Alcohol Withdrawal Seizures

A condition where seizures occur in association with ethanol abuse (ALCOHOLISM) without other identifiable causes. Seizures usually occur within the first 6-48 hours after the cessation of alcohol intake, but may occur during periods of alcohol intoxication. Single generalized tonic-clonic motor seizures are the most common subtype, however, STATUS EPILEPTICUS may occur. (Adams et al., Principles of Neurology, 6th ed, p1174)

Synonym
Alcohol-Related Seizures
Alcohol Withdrawal-Induced Status Epilepticus
Major Motor Seizure, Alcohol Withdrawal-Induced
Alcohol Withdrawal-Induced Seizure
Status Epilepticus, Alcohol Withdrawal-Induced
Alcohol Withdrawal-Induced Major Motor Seizure
Alcohol Withdrawal Seizures
Seizures, Alcoholic

Excerpt	Reference
"Alcohol withdrawal seizures are part of the symptomatology of severe alcohol dependence and are believed to originate from long-term neural adaptations that counter the central nervous system depressant effects of alcohol."	( Atkinson, NS; Ghezzi, A; Krishnan, HR, 2014)

Excerpt	Reference
"Sedatives are important in treatment of alcohol withdrawal seizures and delirium tremens as well as in the prophylaxis of alcohol withdrawal syndrome."	( Batra, A; Lutz, UC, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (0.65)	23.3326
1990's	2 (1.30)	12.5806
2000's	90 (58.44)	18.1394
2010's	59 (38.31)	28.8240
2020's	2 (1.30)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	7	0
5-hydroxytryptophan	low	1	0
acetone	low	2	0
agmatine	low	1	0
1-butanol	low	1	0
carbamates	low	1	0
chlorine	low	1	0
bupropion	low	1	0
cytosine	low	1	0
histamine	low	1	0
nitrous oxide	low	1	0
taurine	low	1	0
thiamine	low	2	0
thymine	low	1	0
urea	low	1	0
2-amino-5-phosphonovalerate	low	3	0
phenytoin	low	3	0
aspirin	low	1	0
baclofen	low	1	0
carbamazepine	low	4	0
chlordiazepoxide	low	3	0
clonidine	low	2	0
nordazepam	low	1	0
amphetamine	low	1	0
diazepam	low	8	0
valproic acid	low	2	0
2-amino-7-phosphonoheptanoic acid	low	2	0
ethosuximide	low	1	0
fenfluramine	low	1	0
fentanyl	low	1	0
flumazenil	low	3	0
fomepizole	low	1	0
gabapentin	low	2	0
haloperidol	low	1	0
2-propanol	low	1	0
ketamine	low	2	0
lorazepam	medium	10	1
memantine	low	2	0
midazolam	low	1	0
neostigmine	low	1	0
nifedipine	low	1	0
oxazepam	medium	1	1
pentobarbital	low	2	0
phenobarbital	low	2	0
phentermine	low	2	0
moxonidine	low	1	0
propofol	low	3	0
riluzole	low	1	0
ro 15-4513	low	1	0
saccharin	low	2	0
temazepam	low	1	0
corticosterone	low	1	0
carbachol	low	1	0
pentylenetetrazole	low	9	0
sucrose	low	2	0
2-chloroadenosine	low	1	0
cyclopentane	low	1	0
bicuculline	low	2	0
4-hydroxybutyric acid	low	1	0
chlormethiazole	low	4	0
d-alpha tocopherol	low	2	0
s,n,n'-tripropylthiocarbamate	low	1	0
n-methylaspartate	low	1	0
magnesium sulfate	low	2	0
phenyl acetate	low	2	0
pregnanolone	low	4	0
transferrin	low	1	0
glutamic acid	low	3	0
azides	low	1	0
oxcarbazepine	low	1	0
fosphenytoin	low	1	0
finasteride	low	2	0
triazoles	low	1	0
acamprosate	low	1	0
nicotine	low	3	0
homocysteine	medium	8	1
vitamin b 6	low	1	0
ezogabine	low	1	0
clorazepate dipotassium	low	1	0
zm 241385	low	1	0
lacosamide	low	1	0
strychnine	low	1	0
phalloidine	low	1	0
cocaine	low	2	0
enkephalin, leucine	low	1	0
isomethyleugenol	low	1	0
xe 991, anthracenone	low	1	0
D-fructopyranose	low	1	0
tamoxifen	low	1	0
6-methyl-2-(phenylethynyl)pyridine	low	1	0
quinine	low	3	0
quercetin	low	1	0
topiramate	low	1	0
dexmedetomidine	low	3	0
cgp 39551	low	1	0
neramexane	low	1	0
tiapamil hydrochloride	low	1	0
ganaxolone	low	1	0
bpc 157	low	1	0
ly 379268	low	1	0
sodium oxybate	low	1	0
piperidines	low	1	0
vitamin b 12	low	1	0
folic acid	low	2	0
preproenkephalin	low	1	0

