4-chromanone profile

4-Chromanone is a heterocyclic compound with a chromanone ring system. It is a valuable building block in organic synthesis, serving as a precursor for various biologically active compounds. Its derivatives have demonstrated diverse pharmacological activities, including anti-inflammatory, antioxidant, and anticancer properties. The compound has also been explored for its potential in treating neurological disorders. Research into 4-chromanone focuses on understanding its structure-activity relationships, developing new synthetic methods for its derivatives, and investigating its biological applications.'

ID Source	ID
PubMed CID	68110
CHEMBL ID	453987
CHEBI ID	180567
SCHEMBL ID	28794
MeSH ID	M0187361

Synonym
AC-3079
2,3-dihydro-1-benzopyran-4-one
CHEBI:180567
2,3-dihydrochromen-4-one
chroman-4-one
isochromanone ,
nsc174058
4-chromanone ,
491-37-2
nsc-174058
chromanone
AB-131/40347218
einecs 207-736-3
1341-36-2
4h-1-benzopyran-4-one, 2,3-dihydro-
2,3-dihydro-4h-chromen-4-one
inchi=1/c9h8o2/c10-8-5-6-11-9-4-2-1-3-7(8)9/h1-4h,5-6h
4-chromanone, 97%
C1175
CHEMBL453987
STK801790
AKOS000120888
nsc 174058
BP-12827
FT-0618277
AM20040557
AB00814
dihydrochromone
2,3-dihydro-4h-1-benzopyran-4-one
3,4-dihydro-2h-benzopyran-4-one
2h-[1]benzopyran-4-one
4-chromanon
SCHEMBL28794
SY003783
mfcd00006840
DTXSID3060081
J-200067
3,4-dihydro-2h-1-benzopyran-4-one
STR01088
BS-3822
2,3-dihydro-4h-chromen-4-one #
2,3-dihydro-2-benzopyran-4-one
2,3-dihydro-4-benzopyranone
CS-W007464
F0001-1283
2h-chromen-4(3h)-one
BCP06538
EN300-18584
Z85920466

