Compounds > jujuboside b
Page last updated: 2024-11-13

jujuboside b

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Description

jujuboside B: from seeds of Ziziphus jujuba; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ZiziphusgenusA plant genus of the family RHAMNACEAE. Members contain nummularogenin (a spirostane) and is the source of an edible fruit.[MeSH]RhamnaceaeThe buckthorn plant family, of the order Rhamnales, includes some species with edible fruits and some that are medicinal.[MeSH]

Cross-References

ID SourceID
PubMed CID24721031
CHEMBL ID3109480
CHEBI ID177644
MeSH IDM0534873

Synonyms (13)

Synonym
CHEBI:177644
jujuboside b
C17832
S9214
AKOS025311225
CHEMBL3109480
Q-100637
jujuboside b, >=98% (hplc)
HY-N0660
HMS3887M09
CCG-270616
CS-0009680
AS-83578

Research Excerpts

Overview

Jujuboside B (JuB) is a main bioactive saponin component isolated from the Chinese anti-insomnia herbal medicine Ziziphi Spinosae Semen. Jujubosides have been proved to exhibit neuroprotective effects recently.

ExcerptReferenceRelevance
"Jujuboside B (JUB) is a saponins isolated from the seeds of "( Jujuboside B Reverse CUMS-Promoted Tumor Progression via Blocking PI3K/Akt and MAPK/ERK and Dephosphorylating CREB Signaling.
Cai, W; Chen, Y; Cheng, Y; Guo, Z; Xiao, Z; Xu, F; Yang, Z; Zhou, T, 2022)		3.61
"Jujuboside B (JuB) is a main bioactive saponin component isolated from the Chinese anti-insomnia herbal medicine Ziziphi Spinosae Semen (ZSS), seed of Ziziphus jujuba Mill, which has been proved to exhibit neuroprotective effects recently."( Jujuboside B inhibits febrile seizure by modulating AMPA receptor activity.
Bai, H; Bai, W; Chen, S; Dong, C; Guo, H; Hao, J; Huang, Z; Jia, Q; Jin, B; Kong, D; Li, Y; Qin, X; Yang, Z; Zhang, W; Zhao, J; Zhao, Z, 2023)		3.07
"Jujuboside B (JB) is a natural compound pressed from the seed of"( Jujuboside B Inhibited High Mobility Group Box Protein 1-Mediated Severe Inflammatory Responses in Human Endothelial Cells and Mice.
Bae, JS; Kim, C; Kim, N; Ryu, SH, 2023)		3.07
"Jujuboside B (JB) is a natural saponin and one of the active constituent of fruits of Zizyphus jujuba."( Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma.
Ninave, PB; Patil, SD, 2019)		1.49
"Jujuboside B (JuB) is a main bioactive saponin constituent of Ziziphi Spinosae Semen, which is a traditional herb for the treatment of insomnia and anxiety. "( Degradation kinetics of jujuboside b by rat intestinal flora in vitro with an RRLC-MS-MS method.
Ma, G; Xie, J; Zhang, K; Zhang, M; Zhang, Y, 2014)		2.15
"Jujuboside B is a natural compound with new pharmacological effects on improving endothelial dysfunction and treating vascular diseases."( Jujuboside B Reduces Vascular Tension by Increasing Ca2+ Influx and Activating Endothelial Nitric Oxide Synthase.
Bian, Y; Fu, Z; Li, J; Liu, B; Sheng, M; Yang, B; Zhang, X; Zhang, Y; Zhao, Y, 2016)		2.6

Effects

ExcerptReferenceRelevance
"Jujuboside B has been reported to have protective effect on many cardiovascular diseases. "( Jujuboside B Reduces Vascular Tension by Increasing Ca2+ Influx and Activating Endothelial Nitric Oxide Synthase.
Bian, Y; Fu, Z; Li, J; Liu, B; Sheng, M; Yang, B; Zhang, X; Zhang, Y; Zhao, Y, 2016)		3.32
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoidAny terpenoid derived from a triterpene. The term includes compounds in which the C30 skeleton of the parent triterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (78)

