miltirone profile

miltirone: from Salvis miltiorrhiza Bunge; central benzodiazepine receptor ligand; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	160142
CHEMBL ID	45830
CHEBI ID	34851
SCHEMBL ID	13568178
MeSH ID	M0188228

Synonym
2-isopropyl-8,8-dimethyl-6,7-dihydro-5h-phenanthrene-3,4-dione
2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-3,4-phenanthrenedione
NCI60_013161
nsc-639662
nsc639662
27210-57-7
miltirone
rosmariquinone
CHEMBL45830 ,
chebi:34851 ,
nsc 639662
5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-3,4-phenanthrenedione
miltiron
miltirone;2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydro-phenanthrene-3,4-dione
bdbm50009219
2-isopropyl-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
8,8-dimethyl-2-propan-2-yl-6,7-dihydro-5h-phenanthrene-3,4-dione
5,6,7,8-tetrahydro-8,8-dimethyl-2-isopropyl-3,4-phenanthrenedione
3,4-phenanthrenedione, 5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-
FT-0628947
AKOS015909796
SCHEMBL13568178
AC-34173
DTXSID20181683
8,8-dimethyl-2-(propan-2-yl)-3,4,5,6,7,8-hexahydrophenanthrene-3,4-dione
FEFAIBOZOKSLJR-UHFFFAOYSA-N
20-nor-5,7,9,13-abietatetraene-11,12-dione
5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-3,4-phenanthrenedione, 9ci
5,6,7,8-tetrahydro-2-isopropyl-8,8-dimethyl-3,4-phenanthraquinone
mfcd00238644
Q27116297
miltirone; nsc 639662; rosmariquinone
MS-24015
miltrione
CS-0018262
HY-N1951

Excerpt	Reference	Relevance
"Miltirone (1) is a diterpene quinone extracted from a well-known Chinese traditional herb (Salvia miltiorrhiza). "	( Miltirone Induces G2/M Cell Cycle Arrest and Apoptosis in CCRF-CEM Acute Lymphoblastic Leukemia Cells. Efferth, T; Wu, CF, 2015)	3.3