Class	Description
chromones	A chromenone that consists of a 1,4-benzopyrone skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID758733	Cytotoxicity against human WM115 cells after 46 hrs by MTT assay	2013	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14	Structure-cytotoxic activity relationship of 3-arylideneflavanone and chromanone (E,Z isomers) and 3-arylflavones.
AID758732	Cytotoxicity against human NALM6 cells after 46 hrs by MTT assay	2013	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14	Structure-cytotoxic activity relationship of 3-arylideneflavanone and chromanone (E,Z isomers) and 3-arylflavones.
AID355880	Pesticidal activity against Dermatophagoides pteronyssinus after 24 hrs	2003	Journal of natural products, May, Volume: 66, Issue:5	Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives.
AID1186725	Cytotoxicity against human HL60 cells by MTT assay	2014	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17	Cytotoxic activity of substituted chalcones in terms of molecular electronic properties.
AID1186726	Cytotoxicity against human NALM6 cells by MTT assay	2014	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17	Cytotoxic activity of substituted chalcones in terms of molecular electronic properties.
AID758734	Cytotoxicity against human HL60 cells after 46 hrs by MTT assay	2013	Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14	Structure-cytotoxic activity relationship of 3-arylideneflavanone and chromanone (E,Z isomers) and 3-arylflavones.
AID1186727	Cytotoxicity against human WM115 cells by MTT assay	2014	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17	Cytotoxic activity of substituted chalcones in terms of molecular electronic properties.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (11.11)	18.2507
2000's	2 (11.11)	29.6817
2010's	9 (50.00)	24.3611
2020's	5 (27.78)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.26%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	18 (94.74%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.01	1	coumarins	fluorescent dye; human metabolite; plant metabolite
phloroglucinol Phloroglucinol: A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.. phloroglucinol : A benzenetriol with hydroxy groups at position 1, 3 and 5.	2.1	1	benzenetriol; phenolic donor	algal metabolite
dibenzofuran Dibenzofurans: Compounds that include the structure of dibenzofuran.. dibenzofurans : Any organic heterotricyclic compound based on a dibenzofuran skeleton and its substituted derivatives thereof.. dibenzofuran : A mancude organic heterotricyclic parent that consists of a furan ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.	7.31	1	dibenzofurans; mancude organic heterotricyclic parent; polycyclic heteroarene	xenobiotic
indole [no description available]	2.31	1	indole; polycyclic heteroarene	Escherichia coli metabolite
benzyl benzoate benzyl benzoate: structure; acarosan, a moist powder composed of wetted cellulose and benzyl benzoate, is used on carpets as an acaricide. benzyl benzoate : A benzoate ester obtained by the formal condensation of benzoic acid with benzyl alcohol. It has been isolated from the plant species of the genus Polyalthia.	2.01	1	benzoate ester; benzyl ester	acaricide; plant metabolite; scabicide
beta-naphthoflavone beta-Naphthoflavone: A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308). beta-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the f side of flavone.	1.99	1	extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound	aryl hydrocarbon receptor agonist
alanine Alanine: A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.. alanine : An alpha-amino acid that consists of propionic acid bearing an amino substituent at position 2.	1.99	1	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite
salicylaldehyde o-hydroxybenzaldehyde: structure in first source	2.08	1	hydroxybenzaldehyde	nematicide; plant metabolite
xanthone xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.	1.98	1	xanthones	insecticide
6-methylcoumarin 6-methylcoumarin: synthetic fragrance causing contact photoallergy. 6-methylcoumarin : A member of the class of coumarins that is coumarin in which the hydrogen at position 6 is replaced by a methyl group.	2.01	1	coumarins	allergen; fragrance
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	1.98	1	xanthene
benzylparaben [no description available]	2.01	1	benzoate ester; benzyl ester
acetophenone acetophenone : A methyl ketone that is acetone in which one of the methyl groups has been replaced by a phenyl group.	7.31	1	acetophenones	animal metabolite; photosensitizing agent; xenobiotic
benzyl salicylate benzyl salicylate: structure given in Merck	2.01	1	benzoate ester; phenols
flavanone flavanone: RN given refers to cpd with unspecified isomeric designation; structure in first source. flavanone : The simplest member of the class of flavanones that consists of flavan bearing an oxo substituent at position 4.	2.75	3	flavanones
indole-3-carbaldehyde indole-3-carbaldehyde: metabolite of tryptophan; structure. indole-3-carbaldehyde : A heteroarenecarbaldehyde that is indole in which the hydrogen at position 3 has been replaced by a formyl group.	2.05	1	heteroarenecarbaldehyde; indole alkaloid; indoles	bacterial metabolite; human xenobiotic metabolite; marine metabolite; plant metabolite
4-chromone 4-chromone: structure given in first source. chromone : The simplest member of the class of chromones that is 4H-chromene with an oxo group at position 4.	2.01	1	chromones; enone
flavone flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.	2.41	2	flavones	metabolite; nematicide
alpha-naphthoflavone alpha-naphthoflavone: inhibits P4501A1 and P4501A2; stimulates some activities of P4503A4. alpha-naphthoflavone : An extended flavonoid resulting from the formal fusion of a benzene ring with the h side of flavone. A synthetic compound, it is an inhibitor of aromatase (EC 1.14.14.14).	1.99	1	extended flavonoid; naphtho-gamma-pyrone; organic heterotricyclic compound	aryl hydrocarbon receptor agonist; aryl hydrocarbon receptor antagonist; EC 1.14.14.14 (aromatase) inhibitor
rhodium Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.	2.08	1	cobalt group element atom
alkenes [no description available]	2.08	1
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.31	1
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.08	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
quinidine Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.	2.31	1	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker
griseofulvin Griseofulvin: An antifungal agent used in the treatment of TINEA infections.. griseofulvin : An oxaspiro compound produced by Penicillium griseofulvum. It is used by mouth as an antifungal drug for infections involving the scalp, hair, nails and skin that do not respond to topical treatment.	2.31	1	1-benzofurans; antibiotic antifungal drug; benzofuran antifungal drug; organochlorine compound; oxaspiro compound	antibacterial agent; Penicillium metabolite
chalcone trans-chalcone : The trans-isomer of chalcone.	2.1	1	chalcone	EC 3.2.1.1 (alpha-amylase) inhibitor
2'-hydroxychalcone 2'-hydroxychalcone : A member of the class of chalcones that is trans-chalcone substituted by a hydroxy group at position 2'.	2.1	1	chalcones; phenols	anti-inflammatory agent
quinine [no description available]	2.31	1	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic
benzyl cinnamate benzyl cinnamate: structure in first source. benzyl cinnamate : The cinnamate ester derived from cinnamic acid and benzyl alcohol. Occuring in Balsam of Peru and Tolu balsam, in Sumatra and Penang benzoin, and as the main constituent of copaiba balsam, it is used in heavy oriental perfumes, as a fixative and as a flavouring agent.	2.01	1	cinnamate ester	antigen; epitope; fixative; flavouring agent; fragrance
quercetin [no description available]	2.08	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.01	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
2'-hydroxy-4-methoxychalcone [no description available]	2.1	1
2',4'-dihydroxychalcone 2',4'-dihydroxychalcone: RN given refers to (E)-isomer; RN for cpd without isomeric designation not available 6/89; structure given in first source	2.1	1
sinomenine sinomenine: isolated from root of Sinomenium acutum; antirheumatic, antineuralgic	2.31	1	morphinane alkaloid
Crotaoprostrin [no description available]	2.1	1	chalcones
2',5'-dihydroxychalcone 2',5'-dihydroxychalcone: structure given in first source	2.1	1	chalcones
morphinans Morphinans: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.	2.31	1	isoquinoline alkaloid fundamental parent; morphinane alkaloid
4-hydroxycoumarin 2-hydroxychromone: structure	2.01	1	hydroxycoumarin

Condition	Relationship Strength	Studies
Alloxan Diabetes [description not available]	2.21	1
Hyperglycemia, Postprandial Abnormally high BLOOD GLUCOSE level after a meal.	2.21	1
Hyperglycemia Abnormally high BLOOD GLUCOSE level.	7.21	1
Benign Neoplasms [description not available]	2.31	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.31	1

4-chromanone

Cross-References

Synonyms (49)

Drug Classes (1)

Bioassays (7)

Research

Studies (18)

Market Indicators

Research Demand Index: 35.95

Study Types