An anti-HSV agent agent that destroys or inhibits the replication of herpes simplex virus-1.
ChEBI ID: 64953
| Member | Definition | Class |
|---|---|---|
| 5,6,7-trimethoxyflavone | A trimethoxyflavone that is the 5,6,7-trimethyl ether derivative of baicalein. It has been isolated from the plant Callicarpa japonica and has been shown to exhibit antiviral activity. | 5,6,7-trimethoxyflavone |
| crambescidin 800 | An organic heteropentacyclic guanidine alkaloid isolated from the marine sponge Crambe crambe and Batzella. It exhibits anti-HIV-1 and anti-HSV-1 activity. | crambescidin 800 |
| ergosta-7,22-dien-3-ol, (3beta,5alpha,6alpha,22e)-isomer | A 3beta-sterol consisting of an ergostane skeleton with double bonds at 7- and 22-positions. | 5alpha-ergosta-7,22-dien-3beta-ol |
| eugeniin | An ellagitannin isolated from the dried flower buds of Eugenia caryophyllata. It exhibits alpha-glucosidase inhibitory activity and antiviral activity against acyclovir and phosphonoacetic acid (PAA)-resistant herpes simplex virus type 1 (HSV-1) as well as the wild-type HSV-1. | eugeniin |
| ginkgetin | A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2. | ginkgetin |
| isomangiferin | A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7 and a 1,5-anhydro-D-glucitol moiety at position 1. | isomangiferin |
| manzamine a | An alkaloid of the class of beta-carbolines isolated from Haliclona and Acanthostrongylophora. It exhibits inhibitory activity against Glycogen Synthase Kinase-3 (EC 2.7.11.26). | manzamine A |
| moronic acid | A pentacyclic triterpenoid that is olean-18-ene substituted at position 3 by an oxo group and position 28 by a carboxy group. | moronic acid |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (0.96) | 18.7374 |
| 1990's | 17 (8.13) | 18.2507 |
| 2000's | 72 (34.45) | 29.6817 |
| 2010's | 83 (39.71) | 24.3611 |
| 2020's | 35 (16.75) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 14 (6.48%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 202 (93.52%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 67.9K protein | Vaccinia virus | Potency | 10.6101 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 18.3564 | 1 | 1 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 0.6310 | 1 | 1 |
| Chain A, Cruzipain | Trypanosoma cruzi | Potency | 39.8107 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.0112 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 44.6684 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 33.5875 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 6.6865 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 13.2000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 3.6400 | 2 | 2 |
| Beta-secretase 1 | Homo sapiens (human) | Ki | 6.8400 | 1 | 1 |
| Class A sortase SrtA | Staphylococcus aureus | IC50 | 150.0000 | 1 | 1 |
| Cyclin-dependent kinase 5 activator 1 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Cyclin-dependent-like kinase 5 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Dipeptidyl peptidase 4 | Homo sapiens (human) | IC50 | 10.2000 | 1 | 1 |
| Glycogen synthase kinase-3 alpha | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 10.2167 | 6 | 6 |
| Low molecular weight phosphotyrosine protein phosphatase | Homo sapiens (human) | IC50 | 24.0000 | 2 | 2 |
| nucleotide-binding oligomerization domain-containing protein 2 isoform 1 | Homo sapiens (human) | IC50 | 8.0770 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| Protein tyrosine phosphatase type IVA 3 | Homo sapiens (human) | IC50 | 25.8000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase F | Homo sapiens (human) | IC50 | 45.6000 | 1 | 1 |
| Replicase polyprotein 1a | Severe acute respiratory syndrome-related coronavirus | IC50 | 32.7000 | 1 | 1 |
| Replicase polyprotein 1ab | Human coronavirus 229E | IC50 | 32.7000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | IC50 | 32.0000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | IC50 | 32.2333 | 3 | 3 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome coronavirus 2 | Ki | 30.2000 | 1 | 1 |
| Replicase polyprotein 1ab | Severe acute respiratory syndrome-related coronavirus | Ki | 30.2000 | 2 | 2 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 1.6000 | 1 | 1 |
| Sterol O-acyltransferase 1 | Homo sapiens (human) | IC50 | 6.3000 | 2 | 2 |
| Sterol O-acyltransferase 2 | Homo sapiens (human) | IC50 | 4.8000 | 1 | 1 |
| tumor necrosis factor | Homo sapiens (human) | IC50 | 10.8800 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 13.2000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | Ki | 8.0000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| nucleotide-binding oligomerization domain-containing protein 1 isoform 1 | Homo sapiens (human) | EC50 | 2.2700 | 1 | 1 |