Class	Description
abietane diterpenoid	A diterpenoid based on an abietane skeleton.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Cocaine esterase	Homo sapiens (human)	Ki	0.0619	0.0063	0.9835	8.0000	AID731513; AID731514
Papain	Carica papaya (papaya)	IC50 (µMol)	88.0000	0.0020	1.5045	10.0000	AID688196
Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)	IC50 (µMol)	0.3000	0.0005	0.5385	7.2000	AID41864
Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)	IC50 (µMol)	0.3000	0.0005	0.5385	7.2000	AID41864
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	IC50 (µMol)	47.5500	0.0300	2.2971	9.5100	AID688188; AID688189; AID688191; AID688308
Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus	Ki	21.5000	0.0075	3.2392	9.1100	AID688190
Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus	IC50 (µMol)	21.1000	0.0040	2.9266	9.9600	AID1805801
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	IC50 (µMol)	21.1000	0.0002	2.4585	9.9600	AID1805801
Gamma-aminobutyric acid receptor subunit alpha-2	Bos taurus (cattle)	IC50 (µMol)	0.3000	0.0005	0.5385	7.2000	AID41864
Gamma-aminobutyric acid receptor subunit alpha-3	Bos taurus (cattle)	IC50 (µMol)	0.3000	0.0005	0.5385	7.2000	AID41864
Gamma-aminobutyric acid receptor subunit alpha-4	Bos taurus (cattle)	IC50 (µMol)	0.3000	0.0005	0.5385	7.2000	AID41864
Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)	IC50 (µMol)	0.3000	0.0005	0.5385	7.2000	AID41864
Acetylcholinesterase	Homo sapiens (human)	Ki	100.0000	0.0000	1.2786	9.7300	AID731511; AID731512
Liver carboxylesterase 1	Homo sapiens (human)	Ki	2.5300	0.0025	2.0136	8.4800	AID1383249; AID731515
Protease	Human immunodeficiency virus 1	IC50 (µMol)	147.6000	0.0000	0.8176	9.8500	AID688197
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
prostaglandin metabolic process	Cocaine esterase	Homo sapiens (human)
xenobiotic metabolic process	Cocaine esterase	Homo sapiens (human)
catabolic process	Cocaine esterase	Homo sapiens (human)
inhibitory synapse assembly	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
monoatomic ion transport	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
gamma-aminobutyric acid signaling pathway	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
cellular response to histamine	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
symbiont-mediated perturbation of host ubiquitin-like protein modification	Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus
symbiont-mediated perturbation of host ubiquitin-like protein modification	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
inhibitory synapse assembly	Gamma-aminobutyric acid receptor subunit alpha-2	Bos taurus (cattle)
cellular response to histamine	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
chloride transmembrane transport	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
inhibitory synapse assembly	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
acetylcholine catabolic process in synaptic cleft	Acetylcholinesterase	Homo sapiens (human)
regulation of receptor recycling	Acetylcholinesterase	Homo sapiens (human)
osteoblast development	Acetylcholinesterase	Homo sapiens (human)
acetylcholine catabolic process	Acetylcholinesterase	Homo sapiens (human)
cell adhesion	Acetylcholinesterase	Homo sapiens (human)
nervous system development	Acetylcholinesterase	Homo sapiens (human)
synapse assembly	Acetylcholinesterase	Homo sapiens (human)
receptor internalization	Acetylcholinesterase	Homo sapiens (human)
negative regulation of synaptic transmission, cholinergic	Acetylcholinesterase	Homo sapiens (human)
amyloid precursor protein metabolic process	Acetylcholinesterase	Homo sapiens (human)
positive regulation of protein secretion	Acetylcholinesterase	Homo sapiens (human)
retina development in camera-type eye	Acetylcholinesterase	Homo sapiens (human)
acetylcholine receptor signaling pathway	Acetylcholinesterase	Homo sapiens (human)
positive regulation of cold-induced thermogenesis	Acetylcholinesterase	Homo sapiens (human)
cholesterol biosynthetic process	Liver carboxylesterase 1	Homo sapiens (human)
cholesterol metabolic process	Liver carboxylesterase 1	Homo sapiens (human)
response to toxic substance	Liver carboxylesterase 1	Homo sapiens (human)
positive regulation of cholesterol efflux	Liver carboxylesterase 1	Homo sapiens (human)
negative regulation of cholesterol storage	Liver carboxylesterase 1	Homo sapiens (human)
epithelial cell differentiation	Liver carboxylesterase 1	Homo sapiens (human)
cholesterol homeostasis	Liver carboxylesterase 1	Homo sapiens (human)
reverse cholesterol transport	Liver carboxylesterase 1	Homo sapiens (human)
medium-chain fatty acid metabolic process	Liver carboxylesterase 1	Homo sapiens (human)
regulation of bile acid biosynthetic process	Liver carboxylesterase 1	Homo sapiens (human)
cellular response to cholesterol	Liver carboxylesterase 1	Homo sapiens (human)
cellular response to low-density lipoprotein particle stimulus	Liver carboxylesterase 1	Homo sapiens (human)
cholesterol ester hydrolysis involved in cholesterol transport	Liver carboxylesterase 1	Homo sapiens (human)
positive regulation of cholesterol metabolic process	Liver carboxylesterase 1	Homo sapiens (human)
regulation of bile acid secretion	Liver carboxylesterase 1	Homo sapiens (human)
lipid catabolic process	Liver carboxylesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
methylumbelliferyl-acetate deacetylase activity	Cocaine esterase	Homo sapiens (human)
carboxylesterase activity	Cocaine esterase	Homo sapiens (human)
carboxylic ester hydrolase activity	Cocaine esterase	Homo sapiens (human)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
GABA-A receptor activity	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
GABA-A receptor activity	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
ligand-gated monoatomic ion channel activity	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
RNA-dependent RNA polymerase activity	Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activity	Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activity	Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activity	Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus
3'-5'-RNA exonuclease activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
RNA-dependent RNA polymerase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
cysteine-type endopeptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
mRNA 5'-cap (guanine-N7-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
mRNA (nucleoside-2'-O-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
5'-3' RNA helicase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
K63-linked deubiquitinase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
K48-linked deubiquitinase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
3'-5'-RNA exonuclease activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cysteine-type endopeptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA 5'-cap (guanine-N7-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA (nucleoside-2'-O-)-methyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
mRNA guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
RNA endonuclease activity, producing 3'-phosphomonoesters	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
ISG15-specific peptidase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
5'-3' RNA helicase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
protein guanylyltransferase activity	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
GABA-A receptor activity	Gamma-aminobutyric acid receptor subunit alpha-3	Bos taurus (cattle)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit alpha-3	Bos taurus (cattle)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
GABA-A receptor activity	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
chloride channel activity	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
GABA-gated chloride ion channel activity	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
amyloid-beta binding	Acetylcholinesterase	Homo sapiens (human)
acetylcholinesterase activity	Acetylcholinesterase	Homo sapiens (human)
cholinesterase activity	Acetylcholinesterase	Homo sapiens (human)
protein binding	Acetylcholinesterase	Homo sapiens (human)
collagen binding	Acetylcholinesterase	Homo sapiens (human)
hydrolase activity	Acetylcholinesterase	Homo sapiens (human)
serine hydrolase activity	Acetylcholinesterase	Homo sapiens (human)
acetylcholine binding	Acetylcholinesterase	Homo sapiens (human)
protein homodimerization activity	Acetylcholinesterase	Homo sapiens (human)
laminin binding	Acetylcholinesterase	Homo sapiens (human)
sterol esterase activity	Liver carboxylesterase 1	Homo sapiens (human)
methylumbelliferyl-acetate deacetylase activity	Liver carboxylesterase 1	Homo sapiens (human)
carboxylesterase activity	Liver carboxylesterase 1	Homo sapiens (human)
carboxylic ester hydrolase activity	Liver carboxylesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
endoplasmic reticulum	Cocaine esterase	Homo sapiens (human)
endoplasmic reticulum lumen	Cocaine esterase	Homo sapiens (human)
intracellular membrane-bounded organelle	Cocaine esterase	Homo sapiens (human)
cytoplasmic vesicle membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
postsynaptic specialization membrane	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
chloride channel complex	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
GABA-A receptor complex	Gamma-aminobutyric acid receptor subunit alpha-1	Bos taurus (cattle)
plasma membrane	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
postsynaptic membrane	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
chloride channel complex	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
GABA-A receptor complex	Gamma-aminobutyric acid receptor subunit beta-1	Bos taurus (cattle)
double membrane vesicle viral factory outer membrane	Replicase polyprotein 1a	Severe acute respiratory syndrome-related coronavirus
double membrane vesicle viral factory outer membrane	Replicase polyprotein 1ab	Severe acute respiratory syndrome-related coronavirus
double membrane vesicle viral factory outer membrane	Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2
cytoplasmic vesicle membrane	Gamma-aminobutyric acid receptor subunit alpha-2	Bos taurus (cattle)
postsynaptic membrane	Gamma-aminobutyric acid receptor subunit alpha-2	Bos taurus (cattle)
chloride channel complex	Gamma-aminobutyric acid receptor subunit alpha-2	Bos taurus (cattle)
postsynaptic membrane	Gamma-aminobutyric acid receptor subunit alpha-3	Bos taurus (cattle)
chloride channel complex	Gamma-aminobutyric acid receptor subunit alpha-3	Bos taurus (cattle)
postsynaptic membrane	Gamma-aminobutyric acid receptor subunit alpha-4	Bos taurus (cattle)
chloride channel complex	Gamma-aminobutyric acid receptor subunit alpha-4	Bos taurus (cattle)
plasma membrane	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
cytoplasmic vesicle membrane	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
postsynaptic specialization membrane	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
chloride channel complex	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
GABA-A receptor complex	Gamma-aminobutyric acid receptor subunit gamma-2	Bos taurus (cattle)
extracellular region	Acetylcholinesterase	Homo sapiens (human)
basement membrane	Acetylcholinesterase	Homo sapiens (human)
extracellular space	Acetylcholinesterase	Homo sapiens (human)
nucleus	Acetylcholinesterase	Homo sapiens (human)
Golgi apparatus	Acetylcholinesterase	Homo sapiens (human)
plasma membrane	Acetylcholinesterase	Homo sapiens (human)
cell surface	Acetylcholinesterase	Homo sapiens (human)
membrane	Acetylcholinesterase	Homo sapiens (human)
neuromuscular junction	Acetylcholinesterase	Homo sapiens (human)
synaptic cleft	Acetylcholinesterase	Homo sapiens (human)
synapse	Acetylcholinesterase	Homo sapiens (human)
perinuclear region of cytoplasm	Acetylcholinesterase	Homo sapiens (human)
side of membrane	Acetylcholinesterase	Homo sapiens (human)
cytoplasm	Liver carboxylesterase 1	Homo sapiens (human)
endoplasmic reticulum	Liver carboxylesterase 1	Homo sapiens (human)
endoplasmic reticulum lumen	Liver carboxylesterase 1	Homo sapiens (human)
lipid droplet	Liver carboxylesterase 1	Homo sapiens (human)
cytosol	Liver carboxylesterase 1	Homo sapiens (human)
lipid droplet	Liver carboxylesterase 1	Homo sapiens (human)
endoplasmic reticulum	Liver carboxylesterase 1	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (107)