Assay IDTitleYearJournalArticle
AID1066748Induction of apoptosis in human AGS cells assessed as increase in pp38 level at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066792Induction of apoptosis in human HCT116 cells assessed as membrane blebbing at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066801Cytotoxicity against human AGS cells after 24 hrs by MTT assay2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066732Induction of apoptosis in human AGS cells assessed as reduction of caspase8 activation at 100 uM after 24 hrs by Western blotting analysis in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066800Cytotoxicity against human HCT116 cells after 24 hrs by MTT assay2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066767Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.68%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066766Induction of apoptosis in human AGS cells assessed as apoptotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066771Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 2.71%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066773Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 2.71%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066738Induction of autophagy in human HCT116 cells assessed as massive vacuole formation at 50 uM after 24 hrs by acridine orange staining-based fluorescence microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066788Induction of apoptosis in human AGS cells assessed as early apoptotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 6.6%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066799Induction of apoptosis in human AGS cells assessed as cell rounding at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066776Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 3.61%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066774Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 2.71%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066802Induction of autophagy in human AGS cells assessed as massive vacuole formation at 50 uM after 24 hrs by acridine orange staining-based fluorescence microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066761Cell cycle arrest in human AGS cells assessed as accumulation at sub G1 phase at 150 uM after 24 hrs by propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066755Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse assessed as reduction of Ki-67 expression at 40 mg/kg, ip administered 3 times a week for 5 weeks by immunohistochemical analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066746Induction of apoptosis in human AGS cells assessed as decrease in pERK level at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066769Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.68%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066747Induction of apoptosis in human AGS cells assessed as increase in pJNK level at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066745Induction of apoptosis in human AGS cells assessed as reduction of caspase8 activation at 100 uM after 24 hrs by Western blotting analysis in presence of SB2021902014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066790Induction of apoptosis in human AGS cells assessed as early apoptotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 6.6%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066779Induction of apoptosis in human AGS cells assessed as necrotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.12%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066734Cytotoxicity against human AGS cells at 100 uM after 24 hrs by MTT assay in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066789Induction of apoptosis in human AGS cells assessed as early apoptotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 6.6%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066795Induction of apoptosis in human AGS cells assessed as formation of apoptotic bodies at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066737Induction of autophagy in human HCT116 cells assessed as massive vacuole formation at 50 uM after 24 hrs by acridine orange staining-based fluorescence microscopy in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066727Induction of apoptosis in human AGS cells assessed as increase in LC3-2 level at 50 uM after 24 hrs by Western blotting analysis in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066754Induction of apoptosis in human AGS cells assessed as caspase-3 activation after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066729Induction of apoptosis in human AGS cells assessed as increase in pJNK level at 100 uM after 24 hrs by Western blotting analysis in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066787Induction of apoptosis in human AGS cells assessed as early apoptotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 6.6%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066728Induction of apoptosis in human AGS cells assessed as increase in FasL level at 100 uM after 24 hrs by Western blotting analysis in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066777Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 3.61%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066786Induction of apoptosis in human AGS cells assessed as late apoptotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 7.3%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066731Induction of apoptosis in human AGS cells assessed as reduction of caspase3 activation at 100 uM after 24 hrs by Western blotting analysis in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066763Induction of apoptosis in human AGS cells assessed as apoptotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066780Induction of apoptosis in human AGS cells assessed as necrotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.12%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066803Induction of apoptosis in human AGS cells assessed as reduction of caspase3 activation at 100 uM after 24 hrs by Western blotting analysis in presence of SB2021902014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066758Cell cycle arrest in human HCT116 cells assessed as accumulation at sub G1 phase after 24 hrs by propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066749Induction of apoptosis in human AGS cells assessed as caspase-9 activation at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066775Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 3.61%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066744Induction of apoptosis in human AGS cells assessed as reduction of caspase8 activation at 100 uM after 24 