Fatty Liver with Encephalopathy

A form of encephalopathy with fatty infiltration of the LIVER, characterized by brain EDEMA and VOMITING that may rapidly progress to SEIZURES; COMA; and DEATH. It is caused by a generalized loss of mitochondrial function leading to disturbances in fatty acid and CARNITINE metabolism.

Synonym
Reye's-Like Syndrome
Reye's Syndrome
Reye-Like Syndrome
Reye's Syndrome, Adult
Reye-Johnson Syndrome
Fatty Liver with Encephalopathy
Reye Syndrome, Adult
Reye Syndrome

Excerpt	Reference
"Since Reye's syndrome is associated with hyperammonemia, we measured the urea-cycle enzymes in hepatic tissue of 13 patients."	( Bove, K; Brown, H; Brown, T; Hug, G; Lansky, L; Lloyd-Still, J; Partin, JC; Ryan, M; Scheve, A; Schubert, WK, 1976)
"Reye syndrome is biochemically distinct from the clinically similar syndrome of systemic carnitine deficiency."	( Chutorian, AM; DiMauro, S; Willner, JH, 1978)
"Reye's syndrome is an acute encephalopathy and fatty liver which has mainly been recognized in children through the age of about 16 years."	( Partin, JC, 1975)
"Reye's syndrome is difined as fatty degeneration of the viscera with encephalopathy."	( Berman, W; Holzhapple, W; Pizzi, FJ; Schut, L, 1976)
"Reye's syndrome is an acute disease of childhood characterized by non-inflammatory cerebral pathology associated with hepatic pathology (steatosis)."	( Hartemann, E, 1990)
"Reye's syndrome is a serious childhood disorder that develops following influenza infections and is characterized in part by an encephalopathy, hyperammonemia and elevated serum transaminases."	( Deshmukh, DR; Thomas, PE, 1985)
"The vomiting of Reye's syndrome is usually persistent, lasting for 24 to 96 hours before the onset of serious brain signs."	( Partin, JC, 1985)
"A patient with Reye syndrome is described in whom cerebral perfusion pressure was reduced to less than 5 mmHg with loss of EEG activity."	( McWilliam, RC; Stephenson, JB, 1985)
"In Europe Reye's syndrome is a rather rare but often fatal disease affecting children and teenagers."	( Plauth, M, 1984)
"Reye's syndrome is a virus-associated biphasic disease that causes acute encephalopathy in infants and children."	( Bagnell, PC; Crocker, JF, 1981)
"Reye's syndrome is a serious childhood disease usually associated with an antecedent viral illness such as influenza or chicken pox."	( Bailey, JM; Low, CE; Pupillo, MB, 1982)
"A case of adult Reye's syndrome is described."	( Arai, M, 1996)
"Reye's syndrome is most frequently seen in children but has also been described in adults."	( Bain, VG; Duerksen, DR; Jewell, LD; Mason, AL, 1997)
"Reye's syndrome is characterized by encephalopathy and fatty degeneration of the liver, usually after influenza or varicella."	( Belay, ED; Bresee, JS; Holman, RC; Khan, AS; Schonberger, LB; Shahriari, A, 1999)
"Because Reye's syndrome is now very rare, any infant or child suspected of having this disorder should undergo extensive investigation to rule out the treatable inborn metabolic disorders that can mimic Reye's syndrome."	( Belay, ED; Bresee, JS; Holman, RC; Khan, AS; Schonberger, LB; Shahriari, A, 1999)
"Reye syndrome is a non-specific descriptive term covering a group of heterogeneous disorders."	( Casteels-Van Daele, M; Eggermont, E; Van Geet, C; Wouters, C, 2000)
"Reye syndrome is characterized by acute encephalopathy and fatty degeneration of the liver almost exclusively in children."	( Calvani, M, 2000)
"Idiopathic Reye syndrome is a rare disease revealed by unexplained encephalopathy and microvesicular liver steatosis."	( Brivet, M; Chevret, L; Debray, D; Devictor, D; Durand, P; Fabre, M; Thabet, F, 2002)
"Reye's syndrome is a serious, acute encephalopathy that has been linked with aspirin (acetylsalicylic acid) use in children and teenagers <18 years of age."	( Glasgow, JF, 2006)
"Reye syndrome is an extremely rare but severe and often fatal disease."	( Schrör, K, 2007)
"Twelve cases of Reye's syndrome are presented with different degrees of encephalopathy, hyperammonemia and hypoglycemia; associated to acetyl salicylic acid (ASA) ingestion."	( Coll, C; Fernández, MA; Filinger, EJ; Lemberg, A; Perazzo, JC; Romay, S; Rosello, DO, 2009)
"The Reye syndrome is a complex disease that remains little-known despite its severity."	( Duh, D; Tanret, I, 2011)
"Reye's syndrome is an acute illness characterized by hepatic encephalopathy and fatty degeneration of the liver."	( Böhm, M; Kaplan, BT; Link, A, 2012)
"Reye syndrome is a rare but a very dangerous emergency that children and teenagers suffer."	( Boyarchuk, O; Chornomydz, A; Chornomydz, I, 2017)
"Reye Syndrome is an acute encephalopathy with increased liver enzymes and blood ammonia, without jaundice."	( Angoulvant, F; Arnoux, JB; Brassier, A; de Lonlay, P; Debray, D; Girard, M; Goetz, V; Heilbronner, C; Lacaille, F; Oualha, M; Pelosi, M; Renolleau, S; Salvador, E; Schiff, M; Yang, DD, 2022)

Excerpt	Reference
"Reye syndrome has emerged as the quintessential example of an acute metabolic encephalopathy."	( De Vivo, DC, 1985)
"The incidence of Reye syndrome has been decreasing in Michigan, perhaps as a result of decreased aspirin use among children."	( Hall, WN; McGee, H; Monto, AS; Remington, PL; Rowley, D, 1986)
"Reye's syndrome has been infrequently described in children receiving long-term salicylate therapy."	( Hendriksen, D; Torretti, D; Williams, RH; Woods, M; Young, RS, 1984)
"The cause of Reye's syndrome has not been completely defined."	( Nakamura, Y; Yamamoto, M, 1994)

Excerpt	Reference
"Fifty-eight children with Reye's syndrome (RS) confirmed by liver biopsy were treated at the University of Cincinnati between 1963 and 1974."	( Linnemann, CC; Partin, JC; Schiff, GM; Schubert, WK; Shea, L, 1975)
"Sixteen patients with Reye's syndrome were seen over a 3-year period and treated with conservative management with an overall mortality of 31%."	( Bresnan, MJ; Lombroso, CT; Lovejoy, FH; Smith, AL, 1975)
"This case study shows that Reye's syndrome causes altered valproate metabolism, consistent with the defective mitochondrial beta-oxidation of medium chain fatty acids, and suggests that valproic acid should not be used in the treatment of seizures in patients with this syndrome."	( Fujii, H; Inoue, Y; Kitamura, K; Kuhara, T; Matsumoto, I; Matsumoto, M; Sakura, N; Shinka, T, 1985)
"A 14-year-old girl in whom Reye syndrome developed during aspirin therapy for an inflammatory disorder proven to be systemic lupus erythematosus is reported."	( Bale, JF; Corbett, AJ; Flanders, DJ; Hansen, JR; McCray, PB, 1985)
"Recent studies of Reye syndrome (RS) patients have suggested aspirin treatment as a possible factor in the etiology of this often fatal childhood disorder."	( Deshmukh, DR; Maassab, HF; Mason, M, 1982)
"Although the underlying cause of Reye syndrome is not understood, an effective approach to treatment is based on reversing the known metabolic and pathological abnormalities."	( Trauner, DA, 1980)
"Because Reye's syndrome is now very rare, any infant or child suspected of having this disorder should undergo extensive investigation to rule out the treatable inborn metabolic disorders that can mimic Reye's syndrome."	( Belay, ED; Bresee, JS; Holman, RC; Khan, AS; Schonberger, LB; Shahriari, A, 1999)
"This report describes a patient with Reye's syndrome and serves as a reminder for health professionals to continue to discourage the use of aspirin for the treatment of viral infections."	( Bhutta, AT; Schexnayder, SM; Van Savell, H, 2003)
"Compared with rats with untreated Reye's syndrome, 1 h pretreatment by low dose resveratrol (10 mg/kg by oral gavage) resulted in marked amelioration in liver functions in the form of significant decrease in serum transaminases (AST, ALT) and plasma ammonia levels, shortening of prothrombin time, and increase in serum albumin levels."	( Abdin, A; Sarhan, N, 2014)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	523 (71.25)	23.3326
1990's	119 (16.21)	12.5806
2000's	64 (8.72)	18.1394
2010's	22 (3.00)	28.8240
2020's	6 (0.82)	9.53

