Compounds > rhamnazin
Page last updated: 2024-11-11

rhamnazin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rhamnazin: has both antiangiogenic and antineoplastic activities [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5320945
CHEMBL ID457148
CHEBI ID133721
SCHEMBL ID39443
MeSH IDM000605781

Synonyms (40)

Synonym
3,5,4'-trihydroxy-7,3'-dimethoxyflavone
3,5-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-chromen-4-one
3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4h-chromen-4-one
flavone, 3,4',5-trihydroxy-3',7-dimethoxy-
276ck9gp9y ,
unii-276ck9gp9y
rhamnacine
NCI60_027977
nsc678106
3,4'-trihydroxy-7,3'-dimethoxyflavone
rhamnazin
nsc-678106
CHEBI:133721
552-54-5
3',7-dimethylquercetin
FT-0667551
CHEMBL457148 ,
7,3'-di-o-methylquercetin
3,4',5-trihydroxy-3',7-dimethoxyflavone
LMPK12112641
bdbm50292355
3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one
SCHEMBL39443
quercetin 3',7-dimethyl ether
quercetin 7,3'-dimethyl ether
4h-1-benzopyran-4-one, 3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-
7,3'-dimethylquercetin
3,7-dimethoxy-3',4',5-trihydroxyflavone
c.i. 75700
3,5-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4h-chromen-4-one #
MYMGKIQXYXSRIJ-UHFFFAOYSA-N
DTXSID00203695
rhamnazin, >=99% (hplc)
Q3116746
rhamnazin with hplc
3 inverted exclamation mark ,7-di-o-methyl quercetin
CS-0143327
HY-N8342
E87182
AKOS040760673

Research Excerpts

Overview

Rhamnazin (RN) is a flavonol isolated from the calyxes and fruits of Physalis alkekengi L. It is known for its antioxidant and anti-inflammatory properties.

ExcerptReferenceRelevance
"Rhamnazin (RN) is a flavonol isolated from the calyxes and fruits of Physalis alkekengi L. "( The alleviative effect of flavonol-type Nrf2 activator rhamnazin from Physalis alkekengi L. var. franchetii (Mast.) Makino on pulmonary disorders.
Hu, HX; Lou, HX; Shen, T; Wang, T; Wang, XN; Wu, XY; Zhang, K; Zhao, BB; Zhao, Y, 2022)		2.41
"Rhamnazin is a natural flavonoid and known for its antioxidant and anti-inflammatory properties."( ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF RHAMNAZIN ON LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY AND INFLAMMATION IN RATS.
Dai, X; Jiang, H; Li, X; Wu, G, 2017)		1.44

Treatment

ExcerptReferenceRelevance
"The rhamnazin pretreated group also showed activation of Nrf2 pathway and attenuation of ROS such as H"( ANTIOXIDANT AND ANTI-INFLAMMATORY EFFECTS OF RHAMNAZIN ON LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY AND INFLAMMATION IN RATS.
Dai, X; Jiang, H; Li, X; Wu, G, 2017)		1.2
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antineoplastic agentA substance that inhibits or prevents the proliferation of neoplasms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
dimethoxyflavoneAny methoxyflavone with two methoxy substituents.
trihydroxyflavoneAny hydroxyflavone carrying three hydroxy groups at unspecified positions.
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (1)

PathwayProteinsCompounds
polymethylated quercetin biosynthesis210
polymethylated quercetin biosynthesis211

