A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
ChEBI ID: 51060
| Member | Definition | Class |
|---|---|---|
| liquiritigenin | A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta. | liquiritigenin |
| tibolone | Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis. | tibolone |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 29 (2.74) | 18.7374 |
| 1990's | 126 (11.92) | 18.2507 |
| 2000's | 557 (52.70) | 29.6817 |
| 2010's | 281 (26.58) | 24.3611 |
| 2020's | 64 (6.05) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 336 (29.53%) | 5.53% |
| Reviews | 150 (13.18%) | 6.00% |
| Case Studies | 27 (2.37%) | 4.05% |
| Observational | 1 (0.09%) | 0.25% |
| Other | 624 (54.83%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 0.0376 | 6 | 6 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 26.6032 | 1 | 1 |
| cytochrome P450 2C9, partial | Homo sapiens (human) | Potency | 16.9319 | 1 | 2 |
| cytochrome P450 2D6 | Homo sapiens (human) | Potency | 38.9018 | 1 | 1 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 22.2367 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 0.0352 | 6 | 6 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 0.1634 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 16.6083 | 5 | 5 |
| G | Vesicular stomatitis virus | Potency | 16.9319 | 1 | 2 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 29.0144 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 9.5205 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 0.0027 | 1 | 1 |
| HLA class I histocompatibility antigen, B alpha chain | Homo sapiens (human) | Potency | 16.9319 | 1 | 2 |
| Inositol hexakisphosphate kinase 1 | Homo sapiens (human) | Potency | 16.9319 | 1 | 4 |
| Interferon beta | Homo sapiens (human) | Potency | 16.9319 | 1 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 23.7083 | 2 | 2 |
| nuclear receptor subfamily 1, group I, member 2 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 0.0169 | 2 | 2 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 32.5548 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 29.0144 | 2 | 2 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 26.0820 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 30.0534 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 26.6032 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 9.1000 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | IC50 | 0.1130 | 1 | 1 |
| Androgen receptor | Rattus norvegicus (Norway rat) | Ki | 0.0754 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 1.2200 | 2 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 14.0400 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 0.4333 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | Ki | 0.1238 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/Wilson-Smith/1933(H1N1)) | IC50 | 5.2000 | 2 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | IC50 | 0.0907 | 1 | 1 |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | Ki | 0.0482 | 1 | 1 |
| Tyrosine-protein kinase Yes | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 70.0000 | 3 | 3 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 11.3000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Estrogen receptor beta | Homo sapiens (human) | EC50 | 0.0365 | 1 | 1 |