Drug	Relationship Strength	Studies	Trials
acetylcarnitine	low	3	0
3-phenylpropionic acid	low	1	0
gamma-aminobutyric acid	low	14	0
4-hydroxybenzoic acid	low	1	0
adipic acid	low	1	0
allantoin	low	3	0
ammonium hydroxide	low	115	0
benzoic acid	low	2	0
carbamates	low	1	0
carnitine	medium	65	1
choline	low	2	0
aconitic acid	low	1	0
chlorine	low	1	0
salicylic acid	low	15	0
octanoic acid	low	5	0
3-hydroxybutyric acid	low	3	0
bupropion	low	1	0
hippuric acid	low	1	0
methylmalonic acid	low	2	0
lactic acid	low	2	0
glutaric acid	low	2	0
glycine	low	4	0
glycerol	low	10	0
hydrogen carbonate	low	2	0
dihydroxyphenylalanine	low	1	0
orotic acid	low	8	0
palmitic acid	low	2	0
pentachlorophenol	low	1	0
propionic acid	low	1	0
putrescine	low	1	0
pyridoxal phosphate	low	1	0
pyruvic acid	low	2	0
spermidine	low	1	0
spermine	low	1	0
succinic acid	low	1	0
uric acid	low	6	0
urea	low	35	0
1-anilino-8-naphthalenesulfonate	low	2	0
2,4-dichlorophenoxyacetic acid	low	1	0
meglutol	low	2	0
3-nitropropionic acid	low	1	0
homovanillic acid	low	2	0
hydroxyindoleacetic acid	low	1	0
acetaminophen	low	32	0
amantadine	low	3	0
amiodarone	low	2	0
aspirin	low	247	0
pantogab	low	11	0
camphor, (+-)-isomer	low	1	0
carbamazepine	low	1	0
diclofenac	low	2	0
ddt	low	2	0
pentetic acid	low	1	0
dipyridamole	low	1	0
valproic acid	low	23	0
domperidone	low	1	0
furosemide	low	3	0
2,5-dihydroxybenzoic acid	low	1	0
hydroxychloroquine	low	1	0
ibuprofen	low	4	0
lidocaine	low	1	0
indomethacin	low	2	0
isoproterenol	low	1	0
metoclopramide	low	2	0
midazolam	low	1	0
deet	low	1	0
apnea	low	2	0
nimesulide	low	1	0
octopamine	low	1	0
pentobarbital	low	10	0
phenobarbital	low	6	0
phenylbutazone	low	1	0
prochlorperazine	low	1	0
promethazine	low	1	0
succinylcholine	low	1	0
sulfacetamide	low	1	0
tyramine	low	5	0
penicillamine	low	1	0
prednisone	low	2	0
chloramphenicol	low	2	0
glutamine	low	4	0
lysine	low	4	0
cyanides	low	2	0
physostigmine	low	2	0
ethinyl estradiol	low	1	0
aminopyrine	low	1	0
adenosine diphosphate	low	5	0
levodopa	low	3	0
tyrosine	low	3	0
leucine	low	2	0
phenylalanine	low	1	0
egtazic acid	low	1	0
barbituric acid	low	1	0
ampicillin	low	2	0
mannitol	low	27	0
cytarabine	low	1	0
ornithine	low	8	0
histidine	low	1	0
arginine	low	12	0
3-mercaptopropionic acid	low	1	0
isobutyric acid	low	1	0
pantothenic acid	low	12	0
methylprednisolone	low	2	0
rotenone	low	2	0
quinoxalines	low	1	0
phenothiazine	low	1	0
propylparaben	low	1	0
3-hydroxybenzoic acid	low	1	0
boric acid	low	1	0
methyl malonate	low	1	0
dicofol	low	1	0
framycetin	low	5	0
thiazoles	low	1	0
evans blue	low	1	0
citrulline	low	9	0
glycocholic acid	low	1	0
fusarium	low	1	0
isovaleric acid	low	1	0
suberic acid	low	1	0
malondialdehyde	low	3	0
ethylmalonic acid	low	1	0
acetylcysteine	low	1	0
glycochenodeoxycholic acid	low	1	0
d-alpha tocopherol	low	1	0
stavudine	low	1	0
vidarabine	low	2	0
gadolinium	low	1	0
gold	low	2	0
ferric chloride	low	1	0
ammonium chloride	low	2	0
tetradecanoylphorbol acetate	low	1	0
bromocriptine	low	1	0
fenitrothion	low	2	0
glutamic acid	low	1	0
s-adenosylmethionine	low	5	0
etoposide	low	1	0
4-pentenoic acid	low	10	0
thiazolyl blue	low	1	0
coenzyme a	low	3	0
n-caproylglycine	low	1	0
propionylcarnitine	low	1	0
valerates	low	8	0
caprylates	low	13	0
octanoyl-coenzyme a	low	1	0
methotrexate	low	1	0
3-hydroxy-2-methylvalerate	low	1	0
saccharopine	low	1	0
5-hydroxyhexanoic acid	low	1	0
biotin	low	2	0
atropine	low	1	0
aflatoxin b1	low	4	0
benzofurans	low	1	0
glycogen	low	9	0
bradykinin	low	1	0
pancuronium	low	4	0
maleic acid	low	1	0
acetyl coenzyme a	low	2	0
arachidonic acid	low	1	0
resveratrol	low	1	0
oleic acid	low	2	0
riboflavin	low	3	0
sodium bicarbonate	low	1	0
dipyrone	low	1	0
stilbenes	low	1	0
malonyl coenzyme a	low	1	0
flunarizine	low	1	0
3-methylglutaconic acid	low	2	0
3-phenylpropionylglycine	low	2	0
D-fructopyranose	low	1	0
digoxin	low	1	0
thiopental	low	3	0
panadiplon	low	1	0
glycodeoxycholic acid	low	1	0
quercetin	low	1	0
bilirubin	low	6	0
linoleic acid	low	1	0
vitamin k semiquinone radical	low	3	0
alpha-linolenic acid	low	1	0
zearalenone	low	1	0
coenzyme q10	low	1	0
isotretinoin	low	1	0
16,16-dimethylprostaglandin e2	low	1	0
lysophosphatidylcholines	low	1	0
bismuth	low	3	0
phosphorus	low	4	0
oleoyl-coenzyme a	low	1	0
antimycin a	low	1	0
trans-2-en-valproate	low	1	0
suberylglycine	low	1	0
tiapamil hydrochloride	low	1	0
octadecenedioic acid	low	1	0
oxadiazoles	low	1	0
lactulose	low	2	0
losartan potassium	low	1	0
octanoylcarnitine	medium	3	1
calcimycin	low	1	0
sepharose	low	1	0
pituitrin	low	1	0
clove	low	1	0
aflatoxin m1	low	1	0
nad	low	2	0
glucagon	low	4	0
phosphatidylcholines	low	1	0
atractyloside	low	1	0
bismuth subsalicylate	low	3	0
ubiquinone	low	3	0
ethybenztropine	low	1	0
bucladesine	low	1	0
colistin	low	1	0
kavain	low	1	0
salicylates	low	88	0
warfarin	low	1	0
choline salicylate	low	2	0
bismuth salicylate	low	1	0
glutaminase	low	1	0
oligomycins	low	2	0
carboxyatractyloside	low	1	0
cyclosporine	low	2	0
exudates	low	4	0
acyclovir	low	3	0
guanosine triphosphate	low	1	0
guanine	low	1	0
didanosine	low	1	0
ganciclovir	low	1	0
trypsinogen	low	1	0

