Compounds > 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one
Page last updated: 2024-11-12

5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4h-1-benzopyran-4-one

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Description

rohitukine : A member of the class of chromones that is 4H-chromen-4-one in which the hydrogens at positions 2,5,7 and 8 are replaced by methyl, hydroxy, hydroxy, and (3S,4R)-3-hydroxy-1-methylpiperidin-4-yl groups, respectively. It is an alkaloid initially isolated from Amoora rohituka and is a precursor of the anti-cancer compound flavopiridol. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Amooragenus[no description available]MeliaceaeThe mahogany plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.[MeSH]
DysoxylumgenusA plant genus. Members contain tirucallane-type TRITERPENES.[MeSH]MeliaceaeThe mahogany plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.[MeSH]

Cross-References

ID SourceID
PubMed CID13422573
CHEMBL ID1077604
CHEBI ID156498
SCHEMBL ID23718142
MeSH IDM0574996

Synonyms (17)

Synonym
rohitukine
nsc623611
5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methyl-4-piperidyl]-2-methyl-chromen-4-one
5,7-dihydroxy-8-[(3r,4s)-3-hydroxy-1-methyl-4-piperidinyl)-2-methyl-4h-chromen-4-one
71294-60-5
5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methylpiperidin-4-yl]-2-methyl-4h-1-benzopyran-4-one
5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methylpiperidin-4-yl]-2-methyl-4h-chromen-4-one
CHEBI:156498
CHEMBL1077604
DTXSID70540347
bdbm50189885
MOCVYVBNJQIVOV-TVQRCGJNSA-N
5,7-dihydroxy-8-[(3r,4s)-3-hydroxy-1-methylpiperidin-4-yl]-2-methylchromen-4-one
5,7-dihydroxy-8-[(3s,4r)-3-hydroxy-1-methylpiperidin-4-yl]-2-methylchromen-4-one
SCHEMBL23718142
AKOS040749359
5,7-dihydroxy-8-((3s,4r)-3-hydroxy-1-methylpiperidin-4-yl)-2-methyl-4h-chromen-4-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (8)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
EC 2.7.11.22 (cyclin-dependent kinase) inhibitorAn EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cyclin-dependent kinase (EC 2.7.11.22).
fungal metaboliteAny eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds.
anti-inflammatory agentAny compound that has anti-inflammatory effects.
anti-ulcer drugOne of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
anticholesteremic drugA substance used to lower plasma cholesterol levels.
antileishmanial agentAn antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
hydroxypiperidine
tertiary amino compoundA compound formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
chromonesA chromenone that consists of a 1,4-benzopyrone skeleton and its substituted derivatives thereof.
resorcinolsAny benzenediol in which the two hydroxy groups are meta to one another.
alkaloidAny of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Cyclin-T1Homo sapiens (human)IC50 (µMol)0.30000.00100.55858.0000AID1313838; AID1479297; AID1572663
Cyclin-A2Homo sapiens (human)IC50 (µMol)7.30000.00041.033910.0000AID1313837; AID1479296; AID1572658
Cyclin-dependent kinase 2Homo sapiens (human)IC50 (µMol)7.30000.00041.044410.0000AID1313837; AID1479296; AID1572658
Cyclin-dependent kinase 9Homo sapiens (human)IC50 (µMol)0.30000.00100.62368.0000AID1313838; AID1479297; AID1572663
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (67)

Processvia Protein(s)Taxonomy
regulation of cyclin-dependent protein serine/threonine kinase activityCyclin-T1Homo sapiens (human)
transcription by RNA polymerase IICyclin-T1Homo sapiens (human)
response to xenobiotic stimulusCyclin-T1Homo sapiens (human)
positive regulation of transcription elongation by RNA polymerase IICyclin-T1Homo sapiens (human)
positive regulation by host of viral transcriptionCyclin-T1Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICyclin-T1Homo sapiens (human)
cell divisionCyclin-T1Homo sapiens (human)
regulation of transcription by RNA polymerase IICyclin-T1Homo sapiens (human)
positive regulation of DNA-templated transcription, elongationCyclin-T1Homo sapiens (human)
G1/S transition of mitotic cell cycleCyclin-A2Homo sapiens (human)
G2/M transition of mitotic cell cycleCyclin-A2Homo sapiens (human)
regulation of DNA replicationCyclin-A2Homo sapiens (human)
DNA-templated transcriptionCyclin-A2Homo sapiens (human)
Ras protein signal transductionCyclin-A2Homo sapiens (human)