hrs by Western blotting analysis in presence of SP6001252014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066768Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.68%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066765Induction of apoptosis in human AGS cells assessed as apoptotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066772Induction of apoptosis in human HCT116 cells assessed as late apoptotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 2.71%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066736Induction of autophagy in human AGS cells assessed as increase in LC3-2 level at 50 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066770Induction of apoptosis in human HCT116 cells assessed as necrotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.68%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066733Cell cycle arrest in human AGS cells assessed as accumulation at sub G1 phase at 100 uM after 24 hrs by propidium iodide staining-based flow cytometry in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066796Induction of apoptosis in human AGS cells assessed as membrane blebbing at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066759Induction of apoptosis in human HCT116 cells assessed as apoptotic cells after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066791Induction of apoptosis in human HCT116 cells assessed as formation of apoptotic bodies at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066778Induction of apoptosis in human HCT116 cells assessed as early apoptotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 3.61%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066797Induction of apoptosis in human AGS cells assessed as cell shrinkage at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066735Induction of autophagy in human HCT116 cells assessed as increase in LC3-2 level at 50 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066782Induction of apoptosis in human AGS cells assessed as necrotic cells at 25 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.12%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066743Induction of apoptosis in human AGS cells assessed as reduction of FasL level at 100 uM after 24 hrs by Western blotting analysis in presence of SB2021902014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066798Cytotoxicity against human Chang cells after 24 hrs by MTT assay2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066762Cell cycle arrest in human AGS cells assessed as accumulation at sub G1 phase at 100 uM after 24 hrs by propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066784Induction of apoptosis in human AGS cells assessed as late apoptotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 7.3%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066739Induction of autophagy in human AGS cells assessed as massive vacuole formation at 50 uM after 24 hrs by acridine orange staining-based fluorescence microscopy in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066751Induction of apoptosis in human AGS cells assessed as increase in FasL level at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066764Induction of apoptosis in human AGS cells assessed as apoptotic cells at 100 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066756Toxicity in BALB/c nude mouse xenografted with human HCT116 cells assessed as change in body weight at 40 mg/kg, ip administered 3 times a week for 5 weeks2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066753Induction of apoptosis in human AGS cells assessed as PARP-1 cleavage after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066781Induction of apoptosis in human AGS cells assessed as necrotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.12%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066742Induction of apoptosis in human AGS cells assessed as reduction of FasL level at 100 uM after 24 hrs by Western blotting analysis in presence of SP6001252014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066730Induction of apoptosis in human AGS cells assessed as increase in pp38 level at 100 uM after 24 hrs by Western blotting analysis in presence of bafilomycin A12014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066757Antitumor activity against human HCT116 cells xenografted in BALB/c nude mouse at 40 mg/kg, ip administered 3 times a week for 5 weeks relative to control2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066785Induction of apoptosis in human AGS cells assessed as late apoptotic cells at 50 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 7.3%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066783Induction of apoptosis in human AGS cells assessed as late apoptotic cells at 150 uM after 24 hrs by annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 7.3%)2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066793Induction of apoptosis in human HCT116 cells assessed as cell shrinkage at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066740Induction of autophagy in human HCT116 cells assessed as massive vacuole formation at 50 uM after 24 hrs by fluorescence microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066750Induction of apoptosis in human AGS cells assessed as procaspase-9 level at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066804Induction of apoptosis in human AGS cells assessed as reduction of caspase3 activation at 100 uM after 24 hrs by Western blotting analysis in presence of SP6001252014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066741Induction of autophagy in human AGS cells assessed as massive vacuole formation at 50 uM after 24 hrs by fluorescence microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066794Induction of apoptosis in human HCT116 cells assessed as cell rounding at >100 uM after 24 hrs by acridine orange staining-based microscopy2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066760Cell cycle arrest in human AGS cells assessed as accumulation at sub G1 phase at 200 uM after 24 hrs by propidium iodide staining-based flow cytometry2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
AID1066752Induction of apoptosis in human AGS cells assessed as caspase-8 activation at 25 to 150 uM after 24 hrs by Western blotting analysis2014Journal of natural products, Feb-28, Volume: 77, Issue:2
Antitumor activity of jujuboside B and the underlying mechanism via induction of apoptosis and autophagy.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (17)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.88)29.6817
2010's8 (47.06)24.3611
2020's8 (47.06)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 22.22