Protein Targets (1,766)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	11	0	0	11
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	5	0	0	5
thioredoxin reductase	45	0	0	45
USP1 protein, partial	33	0	0	33
TDP1 protein	53	0	0	53
vitamin D3 receptor isoform VDRA	23	0	0	23
importin subunit beta-1 isoform 1	9	0	0	9
flap endonuclease 1	15	0	0	15
serine/threonine-protein kinase PLK1	8	0	0	8
snurportin-1	9	0	0	9
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	12	0	0	12
GTP-binding nuclear protein Ran isoform 1	4	0	0	4
DNA polymerase eta isoform 1	7	0	0	7
DNA polymerase iota isoform a (long)	26	0	0	26
urokinase-type plasminogen activator precursor	10	0	0	10
plasminogen precursor	10	0	0	10
urokinase plasminogen activator surface receptor precursor	10	0	0	10
geminin	58	0	0	58
DNA polymerase kappa isoform 1	19	0	0	19
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	3	0	3
Transthyretin	0	0	4	6
Fatty acid-binding protein, intestinal	0	4	1	5
Fatty acid-binding protein, adipocyte	0	8	3	11
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	2	1	3
Cyclin-dependent kinase 2	0	2	2	4
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	7	0	0	7
Fatty acid-binding protein 5	0	5	2	7
Fatty acid-binding protein 5	0	0	2	2
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	3	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	32	0	0	32
Luciferase	26	0	0	26
SMAD family member 2	17	0	0	17
SMAD family member 3	17	0	0	17
AR protein	66	0	0	66
progesterone receptor	34	0	0	34
retinoid X nuclear receptor alpha	43	0	0	43
estrogen-related nuclear receptor alpha	59	0	0	59
estrogen nuclear receptor alpha	85	0	0	85
peroxisome proliferator-activated receptor delta	31	0	0	31
vitamin D (1,25- dihydroxyvitamin D3) receptor	37	0	0	37
thyroid hormone receptor beta isoform 2	51	0	0	51
nuclear factor erythroid 2-related factor 2 isoform 1	47	0	0	47
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial	0	1	0	1
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	0	1	0	1
chromobox protein homolog 1	37	0	0	37
Carbonic anhydrase 12	0	11	0	18
Carbonic anhydrase 1	0	22	0	32
Carbonic anhydrase 2	0	23	2	35
72 kDa type IV collagenase	0	2	0	2
Matrilysin	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	4
Aminopeptidase N	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	4	0	4
Tyrosine-protein phosphatase non-receptor type 1	0	8	0	10
Carbonic anhydrase 7	0	10	0	17
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	0	1	0	1
Alpha-(1,3)-fucosyltransferase 7	0	1	0	1
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	0	1	0	1
Carbonic anhydrase 9	0	13	0	20
Carbonic anhydrase 14	0	10	0	17
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain A, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain M, PROTOCATECHUATE 3,4-DIOXYGENASE	0	2	0	2
Chain A, Protocatechuate 3,4-dioxygenase	0	2	0	2
Chain M, Protocatechuate 3,4-dioxygenase	0	2	0	2
retinoic acid nuclear receptor alpha variant 1	60	0	0	60
Vitamin D3 receptor	0	0	0	1
Carbonic anhydrase 6	0	10	0	17
Carbonic anhydrase	0	3	0	3
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 1	0	0	1	1
Protein skinhead-1	0	1	0	1
Monocarboxylate transporter 2	0	3	0	3
Solute carrier family 22 member 20	0	13	0	13
Solute carrier family 22 member 6	0	13	0	13
RAR-related orphan receptor gamma	52	0	0	52
Stromelysin-1	0	2	2	4
Beta-lactamase	0	1	0	1
glp-1 receptor, partial	12	0	0	12
acetylcholinesterase	24	0	0	24
GLI family zinc finger 3	50	0	0	50
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	16	0	0	16
glucocorticoid receptor [Homo sapiens]	54	0	0	54
euchromatic histone-lysine N-methyltransferase 2	59	0	0	59
aryl hydrocarbon receptor	23	0	0	23
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	29	0	0	29
thyrotropin-releasing hormone receptor	5	0	0	5
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	21	0	0	21
v-jun sarcoma virus 17 oncogene homolog (avian)	25	0	0	25
Histone H2A.x	18	0	0	18
Bloom syndrome protein isoform 1	28	0	0	28
hemoglobin subunit beta	2	0	0	2
heat shock protein beta-1	24	0	0	24
muscarinic acetylcholine receptor M1	18	0	0	18
lamin isoform A-delta10	58	0	0	58
Voltage-dependent calcium channel gamma-2 subunit	22	0	0	22
Cellular tumor antigen p53	48	0	0	48
Delta-aminolevulinic acid dehydratase	0	2	0	2
Glutamate receptor 2	24	2	1	27
Isocitrate lyase 1	0	1	0	1
Isocitrate lyase	0	1	0	1
TAR DNA-binding protein 43	15	0	0	15
Isocitrate lyase	0	1	0	1
Chain A, Aspartate Aminotransferase	0	0	2	2
Chain B, Aspartate Aminotransferase	0	0	2	2
Chain A, Aspartate Aminotransferase	0	0	2	2
Chain B, Aspartate Aminotransferase	0	0	2	2
Chain A, Aspartate aminotransferase	0	0	2	2
Chain B, Aspartate aminotransferase	0	0	2	2
Chain A, Aspartate aminotransferase	0	0	2	2
Chain A, Aspartate aminotransferase	0	0	2	2
Chain A, Aspartate aminotransferase	0	0	2	2
Chain B, Aspartate aminotransferase	0	0	2	2
Polyphenol oxidase 2	0	7	0	13
C-terminal-binding protein 2	0	2	0	2
Kelch-like ECH-associated protein 1	0	0	1	1
estrogen receptor 2 (ER beta)	36	0	0	36
activating transcription factor 6	27	0	0	27
Carbonic anhydrase 3	0	9	0	14
Tyrosinase	0	5	0	5
D(1A) dopamine receptor	0	12	1	14
Carbonic anhydrase 4	0	14	0	21
Adenosine receptor A1	0	6	0	10
Adenosine receptor A2a	0	5	0	9
Carbonic anhydrase 5A, mitochondrial	0	10	1	18
Thiopurine S-methyltransferase	0	1	0	1
Succinate-semialdehyde dehydrogenase, mitochondrial	0	1	0	1
Alpha-glucosidase MAL12	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	2
Carbonic anhydrase 15	0	11	0	16
Carbonic anhydrase 13	0	8	0	14
Toll-like receptor 2	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	10	0	17
Free fatty acid receptor 3	0	0	2	2
ATAD5 protein, partial	26	0	0	26
GLS protein	35	0	0	35
Microtubule-associated protein tau	30	0	0	30
Smad3	15	0	0	15
aldehyde dehydrogenase 1 family, member A1	43	0	0	43
thyroid stimulating hormone receptor	34	0	0	34
nuclear receptor subfamily 1, group I, member 3	37	0	0	37
EWS/FLI fusion protein	27	0	0	27
peroxisome proliferator activated receptor gamma	37	0	0	37
peripheral myelin protein 22	28	0	0	28
cytochrome P450 3A4 isoform 1	22	0	0	22
Gamma-aminobutyric acid receptor subunit pi	22	7	1	30
ATP-binding cassette sub-family C member 3	0	34	0	34
Multidrug resistance-associated protein 4	0	35	0	36
Solute carrier family 22 member 6	0	8	0	10
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	11	0	11
Bile salt export pump	0	55	0	56
Cytochrome P450 2B1	0	1	0	2
Cytochrome P450 1A1	0	0	0	1
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	3	2	6
Cytochrome P450 1A2	0	4	0	5
Prostaglandin G/H synthase 1	0	10	1	12
Cytochrome P450 3A4	0	14	1	17
Cytochrome P450 2D6	0	6	0	6
Cytochrome P450 2C9	0	13	0	14
Polyunsaturated fatty acid lipoxygenase ALOX15	0	8	0	8
Gamma-aminobutyric acid receptor subunit beta-1	22	7	1	30
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	22	7	1	30
Gamma-aminobutyric acid receptor subunit gamma-2	22	7	2	31
UDP-glucuronosyltransferase 1-6	0	4	0	6
Gamma-aminobutyric acid receptor subunit alpha-5	22	7	1	30
Gamma-aminobutyric acid receptor subunit alpha-3	22	7	1	30
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	5	0	8
Prostaglandin G/H synthase 1	0	12	0	12
Gamma-aminobutyric acid receptor subunit gamma-1	22	7	1	30
Gamma-aminobutyric acid receptor subunit alpha-2	22	7	1	30
Gamma-aminobutyric acid receptor subunit alpha-4	22	7	1	30
Gamma-aminobutyric acid receptor subunit gamma-3	22	7	1	30
Gamma-aminobutyric acid receptor subunit alpha-6	22	7	1	30
Prostaglandin G/H synthase 2	0	12	2	16
Nuclear receptor ROR-gamma	16	1	1	18
Cytochrome P450 2J2	0	8	0	8
Gamma-aminobutyric acid receptor subunit alpha-1	22	8	2	32
Gamma-aminobutyric acid receptor subunit beta-3	22	7	1	30
Gamma-aminobutyric acid receptor subunit beta-2	22	7	2	31
GABA theta subunit	22	7	1	30
Canalicular multispecific organic anion transporter 1	0	31	0	32
Gamma-aminobutyric acid receptor subunit epsilon	22	7	1	30
toxin B	0	0	0	1
N-alpha-acetyltransferase 50	0	0	2	2
Chain A, 2-oxoglutarate Oxygenase	25	0	0	25
Chain A, ATP-DEPENDENT DNA HELICASE Q1	14	0	0	14
dopamine D1 receptor	7	0	0	7
15-lipoxygenase, partial	17	0	0	17
pregnane X receptor	6	0	0	6
phosphopantetheinyl transferase	24	0	0	24
NFKB1 protein, partial	13	0	0	13
Thrombopoietin	6	0	0	6
regulator of G-protein signaling 4	26	0	0	26