Protein Targets (1,099)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
aldehyde dehydrogenase 1 family, member A1	19	0	0	19
glucocorticoid receptor [Homo sapiens]	22	0	0	22
farnesoid X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	34	0	0	34
Voltage-dependent calcium channel gamma-2 subunit	9	0	0	9
Cellular tumor antigen p53	16	0	0	16
Glutamate receptor 2	9	4	1	14
Choline O-acetyltransferase	0	1	0	2
euchromatic histone-lysine N-methyltransferase 2	38	0	0	38
Bloom syndrome protein isoform 1	16	0	0	16
peripheral myelin protein 22 isoform 1	6	0	0	6
D(1A) dopamine receptor	12	0	0	12
lamin isoform A-delta10	29	0	0	29
Glutamate receptor 1	0	6	1	7
Glutamate receptor ionotropic, NMDA 1	0	14	2	18
Glutamate receptor ionotropic, kainate 3	0	6	0	6
Glutamate receptor ionotropic, NMDA 2A	0	14	2	18
Glutamate receptor ionotropic, NMDA 2B	0	15	2	19
Glutamate receptor ionotropic, NMDA 2C	0	14	2	18
Glutamate receptor ionotropic, NMDA 2D	0	14	2	18
Glutamate receptor ionotropic, NMDA 3B	0	14	2	18
Glutamate receptor ionotropic, NMDA 3A	0	14	2	18
ATP-dependent phosphofructokinase	10	0	0	10
thioredoxin reductase	22	0	0	22
nonstructural protein 1	6	0	0	6
arylsulfatase A	15	0	0	15
thyroid hormone receptor beta isoform a	11	0	0	11
histone acetyltransferase KAT2A isoform 1	6	0	0	6
neuropeptide S receptor isoform A	4	0	0	4
Chain A, Beta-lactamase	6	0	0	6
glp-1 receptor, partial	6	0	0	6
TDP1 protein	25	0	0	25
Smad3	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
NPYLR7B	0	0	1	1
67.9K protein	5	0	0	5
IDH1	11	0	0	11
cellular tumor antigen p53 isoform a	7	0	0	7
vasopressin V1b receptor	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	7	0	0	7
flap endonuclease 1	5	0	0	5
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	4	0	0	4
plasminogen precursor	4	0	0	4
urokinase plasminogen activator surface receptor precursor	4	0	0	4
geminin	25	0	0	25
survival motor neuron protein isoform d	9	0	0	9
relaxin receptor 1 isoform 1	1	0	0	1
high affinity choline transporter 1 isoform a	0	1	0	1
relaxin receptor 2 isoform 1	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Renin	0	1	0	1
Integrin beta-3	6	1	1	8
Heat shock protein HSP 90-alpha	0	2	1	3
Integrin alpha-IIb	6	1	1	8
Adenosine receptor A3	0	7	1	8
Endoplasmin	0	1	1	2
Adenosine receptor A1	0	5	0	8
Adenosine receptor A1	0	1	0	1
5-hydroxytryptamine receptor 2A	0	5	0	5
Adenosine receptor A3	0	2	0	3
Adenosine receptor A2a	0	6	2	10
Adenosine receptor A2b	0	3	1	7
Adenosine receptor A2b	0	2	1	5
Adenosine receptor A1	0	6	1	8
Adenosine receptor A2a	0	6	2	12
Adenosine receptor A2a	0	0	1	1
Adenosine receptor A1	0	0	1	1
Adenosine deaminase	0	1	0	1
Adenylate cyclase type 5	0	2	0	2
Ataxin-2	9	0	0	9
hypoxia-inducible factor 1 alpha subunit	6	0	0	6
RAR-related orphan receptor gamma	17	0	0	17
GLI family zinc finger 3	21	0	0	21
AR protein	35	0	0	35
retinoic acid nuclear receptor alpha variant 1	20	0	0	20
retinoid X nuclear receptor alpha	10	0	0	10
peroxisome proliferator-activated receptor delta	10	0	0	10
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	15	0	0	15
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	11	0	0	11
Histone H2A.x	6	0	0	6
heat shock protein beta-1	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
Gamma-aminobutyric acid receptor subunit pi	14	14	2	30
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	14	14	2	30
Gamma-aminobutyric acid receptor subunit delta	14	14	2	30
Gamma-aminobutyric acid receptor subunit gamma-2	14	14	4	32
Gamma-aminobutyric acid receptor subunit alpha-5	14	14	2	30
Gamma-aminobutyric acid receptor subunit alpha-3	14	14	2	30
Gamma-aminobutyric acid receptor subunit gamma-1	14	14	2	30
Gamma-aminobutyric acid receptor subunit alpha-2	14	14	2	30
Gamma-aminobutyric acid receptor subunit alpha-4	14	14	2	30
Gamma-aminobutyric acid receptor subunit gamma-3	14	14	2	30
Gamma-aminobutyric acid receptor subunit alpha-6	14	14	2	30
Gamma-aminobutyric acid receptor subunit alpha-1	14	15	4	33
Gamma-aminobutyric acid receptor subunit beta-3	14	14	2	30
Gamma-aminobutyric acid receptor subunit beta-2	14	14	4	32
Tetraspanin	0	1	0	1
Proton-coupled amino acid transporter 1	0	3	0	3
GABA theta subunit	14	14	2	30
Gamma-aminobutyric acid receptor subunit epsilon	14	14	2	30
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Luciferase	7	0	0	7
Nrf2	2	0	0	2
15-lipoxygenase, partial	7	0	0	7
phosphopantetheinyl transferase	13	0	0	13
ATAD5 protein, partial	8	0	0	8
GLS protein	17	0	0	17
Thrombopoietin	4	0	0	4
EWS/FLI fusion protein	14	0	0	14
luciferase	1	0	0	1
Parkin	4	0	0	4
pyruvate kinase	2	0	0	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	4	0	0	4
beta-2 adrenergic receptor	3	0	0	3
cytochrome P450 2D6 isoform 1	10	0	0	10