Assay ID	Title	Year	Journal	Article
AID1243652	Induction of ROS generation in human HepG2 cells at 25 uM after 15 to 30 mins using H2DCFH dye by confocal microscopy in presence of PEG-catalase	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243703	Inhibition of ERK1/2 phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis in presence of NAC	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243706	Inhibition of p38 MAPK phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis in presence of NAC	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243690	Increase of SAPK/JNK phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688189	Inhibition of SARS-CoV 3CLpro expressed in Escherichia coli BL21 (DE3) using Dabcyl-KNSTLQSGLRKE-Edan as substrate after 60 mins by FRET analysis	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID263375	Cytotoxicity against HCT116 cell line	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
AID1383253	Inhibition of human BChE using butyrylthiocholine as substrate at 5 uM by spectrophotometric analysis	2018	European journal of medicinal chemistry, Apr-10, Volume: 149	Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
AID688310	Non competitive inhibition of SARS-CoV 3CLpro expressed in Escherichia coli BL21 (DE3) using Dabcyl-KNSTLQSGLRKE-Edan as substrate by Dixon plot analysis	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243643	Inhibition of p-glycoprotein in human doxorubicin-resistant HepG2 cells assessed as reduction of doxorubicin efflux after 1 hr by flow cytometry	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243711	Increase of SAPK/JNK phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis in presence of SB203580	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243688	Inhibition of p38 MAPK phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243672	Induction of apoptosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as activation of caspase-3/8/9 after 24 hrs by Western blotting	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243664	Induction of oxidative stress in human HepG2 cells assessed as decrease of GSH/GSSG ratio at 3.12 uM after 24 hrs using DTNB by enzymatic kinetic method	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243646	Competitive inhibition of p-glycoprotein in doxorubicin-resistant human HepG2 cells assessed as reduction of doxorubicin efflux after 1 hr by primary Lineweaver-Burk plot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243639	Induction of necrosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as LDH leakage at >50 uM after 24 hrs	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243678	Induction of apoptosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of Z-LEHD-FMK	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688306	Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at IC50 by fluorescence assay	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID688188	Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 30 mins by fluorescence assay	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID731516	Reduction of CPT-11 sensitization to human U373MG cells expressing human iCE treated 1 hr before CPT-11 challenge measured after 72 hrs relative to DMSO control	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243651	Induction of ROS generation in human HepG2 cells at 25 uM after 15 to 30 mins using H2DCFH dye by confocal microscopy in presence of PEG-SOD	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID731512	Inhibition of human AChE using acetylthiocholine as substrate by spectrophotometric assay	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243641	Induction of necrosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as LDH leakage at 25 uM after 24 hrs	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243705	Inhibition of p38 MAPK phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis in presence of NAC	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243708	Increase of SAPK/JNK phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis in presence of NAC	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688191	Inhibition of SARS-CoV PLpro deubiququitination expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence analysis	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID263372	Inhibitory activity against human Cdc25B phosphatase	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
AID1243665	Induction of oxidative stress in human HepG2 cells assessed as decrease of GSH/GSSG ratio at 25 uM after 24 hrs using DTNB by enzymatic kinetic method	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243704	Inhibition of ERK1/2 phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis in presence of NAC	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243637	Cytotoxicity against human PLC/PRF/5 cells after 24 hrs by MTT assay in presence of doxorubicin	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243656	Induction of oxidative stress in human HepG2 cells assessed as increase of GSH level at 3.12 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID612371	Cytotoxicity against human MIAPaCa2 cells after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16	In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
AID688308	Inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by fluorescence assay	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243650	Induction of ROS generation in human HepG2 cells at 25 uM after 15 to 30 mins using H2DCFH dye by confocal microscopy	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID731513	Inhibition of human iCE using CPT-11 as substrate by spectrophotometric assay	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243667	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as decrease of GSH/GSSG ratio at 3.12 uM after 24 hrs using DTNB by enzymatic kinetic method	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243648	Competitive inhibition of p-glycoprotein in human doxorubicin-resistant HepG2 cells assessed as reduction of doxorubicin efflux after 1 hr by secondary Lineweaver-Burk plot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243655	Induction of ROS generation in human doxorubicin-resistant HepG2 cells expressing p-gp at 25 uM after 15 to 30 mins using CM-H2DCFDA by flow cytometry relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688193	Inhibition of chymotrypsin using N-benzoyl-L-tyrosine ethyl ester as substrate assessed as benzoyl-tyrosine production measured every 10 seconds for 6 mins	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243659	Induction of oxidative stress in human HepG2 cells assessed as decrease of GSSG level per gram of protein at 25 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID263373	Inhibitory activity against human PTP1B	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
AID612372	Cytotoxicity against human MV-3 cells after 24 hrs by MTT assay	2011	Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16	In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.
AID731511	Inhibition of human BChE using butyrylthiocholine as substrate by spectrophotometric assay	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243666	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as increase of GSH/GSSG ratio at 1.56 to 3.12 uM after 24 hrs using DTNB by enzymatic kinetic method	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243689	Increase of SAPK/JNK phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243712	Increase of SAPK/JNK phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis in presence of SB203580	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243671	Induction of apoptosis in human HepG2 cells assessed as activation of caspase-3/8/9 after 24 hrs by Western blotting	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243653	Induction of ROS generation in human HepG2 cells after 15 to 30 mins using CM-H2DCFDA by flow cytometry	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243676	Induction of apoptosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of Z-IETD-FMK	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243661	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as decrease of GSH level per gram of protein at 6.25 to 25 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688190	Time dependent inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate at 3 to 100 uM up to 120 mins	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243654	Induction of ROS generation in human HepG2 cells at 25 uM after 15 to 30 mins using CM-H2DCFDA by flow cytometry relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243709	Inhibition of p38 MAPK phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis in presence of SB203580	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243634	Cytotoxicity against human PLC/PRF/5 cells after 24 hrs by MTT assay	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID731510	Inhibition of human iCE in human U373MG cells assessed as 4-MUA substrate hydrolysis at 1 uM after 1 hr by fluorescence spectrometry assay	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243635	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay in presence of doxorubicin	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243677	Induction of apoptosis in human HepG2 cells assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of Z-LEHD-FMK	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID263374	Cytotoxicity against A549 cell line	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