animal organ regenerationCyclin-A2Homo sapiens (human)
response to glucagonCyclin-A2Homo sapiens (human)
cellular response to platelet-derived growth factor stimulusCyclin-A2Homo sapiens (human)
post-translational protein modificationCyclin-A2Homo sapiens (human)
cellular response to leptin stimulusCyclin-A2Homo sapiens (human)
cell cycle G1/S phase transitionCyclin-A2Homo sapiens (human)
positive regulation of DNA-templated transcriptionCyclin-A2Homo sapiens (human)
positive regulation of fibroblast proliferationCyclin-A2Homo sapiens (human)
cell divisionCyclin-A2Homo sapiens (human)
cellular response to cocaineCyclin-A2Homo sapiens (human)
cellular response to luteinizing hormone stimulusCyclin-A2Homo sapiens (human)
cellular response to estradiol stimulusCyclin-A2Homo sapiens (human)
cellular response to hypoxiaCyclin-A2Homo sapiens (human)
cellular response to nitric oxideCyclin-A2Homo sapiens (human)
cochlea developmentCyclin-A2Homo sapiens (human)
cellular response to insulin-like growth factor stimulusCyclin-A2Homo sapiens (human)
positive regulation of DNA biosynthetic processCyclin-A2Homo sapiens (human)
regulation of cyclin-dependent protein serine/threonine kinase activityCyclin-A2Homo sapiens (human)
mitotic cell cycle phase transitionCyclin-A2Homo sapiens (human)
G1/S transition of mitotic cell cycleCyclin-dependent kinase 2Homo sapiens (human)
G2/M transition of mitotic cell cycleCyclin-dependent kinase 2Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICyclin-dependent kinase 2Homo sapiens (human)
DNA replicationCyclin-dependent kinase 2Homo sapiens (human)
DNA repairCyclin-dependent kinase 2Homo sapiens (human)
chromatin remodelingCyclin-dependent kinase 2Homo sapiens (human)
DNA-templated transcriptionCyclin-dependent kinase 2Homo sapiens (human)
protein phosphorylationCyclin-dependent kinase 2Homo sapiens (human)
potassium ion transportCyclin-dependent kinase 2Homo sapiens (human)
centriole replicationCyclin-dependent kinase 2Homo sapiens (human)
Ras protein signal transductionCyclin-dependent kinase 2Homo sapiens (human)
regulation of mitotic cell cycleCyclin-dependent kinase 2Homo sapiens (human)
positive regulation of cell population proliferationCyclin-dependent kinase 2Homo sapiens (human)
peptidyl-serine phosphorylationCyclin-dependent kinase 2Homo sapiens (human)
positive regulation of heterochromatin formationCyclin-dependent kinase 2Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCyclin-dependent kinase 2Homo sapiens (human)
positive regulation of DNA-templated DNA replication initiationCyclin-dependent kinase 2Homo sapiens (human)
telomere maintenance in response to DNA damageCyclin-dependent kinase 2Homo sapiens (human)
post-translational protein modificationCyclin-dependent kinase 2Homo sapiens (human)
positive regulation of DNA replicationCyclin-dependent kinase 2Homo sapiens (human)
positive regulation of DNA-templated transcriptionCyclin-dependent kinase 2Homo sapiens (human)
centrosome duplicationCyclin-dependent kinase 2Homo sapiens (human)
cell divisionCyclin-dependent kinase 2Homo sapiens (human)
meiotic cell cycleCyclin-dependent kinase 2Homo sapiens (human)
cellular response to nitric oxideCyclin-dependent kinase 2Homo sapiens (human)
cellular senescenceCyclin-dependent kinase 2Homo sapiens (human)
regulation of anaphase-promoting complex-dependent catabolic processCyclin-dependent kinase 2Homo sapiens (human)
regulation of G2/M transition of mitotic cell cycleCyclin-dependent kinase 2Homo sapiens (human)
signal transductionCyclin-dependent kinase 2Homo sapiens (human)
regulation of gene expressionCyclin-dependent kinase 2Homo sapiens (human)
response to organic substanceCyclin-dependent kinase 2Homo sapiens (human)
regulation of mitotic cell cycleCyclin-dependent kinase 9Homo sapiens (human)
protein phosphorylationCyclin-dependent kinase 9Homo sapiens (human)
DNA repairCyclin-dependent kinase 9Homo sapiens (human)
regulation of DNA repairCyclin-dependent kinase 9Homo sapiens (human)
transcription by RNA polymerase IICyclin-dependent kinase 9Homo sapiens (human)
transcription initiation at RNA polymerase II promoterCyclin-dependent kinase 9Homo sapiens (human)
transcription elongation by RNA polymerase IICyclin-dependent kinase 9Homo sapiens (human)
cell population proliferationCyclin-dependent kinase 9Homo sapiens (human)