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
cytochrome P450 2C19 precursor	10	0	0	10
cytochrome P450 2C9 precursor	11	0	0	11
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	6	0	0	6
atrial natriuretic peptide receptor 1 precursor	3	0	0	3
chromobox protein homolog 1	13	0	0	13
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
ras-related protein Rab-9A	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	10	0	0	10
cytochrome P450 3A4 isoform 1	14	0	0	14
muscarinic acetylcholine receptor M1	13	0	0	13
pyruvate kinase PKM isoform b	2	0	0	2
Metabotropic glutamate receptor 8	0	4	1	6
Metabotropic glutamate receptor 6	0	3	2	7
Luciferin 4-monooxygenase	0	1	0	1
Cytochrome P450 3A4	0	9	0	10
Ornithine decarboxylase	2	0	0	2
Cytochrome P450 2D6	0	6	0	6
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 5	0	3	2	5
Metabotropic glutamate receptor 5	0	4	2	8
Histamine H2 receptor	12	0	1	14
Glutamate receptor ionotropic, NMDA 2B	0	6	0	6
Metabotropic glutamate receptor 1	0	4	2	8
Metabotropic glutamate receptor 2	0	3	2	7
Metabotropic glutamate receptor 7	0	3	2	7
Metabotropic glutamate receptor 3	0	3	2	7
Metabotropic glutamate receptor 4	0	3	2	7
Amine oxidase [flavin-containing] A	0	1	0	1
phosphoglycerate kinase	2	0	0	2
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
estrogen-related nuclear receptor alpha	25	0	0	25
thyroid hormone receptor beta isoform 2	20	0	0	20
Chain A, Cruzipain	4	0	0	4
NFKB1 protein, partial	7	0	0	7
lethal factor (plasmid)	8	0	0	8
Solute carrier family 22 member 2	0	2	0	6
Solute carrier family 22 member 1	0	12	0	16
Polyamine oxidase 1	0	1	0	1
Solute carrier family 22 member 3	0	4	0	6
Solute carrier family 22 member 3	0	2	0	3
Alpha-2B adrenergic receptor	0	7	0	7
Alpha-2C adrenergic receptor	0	6	0	6
Alpha-2A adrenergic receptor	0	6	0	6
Nischarin	0	4	0	4
Solute carrier family 22 member 1	0	9	0	11
Deoxyhypusine synthase	0	1	0	1
Solute carrier family 22 member 2	0	7	0	9
5-hydroxytryptamine receptor 2C	0	5	1	6
Phenylethanolamine N-methyltransferase	0	2	0	2
Cytochrome P450 2A6	0	4	1	5
Substance-P receptor	0	1	0	1
5-hydroxytryptamine receptor 2A	0	7	1	8
5-hydroxytryptamine receptor 1A	0	18	2	20
Cytochrome P450 2A5	0	2	0	2
Sodium-dependent dopamine transporter	0	6	1	7
5-hydroxytryptamine receptor 1B	0	9	1	10
5-hydroxytryptamine receptor 1D	0	3	1	4
5-hydroxytryptamine receptor 1F	0	3	1	4
5-hydroxytryptamine receptor 2B	0	5	1	6
5-hydroxytryptamine receptor 6	0	1	1	2
5-hydroxytryptamine receptor 7	0	2	1	3
5-hydroxytryptamine receptor 5A	0	1	1	2
5-hydroxytryptamine receptor 5B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	5	1	6
5-hydroxytryptamine receptor 4	0	1	1	2
Beta-2 adrenergic receptor	0	1	0	2
5-hydroxytryptamine receptor 3B	0	1	1	2
Sigma non-opioid intracellular receptor 1	0	4	1	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	6	0	0	6
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	2	0	0	2
thyroid stimulating hormone receptor	14	0	0	14
hypothetical protein, conserved	2	0	0	2
cytochrome P450 family 3 subfamily A polypeptide 4	14	0	0	14
cytochrome P450 2D6	9	0	0	9
glucocerebrosidase	6	0	0	6
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
DNA polymerase kappa isoform 1	5	0	0	5
Prostaglandin-H2 D-isomerase	0	1	0	1
ATP-binding cassette sub-family C member 3	0	21	0	21
Multidrug resistance-associated protein 4	0	21	0	22
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Bile salt export pump	0	31	0	31
Epidermal growth factor receptor	0	3	0	3
Carbonic anhydrase 1	0	12	0	15
Carbonic anhydrase 2	0	13	2	19
Fatty acid-binding protein, liver	0	3	0	3
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	2	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	20	0	20
Sigma non-opioid intracellular receptor 1	0	9	1	10
Carbonic anhydrase 4	0	6	0	8
Carbonic anhydrase	0	3	0	4
Carbonic anhydrase 15	0	4	0	5
regulator of G-protein signaling 4	18	0	0	18
Gamma-aminobutyric acid type B receptor subunit 2	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 2	0	3	0	3
Gamma-aminobutyric acid type B receptor subunit 1	0	2	2	4
Gamma-aminobutyric acid type B receptor subunit 1	0	2	0	2
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	0	12	0	12
Gamma-aminobutyric acid receptor subunit delta	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-1	0	16	8	24
Gamma-aminobutyric acid receptor subunit beta-1	0	12	3	15
Gamma-aminobutyric acid receptor subunit gamma-2	0	15	6	21
Gamma-aminobutyric acid receptor subunit beta-3	0	16	5	21
Gamma-aminobutyric acid receptor subunit alpha-5	0	14	7	21
Gamma-aminobutyric acid receptor subunit alpha-3	0	14	5	19
Gamma-aminobutyric acid receptor subunit alpha-2	0	14	5	19
Gamma-aminobutyric acid receptor subunit beta-2	0	13	5	18