farnesoid X nuclear receptor	31	0	0	31
arylsulfatase A	19	0	0	19
D(1A) dopamine receptor	16	0	0	16
thyroid hormone receptor beta isoform a	29	0	0	29
survival motor neuron protein isoform d	17	0	0	17
Histone deacetylase 3	0	4	0	4
Histone deacetylase 4	0	4	0	4
Histone deacetylase 1	0	4	0	4
Histone deacetylase 7	0	4	0	4
Histone deacetylase 2	0	4	0	4
Polyamine deacetylase HDAC10	0	4	0	4
Histone deacetylase 11	0	4	0	4
Ataxin-2	24	0	0	24
Histone deacetylase 8	0	4	0	4
Histone deacetylase 6	0	4	0	4
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	4	0	4
ATP-dependent phosphofructokinase	35	0	0	35
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	23	0	0	23
Chain B, HADH2 protein	23	0	0	23
Chain A, Ferritin light chain	12	0	0	12
Thymidine kinase	0	2	0	2
atrial natriuretic peptide receptor 1 precursor	4	0	0	4
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
Solute carrier family 22 member 1	0	8	0	13
Purine nucleoside phosphorylase	0	3	0	3
Thymidine kinase, cytosolic	0	2	0	5
POU domain, class 2, transcription factor 2	0	0	0	2
Disintegrin and metalloproteinase domain-containing protein 17	5	0	0	5
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	8	0	14
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	7	0	9
Thymidine kinase	0	2	0	2
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
Heat shock protein HSP 90-beta	0	1	1	3
2-dehydropantoate 2-reductase	0	1	2	3
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	3	0	3
Mu-type opioid receptor	0	10	2	13
Delta-type opioid receptor	0	4	2	7
Kappa-type opioid receptor	0	8	2	11
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	1	1
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	1	2
P2X purinoceptor 4	0	0	2	2
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	10	0	0	10
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	1	1
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	2	1	3
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	2	2
cytochrome P450 family 3 subfamily A polypeptide 4	32	0	0	32
cytochrome P450 2D6	17	0	0	17
histone acetyltransferase KAT2A isoform 1	25	0	0	25
lethal factor (plasmid)	17	0	0	17
Acetylcholinesterase	0	3	0	3
Acetylcholinesterase	0	9	0	10
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	33	0	0	33
RGS12	2	0	0	2
Alpha-synuclein	2	4	0	6
Chain A, Beta-lactamase	16	0	0	16
Chain A, Cruzipain	12	0	0	12
WRN	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	19	0	0	19
thioredoxin glutathione reductase	6	0	0	6
pregnane X nuclear receptor	41	0	0	41
Caspase-7	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	20	0	0	20
phospholipase A2 precursor	0	1	0	1
caspase-3	5	0	0	5
cysteine protease ATG4B isoform a	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	3	2	0	5
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
Free fatty acid receptor 1	0	0	2	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	13	1	0	14
Prostaglandin G/H synthase 1	0	8	0	10
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Trypsin	0	4	0	4
Coagulation factor VII	0	4	0	4
Aromatase	0	8	0	8
Tissue factor	0	5	0	5
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Histamine H2 receptor	19	0	1	21
Prostaglandin G/H synthase 2	0	12	0	13
Free fatty acid receptor 4	0	0	2	2
signal transducer and activator of transcription 6, interleukin-4 induced	2	0	0	2
putative alpha-glucosidase	1	0	0	1
Solute carrier family 22 member 2	0	5	0	7
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Matrix protein 2	0	1	1	2
Matrix protein 2	0	1	2	3
Glutamate receptor ionotropic, NMDA 1	0	6	4	16
Spike glycoprotein	19	1	3	23
Glutamate receptor ionotropic, NMDA 2A	0	6	3	15
Glutamate receptor ionotropic, NMDA 2B	0	7	4	17
Glutamate receptor ionotropic, NMDA 2C	0	6	3	15
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 2D	0	6	3	15
Solute carrier family 22 member 1	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	6	3	15
Multidrug and toxin extrusion protein 1	0	10	0	10
Solute carrier family 22 member 2	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	6	3	15
interleukin 8	13	0	0	13
G	18	0	0	18
histone deacetylase 9 isoform 3	6	0	0	6
Interferon beta	22	0	0	22
HLA class I histocompatibility antigen, B alpha chain	18	0	0	18
Nicotinate phosphoribosyltransferase	0	6	0	6
Inositol hexakisphosphate kinase 1	18	0	0	18
cytochrome P450 2C9, partial	18	0	0	18
ORF73	0	0	1	1
Fumarate hydratase	10	0	0	10
PPM1D protein	8	0	0	8
caspase 7, apoptosis-related cysteine protease	8	0	0	8
polyprotein	10	0	0	10
caspase-3	8	0	0	8
thyroid stimulating hormone receptor	19	0	0	19
cytochrome P450 2D6 isoform 1	7	0	0	7
cellular tumor antigen p53 isoform a	10	0	0	10
cytochrome P450 2C9 precursor	10	0	0	10
potassium voltage-gated channel subfamily H member 2 isoform d	17	0	0	17
huntingtin isoform 2	4	0	0	4
mitogen-activated protein kinase 1	16	0	0	16
serine/threonine-protein kinase mTOR isoform 1	14	0	0	14
nuclear receptor ROR-gamma isoform 1	17	0	0	17
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	3	0	4
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 4	0	18	0	18
Lysine-specific demethylase PHF2	0	1	0	1
Thyroid hormone receptor alpha	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Integrin beta-3	8	1	1	10
Tyrosine-protein kinase Fyn	0	3	0	3
ATP-dependent translocase ABCB1	0	6	0	6
Aldo-keto reductase family 1 member B1	0	19	0	19
Muscarinic acetylcholine receptor M2	0	10	1	14
Muscarinic acetylcholine receptor M4	0	11	1	14
ATP-dependent translocase ABCB1	0	12	2	18
Integrin alpha-IIb	8	1	1	10
Beta-1 adrenergic receptor	0	6	1	7
Muscarinic acetylcholine receptor M5	0	11	1	14
Alpha-2A adrenergic receptor	0	15	1	16
Adenosine receptor A3	0	11	0	11
Cytochrome P450 2C8	0	4	0	5
Thyroid hormone receptor alpha	0	1	0	1
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M1	0	11	1	15
Beta-3 adrenergic receptor	0	3	1	4
D(2) dopamine receptor	0	16	1	17
Androgen receptor	0	10	0	10
Alpha-1B adrenergic receptor	0	15	0	15
Lethal factor	0	2	0	2
Alpha-2B adrenergic receptor	0	15	0	15
Thyroid hormone receptor beta	0	1	0	1
Muscarinic acetylcholine receptor M3	0	11	1	14
ATP-dependent translocase ABCB1	0	6	0	6
Substance-K receptor	0	2	0	2
D(4) dopamine receptor	0	6	0	6
Carnitine O-palmitoyltransferase 2, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	18	1	19
Histamine H2 receptor	0	4	0	4
Endothelin-1 receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	14	1	15
5-hydroxytryptamine receptor 2C	0	18	1	19
Lysine-specific demethylase 5A	0	1	0	1
B2 bradykinin receptor	0	4	1	7
Sodium-dependent serotonin transporter	0	14	0	14
Melanocortin receptor 4	0	2	0	2
C-8 sterol isomerase	0	1	0	1
Melanocortin receptor 5	0	2	0	2
D(3) dopamine receptor	0	15	0	15
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	3	0	4
Squalene synthase	0	1	0	1
5-hydroxytryptamine receptor 2B	0	16	0	16
C-C chemokine receptor type 2	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	14	0	14
D(1A) dopamine receptor	8	0	0	8
5-hydroxytryptamine receptor 6	0	10	0	10
Carnitine O-palmitoyltransferase 1, liver isoform	0	1	0	1
C-C chemokine receptor type 4	0	3	0	3
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Sodium-dependent dopamine transporter	0	14	0	14
Potassium voltage-gated channel subfamily H member 2	0	13	0	13
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	2	0	2
Squalene monooxygenase	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	4	0	4
Lysine-specific demethylase 7A	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	10	1	11
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	0	2	2
Sodium channel protein type 3 subunit alpha	0	3	0	3
Sodium channel protein type 11 subunit alpha	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	7	0	0	7
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
DNA polymerase beta	9	0	0	9
60 kDa heat shock protein, mitochondrial	0	4	0	4
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	4	0	4
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Thiosulfate sulfurtransferase	0	4	0	4
Metallo-beta-lactamase VIM-13	0	0	0	1
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase Toho-1	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	4	0	4
Metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	1	3
10 kDa chaperonin	0	4	0	4