AID1243638	Induction of necrosis in human HepG2 cells assessed as LDH leakage at >50 uM after 24 hrs	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID731515	Inhibition of human CE1 using o-NPA as substrate by spectrophotometric assay	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243700	Effect on nonphosphorylated p38 MAPK level in human doxorubicin-resistant HepG2 cells expressing p-gp at 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243697	Effect on nonphosphorylated ERK1/ERK2 level in human HepG2 cells at 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243673	Induction of apoptosis in human HepG2 cells assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of Z-VAD-FMK	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688305	Time dependent inhibition of SARS-CoV 3CLpro expressed in Escherichia coli BL21 (DE3) using Dabcyl-KNSTLQSGLRKE-Edan as substrate at 1 to 100 uM by FRET analysis	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID688197	Inhibition of Human immunodeficiency virus 1 protease preincubated for 10 mins by FRET assay	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243649	Induction of ROS generation in human doxorubicin-resistant HepG2 cells expressing p-gp at 25 uM after 15 mins using H2DCFH dye by confocal microscopy	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243710	Inhibition of p38 MAPK phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis in presence of SB203580	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243674	Induction of apoptosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of Z-VAD-FMK	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1383249	Inhibition of human liver carboxylesterase 1 using o-nitrophenyl acetate as substrate	2018	European journal of medicinal chemistry, Apr-10, Volume: 149	Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
AID731514	Inhibition of human iCE using o-NPA as substrate by spectrophotometric assay	2013	Journal of natural products, Jan-25, Volume: 76, Issue:1	Modulation of esterified drug metabolism by tanshinones from Salvia miltiorrhiza ("Danshen").
AID1243686	Inhibition of ERK1/2 phosphorylation in human doxorubicin-resistant HepG2 cells expressing p-gp at 1.56 to 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243636	Cytotoxicity against human Hep3B cells after 24 hrs by MTT assay in presence of doxorubicin	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1383252	Inhibition of human AChE using acetylthiocholine as substrate at 5 uM by spectrophotometric analysis	2018	European journal of medicinal chemistry, Apr-10, Volume: 149	Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
AID1243679	Induction of apoptosis in human HepG2 cells assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of trolox	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688196	Inhibition of papaya papain using N-alpha-benzoyl-L-arginine-pnitroanilide as substrate after 5 mins	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243698	Effect on nonphosphorylated ERK1/ERK2 level in human doxorubicin-resistant HepG2 cells expressing p-gp at 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID688307	Inhibition of SARS-CoV PLpro expressed in Escherichia coli (DE3) BL21 using Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 60 mins by fluorescence assay	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID381676	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, Apr-01, Volume: 16, Issue:7	Cytotoxic activity of proflavine diureas: synthesis, antitumor, evaluation and DNA binding properties of 1',1''-(acridin-3,6-diyl)-3',3''-dialkyldiureas.
AID1243642	Cytotoxicity against human doxorubicin-resistant HepG2 cells expressing p-gp assessed as combination index after 24 hrs by MTT assay in presence of doxorubicin	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1383250	Inhibition of human intestinal carboxylesterase using o-nitrophenyl acetate as substrate	2018	European journal of medicinal chemistry, Apr-10, Volume: 149	Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
AID688312	Mixed type inhibition of SARS-CoV PLpro expressed in Escherichia coli BL21 (DE3) using Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon plot analysis	2012	Bioorganic & medicinal chemistry, Oct-01, Volume: 20, Issue:19	Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
AID1243658	Induction of oxidative stress in human HepG2 cells assessed as decrease of GSH level per gram of protein at 25 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243663	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as decrease of GSSG level per gram of protein at 25 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243644	Inhibition of p-glycoprotein in human doxorubicin-resistant HepG2 cells assessed as reduction of doxorubicin efflux at 25 uM after 1 hr by flow cytometry relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243657	Induction of oxidative stress in human HepG2 cells assessed as increase of GSSG level at 3.12 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID41864	Potency related to miltirone (1) at the central benzodiazepine receptor was determined using [3H]flunitrazepam as radioligand	1991	Journal of medicinal chemistry, May, Volume: 34, Issue:5	Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen).
AID1243701	Effect on nonphosphorylated SAPK/JNK level in human HepG2 cells at 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID263371	Inhibitory activity against human Cdc25A phosphatase	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
AID1243662	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as decrease of GSH level per gram of protein at 25 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243660	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as decrease of GSH level per gram of protein at 1.56 to 3.12 uM after 24 hrs using DTNB by enzymatic kinetic method relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243670	Induction of apoptosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as increase in PARP cleavage after 24 hrs by Western blotting	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1383251	Selectivity index, ratio of Ki for human liver carboxylesterase 1 to Ki for human intestinal carboxylesterase	2018	European journal of medicinal chemistry, Apr-10, Volume: 149	Facile synthesis of 1,2-dione-containing abietane analogues for the generation of human carboxylesterase inhibitors.
AID1243631	Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243687	Inhibition of p38 MAPK phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243632	Cytotoxicity against human doxorubicin-resistant HepG2 cells expressing p-gp after 24 hrs by MTT assay	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243702	Effect on nonphosphorylated SAPK/JNK level in human doxorubicin-resistant HepG2 cells expressing p-gp at 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243645	Inhibition of p-glycoprotein in human doxorubicin-resistant HepG2 cells assessed as reduction of doxorubicin efflux at 100 uM after 1 hr by flow cytometry relative to control	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243707	Increase of SAPK/JNK phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis in presence of NAC	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243640	Induction of necrosis in human HepG2 cells assessed as LDH leakage at 25 uM after 24 hrs	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243699	Effect on nonphosphorylated p38 MAPK level in human HepG2 cells at 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243647	Competitive inhibition of p-glycoprotein in human doxorubicin-resistant HepG2 cells assessed as reduction of doxorubicin efflux after 1 hr by primary Dixon plot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243668	Induction of oxidative stress in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as decrease of GSH/GSSG ratio at 25 uM after 24 hrs using DTNB by enzymatic kinetic method	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243669	Induction of apoptosis in human HepG2 cells assessed as increase in PARP cleavage after 24 hrs by Western blotting	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243680	Induction of apoptosis in human doxorubicin-resistant HepG2 cells expressing p-gp assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of trolox	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243675	Induction of apoptosis in human HepG2 cells assessed as activation of caspase-3/8/9 at 12.5 after 24 hrs by Western blotting in presence of Z-IETD-FMK	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243633	Cytotoxicity against human Hep3B cells after 24 hrs by MTT assay	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1243685	Inhibition of ERK1/2 phosphorylation in human HepG2 cells at 1.56 to 25 uM by Western blot analysis	2015	Journal of natural products, Sep-25, Volume: 78, Issue:9	Miltirone Is a Dual Inhibitor of P-Glycoprotein and Cell Growth in Doxorubicin-Resistant HepG2 Cells.
AID1805801	Various Assay from Article 10.1021/acs.jmedchem.1c00409: \\Perspectives on SARS-CoV-2 Main Protease Inhibitors.\\	2021	Journal of medicinal chemistry, 12-09, Volume: 64, Issue:23	Perspectives on SARS-CoV-2 Main Protease Inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (6.45)	18.2507
2000's	4 (12.90)	29.6817
2010's	21 (67.74)	24.3611
2020's	4 (12.90)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (3.23%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	30 (96.77%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
gamma-aminobutyric acid gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.	1.97	1	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule
catechin [no description available]	2.31	1	hydroxyflavan
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate [no description available]	2.31	1	catechin
pk 11195 PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine	2.02	1	aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes	antineoplastic agent
theophylline [no description available]	2.31	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent
bronopol [no description available]	2.31	1	nitro compound