Gamma-aminobutyric acid receptor subunit alpha-4	0	13	3	16
Gamma-aminobutyric acid receptor subunit epsilon	0	12	0	12
Gamma-aminobutyric acid receptor subunit alpha-6	0	13	3	16
Gamma-aminobutyric acid receptor subunit gamma-1	0	12	0	12
Gamma-aminobutyric acid receptor subunit gamma-3	0	12	0	12
Gamma-aminobutyric acid receptor subunit theta	0	12	0	12
USP1 protein, partial	12	0	0	12
Acetylcholine receptor subunit alpha	0	3	1	4
Acetylcholine receptor subunit gamma	0	3	1	4
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	3	1	4
UDP-glucuronosyltransferase 2B7	0	5	1	9
Neuronal acetylcholine receptor subunit beta-2	0	3	1	5
UDP-glucuronosyltransferase 1-6	0	3	1	5
Cytochrome P450 2B6	0	1	1	4
UDP-glucuronosyltransferase 1A1	0	4	1	6
UDP-glucuronosyltransferase 1A4	0	3	1	7
Sodium-dependent noradrenaline transporter	0	14	0	14
Neuronal acetylcholine receptor subunit beta-4	0	3	1	5
Sodium-dependent serotonin transporter	0	8	0	8
Neuronal acetylcholine receptor subunit alpha-3	0	3	1	4
Cytochrome P450 2C19	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	3	1	5
Sodium-dependent dopamine transporter	0	6	0	6
Acetylcholine receptor subunit delta	0	3	1	4
acetylcholinesterase	6	0	0	6
GALC protein	6	0	0	6
peroxisome proliferator activated receptor gamma	8	0	0	8
thyroid stimulating hormone receptor	8	0	0	8
thyrotropin-releasing hormone receptor	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	4	2	7
Muscarinic acetylcholine receptor M2	0	5	2	9
Muscarinic acetylcholine receptor M4	0	5	2	9
Muscarinic acetylcholine receptor M1	0	6	1	9
Muscarinic acetylcholine receptor M3	0	5	1	7
Muscarinic acetylcholine receptor M4	0	6	0	7
Muscarinic acetylcholine receptor M5	0	5	0	6
Muscarinic acetylcholine receptor M5	0	6	2	10
Neuronal acetylcholine receptor subunit alpha-4	1	6	2	10
Muscarinic acetylcholine receptor M2	0	5	0	6
Muscarinic acetylcholine receptor M1	0	6	2	10
Neuronal acetylcholine receptor subunit alpha-2	0	3	2	6
Neuronal acetylcholine receptor subunit beta-2	1	6	2	10
Neuronal acetylcholine receptor subunit beta-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	4	2	7
Muscarinic acetylcholine receptor M1	0	1	1	2
Muscarinic acetylcholine receptor M3	0	5	2	9
Neuronal acetylcholine receptor subunit alpha-5	0	3	2	6
Delta-type opioid receptor	0	10	1	13
Neuronal acetylcholine receptor subunit alpha-6	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-9	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-7	0	7	2	10
Muscarinic acetylcholine receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	3	2	6
pregnane X nuclear receptor	20	0	0	20
Vpr	1	0	0	1
Bile salt export pump	0	4	0	4
Albumin	0	0	3	3
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	4	1	5
Sodium channel protein type 3 subunit alpha	0	2	0	2
Cytochrome P450 2C9	0	7	0	7
Sodium channel protein type 4 subunit alpha	0	5	0	7
Cytochrome P450 2J2	0	3	0	3
Potassium voltage-gated channel subfamily H member 2	0	15	0	15
Sodium channel protein type 9 subunit alpha	0	6	0	6
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	2	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	10	0	0	10
Gamma-aminobutyric acid receptor subunit alpha-1	0	6	0	8
Gamma-aminobutyric acid receptor subunit beta-1	0	6	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	0	6	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	0	6	0	8
Translocator protein	0	4	1	6
Gamma-aminobutyric acid receptor subunit alpha-4	0	6	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	0	6	0	8
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	0	3
Histamine H1 receptor	0	7	2	9
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Translocator protein	0	2	0	2
Translocator protein	0	6	0	6
Chain A, Ferritin light chain	5	0	0	5
nuclear receptor subfamily 1, group I, member 3	17	0	0	17
Beta-1 adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	2	2
Membrane primary amine oxidase	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 1A	0	3	1	4
Alpha-2A adrenergic receptor	0	8	2	10
Alpha-1B adrenergic receptor	0	10	0	10
Alpha-2B adrenergic receptor	0	7	1	8
Alpha-1A adrenergic receptor	0	0	2	2
Alpha-2C adrenergic receptor	0	6	2	8
D	0	4	0	4
D(3) dopamine receptor	0	4	0	4
Amine oxidase [flavin-containing] A	0	3	0	3
Alpha-1D adrenergic receptor	0	5	0	5
Alpha-1D adrenergic receptor	0	8	1	9
D(1B) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	3	0	3
Alpha-2B adrenergic receptor	0	0	0	1
D(4) dopamine receptor	0	3	0	3
Alpha-1A adrenergic receptor	0	3	1	4
Alpha-1B adrenergic receptor	0	3	1	4
Alpha-1A adrenergic receptor	0	9	1	10
5-hydroxytryptamine receptor 7	0	4	0	4
Spike glycoprotein	5	0	2	7
D(2) dopamine receptor	0	5	0	5
Mu-type opioid receptor	0	10	0	11