replication fork processingCyclin-dependent kinase 9Homo sapiens (human)
regulation of mRNA 3'-end processingCyclin-dependent kinase 9Homo sapiens (human)
positive regulation of transcription elongation by RNA polymerase IICyclin-dependent kinase 9Homo sapiens (human)
positive regulation by host of viral transcriptionCyclin-dependent kinase 9Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICyclin-dependent kinase 9Homo sapiens (human)
regulation of muscle cell differentiationCyclin-dependent kinase 9Homo sapiens (human)
nucleus localizationCyclin-dependent kinase 9Homo sapiens (human)
regulation of cell cycleCyclin-dependent kinase 9Homo sapiens (human)
cellular response to cytokine stimulusCyclin-dependent kinase 9Homo sapiens (human)
negative regulation of protein localization to chromatinCyclin-dependent kinase 9Homo sapiens (human)
positive regulation of protein localization to chromatinCyclin-dependent kinase 9Homo sapiens (human)
transcription elongation-coupled chromatin remodelingCyclin-dependent kinase 9Homo sapiens (human)
protein phosphorylationCyclin-dependent kinase 9Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (26)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCyclin-T1Homo sapiens (human)
DNA bindingCyclin-T1Homo sapiens (human)
chromatin bindingCyclin-T1Homo sapiens (human)
protein bindingCyclin-T1Homo sapiens (human)
protein kinase bindingCyclin-T1Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activator activityCyclin-T1Homo sapiens (human)
RNA polymerase bindingCyclin-T1Homo sapiens (human)
7SK snRNA bindingCyclin-T1Homo sapiens (human)
DNA-binding transcription factor bindingCyclin-T1Homo sapiens (human)
molecular condensate scaffold activityCyclin-T1Homo sapiens (human)
protein bindingCyclin-A2Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase regulator activityCyclin-A2Homo sapiens (human)
protein kinase bindingCyclin-A2Homo sapiens (human)
protein domain specific bindingCyclin-A2Homo sapiens (human)
histone kinase activityCyclin-dependent kinase 2Homo sapiens (human)
magnesium ion bindingCyclin-dependent kinase 2Homo sapiens (human)
protein serine/threonine kinase activityCyclin-dependent kinase 2Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activityCyclin-dependent kinase 2Homo sapiens (human)
protein bindingCyclin-dependent kinase 2Homo sapiens (human)
ATP bindingCyclin-dependent kinase 2Homo sapiens (human)
protein domain specific bindingCyclin-dependent kinase 2Homo sapiens (human)
cyclin bindingCyclin-dependent kinase 2Homo sapiens (human)
cyclin-dependent protein kinase activityCyclin-dependent kinase 2Homo sapiens (human)
protein serine kinase activityCyclin-dependent kinase 2Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCyclin-dependent kinase 9Homo sapiens (human)
transcription coactivator bindingCyclin-dependent kinase 9Homo sapiens (human)
DNA bindingCyclin-dependent kinase 9Homo sapiens (human)
chromatin bindingCyclin-dependent kinase 9Homo sapiens (human)
transcription elongation factor activityCyclin-dependent kinase 9Homo sapiens (human)
protein kinase activityCyclin-dependent kinase 9Homo sapiens (human)
protein serine/threonine kinase activityCyclin-dependent kinase 9Homo sapiens (human)
cyclin-dependent protein serine/threonine kinase activityCyclin-dependent kinase 9Homo sapiens (human)
protein bindingCyclin-dependent kinase 9Homo sapiens (human)
ATP bindingCyclin-dependent kinase 9Homo sapiens (human)
RNA polymerase II CTD heptapeptide repeat kinase activityCyclin-dependent kinase 9Homo sapiens (human)
kinase activityCyclin-dependent kinase 9Homo sapiens (human)
protein kinase bindingCyclin-dependent kinase 9Homo sapiens (human)
7SK snRNA bindingCyclin-dependent kinase 9Homo sapiens (human)
protein serine kinase activityCyclin-dependent kinase 9Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (29)

Processvia Protein(s)Taxonomy
nucleolusCyclin-T1Homo sapiens (human)
nucleusCyclin-T1Homo sapiens (human)
nucleusCyclin-T1Homo sapiens (human)
nucleoplasmCyclin-T1Homo sapiens (human)
cytosolCyclin-T1Homo sapiens (human)
cyclin/CDK positive transcription elongation factor complexCyclin-T1Homo sapiens (human)
P-TEFb complexCyclin-T1Homo sapiens (human)
female pronucleusCyclin-A2Homo sapiens (human)
male pronucleusCyclin-A2Homo sapiens (human)
nucleusCyclin-A2Homo sapiens (human)
nucleoplasmCyclin-A2Homo sapiens (human)