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Aldo-keto reductase family 1 member B1Sus scrofa (pig)IC50 (µMol)91.00000.01500.61352.5000AID354608
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID354609Inhibition of pig kidney aldehyde reductase by spectrophotometry1996Journal of natural products, Apr, Volume: 59, Issue:4
Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
AID426928Antiviral activity against HSV1 infected in african green monkey Vero cells assessed as total inhibitory concentration after 3 days by plaque reduction assay2009Journal of natural products, Jun, Volume: 72, Issue:6
7-O-methylkaempferol and -quercetin glycosides from the whole plant of Nervilia fordii.
AID426927Cytotoxicity against african green monkey Vero cells after 3 days by MTT assay2009Journal of natural products, Jun, Volume: 72, Issue:6
7-O-methylkaempferol and -quercetin glycosides from the whole plant of Nervilia fordii.
AID354608Inhibition of pig lens aldose reductase by spectrophotometry1996Journal of natural products, Apr, Volume: 59, Issue:4
Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
AID354610Inhibition of bovine liver NADH oxidase1996Journal of natural products, Apr, Volume: 59, Issue:4
Effect of Polygonum hydropiper sulfated flavonoids on lens aldose reductase and related enzymes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's1 (10.00)29.6817
2010's2 (20.00)24.3611
2020's6 (60.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 24.33

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index24.33 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index23.28 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (24.33)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
3-hydroxyflavone
3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.		3.6570flavonols;
monohydroxyflavone
vicenin ii
vicenin: isolated from the leaves of the Indian plant Ocimum sanctum were tested for their radioprotective effect in mice. isovitexin 8-C-beta-glucoside : A C-glycosyl compound that is isovitexin in which the hydrogen at position 8 is replaced by a beta-D-glucosyl residue.		2.0510C-glycosyl compound;
trihydroxyflavone		metabolite
quercetin
[no description available]		1.99107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
quercetin 3-o-glucopyranoside
quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells		1.9910beta-D-glucoside;
monosaccharide derivative;
quercetin O-glucoside;
tetrahydroxyflavone		antineoplastic agent;
antioxidant;
antipruritic drug;
bone density conservation agent;
geroprotector;
histamine antagonist;
osteogenesis regulator;
plant metabolite
esculetin
esculetin: used in filters for absorption of ultraviolet light; structure. esculetin : A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.		2.0510hydroxycoumarinantioxidant;
plant metabolite;
ultraviolet filter
3-methylquercetin
isorhamnetin : A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.		1.99107-hydroxyflavonol;
monomethoxyflavone;
tetrahydroxyflavone		anticoagulant;
EC 1.14.18.1 (tyrosinase) inhibitor;
metabolite
rhamnetin
rhamnetin: aglycone of xanthorhamnin; from Rhamnus. rhamnetin : A monomethoxyflavone that is quercetin methylated at position 7.		2.0510monomethoxyflavone;
tetrahydroxyflavone		anti-inflammatory agent;
antioxidant;
metabolite
kaempferol-7-methyl ether
rhamnocitrin : A monomethoxyflavone that is the 7-methyl ether derivative of kaempferol.		2.0510flavonols;
monomethoxyflavone;
trihydroxyflavone		plant metabolite
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2.05102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Hypermelanosis
[description not available]		02.4110
Hyperpigmentation
Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.		02.4110
Innate Inflammatory Response
[description not available]		02.8220
Disease, Pulmonary
[description not available]		02.4110
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.		07.8220
Lung Diseases
Pathological processes involving any part of the LUNG.		02.4110
Hepatocellular Carcinoma
[description not available]		07.4110
Cancer of Liver
[description not available]		02.4110
Carcinoma, Hepatocellular
A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.		02.4110
Liver Neoplasms
Tumors or cancer of the LIVER.		02.4110
Carcinoma, Non-Small Cell Lung
[description not available]		02.610
Cancer of Lung
[description not available]		02.610
Carcinoma, Non-Small-Cell Lung
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.		02.610
Lung Neoplasms
Tumors or cancer of the LUNG.		02.610
Encephalopathy, Traumatic
[description not available]		02.4110
Brain Injuries, Traumatic
A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.		02.4110
Lung Injury, Acute
[description not available]		02.1510
Acute Lung Injury
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).		07.1510
Breast Cancer
[description not available]		02.1110
Breast Neoplasms
Tumors or cancer of the human BREAST.		02.1110