Inositol monophosphatase 1	5	0	0	5
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Multidrug and toxin extrusion protein 1	0	1	0	1
Nischarin	0	2	0	2
Chain A, CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain B, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION	0	0	1	1
Chain H, Fab M82G2, Heavy chain	0	0	1	1
Chain L, Fab M82G2, Light chain	0	0	1	1
Chain H, Fab M82g2, Heavy Chain	0	0	1	1
Chain L, Fab M82g2, Light Chain	0	0	1	1
Amyloid-beta precursor protein	0	2	0	2
Fatty acid-binding protein, heart	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Tryptophan 5-hydroxylase 1	0	1	0	1
Liver carboxylesterase 1	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Sodium-dependent serotonin transporter	0	4	1	6
Lysosomal Pro-X carboxypeptidase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Leukotriene B4 receptor 1	0	1	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Leukotriene B4 receptor 2	0	1	0	2
Transporter	0	3	1	5
pregnane X receptor	4	0	0	4
progesterone receptor	9	0	0	9
G	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	9	0	0	9
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	10	0	0	10
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	0	1	1
Androgen receptor	0	4	0	4
C-8 sterol isomerase	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	2	0	2
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	4	1	5
Inositol hexakisphosphate kinase 1	10	0	0	10
cytochrome P450 2C9, partial	10	0	0	10
Deoxycytidine kinase	0	0	0	1
Microtubule-associated protein tau	9	0	0	9
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	3	0	0	3
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
peripheral myelin protein 22	10	0	0	10
Gamma-aminobutyric acid	0	4	2	6
estrogen receptor 2 (ER beta)	6	0	0	6
Voltage-dependent L-type calcium channel subunit alpha-1F	0	6	0	6
Alpha-1-acid glycoprotein 1	0	0	0	2
Albumin	0	0	3	5
ATP-dependent translocase ABCB1	0	10	2	15
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit delta	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit beta-1	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	2	7
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Voltage-dependent L-type calcium channel subunit alpha-1D	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1S	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	0	4	2	6
Gamma-aminobutyric acid receptor subunit pi	0	4	2	6
Sphingosine-1-phosphate lyase 1	0	1	0	1
ATPase family AAA domain-containing protein 5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	4	2	6
Gamma-aminobutyric acid receptor subunit theta	0	4	2	6
Gamma-aminobutyric acid receptor subunit gamma-1	0	4	2	6
vitamin D3 receptor isoform VDRA	5	0	0	5
huntingtin isoform 2	2	0	0	2
Gasdermin-D	0	1	0	1
Gasdermin-D	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	7	0	7
Kappa-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	7	1	8
Kappa-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	8	3	11
Delta-type opioid receptor	0	5	1	6
Kappa-type opioid receptor	0	5	0	5
Kappa-type opioid receptor	0	5	1	6
Mu-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	3
Potassium voltage-gated channel subfamily KQT member 2	0	1	1	4
UDP-glucuronosyltransferase 1A9	0	1	1	5
UDP-glucuronosyltransferase 2B11	0	0	1	1
UDP-glucuronosyltransferase 2B17	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 3	0	0	1	1
UDP-glucuronosyltransferase 2B4	0	0	1	1
UDP-glucuronosyltransferase 2A1	0	0	1	1
UDP-glucuronosyltransferase 2A2	0	0	1	1
UDP-glucuronosyltransferase 1A3	0	0	1	1
UDP-glucuronosyltransferase 1A5	0	0	1	1
UDP-glucuronosyltransferase 2B15	0	0	1	1
Potassium voltage-gated channel subfamily KQT member 4	0	0	1	1
UDP-glucuronosyltransferase 2A3	0	0	1	1
UDP-glucuronosyltransferase 2B28	0	0	1	1
UDP-glucuronosyltransferase 1A7	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 5	0	0	1	2
Potassium voltage-gated channel subfamily KQT member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
D(2) dopamine receptor	0	5	2	9
D(4) dopamine receptor	0	6	1	9
D(3) dopamine receptor	0	5	1	8
SMAD family member 2	3	0	0	3
SMAD family member 3	3	0	0	3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	2	0	2
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	3	0	3
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	3	0	3
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase	0	1	0	1
endonuclease IV	2	0	0	2
muscleblind-like protein 1 isoform 1	3	0	0	3
TAR DNA-binding protein 43	5	0	0	5
Chain A, Dihydrofolate reductase	0	0	1	1
acid sphingomyelinase	1	0	0	1
alpha-galactosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
DNA polymerase beta	2	0	0	2
Thymidylate synthase	0	2	0	2