cytoplasmCyclin-A2Homo sapiens (human)
cytosolCyclin-A2Homo sapiens (human)
cyclin A2-CDK1 complexCyclin-A2Homo sapiens (human)
cyclin A2-CDK2 complexCyclin-A2Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complexCyclin-A2Homo sapiens (human)
nucleusCyclin-A2Homo sapiens (human)
centrosomeCyclin-A2Homo sapiens (human)
cytoplasmCyclin-A2Homo sapiens (human)
chromosome, telomeric regionCyclin-dependent kinase 2Homo sapiens (human)
condensed chromosomeCyclin-dependent kinase 2Homo sapiens (human)
X chromosomeCyclin-dependent kinase 2Homo sapiens (human)
Y chromosomeCyclin-dependent kinase 2Homo sapiens (human)
male germ cell nucleusCyclin-dependent kinase 2Homo sapiens (human)
nucleusCyclin-dependent kinase 2Homo sapiens (human)
nuclear envelopeCyclin-dependent kinase 2Homo sapiens (human)
nucleoplasmCyclin-dependent kinase 2Homo sapiens (human)
cytoplasmCyclin-dependent kinase 2Homo sapiens (human)
endosomeCyclin-dependent kinase 2Homo sapiens (human)
centrosomeCyclin-dependent kinase 2Homo sapiens (human)
cytosolCyclin-dependent kinase 2Homo sapiens (human)
Cajal bodyCyclin-dependent kinase 2Homo sapiens (human)
cyclin A1-CDK2 complexCyclin-dependent kinase 2Homo sapiens (human)
cyclin A2-CDK2 complexCyclin-dependent kinase 2Homo sapiens (human)
cyclin E1-CDK2 complexCyclin-dependent kinase 2Homo sapiens (human)
cyclin E2-CDK2 complexCyclin-dependent kinase 2Homo sapiens (human)
cyclin-dependent protein kinase holoenzyme complexCyclin-dependent kinase 2Homo sapiens (human)
transcription regulator complexCyclin-dependent kinase 2Homo sapiens (human)
cytoplasmCyclin-dependent kinase 2Homo sapiens (human)
nucleusCyclin-dependent kinase 2Homo sapiens (human)
nucleusCyclin-dependent kinase 9Homo sapiens (human)
nucleusCyclin-dependent kinase 9Homo sapiens (human)
nucleoplasmCyclin-dependent kinase 9Homo sapiens (human)
cyclin/CDK positive transcription elongation factor complexCyclin-dependent kinase 9Homo sapiens (human)
membraneCyclin-dependent kinase 9Homo sapiens (human)
PML bodyCyclin-dependent kinase 9Homo sapiens (human)
cytoplasmic ribonucleoprotein granuleCyclin-dependent kinase 9Homo sapiens (human)
transcription elongation factor complexCyclin-dependent kinase 9Homo sapiens (human)
P-TEFb complexCyclin-dependent kinase 9Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (206)

Assay IDTitleYearJournalArticle
AID1313735Inhibition of human MARK1 (2 to 795 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313685Inhibition of human Cdk2/cyclin A at 0.5 uM using Histone H1 substrate after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313780Inhibition of human TAO1 (1 to 356 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313660Inhibition of human Aurora A (2 to 403 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313713Inhibition of human PKD1 (2 to 912 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313781Inhibition of human ASK1 (670 to 950 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313790Inhibition of human Src (1 to 536 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313757Inhibition of human PIM1 (2 to 313 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313723Inhibition of human PHK assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313821Cell cycle arrest in human HL60 cells assessed as accumulation at G2 phase at 1 uM (Rvb = 5 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313768Inhibition of human PAK4 (2 to 591 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479294Growth inhibition of human MCF7 cells at 10 uM after 48 hrs by MTT assay relative to control
AID1479297Inhibition of CDK9/cyclin T1 (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATP by filter binding assay
AID1313696Inhibition of human p38beta MAPK (1 to 364 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313737Inhibition of human MARK4 (2 to 752 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313716Inhibition of human MNK1 (2 to 424 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313686Inhibition of human Cdk9/T1 using YSPTSPSYSPTSPSYSPTSPKKK peptide as substrate at 0.5 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1572658Inhibition of CDK2/cyclin A (unknown origin) using AAKAKKTPKKAKK-CONH2 as substrate after 20 mins by immunoprecipitation analysis2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs.