Metallo-b-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Histamine H3 receptor	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
neuropeptide S receptor isoform A	11	0	0	11
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	2	2
Chain A, SERUM ALBUMIN	0	0	2	2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	7	0	0	7
caspase-1 isoform alpha precursor	5	0	0	5
Fatty-acid amide hydrolase 1	0	2	0	2
60 kDa chaperonin	0	3	0	3
Nuclear receptor subfamily 4 group A member 2	0	0	3	3
Calmodulin	0	0	1	2
Solute carrier organic anion transporter family member 2A1	0	1	0	2
Lanosterol 14-alpha demethylase	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	10	0	12
Cytosolic phospholipase A2 gamma	0	2	0	2
Transient receptor potential cation channel subfamily V member 2	0	3	0	3
Solute carrier organic anion transporter family member 1B1	0	8	0	9
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	3	3
alpha-galactosidase	6	0	0	6
cytochrome P450 2C19 precursor	8	0	0	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	3	0	4
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	2	0	2
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
glucocerebrosidase	6	0	0	6
Rac1 protein	0	0	1	1
IDH1	15	0	0	15
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	4
Epidermal growth factor receptor	0	6	0	6
Fatty acid-binding protein, liver	0	6	0	6
Myeloperoxidase	0	5	0	5
Seed linoleate 13S-lipoxygenase-1	0	5	0	7
Glutathione hydrolase 1 proenzyme	0	1	0	1
Substance-P receptor	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	2	0	2
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	0	1	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
short transient receptor potential channel 6 isoform 1	0	0	1	1
Muscarinic acetylcholine receptor M1	0	3	1	6
Muscarinic acetylcholine receptor M3	0	3	1	6
Muscarinic acetylcholine receptor M4	0	3	1	6
Muscarinic acetylcholine receptor M5	0	3	1	6
Muscarinic acetylcholine receptor M2	0	4	1	8
Muscarinic acetylcholine receptor M1	0	0	0	1
Alpha-1D adrenergic receptor	0	14	1	15
Muscarinic acetylcholine receptor M4	0	1	0	1
5-hydroxytryptamine receptor 7	0	6	0	6
Reverse transcriptase/RNaseH	0	2	1	5
Muscarinic acetylcholine receptor	0	1	1	2
Chain A, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
Chain B, Oxygen-insensitive Nad(p)h Nitroreductase	0	1	0	1
D-amino-acid oxidase	0	0	1	1
Neuronal acetylcholine receptor subunit alpha-4	3	5	0	8
Neuronal acetylcholine receptor subunit beta-2	3	5	0	8
D-amino-acid oxidase	0	2	1	3
Metabotropic glutamate receptor 5	0	1	2	4
Monocarboxylate transporter 1	0	1	0	3
D-aspartate oxidase	0	1	0	1
Serine racemase	0	2	0	2
Chain A, Putative fructose-1,6-bisphosphate aldolase	13	0	0	13
Caspase-7	5	0	0	5
Chain A, Avidin	0	0	1	1
Chain A, Protein (streptavidin)	0	0	1	1
Chain B, Protein (streptavidin)	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain D, Streptavidin	0	0	1	1
Chain A, Streptavidin Complex With Biotin	0	0	1	1
Chain D, Circularly Permuted Core-streptavidin E51/a46	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Core-streptavidin	0	0	1	1
Chain D, Core-streptavidin	0	0	1	1
Chain A, Avidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
Chain A, Streptavidin	0	0	1	1
Chain B, Streptavidin	0	0	1	1
nonstructural protein 1	0	1	0	1
green fluorescent protein, partial	0	1	0	1
insulin-degrading enzyme isoform 1	0	0	1	1
Streptavidin	0	0	1	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	2
Beta-lactamase	0	1	0	1
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	1	4	5
Genome polyprotein	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	1	2
Alpha-2C adrenergic receptor	0	11	0	11
D	0	2	0	3
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	13	2	16
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
D(1B) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	9	1	10
D(4) dopamine receptor	0	2	0	2
D(2) dopamine receptor	0	6	1	8
ATPase family AAA domain-containing protein 5	17	0	0	17
vasopressin V1b receptor	1	0	0	1
cAMP-dependent protein kinase type I-alpha regulatory subunit	0	0	1	1
cAMP-dependent protein kinase type II-beta regulatory subunit	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta isoform 1	0	0	1	1
relaxin receptor 1 isoform 1	1	0	0	1
relaxin receptor 2 isoform 1	1	0	0	1
cAMP-dependent protein kinase catalytic subunit beta isoform 3	0	0	1	1
Acetylcholine receptor subunit alpha	0	1	0	1
Acetylcholine receptor subunit gamma	0	1	0	1
Integrin alpha-5	0	1	0	1
Acetylcholine receptor subunit beta	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	4	0	8
Neuronal acetylcholine receptor subunit beta-2	0	1	0	2
Cytochrome P450 2B6	0	1	1	4
UDP-glucuronosyltransferase 1A4	0	3	0	3
Sodium-dependent dopamine transporter	0	3	0	3
Neuronal acetylcholine receptor subunit beta-4	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Cytochrome P450 2C19	0	4	0	4
UDP-glucuronosyltransferase 2B10	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	2
Acetylcholine receptor subunit delta	0	1	0	1
endonuclease IV	8	0	0	8
ClpP	5	0	0	5
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
TSHR protein	1	0	0	1
nonstructural protein 1	11	0	0	11
67.9K protein	18	0	0	18
Parkin	7	0	0	7
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
serine-protein kinase ATM isoform a	3	0	0	3
lysosomal alpha-glucosidase preproprotein	7	0	0	7
hexokinase-4 isoform 1	5	0	0	5
NPC intracellular cholesterol transporter 1 precursor	4	0	0	4
peripheral myelin protein 22 isoform 1	13	0	0	13
type-1 angiotensin II receptor	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	15
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	9	0	0	9
glucokinase regulatory protein	5	0	0	5
ras-related protein Rab-9A	5	0	0	5
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	2	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	4	0	0	4
streptokinase A precursor	0	0	2	2
Rap guanine nucleotide exchange factor 3	7	0	0	7
Amyloid-beta precursor protein	1	2	1	4
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
Albumin	0	0	5	5
Major prion protein	0	0	2	2
Sodium channel protein type 1 subunit alpha	0	3	0	3
Sodium channel protein type 2 subunit alpha	0	5	0	5
Sodium channel protein type 3 subunit alpha	0	3	0	3
Frizzled-8	0	0	1	1
P2X purinoceptor 4	0	1	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Solute carrier family 22 member 16	0	0	0	1
Solute carrier family 22 member 21	0	0	0	1
Solute carrier family 22 member 5	0	0	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	2	0	2
30S ribosomal protein S7	0	2	0	2
50S ribosomal protein L15	0	2	0	2
50S ribosomal protein L10	0	2	0	2
50S ribosomal protein L11	0	2	0	2
50S ribosomal protein L7/L12	0	2	0	2
50S ribosomal protein L19	0	2	0	2
50S ribosomal protein L1	0	2	0	2
50S ribosomal protein L20	0	2	0	2
50S ribosomal protein L27	0	2	0	2
50S ribosomal protein L28	0	2	0	2
50S ribosomal protein L29	0	2	0	2
50S ribosomal protein L31	0	2	0	2
50S ribosomal protein L31 type B	0	2	0	2
50S ribosomal protein L32	0	2	0	2
50S ribosomal protein L33	0	2	0	2
50S ribosomal protein L34	0	2	0	2
50S ribosomal protein L35	0	2	0	2
50S ribosomal protein L36	0	2	0	2
30S ribosomal protein S10	0	2	0	2
30S ribosomal protein S11	0	2	0	2
30S ribosomal protein S12	0	2	0	2
30S ribosomal protein S13	0	2	0	2
30S ribosomal protein S16	0	2	0	2
30S ribosomal protein S18	0	2	0	2
30S ribosomal protein S19	0	2	0	2
30S ribosomal protein S20	0	2	0	2
30S ribosomal protein S2	0	2	0	2
30S ribosomal protein S3	0	2	0	2
30S ribosomal protein S4	0	2	0	2
30S ribosomal protein S5	0	2	0	2
30S ribosomal protein S8	0	2	0	2
30S ribosomal protein S9	0	2	0	2
50S ribosomal protein L13	0	2	0	2
50S ribosomal protein L14	0	2	0	2
50S ribosomal protein L16	0	2	0	2
50S ribosomal protein L23	0	2	0	2
30S ribosomal protein S15	0	2	0	2
50S ribosomal protein L17	0	2	0	2
50S ribosomal protein L21	0	2	0	2
50S ribosomal protein L30	0	2	0	2
50S ribosomal protein L6	0	2	0	2
30S ribosomal protein S14	0	2	0	2
30S ribosomal protein S17	0	2	0	2
30S ribosomal protein S1	0	2	0	2
50S ribosomal protein L18	0	2	0	2
50S ribosomal protein L2	0	2	0	2
50S ribosomal protein L3	0	2	0	2
50S ribosomal protein L24	0	2	0	2
50S ribosomal protein L4	0	2	0	2
50S ribosomal protein L22	0	2	0	2
50S ribosomal protein L5	0	2	0	2
30S ribosomal protein S21	0	2	0	2
50S ribosomal protein L25	0	2	0	2
