thioctic acid0medium11
niacin0low10
nitrites0low10
thiamine0medium81
benphothiamine0medium31
desipramine0low10
disulfiram0low10
ethylenediamine0medium11
gabapentin0medium11
isoniazid0low20
clorgyline0low10
pargyline0low10
carbachol0low10
lysine0low10
catechin0low10
thiamine pyrophosphate0low10
malondialdehyde0low10
d-alpha tocopherol0low50
tocopherols0low10
zalcitabine0low30
transferrin0low10
glutamic acid0low10
tramadol0low10
paclitaxel0low10
fomesafen0low20
mifepristone0low10
epigallocatechin gallate0low10
triazoles0low10
fluorodeoxyglucose f180low10
homocysteine0low10
vitamin b 60low10
ropivacaine0low10
cp 101,6060low10
cortisone0low10
strychnine0low20
riboflavin0low10
curcumin0low10
capsaicin0low10
quercetin0low20
coenzyme q100low10
lysophosphatidylcholines0low10
arsenic0low10
mocetinostat0low10
tocotrienols0low20
ubiquinone0low10
bucladesine0low10
piperidines0low10
vitamin b 120low40
folic acid0low40

Protein Targets (962)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE120012
glp-1 receptor, partial6006
ATAD5 protein, partial7007
vasopressin V1b receptor1001
cAMP-dependent protein kinase type I-alpha regulatory subunit0011
cAMP-dependent protein kinase type II-beta regulatory subunit0011
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
cAMP-dependent protein kinase catalytic subunit beta isoform 10011
urokinase plasminogen activator surface receptor precursor4004
geminin130013
relaxin receptor 1 isoform 11001
relaxin receptor 2 isoform 11001
neuropeptide S receptor isoform A7007
cAMP-dependent protein kinase catalytic subunit beta isoform 30011
Chain A, HADH2 protein100010
Chain B, HADH2 protein100010
15-lipoxygenase, partial5005
phosphopantetheinyl transferase8008
RAR-related orphan receptor gamma100010
GLS protein100010
TDP1 protein130013
GLI family zinc finger 3100010
Microtubule-associated protein tau8008
AR protein160016
aldehyde dehydrogenase 1 family, member A1120012
estrogen receptor 2 (ER beta)7007
nuclear receptor subfamily 1, group I, member 39009
progesterone receptor8008
retinoic acid nuclear receptor alpha variant 1120012
estrogen-related nuclear receptor alpha120012
pregnane X nuclear receptor120012
estrogen nuclear receptor alpha190019
67.9K protein4004
glucocerebrosidase4004
peroxisome proliferator-activated receptor delta100010
peroxisome proliferator activated receptor gamma120012
vitamin D (1,25- dihydroxyvitamin D3) receptor110011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a5005
chromobox protein homolog 17007
thyroid hormone receptor beta isoform 28008
mitogen-activated protein kinase 17007
nuclear factor erythroid 2-related factor 2 isoform 1110011
DNA polymerase iota isoform a (long)6006
nuclear receptor ROR-gamma isoform 17007
peripheral myelin protein 228008
survival motor neuron protein isoform d6006
cytochrome P450 3A4 isoform 1100010
transient receptor potential cation channel subfamily V member 11001
lamin isoform A-delta10140014
Gamma-aminobutyric acid receptor subunit pi102012
Transient receptor potential cation channel subfamily V member 10213
Lysine-specific histone demethylase 1A0303
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump014014
NADH-ubiquinone oxidoreductase chain 10101
Cytochrome P450 1A20404
Polyunsaturated fatty acid 5-lipoxygenase0303
Gamma-aminobutyric acid receptor subunit beta-1102012
Gamma-aminobutyric acid receptor subunit delta102012
Gamma-aminobutyric acid receptor subunit gamma-2102113
Glutamate receptor 25218
Gamma-aminobutyric acid receptor subunit alpha-5102012
Gamma-aminobutyric acid receptor subunit alpha-3102012
Cannabinoid receptor 10202
Acetylcholinesterase0505
Prostaglandin G/H synthase 10303
Gamma-aminobutyric acid receptor subunit gamma-1102012
Gamma-aminobutyric acid receptor subunit alpha-2102012
Gamma-aminobutyric acid receptor subunit alpha-4102012
Gamma-aminobutyric acid receptor subunit gamma-3102012
Gamma-aminobutyric acid receptor subunit alpha-6102012
Cannabinoid receptor 2 0202
Nuclear receptor ROR-gamma3003
Spike glycoprotein5117
D(2) dopamine receptor0011
Gamma-aminobutyric acid receptor subunit alpha-1102113
Gamma-aminobutyric acid receptor subunit beta-3102012
Gamma-aminobutyric acid receptor subunit beta-2102113
Inositol monophosphatase 14004
Potassium voltage-gated channel subfamily A member 10112
Corticotropin-releasing factor receptor 20101
Transient receptor potential cation channel subfamily V member 10214
GABA theta subunit102012