AID1313822Cell cycle arrest in human HL60 cells assessed as accumulation at G2 phase at 5 uM (Rvb = 5 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313812Inhibition of human TRKA (441 to 760 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479293Growth inhibition of human MIAPaCa2 cells at 10 uM after 48 hrs by MTT assay relative to control
AID1572663Inhibition of CDK9/cyclin T (unknown origin)2019Bioorganic & medicinal chemistry, 03-01, Volume: 27, Issue:5
A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs.
AID1313714Inhibition of human STK33 (1 to 514 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313765Inhibition of human HIPK3 (161 to 562 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313773Inhibition of human MST4 (2 to 416 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479295Growth inhibition of human Caco2 cells at 10 uM after 48 hrs by MTT assay relative to control
AID1313800Inhibition of human EPHA2 (591 to 976 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313718Inhibition of human MAPKAPK3 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479301Growth inhibition of human MCF7 cells after 48 hrs by MTT assay
AID1313774Inhibition of human GCK (2 to 812 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313841Stability in pH 4 buffer at 120 ug/ml after 8 hrs by RP-HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313829Thermodynamic equilibrium solubility in water at 120 ug/ml by HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313835Distribution coefficient, logD of the compound in water/PBS buffer at pH 7.4 at 25 degC after 20 mins by shake flask method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313806Inhibition of human EPHB4 (561 to 997 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313820Cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 10 uM (Rvb = 59 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID468351Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.
AID468352Cytotoxicity against human A549 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.
AID1313830Thermodynamic equilibrium solubility in PBS buffer at 120 ug/ml at pH 7.4 by HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313804Inhibition of human EPHB2 (560 to 987 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313843Stability in pH 7.4 buffer at 120 ug/ml after 8 hrs by RP-HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479292Growth inhibition of human PC3 cells at 10 uM after 48 hrs by MTT assay relative to control
AID468350Cytotoxicity against human NCI-H226 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.