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index22.22 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index5.82 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (22.22)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
pyrogallol
benzenetriol : A triol in which three hydroxy groups are substituted onto a benzene ring.		2.2110benzenetriol;
phenolic donor		plant metabolite
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.		2.610non-proteinogenic alpha-amino acid
clonidine
Clonidine: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.. clonidine (amino form) : A clonidine that is 4,5-dihydro-1H-imidazol-2-amine in which one of the amino hydrogens is replaced by a 2,6-dichlorophenyl group.		2.2110clonidine;
imidazoline
pyrazolanthrone
pyrazolanthrone: JNK (c-Jun N-terminal kinase) inhibitor; structure in first source. anthra[1,9-cd]pyrazol-6(2H)-one : A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.		2.110anthrapyrazole;
aromatic ketone;
cyclic ketone		antineoplastic agent;
c-Jun N-terminal kinase inhibitor;
geroprotector
betulinic acid
[no description available]		2.4620hydroxy monocarboxylic acid;
pentacyclic triterpenoid		anti-HIV agent;
anti-inflammatory agent;
antimalarial;
antineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
plant metabolite
swertisin
swertisin: from Wilbrandia ebracteata; structure in first source. swertisin : A flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue.		2.1510dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone;
monosaccharide derivative;
polyphenol		adenosine A1 receptor antagonist;
anti-inflammatory agent;
antioxidant;
hypoglycemic agent;
plant metabolite
spinosin
spinosin: isolated from seeds of Ziziph spinosa; structure given in first source. spinosin : A flavone C-glycoside that is flavone substituted by hydroxy groups at positions 5 and 4', a methoxy group at position 7 and a 2-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl residue at position 6 via a C-glycosidic linkage.		2.1510dihydroxyflavone;
flavone C-glycoside;
monomethoxyflavone		anxiolytic drug;
plant metabolite
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.2110
quercetin
[no description available]		2.25107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigenin
Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.		2.1510trihydroxyflavoneantineoplastic agent;
metabolite
bafilomycin a1
bafilomycin A1: from Streptomyces griseus; structure given in first source. bafilomycin A1 : The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.		2.110cyclic hemiketal;
macrolide antibiotic;
oxanes		apoptosis inducer;
autophagy inhibitor;
bacterial metabolite;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor;
ferroptosis inhibitor;
fungicide;
potassium ionophore;
toxin
beta-escin
[no description available]		4.31160
jujuboside a
[no description available]		3.3860triterpenoid
ConditionIndicatedRelationship StrengthStudiesTrials
Convulsions, Febrile
[description not available]		02.610
Seizures, Febrile
Seizures that occur during a febrile episode. It is a common condition, affecting 2-5% of children aged 3 months to five years. An autosomal dominant pattern of inheritance has been identified in some families. The majority are simple febrile seizures (generally defined as generalized onset, single seizures with a duration of less than 30 minutes). Complex febrile seizures are characterized by focal onset, duration greater than 30 minutes, and/or more than one seizure in a 24 hour period. The likelihood of developing epilepsy (i.e., a nonfebrile seizure disorder) following simple febrile seizures is low. Complex febrile seizures are associated with a moderately increased incidence of epilepsy. (From Menkes, Textbook of Child Neurology, 5th ed, p784)		02.610
Blood Poisoning
[description not available]		02.610
Sepsis
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.		02.610
Chronic Insomnia
[description not available]		02.610
Sleep Initiation and Maintenance Disorders
Disorders characterized by impairment of the ability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.		02.610
Asthma, Bronchial
[description not available]		02.2110
Anochlesia
[description not available]		02.2110
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2110
Eosinophilia, Tropical
[description not available]		02.2110
Leukocytosis
A transient increase in the number of leukocytes in a body fluid.		02.2110
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		07.2110
Eosinophilia
Abnormal increase of EOSINOPHILS in the blood, tissues or organs.		02.2110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.110
Embolism, Pulmonary
[description not available]		02.0810
Pulmonary Embolism
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.		02.0810