caffeine [no description available]	2.31	1	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic
N-[4-methyl-1-oxo-1-(1-oxohexan-2-ylamino)pentan-2-yl]carbamic acid (phenylmethyl) ester [no description available]	2.31	1	leucine derivative
carmofur [no description available]	2.31	1	organohalogen compound; pyrimidines
diazepam Diazepam: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.. diazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.	1.97	1	1,4-benzodiazepinone; organochlorine compound	anticonvulsant; anxiolytic drug; environmental contaminant; sedative; xenobiotic
disulfiram [no description available]	2.31	1	organic disulfide; organosulfur acaricide	angiogenesis inhibitor; antineoplastic agent; apoptosis inducer; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 3.1.1.1 (carboxylesterase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; ferroptosis inducer; fungicide; NF-kappaB inhibitor
ebselen ebselen : A benzoselenazole that is 1,2-benzoselenazol-3-one carrying an additional phenyl substituent at position 2. Acts as a mimic of glutathione peroxidase.	2.31	1	benzoselenazole	anti-inflammatory drug; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 3.5.4.1 (cytosine deaminase) inhibitor; EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor; enzyme mimic; ferroptosis inhibitor; genotoxin; hepatoprotective agent; neuroprotective agent; radical scavenger
flunitrazepam Flunitrazepam: A benzodiazepine with pharmacologic actions similar to those of DIAZEPAM that can cause ANTEROGRADE AMNESIA. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug.. flunitrazepam : A 1,4-benzodiazepinone that is nitrazepam substituted by a methyl group at position 1 and by a fluoro group at position 2'. It is a potent hypnotic, sedative, and amnestic drug used to treat chronic insomnia.	2.4	2	1,4-benzodiazepinone; C-nitro compound; monofluorobenzenes	anxiolytic drug; GABAA receptor agonist; sedative
hexachlorophene Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797). hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union.	2.31	1	bridged diphenyl fungicide; polyphenol; trichlorobenzene	acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug
hydroxychloroquine Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970). hydroxychloroquine : An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.	2.31	1	aminoquinoline; organochlorine compound; primary alcohol; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; dermatologic drug
2-propanol 2-Propanol: An isomer of 1-PROPANOL. It is a colorless liquid having disinfectant properties. It is used in the manufacture of acetone and its derivatives and as a solvent. Topically, it is used as an antiseptic.. propan-2-ol : A secondary alcohol that is propane in which one of the hydrogens attached to the central carbon is substituted by a hydroxy group.	2.11	1	secondary alcohol; secondary fatty alcohol	protic solvent
beta-lapachone beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.	2.31	1	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite
vitamin k 3 Vitamin K 3: A synthetic naphthoquinone without the isoprenoid side chain and biological activity, but can be converted to active vitamin K2, menaquinone, after alkylation in vivo.	2.31	1	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical
niclosamide Niclosamide: An antihelmintic that is active against most tapeworms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p48). niclosamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 5-chlorosalicylic acid with the amino group of 2-chloro-4-nitroaniline. It is an oral anthelmintic drug approved for use against tapeworm infections.	2.31	1	benzamides; C-nitro compound; monochlorobenzenes; salicylanilides; secondary carboxamide	anthelminthic drug; anticoronaviral agent; antiparasitic agent; apoptosis inducer; molluscicide; piscicide; STAT3 inhibitor
phenacetin Saridon: contains phenacetin, caffeine, propyphenazone & pyrithyldione	2.08	1	acetamides; aromatic ether	cyclooxygenase 3 inhibitor; non-narcotic analgesic; peripheral nervous system drug
protoporphyrin ix protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685. protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.	2.31	1
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one [no description available]	2.31	1	indoles
alkannin [no description available]	2.31	1	naphthoquinone
tolbutamide Tolbutamide: A sulphonylurea hypoglycemic agent with actions and uses similar to those of CHLORPROPAMIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290). tolbutamide : An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position.	2.08	1	N-sulfonylurea	human metabolite; hypoglycemic agent; insulin secretagogue; potassium channel blocker
triclosan [no description available]	2.31	1	aromatic ether; dichlorobenzene; monochlorobenzenes; phenols	antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic
acenaphthenequinone acenaphthoquinone : An orthoquinone that is the 1,2-dioxo derivative of acenaphthene.	2.08	1	orthoquinones	chain carrier; epitope
9,10-phenanthrenequinone 9,10-phenanthrenequinone: structure	2.08	1	phenanthrenes
n-vinyl-2-pyrrolidinone N-vinyl-2-pyrrolidinone: monomer of POVIDONE; structure given in first source	2.11	1	pyrrolidin-2-ones
pyromellitic acid pyromellitic acid: RN given refers to parent cpd; structure. pyromellitic acid : A tetracarboxylic acid that is benzene substituted by four carboxy groups at positions 1, 2, 4 and 5 respectively.	2.31	1	benzoic acids; tetracarboxylic acid
chloranil Chloranil: A quinone fungicide used for treatment of seeds and foliage.. tetrachloro-1,4-benzoquinone : A member of the class of 1,4-benzoquiones that is 1,4-benzoquinone in which all four hydrogens are substituted by chlorines.	2.31	1	1,4-benzoquinones; organochlorine compound	EC 2.7.1.33 (pantothenate kinase) inhibitor; metabolite
benzil benzil: structure. benzil : An alpha-diketone that is ethane-1,2-dione substituted by phenyl groups at positions 1 and 2 respectively.	2.08	1	alpha-diketone; aromatic ketone
plumbagin plumbagin: a superoxide anion generator. plumbagin : A hydroxy-1,4-naphthoquinone that is 1,4-naphthoquinone in which the hydrogens at positions 2 and 5 are substituted by methyl and hydroxy groups, respectively.	2.31	1	hydroxy-1,4-naphthoquinone; phenols	anticoagulant; antineoplastic agent; immunological adjuvant; metabolite
dithiol dithiol: structure	2.31	1
dihydroergotamine Dihydroergotamine: A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.. dihydroergotamine : Ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension.	2.31	1	ergot alkaloid; semisynthetic derivative	dopamine agonist; non-narcotic analgesic; serotonergic agonist; sympatholytic agent; vasoconstrictor agent
abietic acid abietic acid : An abietane diterpenoid that is abieta-7,13-diene substituted by a carboxy group at position 18.	2.31	1	abietane diterpenoid; monocarboxylic acid	plant metabolite
4-(dimethylamino)benzoic acid [no description available]	2.31	1
agaric acid agaric acid: adenine nucleotide translocase antagonist	2.31	1
phenethyl isothiocyanate phenethyl isothiocyanate: a dietary liver aldehyde dehydrogenase inhibitor; promotes urinary bladder carcinoma. phenethyl isothiocyanate : An isothiocyanate having a phenethyl group attached to the nitrogen. It is a naturally occurring compound found in some cruciferous vegetables (e.g. watercress) and is known to possess anticancer properties.	2.31	1	isothiocyanate	antineoplastic agent; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; metabolite
1,2-benzisothiazoline-3-one 1,2-benzisothiazoline-3-one: a preservative in water-based solutions such as paints, cutting fluids, printing inks, cleaning agents, polyvinyl chloride gloves, etc.. benzo[d]isothiazol-3-one : An organic heterobicyclic compound based on a fused 1,2-thiazole and benzene bicyclic ring skeleton, with the S atom positioned adjacent to one of the positions of ring fusion.	2.31	1	organic heterobicyclic compound; organonitrogen heterocyclic compound	disinfectant; drug allergen; environmental contaminant; platelet aggregation inhibitor; sensitiser; xenobiotic
camptothecin NSC 100880: carboxylate (opened lactone) form of camptothecin; RN refers to (S)-isomer; structure given in first source	2.06	1	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite
etoposide [no description available]	2.04	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
zinc ethylphenyldithiocarbamate [no description available]	2.31	1
baicalin [no description available]	2.31	1	dihydroxyflavone; glucosiduronic acid; glycosyloxyflavone; monosaccharide derivative	antiatherosclerotic agent; antibacterial agent; anticoronaviral agent; antineoplastic agent; antioxidant; cardioprotective agent; EC 2.7.7.48 (RNA-directed RNA polymerase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; ferroptosis inhibitor; neuroprotective agent; non-steroidal anti-inflammatory drug; plant metabolite; prodrug
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose pentagalloylglucose: pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent. 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.	2.31	1	gallate ester; galloyl beta-D-glucose	anti-inflammatory agent; antineoplastic agent; geroprotector; hepatoprotective agent; plant metabolite; radiation protective agent; radical scavenger
vanitiolide [no description available]	2.31	1	methoxybenzenes; phenols
LSM-4272 [no description available]	2.31	1	beta-carbolines
lopinavir [no description available]	2.31	1	amphetamines; dicarboxylic acid diamide	anticoronaviral agent; antiviral drug; HIV protease inhibitor
sugiol sugiol: diterpene with anti-inflammatory activity from Calocedrus formosana bark; structure in first source. sugiol : An abietane diterpenoid that is ferruginol in which the methylene group para to the phenolic hydroxy group has been substituted by an oxo group.	2.06	1	abietane diterpenoid; carbotricyclic compound; cyclic terpene ketone; meroterpenoid; phenols	antineoplastic agent; antioxidant; antiviral agent; plant metabolite; radical scavenger