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Alpha-synuclein	4	1	0	5
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Solute carrier organic anion transporter family member 1A3	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	0	0	1
Multidrug resistance associated protein	0	0	0	1
Alcohol dehydrogenase E chain	0	1	1	2
Alcohol dehydrogenase S chain	0	1	1	2
thioredoxin glutathione reductase	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	2
Hsf1 protein	0	0	1	1
bromodomain adjacent to zinc finger domain 2B	4	0	0	4
transcriptional regulator ERG isoform 3	3	0	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	5	0	0	5
Histone deacetylase 3	0	3	0	3
Sodium- and chloride-dependent GABA transporter 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	3
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	4	0	4
Sodium- and chloride-dependent GABA transporter 3	0	4	0	4
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	4	0	4
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Histone deacetylase 4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Histone deacetylase 1	0	4	0	4
Sterol O-acyltransferase 1	0	0	1	1
Histone deacetylase 7	0	3	0	3
Histone deacetylase 2	0	3	0	3
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	3	0	3
Histone deacetylase 8	0	3	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	3	0	3
Histone deacetylase 5	0	3	0	3
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	3	0	3
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	3	0	3
Glutathione reductase, mitochondrial	0	5	0	5
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Prothrombin	0	1	2	3
ATP-citrate synthase	0	1	0	1
Glutamate receptor 3	0	4	1	5
Glutamate receptor 4	0	4	1	5
Glutamate receptor ionotropic, kainate 1	0	4	1	5
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Glutamate receptor ionotropic, kainate 2	0	4	1	5
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Glutamate receptor ionotropic, kainate 4	0	4	0	4
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	0	5
Glutamate receptor ionotropic, NMDA 2A	0	5	0	5
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	3	0	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	2
Glutamate receptor ionotropic, kainate 5	0	4	0	4
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	1	0	1
Glutamate receptor ionotropic, NMDA 3A	0	3	0	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Fumarate hydratase	3	0	0	3
caspase 7, apoptosis-related cysteine protease	4	0	0	4
polyprotein	3	0	0	3
caspase-3	4	0	0	4
Adenylate cyclase type 1	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	4	1	0	5
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Potassium channel subfamily K member 2	0	2	2	4
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	10	0	10
Beta-2 adrenergic receptor	0	2	0	2
Angiotensin-converting enzyme	0	3	0	3
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Beta-1 adrenergic receptor	0	1	0	1
D(2) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	0	4	0	5
D(1B) dopamine receptor	0	2	0	3
Adenylate cyclase type 3	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Histamine H2 receptor	0	5	2	7
Beta-3 adrenergic receptor	0	1	0	1
Adenylate cyclase type 2	0	1	0	1
Adenylate cyclase type 4	0	1	0	1
5-hydroxytryptamine receptor 2C	0	8	0	8
Histamine H1 receptor	0	4	1	5
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	4	0	4
Adenylate cyclase type 8	0	1	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
5-hydroxytryptamine receptor 2A	0	1	0	1
D(1A) dopamine receptor	2	1	0	3
5-hydroxytryptamine receptor 6	0	3	0	3
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
Sodium channel protein type 7 subunit alpha	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
Adenylate cyclase type 6	0	1	0	1
5-hydroxytryptamine receptor 4	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	4	0	4
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Protease	0	2	0	2
Adenylyl cyclase 7	0	1	0	1
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	4	0	4
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	4	0	4
Sodium channel protein type 11 subunit alpha	0	2	0	2
Sodium channel protein type 8 subunit alpha	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	2	0	2
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Carbonic anhydrase 12	0	4	0	6
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	4	0	5
Macrophage migration inhibitory factor	0	2	0	2
Carbonic anhydrase 6	0	5	0	7
5-hydroxytryptamine receptor 1D	0	0	0	1
Histamine H1 receptor	0	1	2	3
Carbonic anhydrase 5A, mitochondrial	0	4	1	7
Carbonic anhydrase 7	0	4	0	6
Carbonic anhydrase	0	2	0	4
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	5	1	8
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	1	0	3