Transient receptor potential cation channel subfamily V member 40011
Gamma-aminobutyric acid receptor subunit epsilon102012
Transient receptor potential cation channel subfamily V member 20011
ATP-dependent phosphofructokinase9009
Chain A, Beta-lactamase5005
acetylcholinesterase6006
GALC protein2002
IDH14004
thyroid stimulating hormone receptor6006
thyrotropin-releasing hormone receptor5005
v-jun sarcoma virus 17 oncogene homolog (avian)9009
Bloom syndrome protein isoform 17007
Neuronal acetylcholine receptor subunit alpha-30101
Muscarinic acetylcholine receptor M20225
Muscarinic acetylcholine receptor M40225
Muscarinic acetylcholine receptor M10215
Muscarinic acetylcholine receptor M30214
Muscarinic acetylcholine receptor M40203
Muscarinic acetylcholine receptor M50203
Muscarinic acetylcholine receptor M50225
Neuronal acetylcholine receptor subunit alpha-41102
Muscarinic acetylcholine receptor M20203
Muscarinic acetylcholine receptor M10225
Neuronal acetylcholine receptor subunit alpha-20101
Neuronal acetylcholine receptor subunit beta-21102
Neuronal acetylcholine receptor subunit beta-30101
Neuronal acetylcholine receptor subunit beta-40101
Muscarinic acetylcholine receptor M10112
Muscarinic acetylcholine receptor M30225
Neuronal acetylcholine receptor subunit alpha-50101
Delta-type opioid receptor0102
Neuronal acetylcholine receptor subunit alpha-60101
Neuronal acetylcholine receptor subunit alpha-90101
Neuronal acetylcholine receptor subunit alpha-70101
Sigma non-opioid intracellular receptor 10112
Muscarinic acetylcholine receptor0202
Muscarinic acetylcholine receptor M30013
Muscarinic acetylcholine receptor M20003
Neuronal acetylcholine receptor subunit alpha-100101
Chain A, 2-oxoglutarate Oxygenase6006
Chain A, ATP-DEPENDENT DNA HELICASE Q15005
thioredoxin reductase100010
arylsulfatase A6006
euchromatic histone-lysine N-methyltransferase 2150015
peripheral myelin protein 22 isoform 14004
DNA polymerase beta6006
flap endonuclease 15005
DNA polymerase eta isoform 12002
DNA polymerase kappa isoform 14004
Prostaglandin G/H synthase 1 0101
Arginase 0303
Pancreatic triacylglycerol lipase0202
Prothrombin0235
Carbonic anhydrase 10405
Carbonic anhydrase 20405
Prostaglandin G/H synthase 10314
Aldo-keto reductase family 1 member B10404
Carbonic anhydrase 40303
Carbonic anhydrase 60303
Sucrase-isomaltase, intestinal0101
Adenosine receptor A11214
Adenosine receptor A2a0213
Prostaglandin G/H synthase 20303
Mu-type opioid receptor0517
Delta-type opioid receptor0304
Kappa-type opioid receptor0506
Xanthine dehydrogenase/oxidase0404
Melatonin receptor type 1A0011
Melatonin receptor type 1B0011
Death-associated protein kinase 10202
Beta-secretase 10505
Prostaglandin G/H synthase 20101
Carbonic anhydrase 30202
Dihydroorotate dehydrogenase 0101
USP1 protein, partial8008
Thrombopoietin3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor100010
regulator of G-protein signaling 48008
Parkin3003
cytochrome P450 2D6 isoform 14004
NPC intracellular cholesterol transporter 1 precursor2002
cytochrome P450 2C19 precursor3003
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 16006
ras-related protein Rab-9A1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
muscarinic acetylcholine receptor M16006
lethal factor (plasmid)4004
Acetylcholinesterase0303
Sigma non-opioid intracellular receptor 10101
Cytochrome P450 2B10101
Cholinesterase0303
Amine oxidase [flavin-containing] B0303
Amine oxidase [flavin-containing] A 0303
Amine oxidase [flavin-containing] A0707
Amine oxidase [flavin-containing] A 0303
Amine oxidase [flavin-containing] B0617
Amine oxidase [flavin-containing] B0303
Cholinesterase0202
Sigma intracellular receptor 20101
endonuclease IV1001
dopamine D1 receptor2002
pregnane X receptor4004
glucocorticoid receptor [Homo sapiens]100010
retinoid X nuclear receptor alpha100010
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a8008
atrial natriuretic peptide receptor 1 precursor2002
heat shock protein beta-17007
M-phase phosphoprotein 84004
Glucocorticoid receptor1429
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10505
Corticosteroid-binding globulin0101
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
TAR DNA-binding protein 435005
Multidrug and toxin extrusion protein 10202
cytochrome P450 2D66006
Glutamate receptor ionotropic, NMDA 2D0303
Glutamate receptor ionotropic, NMDA 3B0303
Cytochrome P450 3A40606
Cytochrome P450 2D60303
Alpha-1B adrenergic receptor0606