50S ribosomal protein L36 2	0	2	0	2
Methionine--tRNA ligase, mitochondrial	0	0	1	1
Carbonic anhydrase	0	6	0	11
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	1	0	2
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	1	0	1
Neuronal acetylcholine receptor subunit beta-4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-5	0	1	0	1
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	1	0	2
Neuronal acetylcholine receptor subunit alpha-6	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-9	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	3	0	3
High affinity choline transporter 1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-10	0	1	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
General amino-acid permease GAP1	0	0	0	1
Histone acetyltransferase p300	0	1	0	1
Histone acetyltransferase KAT2B	0	1	0	1
Histone acetyltransferase KAT5	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	3	0	3
transactivating tegument protein VP16 [Human herpesvirus 1]	0	3	0	3
nuclear receptor coactivator 3 isoform a	0	3	0	3
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
nuclear factor NF-kappa-B p105 subunit isoform 1	4	0	1	5
Chain A, Odorant binding protein	0	0	1	1
Chain B, Odorant binding protein	0	0	1	1
Gamma-aminobutyric acid	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Albumin	0	6	8	15
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	5	3	8
Translocator protein	0	2	2	5
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	4	2	6
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	4	2	6
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	3	6
Gamma-aminobutyric acid receptor subunit beta-2	0	4	3	7
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	4	1	5
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	2	3
Dihydrofolate reductase	0	8	0	9
Cytochrome c oxidase subunit 2	0	2	0	2
Interleukin-8	0	2	0	2
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	5	0	5
Sodium- and chloride-dependent GABA transporter 1	0	5	0	5
C-X-C chemokine receptor type 1	0	2	0	2
Sodium- and chloride-dependent GABA transporter 2	0	5	0	5
Sodium- and chloride-dependent GABA transporter 3	0	5	0	5
Prostaglandin G/H synthase 2	0	6	0	7
UDP-glucuronosyltransferase 1A3	0	0	0	3
Sodium- and chloride-dependent betaine transporter	0	5	0	5
Prostaglandin G/H synthase 2	0	3	0	4
Prostaglandin G/H synthase 1	0	6	0	7
Carbonic anhydrase 4	0	3	0	4
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Peroxisome proliferator-activated receptor alpha	4	0	3	7
PAX8	0	0	0	1
STAT3, partial	0	1	0	1
tumor necrosis factor	2	0	0	2
signal transducer and activator of transcription 1-alpha/beta isoform alpha	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit beta-1	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Replicase polyprotein 1ab	0	5	3	8
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-2	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
Glutamate receptor 1	3	2	1	6
Glutamate receptor 3	3	2	1	6
Glutamate receptor 4	3	2	1	6
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Protein cereblon	0	2	0	2
Chain A, Breast cancer type 1 susceptibility protein	2	0	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	2	0	2
DNA polymerase III, partial	2	0	0	2
isocitrate dehydrogenase 1, partial	1	0	0	1
LANA	0	0	0	1
NPYLR7B	0	0	3	3
bromodomain adjacent to zinc finger domain 2B	9	0	0	9
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	6	0	0	6
tumor susceptibility gene 101 protein	2	0	0	2
muscleblind-like protein 1 isoform 1	10	0	0	10
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	2	0	2
Exopolyphosphatase PRUNE1	0	1	0	1
Multidrug and toxin extrusion protein 2	0	4	0	4
Rap guanine nucleotide exchange factor 4	7	0	0	7
Equilibrative nucleoside transporter 1	0	2	0	2
Single-stranded DNA cytosine deaminase	1	0	0	1
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	1	5
Phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
GALC protein	2	0	0	2
atrial natriuretic peptide receptor 2 precursor	4	0	0	4
M-phase phosphoprotein 8	17	0	0	17
Retinoic acid receptor RXR-alpha	0	0	1	1
Histamine H1 receptor	0	8	0	8
5-hydroxytryptamine receptor 3A	0	3	1	4
5-hydroxytryptamine receptor 3B	0	3	1	4
Estrogen receptor	0	3	1	4
Glucocorticoid receptor	0	6	1	7
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Glycine receptor subunit alpha-3	0	6	0	6
Adenosine receptor A2a	0	2	0	2
Sulfotransferase 1A1	0	2	1	4
Aldehyde oxidase	0	1	0	1
Nuclear receptor subfamily 1 group I member 3	0	1	0	1
Estrogen receptor beta	0	1	2	3
Prothrombin	0	1	2	4
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 2-alpha	0	3	1	9
DNA topoisomerase 2	0	0	0	1
Serum paraoxonase/arylesterase 1	0	4	0	4
Caspase-3	0	2	0	2
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	2	0	2
Integrase	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
Similar to alpha-tubulin isoform 1	0	2	0	2
Luciferin 4-monooxygenase	0	2	1	3
Nuclear factor NF-kappa-B p105 subunit	0	1	0	2
Tyrosine-protein phosphatase 1	0	1	0	1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
Vesicular glutamate transporter 3	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1G	0	0	1	1
Potassium channel subfamily K member 2	0	1	1	2
Voltage-dependent T-type calcium channel subunit alpha-1H	0	0	1	1
Angiotensin-converting enzyme	0	4	0	4
Cannabinoid receptor 1	0	4	0	4
Delta-type opioid receptor	0	4	0	5
Voltage-dependent L-type calcium channel subunit beta-1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	2	0	2
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Nuclear receptor subfamily 3 group C member 3	0	4	0	4
Potassium channel subfamily K member 2	0	1	0	1
Voltage-dependent T-type calcium channel subunit alpha-1I	0	0	1	1
Prostaglandin D2 receptor 2	0	2	1	3
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	3	0	3
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
G-protein coupled receptor 35	0	2	2	4
CDGSH iron-sulfur domain-containing protein 1	0	4	0	4
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	4	0	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	3	0	4
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Cannabinoid receptor 2	0	0	1	1
Guanylate cyclase soluble subunit alpha-1	0	0	1	1
Guanylate cyclase soluble subunit beta-1	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	2	0	0	2
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Excitatory amino acid transporter 4	0	1	0	1
Glutathione reductase, mitochondrial	0	5	0	5
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
ATP-citrate synthase	0	1	0	1
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	1	1	2
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	7
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Prolyl 4-hydroxylase	0	3	0	3
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Protein-glutamine gamma-glutamyltransferase 2	0	1	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Asc-type amino acid transporter 1	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
Chain A, Protein (aspartate Aminotransferase)	0	0	2	2
Chain A, Aspartate Aminotransferase	0	0	2	2
Solute carrier family 22 member 7	0	0	0	1
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	7	0	8
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Ileal sodium/bile acid cotransporter	0	0	0	2
G-protein coupled bile acid receptor 1	0	0	3	3
Bile acid receptor	0	0	1	1
Sodium/bile acid cotransporter	0	0	0	1
Solute carrier organic anion transporter family member 1A1	0	1	0	2
Multidrug resistance associated protein	0	1	0	3
Bile salt export pump	0	0	0	1
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	1	0	2
Chain A, Uracil Phosphoribosyltransferase	0	0	1	1
Chain B, Uracil Phosphoribosyltransferase	0	0	1	1
Chain C, Uracil Phosphoribosyltransferase	0	0	1	1
Ras-related protein Rab-7a	0	0	1	1
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9	0	2	0	2
Solute carrier family 22 member 8	0	1	0	2
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Plasma kallikrein	0	0	0	5
Histidine-binding periplasmic protein	0	0	1	1
5-hydroxytryptamine receptor 1D	0	0	0	1
Carbonic anhydrase	0	1	0	6
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase	0	1	0	6
Carbonic anhydrase 13	0	2	0	4
Spike glycoprotein	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