zpck ZPCK: alkylates histidine residue at active center of bovine chymotrypsin	2.31	1
tingenone tingenone: quinonoid triterpene isolated from Euonymus tingens	2.31	1
tanshinone tanshinone: from root of Salvia miltiorrhiza Bunge; RN given refers to tanshinone I; cardioprotective agent and neuroprotective agent	5.14	13	abietane diterpenoid	anticoronaviral agent
celastrol [no description available]	2.31	1	monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory drug; antineoplastic agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; Hsp90 inhibitor; metabolite
moxifloxacin Moxifloxacin: A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.. moxifloxacin : A quinolone that consists of 4-oxo-1,4-dihydroquinoline-3-carboxylic acid bearing a cyclopropyl substituent at position 1, a fluoro substitiuent at position 6, a (4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl group at position 7 and a methoxy substituent at position 8. A member of the fluoroquinolone class of antibacterial agents.	2.31	1	aromatic ether; cyclopropanes; fluoroquinolone antibiotic; pyrrolidinopiperidine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone	antibacterial drug
celastrol methyl ester celastrol methyl ester: isolated from Tripterygium wilfordii; potent inhibitory activity on both Kir2.1 and ERG1 potassium channels, leading to LONG QT SYNDROME	2.31	1	carboxylic ester
cryptotanshinone cryptotanshinone: from Salvia miltiorrhiza	3.73	9	abietane diterpenoid	anticoronaviral agent
tanshinone ii a tashinone IIA: a cardiovascular agent with antineoplastic activity; isolated from Salvia miltiorrhiza; structure in first source	3.02	4	abietane diterpenoid
2-phenyl-1,2-benzisothiazol-3-(2h)-one 2-phenyl-1,2-benzisothiazol-3-(2H)-one: structure given in first source; sulfur analog of ebselen	2.31	1
carboxyebselen carboxyebselen: a nitric oxide synthase inhibitor	2.31	1
darunavir Darunavir: An HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.. darunavir : An N,N-disubstituted benzenesulfonamide bearing an unsubstituted amino group at the 4-position, used for the treatment of HIV infection. A second-generation HIV protease inhibitor, darunavir was designed to form robust interactions with the protease enzyme from many strains of HIV, including those from treatment-experienced patients with multiple resistance mutations to other protease inhibitors.	2.31	1	carbamate ester; furofuran; sulfonamide	antiviral drug; HIV protease inhibitor
1-methylpropyl-2-imidazolyl disulfide 1-methylpropyl-2-imidazolyl disulfide: a thioredoxin inhibitor with antineoplastic activity	2.31	1	imidazoles
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.31	1
nsc 95397 [no description available]	2.31	1	1,4-naphthoquinones
nsc 663284 NSC 663284: structure in first source	2.31	1	quinolone
abacavir abacavir: a carbocyclic nucleoside with potent selective anti-HIV activity. abacavir : A 2,6-diaminopurine that is (1S)-cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.	2.31	1	2,6-diaminopurines	antiviral drug; drug allergen; HIV-1 reverse transcriptase inhibitor
ferruginol ferruginol: structure in first source. ferruginol : An abietane diterpenoid that is abieta-8,11,13-triene substituted by a hydroxy group at positions 12.	2.53	2	abietane diterpenoid; carbotricyclic compound; meroterpenoid; phenols	antibacterial agent; antineoplastic agent; plant metabolite; protective agent
isopimaric acid isopimaric acid: isolated from the bark of Illicium jadifengpi	2.31	1	carbotricyclic compound; diterpenoid; monocarboxylic acid
royleanone royleanone: from root of Salvia officinalis; structure given in first source	2.06	1
acetylleucyl-leucyl-norleucinal acetylleucyl-leucyl-norleucinal: a proteasome inhibitor. acetylleucyl-leucyl-norleucinal : A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.	2.31	1	aldehyde; tripeptide	cysteine protease inhibitor
gw 3965 GW 3965: a liver X receptor ligand	2.31	1	diarylmethane
benzyloxycarbonylleucyl-leucyl-leucine aldehyde benzyloxycarbonylleucyl-leucyl-leucine aldehyde: proteasome inhibitor. N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal : A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.	2.31	1	amino aldehyde; carbamate ester; tripeptide	proteasome inhibitor
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	2.31	1	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
1-(2-Naphthylmethyl)-2,3-dioxo-indoline-5-carboxamide [no description available]	2.31	1	indolecarboxamide	anticoronaviral agent
1-(4-Methoxyphenyl)-2-nitroethylene 4-methoxy-beta-nitrostyrene: has vasodilator activity; structure in first source	2.31	1	methoxybenzenes
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.31	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2.31	1	cinnamate ester; tannin	food component; plant metabolite
horminone horminone: RN refers to (4bS-(4balpha,8abeta,10beta))-isomer; from root of Salvia officinalis; structure given in second source. horminone : An abietane diterpenoid that is abieta-8,12-diene substituted by hydroxy groups at positions 7 and 12 and oxo groups at positions 11 and 14 (the 7alpha stereoisomer) .	2.06	1
5-(4-Chloro-benzenesulfonyl)-pyrimidine-2,4-diamine [no description available]	2.31	1	sulfonic acid derivative	anticoronaviral agent
S-[5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl] 5-(phenylethynyl)furan-2-carbothioate [no description available]	2.31	1	acetylenic compound; furans; organofluorine compound; thioester; triazoles
telaprevir [no description available]	2.31	1	cyclopentapyrrole; cyclopropanes; oligopeptide; pyrazines	antiviral drug; hepatitis C protease inhibitor; peptidomimetic
N-(4-Butan-2-ylphenyl)-N-[2-(cyclopentylamino)-2-oxo-1-pyridin-3-ylethyl]furan-2-carboxamide [no description available]	2.31	1	aromatic amide; furans	anticoronaviral agent
8-(Trifluoromethyl)-9H-purin-6-amine [no description available]	2.31	1	6-aminopurines	anticoronaviral agent
l 663536 MK-886: orally active leukotriene biosynthesis inhibitor. 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid : A member of the class of indoles that is 1H-indole substituted by a isopropyl group at position 5, a tert-butylsulfanediyl group at position 3, a 4-chlorobenzyl group at position 1 and a 2-carboxy-2-methylpropyl group at position 2. It acts as an inhibitor of arachidonate 5-lipoxygenase.	2.31	1	aryl sulfide; indoles; monocarboxylic acid; monochlorobenzenes	antineoplastic agent; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; leukotriene antagonist
suramin sodium suramin(6-) : An organosulfate oxoanion that is the hexanion of suramin resulting from the deprotonation of the six sulfo groups; major species at pH 7.3.	2.31	1	organosulfate oxoanion
4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione: a GSK3beta inhibitor. TDZD-8 : A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a methyl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta). An experimental compound which was being developed for the potential treatment of Alzheimer's disease.	2.31	1	benzenes; thiadiazolidine	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.17	1
sitagliptin sitagliptin : A triazolopyrazine that exhibits hypoglycemic activity.	2.31	1	triazolopyrazine; trifluorobenzene	EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor; environmental contaminant; hypoglycemic agent; serine proteinase inhibitor; xenobiotic
ginkgetin ginkgetin: from Cephalotaxus drupacea; biflavone; active against HSV-1; structure given in first source. ginkgetin : A biflavonoid that is the 7,4'-dimethyl ether derivative of amentoflavone. Isolated from Ginkgo biloba and Dioon, it exhibits anti-HSV-1, antineoplastic and inhibitory activities towards arachidonate 5-lipoxygenase and cyclooxygenase 2.	2.31	1	biflavonoid; hydroxyflavone; methoxyflavone; ring assembly	anti-HSV-1 agent; antineoplastic agent; cyclooxygenase 2 inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; metabolite
quercetin [no description available]	2.31	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.31	1	trihydroxyflavone	antineoplastic agent; metabolite
luteolin [no description available]	2.31	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
amentoflavone [no description available]	2.31	1	biflavonoid; hydroxyflavone; ring assembly	angiogenesis inhibitor; antiviral agent; cathepsin B inhibitor; P450 inhibitor; plant metabolite
baicalein [no description available]	2.31	1	trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger
sciadopitysin sciadopitysin: biflavonoid from Taxus celebica & Ginkgo biloba. sciadopitysin : A biflavonoid that is a 7, 4', 4'''-trimethyl ether derivative of amentoflavone.	2.31	1	biflavonoid; hydroxyflavone; methoxyflavone; ring assembly	bone density conservation agent; platelet aggregation inhibitor
scutellarein scutellarein: aglycone of scutellarin from Scutellaria baicalensis; carthamidin is 2S isomer of scutellarein; do not confuse with isoscutellarein and/or isocarthamidin which are respective regioisomers, or with the scutelarin protein. scutellarein : Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.	2.31	1	tetrahydroxyflavone	metabolite
benzyloxycarbonyl-phe-ala-fluormethylketone cathepsin B inhibitor : A cysteine protease inhibitor which inhibits cathepsin B (EC 3.4.22.1).	2.31	1
bilobetin bilobetin: a phospholipase A2 antagonist	2.31	1	flavonoid oligomer
dextromethorphan Dextromethorphan: Methyl analog of DEXTRORPHAN that shows high affinity binding to several regions of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (RECEPTORS, N-METHYL-D-ASPARTATE) and acts as a non-competitive channel blocker. It is one of the widely used ANTITUSSIVES, and is also used to study the involvement of glutamate receptors in neurotoxicity.. dextromethorphan : A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.	2.08	1	6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene	antitussive; environmental contaminant; neurotoxin; NMDA receptor antagonist; oneirogen; prodrug; xenobiotic