Prolyl endopeptidase0101
Alpha-1D adrenergic receptor0202
Glutamate receptor ionotropic, NMDA 1 0314
Alpha-1A adrenergic receptor0505
Glutamate receptor ionotropic, NMDA 2A 0314
Glutamate receptor ionotropic, NMDA 2B0314
Glutamate receptor ionotropic, NMDA 2C0314
Glutamate receptor ionotropic, NMDA 10303
Potassium voltage-gated channel subfamily H member 20405
Glutamate receptor ionotropic, NMDA 2A0303
Glutamate receptor ionotropic, NMDA 2B0303
Glutamate receptor ionotropic, NMDA 2C0303
Glutamate receptor ionotropic, NMDA 3A0303
Chain A, TYROSYL-DNA PHOSPHODIESTERASE7007
Chain A, Breast cancer type 1 susceptibility protein2002
Chain A, Putative fructose-1,6-bisphosphate aldolase5005
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Chain A, Ferritin light chain5005
Chain A, Cruzipain4004
Luciferase7007
interleukin 81001
Nrf22002
hypoxia-inducible factor 1 alpha subunit5005
SMAD family member 26006
SMAD family member 36006
alkaline phosphatase, intestinal0101
thioredoxin glutathione reductase3003
Smad33003
apical membrane antigen 1, AMA13003
caspase 7, apoptosis-related cysteine protease2002
PINK11001
EWS/FLI fusion protein7008
farnesoid X nuclear receptor4004
bromodomain adjacent to zinc finger domain 2B7007
toll-like receptor 90101
caspase-32002
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
TPA: protein transporter TIM100101
aryl hydrocarbon receptor6006
activating transcription factor 68008
Histone H2A.x6006
lysosomal alpha-glucosidase preproprotein4004
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein0101
hemoglobin subunit beta1001
cellular tumor antigen p53 isoform a3003
polyunsaturated fatty acid lipoxygenase ALOX123003
perilipin-50202
vitamin D3 receptor isoform VDRA3003
intestinal alkaline phosphatase precursor0101
thyroid hormone receptor beta isoform a7007
perilipin-10202
potassium voltage-gated channel subfamily H member 2 isoform d7007
transcriptional regulator ERG isoform 32002
huntingtin isoform 24004
importin subunit beta-1 isoform 12002
pyruvate kinase PKM isoform a2002
nuclear factor NF-kappa-B p105 subunit isoform 13003
snurportin-12002
histone-lysine N-methyltransferase 2A isoform 2 precursor4004
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 12002
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0202
muscleblind-like protein 1 isoform 13003
DNA dC->dU-editing enzyme APOBEC-3G isoform 11102
alkaline phosphatase, germ cell type preproprotein0101
caspase-1 isoform alpha precursor2002
hypothetical protein SA14220101
DNA dC->dU-editing enzyme APOBEC-3F isoform a1001
Prostaglandin E synthase0202
Polyunsaturated fatty acid lipoxygenase ALOX15B4105
Histone deacetylase 30404
D-amino-acid oxidase0101
Phospholipase A20202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 10404
Cellular tumor antigen p53100010
Amyloid-beta precursor protein1406
Integrin beta-33115
Neuronal proto-oncogene tyrosine-protein kinase Src 0101
Heme oxygenase 1 0202
Integrin alpha-IIb3014
Glutathione S-transferase P0202
60 kDa chaperonin0404
Replicase polyprotein 1ab0527
Replicase polyprotein 1ab0628
Microtubule-associated protein tau0203
60 kDa heat shock protein, mitochondrial0404
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0101
Tissue factor0202
Tyrosinase0202
Aminopeptidase N0101
Aminopeptidase N0101
Sarcoplasmic/endoplasmic reticulum calcium ATPase 20202
Glycogen synthase kinase-3 beta0202
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Heme oxygenase 20202
Voltage-dependent L-type calcium channel subunit alpha-1D0101
Proteasome subunit beta type-50303
17-beta-hydroxysteroid dehydrogenase type 20202
Alpha-synuclein3216
Histamine H2 receptor4106
Glycogen synthase kinase-3 beta0202
Caspase-72002
Histone deacetylase 40303
10 kDa heat shock protein, mitochondrial0404
Guanine nucleotide-binding protein G2002
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Lactoylglutathione lyase0303
Histone acetyltransferase p3000202
Serine/threonine-protein kinase PAK 10101
Histone deacetylase 10505
5-hydroxytryptamine receptor 40011
Sodium/bile acid cotransporter0011
Nuclear factor erythroid 2-related factor 20011
Thiosulfate sulfurtransferase0404
Thioredoxin reductase 1, cytoplasmic0101
60 kDa chaperonin 0404
10 kDa chaperonin 0404
Thioredoxin reductase 30101
Sortase A0101
Histone deacetylase 70303
Histone deacetylase 20505
CREB-binding protein0202
Sarcoplasmic/endoplasmic reticulum calcium ATPase 30202
Cysteine protease 0101
Polyamine deacetylase HDAC100202