AID1313738Inhibition of human BRSK1 (2 to 778 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313691Inhibition of human ERK1 (1 to 379) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313675Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313690Inhibition of human ERK2 (2 to 360 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313754Inhibition of human IKKb (1 to 736 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313704Inhibition of human PKBbeta assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479302Growth inhibition of human Caco2 cells after 48 hrs by MTT assay
AID1313799Inhibition of human TIE2 (771 to 1124 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313786Inhibition of human OSR1 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313825Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 5 uM (Rvb = 36 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313788Inhibition of human MPSK1 (1 to 305 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313836Ionization constant, pKa of the compound in buffer at pH 1 to 13 by uV spectrophotometry2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313669Cytotoxicity against human BxPC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313837Inhibition of human Cdk2/cyclin A using histone H1 substrate after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313798Inhibition of human ZAP70 (1 to 619 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313828Partition coefficient, logP of the compound in water/PBS buffer at 25 degC by OECD guidelines based method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313748Inhibition of human TTBK1 (1 to 1321 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313688Inhibition of human MKK2 (2 to 400 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313758Inhibition of human PIM2 (2 to 334 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313667Cytotoxicity against human MIAPaCa2 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313725Inhibition of human CHK1 (1 to 476 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313741Inhibition of human NUAK1 (2 to 660 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313717Inhibition of human MNK2 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313710Inhibition of human PKCalpha (1 to 672 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313663Cytotoxicity against human HL60 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313785Inhibition of human IRAK4 (14 to 460 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313750Inhibition of human DYRK2 (3 to 528 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313814Inhibition of human VEGFR assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313805Inhibition of human EPHB3 (561 to 998 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313777Inhibition of human MLK1 (132 to 413 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313678Cytotoxicity against human T47D cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479296Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATP by filter binding assay
AID1313689Inhibition of human MKK6 (2 to 334 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313824Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 1 uM (Rvb = 36 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313731Inhibition of human Aurora B (1 to 344 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313813Inhibition of human DDR2 (467 to 854 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313722Inhibition of human SmMLCK (475 to 838 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313732Inhibition of human TLK1 (1 to 766 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313766Inhibition of human CLK2 (138 to 499 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313791Inhibition of human LCK (2 to 509 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313772Inhibition of human MST3 (2 to 431 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313730Inhibition of human PLK1 (1 to 603 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313698Inhibition of human p38delta MAPK (1 to 365 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313770Inhibition of human PAK6 (2 to 681 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313680Cytotoxicity against human U251 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313679Cytotoxicity against human SF295 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313733Inhibition of human LKB1 (1 to 433 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313845Stability in SIF solution assessed as reduction in compound AUC at 120 ug/ml after 8 hrs by RP-HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID468348Cytotoxicity against human HL60 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.
AID1313705Inhibition of human SGK1 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313729Inhibition of human Cdk9/T1 using YSPTSPSYSPTSPSYSPTSPKKK peptide as substrate assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313708Inhibition of rat ROCK2 (2 to 543 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313677Cytotoxicity against human Hs578T cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313826Cell cycle arrest in human HL60 cells assessed as accumulation at S phase at 10 uM (Rvb = 36 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313816Induction of apoptosis in human HL60 cells assessed as apoptotic cells at 1 uM (Rvb = 1 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313753Inhibition of human NEK6 (8 to 313 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313761Inhibition of human EF2K (2 to 725 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313755Inhibition of human IKKe (1 to 716 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313706Inhibition of human S6K1 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313747Inhibition of human CK2 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313794Inhibition of human ABL (118 to 535 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313683Cytotoxicity against human FR2 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313762Inhibition of human EIF2AK3 (536 to 1116 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313775Inhibition of human MINK1 (1 to 320 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479290Inhibition of CDK9/cyclin T1 (unknown origin) at 0.5 uM using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATP by filter binding assay relative to control
AID1313673Cytotoxicity against human DU145 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313751Inhibition of human DYRK3 (1 to 588 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313728Inhibition of human Cdk2/cyclin A assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313808Inhibition of human HER4 (706 to 991 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313662Inhibition of human MARK2 (2 to 691 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313739Inhibition of human BRSK2 (2 to 674residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313681Cytotoxicity against human SNB75 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313695Inhibition of human p38alpha MAPK (1-360 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313664Cytotoxicity against human MOLT4 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313719Inhibition of human PRAK (1 to 471 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313715Inhibition of human MSK1 (2 to 802 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313687Inhibition of human MKK1 (2 to 393 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479299Growth inhibition of human PC3 cells after 48 hrs by MTT assay
AID1479291Growth inhibition of human HL60 cells at 10 uM after 48 hrs by MTT assay relative to control
AID1313694Inhibition of human JNK3 (40 to 422 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313815Induction of apoptosis in human HL60 cells assessed as apoptotic cells at 5 uM (Rvb = 1 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313707Inhibition of human PKA assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313833Partition coefficient, logP of the compound in water/PBS buffer at 25 degC by retention time method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313782Inhibition of human TAK1 (1 to 303 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313746Inhibition of human CK1delta (1 to 415 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313802Inhibition of human EPHA4 (580 to 986 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1304593Antiinflammatory activity in po dosed rat assessed as inhibition of reverse passive arthus reaction2016Journal of natural products, Mar-25, Volume: 79, Issue:3
Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).