indinavir sulfate Indinavir: A potent and specific HIV protease inhibitor that appears to have good oral bioavailability.	2.31	1	dicarboxylic acid diamide; N-(2-hydroxyethyl)piperazine; piperazinecarboxamide	HIV protease inhibitor
cinanserin Cinanserin: A serotonin antagonist with limited antihistaminic, anticholinergic, and immunosuppressive activity.. cinanserin : An aryl sulfide that is (2E)-3-phenyl-N-(2-sulfanylphenyl)prop-2-enamide in which the hydrogen of the thiol group is substituted by a 3-(dimethylamino)propyl group. It is a 5-hydroxytryptamine receptor antagonist and an inhibitor of SARS-CoV replication.	2.31	1	aryl sulfide; cinnamamides; secondary carboxamide; tertiary amino compound	anticoronaviral agent; antiviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-leucinamide N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valyl-N-{(2S,3E)-5-(benzyloxy)-5-oxo-1-[(3S)-2-oxopyrrolidin-3-yl]pent-3-en-2-yl}-L-leucinamide : A tripeptide resulting from the formal condensation of the carboxy group of N-[(5-methyl-1,2-oxazol-3-yl)carbonyl]-L-alanyl-L-valine with the amino group of benzyl (2E,4S)-4-(L-leucylamino)-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate. It is an inhibitor of the main protease of SARS-CoV-2.	2.31	1	benzyl ester; isoxazoles; pyrrolidin-2-ones; tripeptide	anticoronaviral agent; antiviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
salvianolic acid B salvianolic acid B: isolated from Salvia miltiorrhiza. salvianolic acid B : A member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza	2.31	1	1-benzofurans; catechols; dicarboxylic acid; enoate ester; polyphenol	anti-inflammatory agent; antidepressant; antineoplastic agent; antioxidant; apoptosis inducer; autophagy inhibitor; cardioprotective agent; hepatoprotective agent; hypoglycemic agent; neuroprotective agent; osteogenesis regulator; plant metabolite
Ethyl (E,4S)-4-[[(2S)-2-[[(2S)-3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]-3-phenylpropanoyl]amino]-5-[(3S)-2-oxopyrrolidin-3-yl]pent-2-enoate [no description available]	2.31	1	dipeptide	anticoronaviral agent
mdl 201053 MDL 201053: Immunosuppressive Agent; RN given refers to compound with no isomeric designation	2.31	1
5-Chloro-3-pyridinyl 2-furoate [no description available]	2.31	1	carboxylic ester	anticoronaviral agent
proflavine hemisulfate [no description available]	2.04	1
sp 100030 N-(3,5-bis(trifluoromethyl)phenyl)-2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxamide: transcription factor inhibitor specific to T-cells	2.31	1
gw0742 GW 610742: structure in first source	2.31	1	monocarboxylic acid
benzyloxycarbonyl-isoleucyl-glutamyl(o-tert-butyl)-alanyl-leucinal benzyloxycarbonyl-isoleucyl-glutamyl(O-tert-butyl)-alanyl-leucinal: inhibits chymotrypsin activity of the proteasome	2.31	1
1-oxomiltirone 1-oxomiltirone: from roots of the Iranian medicinal plant Perovskia abrotanoides; structure in first source	2.5	2
sepantronium sepantronium: a survivin suppressant with antineoplastic activity. sepantronium : An organic cation that is 1-(2-methoxyethyl)-2-methyl-1H-naphtho[2,3-d]imidazole-4,9-dione in which the nitrogen at position 3 of the napthoimidazole moiety has been alkylated by a pyrazin-2-ylmethyl group.	2.31	1	organic cation
n-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide boceprevir : A synthetic tripeptide consisting of N-(tert-butylcarbamoyl)-3-methyl-L-valyl, a cyclopropyl-fused prolyl and 3-amino-4-cyclobutyl-2-oxobutanamide residues joined in sequence. Used for treatment of chronic hepatitis C virus genotype 1 infection.	2.31	1	tripeptide; ureas	antiviral drug; hepatitis C protease inhibitor; peptidomimetic
triptohypol C triptohypol C : A pentacyclic triterpenoid with formula C29H40O4, originally isolated from the root bark of Tripterygium regelii.	2.31	1	benzenediols; monocarboxylic acid; pentacyclic triterpenoid	apoptosis inducer; plant metabolite
2-(4-chlorophenyl)-1,2-benzothiazol-3-one [no description available]	2.31	1	benzothiazoles
np 031112 tideglusib: an NSAID and neuroprotective agent. tideglusib : A member of the class of thiadiazolidines that is 1,2,4-thiadiazolidine-3,5-dione which is substituted by a naphthalen-1-yl group at position 2 and by a benzyl group at position 4. It is a non-ATP competitive inhibitor of glycogen synthase kinase 3beta (GSK3beta) and has neuroprotective effects. Currently under clinical investigation for the treatment of Alzheimer's disease and progressive supranuclear palsy.	2.31	1	benzenes; naphthalenes; thiadiazolidine	anti-inflammatory agent; apoptosis inducer; EC 2.7.11.26 (tau-protein kinase) inhibitor; neuroprotective agent
Dihydrotanshinone I dihydrotanshinone I: extracted from Radix Salviae	3.21	5	abietane diterpenoid	anticoronaviral agent
mk-0893 [no description available]	2.31	1
Benzotriazol-1-yl 1H-indole-5-carboxylate [no description available]	2.31	1	indolyl carboxylic acid	anticoronaviral agent
tannins gallotannin : A class of hydrolysable tannins obtained by condensation of the carboxy group of gallic acid (and its polymeric derivatives) with the hydroxy groups of a monosaccharide (most commonly glucose).	2.31	1	tannin
oritavancin oritavancin : A semisynthetic glycopeptide used (as its bisphosphate salt) for the treatment of acute bacterial skin and skin structure infections caused or suspected to be caused by susceptible isolates of designated Gram-positive microorganisms including MRSA.	2.31	1	disaccharide derivative; glycopeptide; semisynthetic derivative	antibacterial drug; antimicrobial agent
5-Bromopyridin-3-yl furan-2-carboxylate [no description available]	2.31	1	carboxylic ester	anticoronaviral agent
(5-Chloropyridin-3-yl) 1H-indole-5-carboxylate [no description available]	2.31	1	indolyl carboxylic acid	anticoronaviral agent
5-Chloropyridin-3-yl 1H-indole-2-carboxylate [no description available]	2.31	1	indolyl carboxylic acid	anticoronaviral agent
phenylmercuric acetate Phenylmercuric Acetate: A phenyl mercury compound used mainly as a fungicide. Has also been used as a herbicide, slimicide, and bacteriocide.	2.31	1	arylmercury compound; benzenes
thimerosal Thimerosal: An ethylmercury-sulfidobenzoate that has been used as a preservative in VACCINES; ANTIVENINS; and OINTMENTS. It was formerly used as a topical antiseptic. It degrades to ethylmercury and thiosalicylate.. thimerosal : An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.	2.31	1	alkylmercury compound	antifungal drug; antiseptic drug; disinfectant; drug allergen
tanshinone ii a sodium sulfonate tanshinone II A sodium sulfonate: has cardioprotective activity; water-soluble derivative of tanshinone II A; isolated from Salvia militiorrhiza; relieves anginal pain; structure	2.08	1
(5-Chloropyridin-3-yl) 1H-indole-4-carboxylate [no description available]	2.31	1	indolyl carboxylic acid	anticoronaviral agent
piperidines Piperidines: A family of hexahydropyridines.	2.21	1
Benzyl N-[(2S)-3-methyl-1-[[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]-1-(1,3-thiazol-2-yl)propan-2-yl]amino]pentan-2-yl]amino]-1-oxobutan-2-yl]carbamate [no description available]	2.31	1	dipeptide	anticoronaviral agent
amg-837 AMG-837: GPR40 agonist	2.31	1
N-[(1R)-2-(tert-butylamino)-2-oxo-1-(3-pyridinyl)ethyl]-N-(4-tert-butylphenyl)-2-furancarboxamide [no description available]	2.31	1	aromatic amide; furans
dicumarol Dicumarol: An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases.	2.13	1	hydroxycoumarin	anticoagulant; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; Hsp90 inhibitor; vitamin K antagonist
bictegravir bictegravir: HIV Integrase Inhibitors. bictegravir : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxylic acid with the amino group of 2,4,6-trifluorobenzylamine. It is a second-generation integrase strand transfer inhibitor (INSTI) and used (as its sodium salt) for the treatment of HIV-1.	2.31	1	monocarboxylic acid amide; organic heterotetracyclic compound; secondary carboxamide; trifluorobenzene	HIV-1 integrase inhibitor
sildenafil sildenafil : A pyrazolo[4,3-d]pyrimidin-7-one having a methyl substituent at the 1-position, a propyl substituent at the 3-position and a 2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl group at the 5-position.	2.31	1	piperazines; pyrazolopyrimidine; sulfonamide	EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent
amg531 [no description available]	2.31	1
N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 1H-indole-2-carboxylic acid with the primary amino group of 3-cyclohexyl-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-alaninamide. It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture (EC50 = 0.53 muM).	2.31	1	aldehyde; indolecarboxamide; oligopeptide; pyrrolidin-2-ones; secondary carboxamide	anticoronaviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide 3-fluoro-Nalpha-(1H-indol-2-ylcarbonyl)-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide : A secondary carboxamide resulting from the formal condensation of the carboxy group of 1H-indole-2-carboxylic acid with the primary amino group of 3-fluoro-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide. It is an inhibitor of SARS coronavirus main proteinase and inhibits SARS-CoV-2 replication in cell culture (EC50 = 0.72 muM).	2.31	1	aldehyde; indolecarboxamide; monofluorobenzenes; oligopeptide; pyrrolidin-2-ones; secondary carboxamide	anticoronaviral agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
phenanthrenes Phenanthrenes: POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.. phenanthrenes : Any benzenoid aromatic compound that consists of a phenanthrene skeleton and its substituted derivatives thereof.	5.75	25