Histone deacetylase 11 0303
NACHT, LRR and PYD domains-containing protein 3 0101
ATPase family AAA domain-containing protein 53003
Ataxin-24004
Histone deacetylase 80404
Thioredoxin reductase 2, mitochondrial0101
CDGSH iron-sulfur domain-containing protein 10202
Histone deacetylase 60303
Histone deacetylase 90202
Broad substrate specificity ATP-binding cassette transporter ABCG20224
Histone deacetylase 50303
Lymphocyte antigen 960011
Beta lactamase (plasmid)0101
cytochrome P450 family 3 subfamily A polypeptide 49009
Rap guanine nucleotide exchange factor 31001
Alpha-tocopherol transfer protein0011
NFKB1 protein, partial4004
D(1A) dopamine receptor5005
atrial natriuretic peptide receptor 2 precursor3003
serine/threonine-protein kinase mTOR isoform 13003
Solute carrier family 22 member 20101
Solute carrier family 22 member 1 0405
ATP-binding cassette sub-family C member 30707
Multidrug resistance-associated protein 40708
Solute carrier family 22 member 30101
Solute carrier family 22 member 30101
Albumin0022
5-hydroxytryptamine receptor 2C0101
Alpha-2A adrenergic receptor0303
Tryptophan 5-hydroxylase 10101
Cytochrome P450 2C9 0415
Angiotensin-converting enzyme0202
5-hydroxytryptamine receptor 2A0101
Alpha-2B adrenergic receptor0505
Alpha-2C adrenergic receptor0101
5-hydroxytryptamine receptor 1A0303
Sodium-dependent noradrenaline transporter 0426
Sodium-dependent dopamine transporter0303
5-hydroxytryptamine receptor 2A0101
5-hydroxytryptamine receptor 1B0101
5-hydroxytryptamine receptor 1D0101
5-hydroxytryptamine receptor 1F0101
5-hydroxytryptamine receptor 2B0101
5-hydroxytryptamine receptor 60101
Histamine H1 receptor0101
Sodium-dependent serotonin transporter0202
Sodium-dependent serotonin transporter0303
5-hydroxytryptamine receptor 7 0101
5-hydroxytryptamine receptor 5A0101
5-hydroxytryptamine receptor 5B0101
5-hydroxytryptamine receptor 3A0101
D(1A) dopamine receptor2002
5-hydroxytryptamine receptor 70101
Cytochrome P450 2J20101
Voltage-dependent N-type calcium channel subunit alpha-1B0101
Sodium-dependent dopamine transporter 0404
Sodium channel protein type 5 subunit alpha0101
5-hydroxytryptamine receptor 4 0101
Solute carrier family 22 member 10303
Nuclear receptor subfamily 3 group C member 3 0202
Canalicular multispecific organic anion transporter 10707
5-hydroxytryptamine receptor 3B0101
Histamine H3 receptor0101
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Transporter0202
Histamine H3 receptor0101
Fumarate hydratase2002
PPM1D protein2002
hypothetical protein, conserved2002
nonstructural protein 12002
G3003
polyprotein2002
pyruvate kinase1001
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase0101
LacZ protein (plasmid)0011
Caspase-71001
Spike glycoprotein0112
Replicase polyprotein 1ab0213
beta-2 adrenergic receptor2002
type-1 angiotensin II receptor0101
cytochrome P450 2C9 precursor2002
runt-related transcription factor 1 isoform AML1b1001
glucose-6-phosphate 1-dehydrogenase isoform b0101
caspase-31001
histone deacetylase 9 isoform 32002
core-binding factor subunit beta isoform 21001
polypyrimidine tract-binding protein 1 isoform a1001
serine/threonine-protein kinase PLK11001
apelin receptor0101
heat shock protein HSP 90-alpha isoform 20001
Vpr1001
histone acetyltransferase KAT2A isoform 15005
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase0202
pyruvate kinase PKM isoform b1001
Fatty-acid amide hydrolase 10101
Transmembrane protease serine 20112
Transient receptor potential cation channel subfamily A member 10011
Carbamate kinase0101
Retinal dehydrogenase 10101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 3003
Aldehyde dehydrogenase, mitochondrial0101
Procathepsin L0112
Ornithine decarboxylase1001
Fructose-1,6-bisphosphatase 10101
Replicase polyprotein 1a0112
Replicase polyprotein 1ab0112
Adenosine receptor A30303
Polyunsaturated fatty acid lipoxygenase ALOX150303
D(2) dopamine receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0303
C-X-C chemokine receptor type 20202
Mitogen-activated protein kinase 3 0101
Protein-lysine 6-oxidase0101
Lysine-specific demethylase 5A0101
Caspase-10101
D(3) dopamine receptor0202
5-hydroxytryptamine receptor 2B0202
C-C chemokine receptor type 20202
5-hydroxytryptamine receptor 60202
C-C chemokine receptor type 40303
C-C chemokine receptor type 50202
Gasdermin-D0101
Lysyl oxidase homolog 30101
NACHT, LRR and PYD domains-containing protein 3 0101
Inositol hexakisphosphate kinase 13003