AID1313769Inhibition of human PAK5 (2 to 719 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313811Inhibition of human IRR (944 to 1236 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313671Cytotoxicity against human PSN1 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313776Inhibition of human MEKK1 (877 to1563 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313712Inhibition of human PKCzeta (2 to 592 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313783Inhibition of human IRAK1 (1 to 712 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313823Cell cycle arrest in human HL60 cells assessed as accumulation at G2 phase at 10 uM (Rvb = 5 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313832Thermodynamic equilibrium solubility in stimulated intestinal fluid at 120 ug/ml at pH 6.8 by HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313801Inhibition of human BRK (1 to 451 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313674Cytotoxicity against human LNCAP cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313740Inhibition of human MELK (2 to 651 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313819Cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 5 uM (Rvb = 59 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313838Inhibition of human Cdk9/T1 using YSPTSPSYSPTSPSYSPTSPKKK peptide as substrate after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313742Inhibition of human SIK2 (2 to 962 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313779Inhibition of human TESK1 (1 to 345 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313684Cytotoxicity against HEK293 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313700Inhibition of human RSK1 (1 to 735 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313721Inhibition of human CAMK1 (1 to 541 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313792Inhibition of human CSK (1 to 450 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313666Cytotoxicity against human THP1 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313844Stability in SGF solution at 120 ug/ml after 8 hrs by RP-HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313793Inhibition of human YES1 (1 to 543 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313749Inhibition of human DYRK1A (1 to 502 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313724Inhibition of human DAPK1 (1 to 363) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313701Inhibition of human RSK2 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313709Inhibition of human PRK2 (501 to 984 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313817Induction of apoptosis in human HL60 cells assessed as apoptotic cells at 10 uM (Rvb = 1 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313697Inhibition of human p38gamma MAPK (1 to 367 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313736Inhibition of human MARK3 (2 to 729 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479298Growth inhibition of human HL60 cells after 48 hrs by MTT assay
AID1313795Inhibition of human BTK (2 to 659 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313797Inhibition of human SYK (1 to 635 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313745Inhibition of human CK1gamma2 (1 to 415 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313676Cytotoxicity against human MDA-MB-468 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313764Inhibition of human HIPK2 (165 to 564 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313661Inhibition of human MAPKAPK2 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313756Inhibition of human TBK1 (1 to 729 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313699Inhibition of human ERK8 (2 to 544 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313711Inhibition of human PKCgamma (1 to 697 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313787Inhibition of human TTK (1 to 857 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313760Inhibition of human SRPK1 (2 to 654 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313763Inhibition of human HIPK1 (158 to 555 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID468349Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay2009Journal of natural products, Oct, Volume: 72, Issue:10
Chrotacumines A-D, chromone alkaloids from Dysoxylum acutangulum.
AID1313720Inhibition of human CAMKKbeta (1 to 541 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313778Inhibition of human MLK3 (96 to 386 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313726Inhibition of human CHK2 (5 to 543 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313818Cell cycle arrest in human HL60 cells assessed as accumulation at G1 phase at 1 uM (Rvb = 59 %)2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313803Inhibition of human EPHB1 (565 to 984 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313692Inhibition of human JNK1 (1 to 384 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313682Cytotoxicity against human SF539 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313807Inhibition of human FGFR1 (400 to 820 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313744Inhibition of human TSSK1 (1 to 367 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313810Inhibition of human IR (1001 to 1382 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313727Inhibition of human GSK3beta (2 to 420 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313809Inhibition of human IGF1R (954 to 1367 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313784Inhibition of human RIPK2 (2 to 311 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479289Inhibition of CDK2/cyclin A (unknown origin) at 0.5 uM using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATP by filter binding assay relative to control