Carbonic anhydrase	0	2	0	4
Carbonic anhydrase	0	1	0	3
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	2	0	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Carbonic anhydrase 4	0	2	0	3
Carbonic anhydrase 13	0	2	0	4
Histamine H4 receptor	0	1	2	3
Histamine H3 receptor	0	1	0	1
Carboxylic ester hydrolase	0	0	0	1
Carbonic anhydrase 14	0	4	0	6
Carbonic anhydrase 5B, mitochondrial	0	4	0	6
Histamine H3 receptor	0	1	2	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Acetylcholinesterase	0	3	0	3
Cholinesterase	0	3	0	3
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Acetylcholinesterase	0	4	0	4
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
aryl hydrocarbon receptor	9	0	0	9
Rap guanine nucleotide exchange factor 4	1	0	0	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Cholinesterase	0	3	0	3
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Cytochrome P450 1A2	0	4	0	4
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	2	0	0	2
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
M-phase phosphoprotein 8	3	0	0	3
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Phospholipase A2, membrane associated	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Platelet-activating factor receptor	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	3
polyadenylate-binding protein 1	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Trace amine-associated receptor 1	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	2
Voltage-dependent calcium channel subunit alpha-2/delta-2	0	1	0	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	1	0	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, APH(2')-Id	0	1	0	1
glucose-6-phosphate dehydrogenase	0	1	0	1
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
DNA polymerase III, partial	2	0	0	2
Neuraminidase	0	2	0	2
hexokinase	0	1	0	1
Spike glycoprotein	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
galactokinase	1	0	0	1
interferon gamma precursor	0	0	0	2
histone deacetylase 9 isoform 3	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Transmembrane protease serine 2	0	0	2	2
Polyphenol oxidase 2	0	1	0	2
Maltase-glucoamylase, intestinal	0	1	0	1
NUAK family SNF1-like kinase 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
B2 bradykinin receptor	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Arginase	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Prothrombin	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Cationic trypsin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Chymotrypsin-like elastase family member 1	0	1	0	1
Beta-lactamase	0	1	0	1
Protein E6	0	1	0	1
Neuraminidase	0	1	0	1
Interstitial collagenase	0	1	1	2
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Cytochrome P450 1A1	0	2	1	3
Beta-lactamase	0	1	0	1
Tyrosine-protein kinase Lck	0	2	0	2
Cyclin-dependent kinase 1	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Epoxide hydrolase 1	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Procathepsin L	0	0	2	2
Tyrosine-protein kinase Yes	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Neutrophil elastase	0	2	0	2
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
Hepatocyte growth factor receptor	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Replicase polyprotein 1a	0	0	2	2
Replicase polyprotein 1ab	0	0	2	2
Replicase polyprotein 1ab	0	2	2	4
Calmodulin-1	0	1	0	1
Replicase polyprotein 1ab	0	2	2	4
Alpha-amylase 1A	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Sialidase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Cytochrome P450 2C8	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 2	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	1	2
Aromatase	0	1	0	1
Cyclin-dependent kinase 4	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Sucrase-isomaltase, intestinal	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Tyrosinase	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Urease subunit alpha	0	3	0	3
Serine/threonine-protein kinase B-raf	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Casein kinase II subunit alpha'	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
5'-nucleotidase	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Cyclin-dependent kinase 2	0	1	0	1
C-X-C chemokine receptor type 1	0	1	0	1
Dipeptidyl peptidase 4	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Cytosol aminopeptidase	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Vasopressin V2 receptor	0	1	0	1
Tyrosine-protein kinase receptor UFO	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Trypsin-3	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Glutathione reductase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Collagenase 3	0	1	0	1