Lysyl oxidase homolog 40101
Histone-lysine N-methyltransferase EHMT20101
Monoglyceride lipase0101
Angiotensin-converting enzyme 2 0112
Gasdermin-D0101
Histone-lysine N-methyltransferase EHMT10101
Lysyl oxidase homolog 20101
cytochrome P450 2C9, partial3003
heat shock protein 90, putative0001
hypothetical protein CAALFM_CR05890CA0001
H3 histone acetyltransferase0001
large T antigen0101
Chain A, Troponin C, slow skeletal and cardiac muscles0011
Chain A, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10011
Chain A, POLYMERASE PA0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Chain A, Polymerase Pa0101
Genome polyprotein 0101
galactokinase2002
POsterior Segregation0011
Telomerase reverse transcriptase0101
Polycomb protein EED0011
NAD kinase0213
Dihydrofolate reductase0001
Urokinase-type plasminogen activator0202
Tissue-type plasminogen activator0101
Transthyretin0011
Polymerase acidic protein0101
Plasminogen activator inhibitor 10101
Urokinase-type plasminogen activator0101
ATP-dependent translocase ABCB10316
Heat shock protein HSP 90-beta0101
Neutrophil elastase0303
72 kDa type IV collagenase0202
Hepatocyte growth factor receptor0303
Matrilysin0101
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI0202
Alpha-amylase 1A 0202
Apoptosis regulator Bcl-20303
Glucose-6-phosphate 1-dehydrogenase0101
Fatty acid synthase0101
CPG DNA methylase0101
Lethal factor0101
Phosphoglycerate mutase 10101
DNA (cytosine-5)-methyltransferase 10101
Dipeptidyl peptidase 40202
Signal transducer and activator of transcription 1-alpha/beta0011
DNA repair protein RAD52 homolog0101
Fatty acid synthase0101
Matrix metalloproteinase-140101
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT60101
Squalene monooxygenase 0101
6-phosphogluconate dehydrogenase, decarboxylating0101
BH3-interacting domain death agonist0101
Disintegrin and metalloproteinase domain-containing protein 172103
Lactoperoxidase0102
Bcl-2-like protein 10202
Induced myeloid leukemia cell differentiation protein Mcl-10101
Alpha-(1,3)-fucosyltransferase 70101
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 10101
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Mitogen-activated protein kinase 140303
Bcl-2-related protein A10101
Dual specificity tyrosine-phosphorylation-regulated kinase 1A0101
Reverse transcriptase/RNaseH 0214
3-oxoacyl-[acyl-carrier-protein] reductase 0101
MAP kinase-activated protein kinase 50101
Histone acetyltransferase KAT2B0101
Bcl-2-like protein 20101
Bcl2-associated agonist of cell death 0101
Histone acetyltransferase KAT50101
Enoyl-acyl-carrier protein reductase 0404
3-oxoacyl-acyl-carrier protein reductase 0202
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)0202
Bcl-2-like protein 100101
Zinc finger protein mex-50011
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha0101
Protein farnesyltransferase subunit beta0101
Glutaminyl-peptide cyclotransferase0101
Chain A, Dihydrofolate reductase0011
acid sphingomyelinase1001
alpha-galactosidase1001
nuclear factor erythroid 2-related factor 2 isoform 23003
Thymidylate synthase0202
Thymidylate synthase0101
Dihydrofolate reductase0011
Aldo-keto reductase family 1 member B10303
Folylpolyglutamate synthase, mitochondrial0001
Solute carrier organic anion transporter family member 1A30101
Folylpolyglutamate synthase, mitochondrial0001
Multidrug resistance associated protein0001
ubiquitin carboxyl-terminal hydrolase 2 isoform a3003
Voltage-dependent calcium channel subunit alpha-2/delta-10101
Gamma-aminobutyric acid 0011
Gamma-aminobutyric acid receptor subunit rho-30012
Hsf1 protein0011
Gamma-aminobutyric acid receptor subunit pi0101
Gamma-aminobutyric acid receptor subunit delta0101
Gamma-aminobutyric acid type B receptor subunit 20011
Gamma-aminobutyric acid type B receptor subunit 20101
Gamma-aminobutyric acid receptor subunit alpha-10112
Gamma-aminobutyric acid receptor subunit alpha-60011
Gamma-aminobutyric acid receptor subunit beta-10112
Gamma-aminobutyric acid receptor subunit gamma-20112
Gamma-aminobutyric acid receptor subunit gamma-20011
Gamma-aminobutyric acid receptor subunit delta0011
Sodium- and chloride-dependent GABA transporter 10202
Gamma-aminobutyric acid receptor subunit rho-10023
Gamma-aminobutyric acid receptor subunit alpha-20011
Gamma-aminobutyric acid receptor subunit alpha-30011
Gamma-aminobutyric acid receptor subunit gamma-30011
Gamma-aminobutyric acid receptor subunit beta-30112