Transmembrane protease serine 2	0	1	3	4
Procathepsin L	0	3	3	6
Replicase polyprotein 1a	0	1	3	4
Replicase polyprotein 1ab	0	1	3	4
Replicase polyprotein 1ab	0	4	3	7
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	3	4
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Uracil nucleotide/cysteinyl leukotriene receptor	0	3	0	3
Acid-sensing ion channel 3	0	1	0	1
Albumin	0	1	0	1
Cholinesterase	0	5	0	5
Polyunsaturated fatty acid 5-lipoxygenase	0	4	0	6
Prostaglandin G/H synthase 1	0	2	0	2
Caspase-1	0	1	0	2
Aldo-keto reductase family 1 member C3	0	4	0	4
Caspase-4	0	1	0	1
Caspase-5	0	1	0	1
Caspase-9	0	1	0	1
Acid-sensing ion channel 1	0	1	0	1
Mu-type opioid receptor	0	4	0	4
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
Androgen receptor	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member C4	0	1	0	1
Thromboxane-A synthase	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Multidrug resistance-associated protein 1	0	2	0	3
Bifunctional epoxide hydrolase 2	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	3	0	3
Aldo-keto reductase family 1 member C1	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
Chain A, meta-Cleavage product hydrolase	0	1	0	1
Beta-1 adrenergic receptor	0	0	1	2
Beta-2 adrenergic receptor	0	2	2	5
Beta-2 adrenergic receptor	0	2	1	3
Beta-1 adrenergic receptor	0	3	1	5
Beta-2 adrenergic receptor	0	0	1	1
Alpha-1D adrenergic receptor	0	4	0	4
Beta-adrenergic receptor kinase 1	0	0	1	1
Beta-3 adrenergic receptor	0	0	1	1
Beta-3 adrenergic receptor	0	1	1	2
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	1	1	2
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1B adrenergic receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	0	1
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	2	1	3
Taste receptor type 2 member 42	0	0	1	1
Beta-2 adrenergic receptor	0	1	2	3
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	1	2
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Ornithine decarboxylase	0	0	0	1
Retinoic acid receptor alpha	0	1	0	1
Retinoic acid receptor gamma	0	1	0	1
Retinoic acid receptor beta	0	1	0	1
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	0	1
Retinoic acid receptor RXR-beta	0	1	0	1
Retinoic acid receptor RXR-gamma	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, AMINOPEPTIDASE	0	2	0	2
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	3	0	3
Intestinal-type alkaline phosphatase	0	3	0	3
Phospholipase A-2-activating protein	0	3	0	3
integrase, partial	0	1	0	1
lens epithelium-derived growth factor p75	0	1	0	1
pyruvate kinase	2	0	0	2
Tyrosine-protein kinase Lck	0	3	0	3
SLC16A10 protein	0	0	0	4
Monocarboxylate transporter 10	0	0	0	4
phosphoglycerate kinase	2	0	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sterol O-acyltransferase 1	0	2	0	2
Fatty acid-binding protein, heart	0	2	0	2
Tyrosine-protein phosphatase non-receptor type 7	0	1	0	1
Sterol O-acyltransferase 1	0	2	0	2
Dual specificity protein phosphatase 3	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Carnitine O-palmitoyltransferase 1, muscle isoform	0	1	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	2	0	2
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	2
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	3
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	1	4
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	2	1	3
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	1	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	4	1	6
Mu-type opioid receptor	0	5	1	9
Kappa-type opioid receptor	0	3	1	5
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Solute carrier family 22 member 11	0	1	0	2
Protein-arginine deiminase type-4	0	1	0	1
Serine racemase	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
D(2) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	1	2
5-hydroxytryptamine receptor 1F	0	1	1	2
5-hydroxytryptamine receptor 2B	0	1	1	2
5-hydroxytryptamine receptor 3A	0	0	3	3
Lactoperoxidase	0	2	0	2
5-hydroxytryptamine receptor 4	0	1	1	3
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Acetylcholinesterase	0	5	0	6
Opioid receptor homologue	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	2	0	2
Kappa-type opioid receptor	0	2	1	4
Kappa-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	2	1	5
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Interstitial collagenase	0	2	1	3
Leukotriene A-4 hydrolase	0	2	0	2
G-protein coupled receptor 84	0	1	1	2
POU domain, class 2, transcription factor 1	0	0	0	1
Trace amine-associated receptor 1	0	0	2	2
Chain A, Adipocyte Lipid-binding Protein	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, MUSCLE FATTY ACID BINDING PROTEIN	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
putative potassium channel subunit	0	0	1	1
bcl-2-like protein 11 isoform 1	0	0	1	1
Fatty acid-binding protein, liver	0	0	1	1
Protein kinase C alpha type	0	1	2	4
Peroxisome proliferator-activated receptor delta	0	0	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, Arginase 1	0	1	0	1
Chain A, ARGINASE 1	0	1	0	1
Chain A, L-ARGININE\\:GLYCINE AMIDINOTRANSFERASE	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 9	0	2	2	4
Chain A, Fatty acid-binding protein, adipocyte	0	1	0	1
Toll-like receptor 2	0	1	0	1
Type II pantothenate kinase	0	0	0	1
Type III pantothenate kinase	0	0	0	1
Cystathionine gamma-lyase	0	2	0	2
Succinyl-diaminopimelate desuccinylase	0	1	0	1
Chain C, Respiratory nitrate reductase 1 gamma chain	0	1	0	1
PINK1	1	0	0	1
Pentachlorophenol 4-monooxygenase	0	0	1	1
ATP phosphoribosyltransferase	0	1	0	1
NADPH oxidase 1	0	1	0	1
Snq2p	0	0	0	3
rac GTPase-activating protein 1 isoform a	0	1	0	1
Amine oxidase [flavin-containing] A	0	3	0	4
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Estrogen receptor 1	0	1	0	1
fMet-Leu-Phe receptor	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Cholinesterase	0	3	0	4
Cholinesterase	0	1	0	1
Acyl-CoA:cholesterol acyltransferase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Mcl-1	0	1	0	1
neutrophil cytosol factor 1	0	1	0	1
Calmodulin-1	0	2	0	2
Trypanothione reductase	0	2	0	2
Chloroquine resistance transporter	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Free fatty acid receptor 2	0	1	1	2
Free fatty acid receptor 2	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	3	3
Chain A, PUTRESCINE-BINDING PROTEIN	0	0	1	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Ornithine decarboxylase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
S-adenosylmethionine decarboxylase proenzyme	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain B, (3R)-hydroxymyristoyl-acyl carrier protein dehydratase	0	1	0	1
Chain A, APH(2')-Id	0	1	0	1
glucose-6-phosphate dehydrogenase	0	1	0	1
Nrf2	1	0	0	1
Neuraminidase	0	2	0	2
hexokinase	0	2	0	2
galactokinase	1	0	0	1
interferon gamma precursor	0	0	0	1
tyrosine-protein kinase Yes	1	0	0	1
Maltase-glucoamylase, intestinal	0	1	0	1
NUAK family SNF1-like kinase 1	0	1	0	1
Lysine-specific histone demethylase 1A	0	2	0	2
B2 bradykinin receptor	0	1	0	1
G2/mitotic-specific cyclin-B2	0	1	0	1
Arginase	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	2
Prothrombin	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Cationic trypsin	0	1	0	1
Chymotrypsinogen A	0	1	0	1
Chymotrypsin-like elastase family member 1	0	1	0	1
Protein E6	0	1	0	1
Neuraminidase	0	1	0	1
Phospholipase A2	0	1	0	1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Beta-lactamase	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Glycogen phosphorylase, liver form	0	1	0	1
Epoxide hydrolase 1	0	1	0	1
Trypsin-1	0	1	0	1
Trypsin-2	0	1	0	1
Tyrosine-protein kinase Yes	0	1	0	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	0	1
Insulin-like growth factor 1 receptor	0	1	0	1
Neutrophil elastase	0	2	0	2
Hepatocyte growth factor receptor	0	1	0	1
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Alpha-amylase 1A	0	1	0	1
Lysosomal alpha-glucosidase	0	1	0	1
Sialidase	0	1	0	1
Malate dehydrogenase	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 2	0	1	0	1
Serine/threonine-protein kinase pim-1	0	1	1	2
Cyclin-dependent kinase 4	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Sucrase-isomaltase, intestinal	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Urease subunit alpha	0	3	0	3