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	2	0	2
C-C chemokine receptor type 4	0	1	0	1
Serine/threonine-protein kinase Nek2	0	1	0	1
Oligo-1,6-glucosidase IMA1	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Monocarboxylate transporter 1	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Beta-secretase 1	0	2	0	2
Anthrax toxin receptor 2	0	1	0	1
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	3	0	3
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Lactoperoxidase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	3
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Heat shock factor protein 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Cyclin homolog	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Lactoylglutathione lyase	0	2	0	2
Focal adhesion kinase 1	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	0	1
ELAV-like protein 3	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
ELAV-like protein 1	0	1	0	1
Serine/threonine-protein kinase N1	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Cytochrome P450 1B1	0	2	1	3
Probable maltase-glucoamylase 2	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Substance-K receptor	0	1	0	1
Integrase	0	1	0	1
Casein kinase II subunit alpha 3	0	2	0	2
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Aldo-keto reductase family 1 member C21	0	2	0	2
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Aurora kinase B	0	1	0	1
Chymotrypsin-C	0	1	0	1
Angiotensin-converting enzyme 2	0	0	2	2
Cyclin-dependent kinase 1	0	1	0	1
Phosphodiesterase	0	1	0	1
G-protein coupled receptor 35	0	1	1	2
Serine/threonine-protein kinase Nek6	0	1	0	1
NADPH oxidase 4	0	1	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Sialidase-2	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Histidine-rich protein PFHRP-II	0	1	0	1
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
Cytochrome P450 2D4	0	1	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	2	0	2
Coagulation factor X	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
Taste receptor type 2 member 31	0	0	1	1
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
RmtA	0	1	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Glycine receptor subunit alpha-1	0	1	0	1
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	1	0	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 10	0	0	1	2
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
Chain A, CES1 protein	0	1	0	1
PPM1D protein	1	0	0	1
Caspase-7	1	0	0	1
caspase-3	1	0	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
streptokinase A precursor	0	0	1	1
Serine/threonine-protein kinase D3	0	1	0	1
Estrogen receptor	0	2	1	4
Lysosomal acid glucosylceramidase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C alpha type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor	0	0	1	2
Tyrosine-protein kinase Fyn	0	1	0	1
Progesterone receptor	0	1	0	1
Beta-1 adrenergic receptor	0	2	0	2
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Steroid hormone receptor ERR1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Protein kinase C alpha type	0	1	0	1
Substance-K receptor	0	2	0	2
Protein kinase C eta type	0	1	0	1
Substance-P receptor	0	2	0	2
B2 bradykinin receptor	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Protein kinase C iota type	0	1	0	1
Melanocortin receptor 3	0	2	0	2
Estrogen-related receptor gamma	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Phospholipase D1	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C theta type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
Protein kinase C delta type	0	1	0	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Phospholipase D1	0	1	0	1
Serine/threonine-protein kinase D1	0	1	0	1
Estrogen receptor beta	0	0	1	2
Protein kinase C eta type	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Estrogen receptor beta	0	2	1	3
Emopamil-binding protein-like	0	1	0	1
7-dehydrocholesterol reductase	0	1	1	2
Protein kinase C theta type	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Thymidine phosphorylase	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Tissue factor	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Chain A, Human Adenosine A2A receptor/T4 lysozyme chimera	0	0	1	1
Chain A, Adenosine receptor A2a	0	0	1	1
Chain A, Adenosine receptor A2a	0	0	1	1
Hexokinase-4	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Alcohol Withdrawal Seizures

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (154)

Protein Targets (1,099)

Alcohol Withdrawal Seizures

Synonyms(8)

Research Excerpts

Overview

Treatment

Research

Studies (154)

Drugs Studied (118)

Protein Targets (1,099)