Gamma-aminobutyric acid receptor subunit rho-20012
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent taurine transporter0101
Gamma-aminobutyric acid receptor subunit alpha-50112
Sodium- and chloride-dependent GABA transporter 20202
Sodium- and chloride-dependent GABA transporter 30202
Sodium- and chloride-dependent GABA transporter 10101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-30112
Gamma-aminobutyric acid receptor subunit alpha-20112
Gamma-aminobutyric acid receptor subunit beta-20112
Sodium- and chloride-dependent betaine transporter0202
Sodium- and chloride-dependent betaine transporter0101
Sodium- and chloride-dependent GABA transporter 30101
Gamma-aminobutyric acid receptor subunit alpha-40112
Gamma-aminobutyric acid receptor subunit beta-10011
Gamma-aminobutyric acid receptor subunit alpha-10011
Gamma-aminobutyric acid receptor subunit beta-30011
Gamma-aminobutyric acid receptor subunit epsilon0101
4-aminobutyrate aminotransferase, mitochondrial0001
4-aminobutyrate aminotransferase, mitochondrial0001
Gamma-aminobutyric acid receptor subunit alpha-60112
Sterol O-acyltransferase 10011
Proton-coupled amino acid transporter 10101
Gamma-aminobutyric acid receptor subunit alpha-50011
Gamma-aminobutyric acid receptor subunit gamma-10101
Gamma-aminobutyric acid receptor subunit pi0011
Gamma-aminobutyric acid receptor subunit gamma-30101
Gamma-aminobutyric acid receptor subunit alpha-40011
Platelet glycoprotein VI0011
Gamma-aminobutyric acid receptor subunit theta0011
Sodium- and chloride-dependent GABA transporter 20101
Gamma-aminobutyric acid receptor subunit gamma-10011
Gamma-aminobutyric acid type B receptor subunit 10011
Gamma-aminobutyric acid receptor subunit theta0101
Gamma-aminobutyric acid type B receptor subunit 10101
Chain A, GLUTAMATE RECEPTOR SUBUNIT 20101
Chain A, Glutamate Receptor Subunit 20101
Chain B, Glutamate Receptor Subunit 20101
Chain A, Slr1257 protein0011
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]0101
Metabotropic glutamate receptor 80202
Metabotropic glutamate receptor 60113
Excitatory amino acid transporter 40101
Glutathione reductase, mitochondrial0505
Bifunctional aspartokinase/homoserine dehydrogenase 10101
ATP-citrate synthase 0101
Glutamate receptor 11214
Glutamate receptor 31214
Glutamate receptor 41214
Glutamate receptor ionotropic, kainate 10213
Metabotropic glutamate receptor 10112
Metabotropic glutamate receptor 20011
Metabotropic glutamate receptor 30011
Metabotropic glutamate receptor 40112
Metabotropic glutamate receptor 50011
Metabotropic glutamate receptor 60011
Metabotropic glutamate receptor 70011
Glutamate receptor ionotropic, kainate 10112
Metabotropic glutamate receptor 50113
Glutamate receptor ionotropic, kainate 20213
Glutamate receptor 10213
Glutamate receptor 20213
Glutamate receptor 30112
Glutamate receptor ionotropic, kainate 30202
Excitatory amino acid transporter 10203
Excitatory amino acid transporter 20203
Excitatory amino acid transporter 30203
Metabotropic glutamate receptor 80011
Glutamate receptor 40213
Excitatory amino acid transporter 3 0001
Glutamate racemase0001
Metabotropic glutamate receptor 80112
Fatty-acid amide hydrolase 10101
Glutamate receptor ionotropic, kainate 40202
Glutamate carboxypeptidase 20101
Glutamate receptor ionotropic, kainate 20112
Glutamate receptor ionotropic, kainate 30101
Metabotropic glutamate receptor 10113
Metabotropic glutamate receptor 20113
Metabotropic glutamate receptor 70113
Metabotropic glutamate receptor 30113
Metabotropic glutamate receptor 40113
Glutamate receptor ionotropic, kainate 50101
Carbonic anhydrase-like protein, putative0001
Glutamate receptor ionotropic, NMDA 2D0213
Glutamate receptor ionotropic, kainate 50202
Glutamate racemase0001
Prolyl 4-hydroxylase0101
Glutamate receptor ionotropic, NMDA 3B0213
Alpha-ketoglutarate-dependent dioxygenase FTO0101
Glutamate receptor ionotropic, NMDA 3A0213
N(G),N(G)-dimethylarginine dimethylaminohydrolase 10101
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
N-glycosylase/DNA lyase0101
Polyphenol oxidase 20304
Bile salt export pump0202
Myeloperoxidase0202
Formamidopyrimidine-DNA glycosylase0101
DNA gyrase subunit A0101
DNA gyrase subunit B0101
Cytochrome P450 2C80303
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Cytochrome P450 2C190202
Endonuclease III-like protein 10101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Enoyl-[acyl-carrier-protein] reductase [NADH]0102