AID1313743Inhibition of human SIK3 (2 to 1369 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313767Inhibition of human PAK2 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313703Inhibition of human PKBalpha assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313668Cytotoxicity against human PANC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313759Inhibition of human PIM3 (2 to 326 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313789Inhibition of human WNK1 (1 to 661 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313831Thermodynamic equilibrium solubility in stimulated gastric fluid at 120 ug/ml at pH 1.2 by HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313834Partition coefficient, logP of the compound in water/PBS buffer at pH 7.4 at 25 degC after 20 mins by shake flask method2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313771Inhibition of human MST2 (2 to 491 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313842Stability in pH 6.8 buffer at 120 ug/ml after 8 hrs by RP-HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313752Inhibition of human NEK2a (1 to 445 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1479300Growth inhibition of human MIAPaCa2 cells after 48 hrs by MTT assay
AID1313672Cytotoxicity against human PC3 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313693Inhibition of human JNK2 (1 to 424 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313840Stability in pH 1.2 buffer at 120 ug/ml after 8 hrs by RP-HPLC analysis2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313670Cytotoxicity against human AsPC1 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313702Inhibition of human PDK1 (52 to 556 residues) assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313796Inhibition of human JAK2 assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313665Cytotoxicity against human K562 cells assessed as cell growth inhibition after 48 hrs by MTT assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
AID1313734Inhibition of human AMPK assessed as remaining enzyme activity at 50 uM after 30 mins by 33P-ATP filter-binding assay2016Bioorganic & medicinal chemistry letters, 08-01, Volume: 26, Issue:15
A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (40.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other3 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
quercetin
[no description available]		3.31107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		3.3110trihydroxyflavoneantineoplastic agent;
metabolite
luteolin
[no description available]		3.31103'-hydroxyflavonoid;
tetrahydroxyflavone		angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
kaempferol
[no description available]		3.31107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
baicalein
[no description available]		3.3110trihydroxyflavoneangiogenesis inhibitor;
anti-inflammatory agent;
antibacterial agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antioxidant;
apoptosis inducer;
EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor;
EC 4.1.1.17 (ornithine decarboxylase) inhibitor;
ferroptosis inhibitor;
geroprotector;
hormone antagonist;
plant metabolite;
prostaglandin antagonist;
radical scavenger
chrysin
chrysin : A dihydroxyflavone in which the two hydroxy groups are located at positions 5 and 7.		3.31107-hydroxyflavonol;
dihydroxyflavone		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
EC 2.7.11.18 (myosin-light-chain kinase) inhibitor;
hepatoprotective agent;
plant metabolite
fisetin
[no description available]		3.31103'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
hispidulin
hispidulin : A monomethoxyflavone that is scutellarein methylated at position 6.		3.3110monomethoxyflavone;
trihydroxyflavone		anti-inflammatory agent;
anticonvulsant;
antineoplastic agent;
antioxidant;
apoptosis inducer;
plant metabolite
morin
morin: a light yellowish pigment found in the wood of old fustic (Chlorophora tinctoria). morin : A pentahydroxyflavone that is 7-hydroxyflavonol bearing three additional hydroxy substituents at positions 2' 4' and 5.		3.31107-hydroxyflavonol;
pentahydroxyflavone		angiogenesis modulating agent;
anti-inflammatory agent;
antibacterial agent;
antihypertensive agent;
antineoplastic agent;
antioxidant;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
hepatoprotective agent;
metabolite;
neuroprotective agent
myricetin
[no description available]		3.31107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
quercetagetin
quercetagetin: structure given in first source; inhibits aldose reductase in rat lens. quercetagetin : A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.		3.3110flavonols;
hexahydroxyflavone		antioxidant;
antiviral agent;
plant metabolite
tricetin
tricetin : Flavone hydroxylated at positions 3', 4', 5, 5' and 7.		3.3110pentahydroxyflavoneantineoplastic agent;
metabolite
wogonin
wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.		3.3110dihydroxyflavone;
monomethoxyflavone		angiogenesis inhibitor;
antineoplastic agent;
cyclooxygenase 2 inhibitor;
plant metabolite
alvocidib
alvocidib: structure given in first source. alvocidib : A synthetic dihydroxyflavone that is 5,7-dihydroxyflavone which is substituted by a 3-hydroxy-1-methylpiperidin-4-yl group at position 8 and by a chlorine at the 2' position (the (-)-3S,4R stereoisomer). A cyclin-dependent kinase 9 (CDK9) inhibitor, it has been studied for the treatment of acute myeloid leukaemia, arthritis and atherosclerotic plaque formation.		4.4530dihydroxyflavone;
hydroxypiperidine;
monochlorobenzenes;
tertiary amino compound		antineoplastic agent;
antirheumatic drug;
apoptosis inducer;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
p276-00
P276-00: antineoplastic, cyclin-dependent kinase inhibitor; structure in first source		3.3110
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		03.1210
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.1210