RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding

Definition

Target type: molecularfunction

Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]

RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding is a critical process in gene regulation. Introns, non-coding sequences within genes, play a significant role in modulating gene expression. Intronic regions can harbor regulatory elements that influence the efficiency of transcription initiation, elongation, and termination. RNA polymerase II (RNAP II), the primary enzyme responsible for transcribing protein-coding genes, interacts with specific DNA sequences within introns to regulate these processes. These intronic regulatory elements can be either positive or negative in their effect on transcription, acting as enhancers or silencers, respectively. RNAP II binds to these elements through a complex interplay of transcription factors and co-factors. These proteins recognize specific DNA sequences within the intronic regions and recruit RNAP II to the promoter region, thus influencing the rate of transcription initiation. Furthermore, RNAP II can also interact with intronic regulatory elements during elongation, potentially influencing the efficiency of transcription through the gene. In addition to its role in transcription initiation and elongation, RNAP II can also interact with intronic regulatory elements that influence pre-mRNA processing, including splicing and polyadenylation. Therefore, RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding is a multifaceted process that plays a pivotal role in the regulation of gene expression. It is essential for proper gene expression and is involved in a variety of cellular processes.'
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Proteins (2)

Compounds (13)