Pantothenate synthetase0101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast0101
Cationic amino acid transporter 30101
Chain A, PROGESTERONE RECEPTOR0101
Glucocorticoid receptor 0101
nuclear receptor subfamily 1, group I, member 22002
Estrogen receptor1214
Tyrosine-protein kinase Fyn0202
Progesterone receptor0215
Tegument protein VP160011
Glucocorticoid receptor0113
Glucocorticoid receptor0101
Mineralocorticoid receptor 1215
Coagulation factor VII0101
Androgen receptor1214
Thyroid hormone receptor alpha0101
Thyroid hormone receptor beta0101
Steroid 17-alpha-hydroxylase/17,20 lyase 0101
Androgen receptor0202
ATP-dependent translocase ABCB10112
Substance-P receptor0202
Progesterone receptor0011
Estrogen receptor beta1214
Sigma non-opioid intracellular receptor 10202
Glucocorticoid receptor0101
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Integrin alpha-40101
Nuclear receptor corepressor 20101
Cholesteryl ester transfer protein0101
D-amino-acid oxidase0101
Hydroxycarboxylic acid receptor 30011
Nicotinamidase0101
Hydroxycarboxylic acid receptor 20011
Hydroxycarboxylic acid receptor 20213
D-aspartate oxidase0101
Hydroxycarboxylic acid receptor 20112
Carbonic anhydrase0101
Carbonic anhydrase 150101
Genome polyprotein 0101
Tyrosine-protein kinase ABL10101
Epidermal growth factor receptor0202
Tubulin alpha-1A chain0012
Tubulin beta chain0011
Tubulin beta-4A chain0113
Receptor tyrosine-protein kinase erbB-20101
Integrin alpha-V 0101
Tubulin beta chain0113
Tubulin alpha-3C chain0113
Botulinum neurotoxin type A 0101
Fibroblast growth factor receptor 10101
Proto-oncogene tyrosine-protein kinase Src0202
UDP-glucuronosyltransferase 2B70101
UDP-glucuronosyltransferase 1-60101
Substance-K receptor0202
UDP-glucuronosyltransferase 1A1 0101
UDP-glucuronosyltransferase 1A40101
Serum paraoxonase/arylesterase 10101
Cholecystokinin receptor type A0202
Melanocortin receptor 50202
UDP-glucuronosyltransferase 2B10 0101
Tubulin alpha-1B chain0113
Tubulin alpha-4A chain0113
Tubulin beta-4B chain0113
Tyrosine-protein kinase Mer0101
Tubulin beta-3 chain0214
Tubulin beta-2A chain0113
Beta-tubulin 0101
Tubulin beta-8 chain0113
Tubulin beta-2B chain0013
Tubulin alpha-3E chain0113
Tubulin alpha-1A chain0113
Similar to alpha-tubulin isoform 1 0013
Similar to alpha-tubulin isoform 1 0002
Tubulin alpha-1C chain0113
Tubulin beta-6 chain0113
Tubulin beta-2B chain0113
Tubulin beta-1 chain0113
Nucleotide-binding oligomerization domain-containing protein 20101
Solute carrier organic anion transporter family member 1B30202
Solute carrier organic anion transporter family member 1B10202
Pyrroline-5-carboxylate reductase 1, mitochondrial0101
Renin0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase0101
Chain A, APH(2')-Id0101
glucose-6-phosphate dehydrogenase0101
signal transducer and activator of transcription 6, interleukin-4 induced1001
DNA polymerase III, partial1001
Neuraminidase 0202
hexokinase0202
interferon gamma precursor0001
tyrosine-protein kinase Yes1001
Maltase-glucoamylase, intestinal0101
Carbonic anhydrase 120101
NUAK family SNF1-like kinase 10101
B2 bradykinin receptor0101
G2/mitotic-specific cyclin-B20101
Prothrombin 0101
Cationic trypsin0101
Chymotrypsinogen A0101
Chymotrypsin-like elastase family member 10101
Beta-lactamase0101
Protein E60101
Neuraminidase0101
Interstitial collagenase0112
Cytochrome P450 1A10213
Beta-lactamase0101
Tyrosine-protein kinase Lck0101
Cyclin-dependent kinase 10101
Glycogen phosphorylase, liver form0101
Epoxide hydrolase 1 0101
Carbonic anhydrase 30101
Trypsin-10101
Trypsin-20101
Tyrosine-protein kinase Yes0101
Proto-oncogene tyrosine-protein kinase receptor Ret0101
Insulin-like growth factor 1 receptor0101
Seed linoleate 13S-lipoxygenase-10103
Stromelysin-10101
5-hydroxytryptamine receptor 1A0011
Heterogeneous nuclear ribonucleoprotein A10011
Calmodulin-10101
Lysosomal alpha-glucosidase0101
Sialidase0101
Malate dehydrogenase0101
Solute carrier family 2, facilitated glucose transporter member 20101
Serine/threonine-protein kinase pim-10112
Aromatase0101
Cyclin-dependent kinase 40101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cystic fibrosis transmembrane conductance regulator0011
Sucrase-isomaltase, intestinal0101
G2/mitotic-specific cyclin-B10101
Matrix metalloproteinase-90101
Urease subunit alpha0202
Serine/threonine-protein kinase B-raf0101
G2/mitotic-specific cyclin-B0101
Cytochrome P450 11B1, mitochondrial0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Aldo-keto reductase family 1 member B10101