Condition	Relationship Strength	Studies
Respiratory Syndrome, Acute, Severe [description not available]	2.07	1
Severe Acute Respiratory Syndrome A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.	2.07	1
Cancer of Liver [description not available]	2.11	1
Liver Neoplasms Tumors or cancer of the LIVER.	2.11	1
Leucocythaemia [description not available]	2.61	2
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	7.61	2
Benign Neoplasms [description not available]	2.6	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.6	1
Agnogenic Myeloid Metaplasia [description not available]	2.21	1
Cell Transformation, Neoplastic Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.	2.21	1
Hemorrhagic Thrombocythemia [description not available]	2.21	1
Thrombocythemia, Essential A clinical syndrome characterized by repeated spontaneous hemorrhages and a remarkable increase in the number of circulating platelets.	2.21	1
Primary Myelofibrosis A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.	2.21	1
Acute Lymphoid Leukemia [description not available]	2.11	1
Precursor Cell Lymphoblastic Leukemia-Lymphoma A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.	2.11	1
Cancer of Colon [description not available]	2.13	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.13	1
Acute Confusional Senile Dementia [description not available]	2.15	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.15	1
Bowel Diseases, Inflammatory [description not available]	2.15	1
Inflammatory Bowel Diseases Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.	2.15	1
Atherogenesis [description not available]	2.13	1
Atherosclerosis A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.	2.13	1
Drug Withdrawal Symptoms [description not available]	2.43	2
Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.	2.43	2
Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.	2.03	1

miltirone

Description

Cross-References

Synonyms (36)

Research Excerpts

Overview

Drug Classes (1)

Protein Targets (14)

Inhibition Measurements

Biological Processes (39)

Molecular Functions (30)

Ceullar Components (25)

Bioassays (107)

Research

Studies (31)

Market Indicators

Research Demand Index: 23.52

Study Types

miltirone

Description

Cross-References

Synonyms (36)

Research Excerpts

Overview

Drug Classes (1)

Protein Targets (14)

Inhibition Measurements

Biological Processes (39)

Molecular Functions (30)

Ceullar Components (25)

Bioassays (107)

Research

Studies (31)

Market Indicators

Research Demand Index: 23.52

Study Types

Related Drugs (137)

Related Conditions (26)