Serine/threonine-protein kinase B-raf	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Chymotrypsinogen B	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX12	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 4	0	1	0	1
Casein kinase II subunit alpha'	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	0	1
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	0	1	0	1
G1/S-specific cyclin-D1	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	3
Dipeptidyl peptidase 4	0	3	0	3
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	1
Proteasome subunit beta type-5	0	1	0	1
Cytosol aminopeptidase	0	1	0	1
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1	0	2	0	2
Vasopressin V2 receptor	0	1	0	1
Tyrosine-protein kinase receptor UFO	0	1	0	1
RAC-alpha serine/threonine-protein kinase	0	1	0	1
Trypsin-3	0	1	0	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Receptor-type tyrosine-protein kinase FLT3	0	1	0	1
17-beta-hydroxysteroid dehydrogenase type 2	0	1	0	1
Macrophage metalloelastase	0	1	0	1
Glutathione reductase	0	1	0	1
Tyrosine-protein kinase SYK	0	1	1	2
Collagenase 3	0	1	0	1
1-deoxy-D-xylulose 5-phosphate reductoisomerase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
Glycogen synthase kinase-3 alpha	0	1	0	1
Glycogen synthase kinase-3 beta	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	2	0	2
Serine/threonine-protein kinase Nek2	0	1	0	1
Oligo-1,6-glucosidase IMA1	0	1	0	1
Serine/threonine-protein kinase PLK1	0	1	0	1
Death-associated protein kinase 1	0	1	0	1
Mitogen-activated protein kinase 10	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Beta-secretase 1	0	2	1	3
Anthrax toxin receptor 2	0	1	0	1
Casein kinase II subunit beta	0	2	0	2
Casein kinase II subunit alpha	0	2	0	2
Urease subunit beta	0	3	0	3
Aldo-keto reductase family 1 member B1	0	1	0	1
Xanthine dehydrogenase/oxidase	0	3	0	4
Cyclin-dependent kinase 6	0	1	0	1
Cyclin-dependent-like kinase 5	0	1	0	1
Heat shock factor protein 1	0	1	0	1
Sorbitol dehydrogenase	0	1	0	1
Cyclin homolog	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Dual specificity mitogen-activated protein kinase kinase 1	0	1	0	1
Focal adhesion kinase 1	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	1	0	1
ELAV-like protein 3	0	1	0	1
Cyclin-dependent kinase 5 activator 1	0	1	0	1
ELAV-like protein 1	0	1	0	1
Serine/threonine-protein kinase N1	0	1	0	1
Cytochrome P450 1B1	0	4	1	5
Probable maltase-glucoamylase 2	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Substance-K receptor	0	1	0	1
Casein kinase II subunit alpha 3	0	2	0	2
Inositol polyphosphate multikinase	0	1	0	1
G2/mitotic-specific cyclin-B3	0	1	0	1
Aldo-keto reductase family 1 member C21	0	2	0	2
Enoyl-acyl-carrier protein reductase	0	2	0	2
3-oxoacyl-acyl-carrier protein reductase	0	1	0	1
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)	0	1	0	1
Aurora kinase B	0	1	0	1
Chymotrypsin-C	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Phosphodiesterase	0	1	0	1
Serine/threonine-protein kinase Nek6	0	1	0	1
NADPH oxidase 4	0	1	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	1	0	1
Dipeptidyl peptidase 3	0	1	0	1
Inositol hexakisphosphate kinase 2	0	1	0	1
Short transient receptor potential channel 5	0	1	0	1
ALK tyrosine kinase receptor	0	1	0	1
Sialidase-2	0	1	0	1
Cytochrome P450 3A5	0	0	0	1
ATP-binding cassette sub-family C member 8	0	1	1	2
Chain A, Troponin C, slow skeletal and cardiac muscles	0	0	1	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
Chain A, Leukotriene A-4 hydrolase	0	1	0	1
BRCA1	1	0	0	1
P53	1	0	0	1
M18 aspartyl aminopeptidase	0	1	0	1
cathepsin L1	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
Vif	0	2	0	2
transcription factor p65 isoform 1	0	0	1	1
serine/threonine-protein kinase 33 isoform a	0	0	2	2
POsterior Segregation	0	0	1	1
Aryl hydrocarbon receptor	0	1	0	1
Estrogen receptor beta	0	0	1	2
Myc proto-oncogene protein	0	1	0	2
Cathepsin D	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	0	1
Breakpoint cluster region protein	0	1	0	2
Tyrosinase	0	3	0	3
Ornithine decarboxylase	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Estrogen receptor	0	0	1	2
Endothelin receptor type B	1	0	0	1
Sucrase-isomaltase, intestinal	0	1	0	1
Endothelin-1 receptor	1	0	0	1
Cannabinoid receptor 1	0	1	0	1
Nuclear factor NF-kappa-B p100 subunit	0	1	0	1
Squalene synthase	0	1	0	1
Transcription factor p65	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	0	1
Nuclear factor erythroid 2-related factor 2	0	0	1	2
N1L	0	1	0	1
NAD(P)H dehydrogenase [quinone] 1	0	0	0	3
Lysosomal alpha-glucosidase	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	0	1	1
NAD-dependent protein deacetylase sirtuin-1	0	0	1	3
Prenyltransferase homolog	0	0	0	1
Zinc finger protein mex-5	0	0	1	1
large T antigen	0	1	0	1
Chain A, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain B, 6,7-Dimethyl-8-ribityllumazine Synthase	0	0	1	1
Chain H, Immunoglobulin Igg1 Heavy chain	0	0	1	1
Chain L, Immunoglobulin Igg1 Lambda Light Chain	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain A, DODECIN	0	0	1	1
Chain C, DODECIN	0	0	1	1
Chain E, DODECIN	0	0	1	1
Riboflavin-binding protein	0	1	1	2
NADH-ubiquinone oxidoreductase chain 1	0	1	0	1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase (fumarate)	0	1	0	1
Acyl carrier protein, mitochondrial	0	1	0	1
Dihydroorotate dehydrogenase	0	1	0	1
Met repressor	0	0	2	2
Protein arginine N-methyltransferase 5	0	0	1	1
Histone H3K27 methylase	0	0	0	1
Phenylethanolamine N-methyltransferase	0	0	1	2
S-adenosylmethionine decarboxylase proenzyme	0	1	0	2
Protein-L-isoaspartate(D-aspartate) O-methyltransferase	0	1	0	1
Catechol O-methyltransferase	0	0	0	1
Protein arginine N-methyltransferase 1	0	1	0	1
Methylosome protein 50	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, Lysr-type Regulatory Protein	0	0	1	1
Chain A, 146aa long hypothetical transcriptional regulator	0	0	1	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain B, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain C, Anthranilate phosphoribosyltransferase	0	1	0	1
Chain A, Anthranilate phosphoribosyltransferase	0	1	0	1
Anthranilate phosphoribosyltransferase	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Pyruvate kinase PKM	0	1	0	1
Sulfate anion transporter 1	0	0	0	1
Caspase-2	0	0	1	1
Thymidine kinase 2	0	1	0	1
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
NADP-dependent malic enzyme, mitochondrial	0	0	0	1
Solute carrier family 13 member 3	0	1	0	1
Egl nine homolog 1	0	1	1	2
Methyl-accepting chemotaxis protein NahY	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
Ubiquitin-like modifier activating enzyme 2	0	1	0	1
SUMO1 activating enzyme subunit 1	0	1	0	1
SUMO-conjugating enzyme UBC9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
Tat	0	1	0	1
bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase	0	1	0	1
Chain A, Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
guanine nucleotide-binding protein subunit alpha-15	0	1	1	2
D(3) dopamine receptor isoform e	1	0	0	1
trace amine-associated receptor 1	0	1	1	2
Phenylethanolamine N-methyltransferase	0	1	0	1
Dopamine beta-hydroxylase	0	0	0	1
5-hydroxytryptamine receptor 6	0	0	1	1
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Trace amine-associated receptor 1	0	0	1	1
Histamine H3 receptor	0	0	0	1
Chain A, CHORISMATE MUTASE	0	1	0	1
Chain A, TYROSYL-tRNA SYNTHETASE	0	0	1	1
Tubulin--tyrosine ligase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Carbonic anhydrase	0	1	0	1
Cocaine esterase	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Liver carboxylesterase 1	0	1	0	1
Aldo-keto reductase family 1 member A1	0	1	0	1
Aldo-keto reductase family 1 member B7	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
Histamine H1 receptor	0	0	1	1
Adenosylhomocysteinase	0	1	0	1
Adenosine deaminase	0	0	0	1
RNA-directed RNA polymerase	0	1	1	2
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
PTK2B protein tyrosine kinase 2 beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Fatty Liver with Encephalopathy

Synonyms(8)

Research Excerpts

Overview

Context

Treatment

Research

Studies (734)

Protein Targets (1,766)

Fatty Liver with Encephalopathy

Synonyms(8)

Research Excerpts

Overview

Context

Treatment

Research

Studies (734)

Drugs Studied (258)

Protein Targets (1,766)