Chymotrypsinogen B0101
Tyrosine-protein phosphatase non-receptor type 10101
Polyunsaturated fatty acid lipoxygenase ALOX120101
Solute carrier family 2, facilitated glucose transporter member 4 0101
Casein kinase II subunit alpha'0202
5'-nucleotidase0101
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal0101
G1/S-specific cyclin-D10101
Cyclin-dependent kinase 20101
C-X-C chemokine receptor type 10101
Phosphatidylinositol 3-kinase regulatory subunit alpha0101
Cytosol aminopeptidase0101
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 10101
Nitric oxide synthase, inducible0101
Vasopressin V2 receptor0101
Tyrosine-protein kinase receptor UFO0101
RAC-alpha serine/threonine-protein kinase0101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20101
Trypsin-30101
Carbonic anhydrase 5A, mitochondrial0101
Prostaglandin G/H synthase 2 0101
Vascular endothelial growth factor receptor 20101
Receptor-type tyrosine-protein kinase FLT30101
Macrophage metalloelastase0101
Kappa-type opioid receptor0101
Glutathione reductase0101
Carbonic anhydrase 70101
Tyrosine-protein kinase SYK0112
Collagenase 30101
1-deoxy-D-xylulose 5-phosphate reductoisomerase0101
Prolyl endopeptidase0101
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 0101
Glycogen synthase kinase-3 alpha0101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Serine/threonine-protein kinase Nek20101
Oligo-1,6-glucosidase IMA10101
Serine/threonine-protein kinase PLK10101
Mitogen-activated protein kinase 100101
Monocarboxylate transporter 10101
Anthrax toxin receptor 20101
Casein kinase II subunit beta0202
Casein kinase II subunit alpha0202
Urease subunit beta0202
Aldo-keto reductase family 1 member B10101
Xanthine dehydrogenase/oxidase0203
Cyclin-dependent kinase 60101
Cyclin-dependent-like kinase 5 0101
Heat shock factor protein 10101
Sorbitol dehydrogenase0101
Cyclin homolog0101
cGMP-dependent 3',5'-cyclic phosphodiesterase0101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B0101
Dual specificity mitogen-activated protein kinase kinase 10101
Focal adhesion kinase 10101
Calcium/calmodulin-dependent protein kinase type II subunit beta0101
ELAV-like protein 30101
Cyclin-dependent kinase 5 activator 10101
ELAV-like protein 10101
Serine/threonine-protein kinase N10101
Cytochrome P450 1B10213
Carbonic anhydrase 90101
Probable maltase-glucoamylase 20101
Monocarboxylate transporter 20101
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C0101
Prostaglandin G/H synthase 1 0101
Substance-K receptor0101
Integrase 0101
Casein kinase II subunit alpha 30202
Inositol polyphosphate multikinase0101
G2/mitotic-specific cyclin-B30101
Aldo-keto reductase family 1 member C210202
Aurora kinase B0101
Chymotrypsin-C0101
Carbonic anhydrase 130101
Cyclin-dependent kinase 10101
Phosphodiesterase 0101
G-protein coupled receptor 350112
Serine/threonine-protein kinase Nek60101
NADPH oxidase 40101
Hypoxia-inducible factor 1-alpha inhibitor0101
Dipeptidyl peptidase 30101
Inositol hexakisphosphate kinase 20101
Short transient receptor potential channel 50101
Carbonic anhydrase 140101
ALK tyrosine kinase receptor0101
Carbonic anhydrase 5B, mitochondrial0101
Sialidase-20101
phosphoglycerate kinase1001
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase0011
Chain H, Immunoglobulin Igg1 Heavy chain0011
Chain L, Immunoglobulin Igg1 Lambda Light Chain0011
Chain A, DODECIN0011
Chain A, DODECIN0011
Chain C, DODECIN0011
Chain E, DODECIN0011
NPYLR7B0011
tumor necrosis factor1001
Riboflavin-binding protein0112
Potassium channel subfamily K member 30101
Glycine receptor subunit alpha-10202
Glycine receptor subunit beta0101
Taste receptor type 2 member 460011
Taste receptor type 2 member 100012
Chain A, ykoF0011
Chain B, ykoF0011
Chain A, ThiT0011
Thiamine transporter ThiT0011
Transketolase0011
Thiamine-binding periplasmic protein0011
1-deoxy-D-xylulose-5-phosphate synthase0011
1-deoxy-D-xylulose-5-phosphate synthase0011
Ubiquitin-like modifier activating enzyme 20101
SUMO1 activating enzyme subunit 10101
SUMO-conjugating enzyme UBC90101
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
eukaryotic translation initiation factor 4E isoform 10101
lethal(3)malignant brain tumor-like protein 1 isoform I1001
Vif0101
Tat0101
Deoxycytidine kinase0101
C-X-C chemokine receptor type 40011
Solute carrier family 22 member 70001
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]