Compounds > 4,4'-Dihydroxybenzophenone
Page last updated: 2024-09-23

4,4'-Dihydroxybenzophenone

Cross-References

ID SourceID
PubMed CID69150
CHEMBL ID194859
CHEBI ID34365
SCHEMBL ID18423

Synonyms (74)

Synonym
AC-348
BIDD:ER0179
nsc2831
methanone, bis(4-hydroxyphenyl)-
611-99-4
nsc-2831
bis(p-hydroxy)benzophenone
benzophenone, 4,4'-dihydroxy-
bis(4-hydroxyphenyl) ketone
brn 1874572
p,p'-dihydroxybenzophenone
4,4'-dihydroxydiphenyl ketone
hbp (ketone)
einecs 210-288-1
ai3-00127
nsc 2831
bis(4-hydroxyphenyl)methanone
4,4'-dihydroxybenzophenone
OPREA1_287266
4,4 -dihydroxybenzophenone
compound 0627-0373 (dhbp)
4-[(4-hydroxyphenyl)carbonyl]phenol
bdbm25807
4,4'-dihydroxybenzophenone, 99%
4,4'-dihydoxy-benzophenone
D0577
DB07635
4,4-dihydroxybenzophenone
CHEMBL194859
chebi:34365 ,
STK668062
A833093
NCGC00248695-01
tox21_200550
NCGC00258104-01
4,4'-dihydoxybenzophenone
dtxsid1022425 ,
cas-611-99-4
dtxcid602425
AKOS005206702
4-08-00-02452 (beilstein handbook reference)
hzr7d31sby ,
unii-hzr7d31sby
ccris 9457
4-(4-hydroxybenzoyl)phenol
4,4-dihydroxy benzophenone
FT-0617057
AM20050154
4,4'dihydroxybenzophenone
4,4' dihydroxybenzophenone
4,4'dihydroxy-benzophenone
4,4'-dihydroxybenzophenon
4,4'-dihydroxy benzophenone
bis-(4-hydroxy-phenyl)-methanone
bis(4-hydroxyphenyl)-methanone
4,4'-dihydroxy-benzophenone
SCHEMBL18423
4,4 inverted exclamation mark -dihydroxybenzophenone
SY005681
mfcd00002358
W-105181
sr-01000393027
SR-01000393027-1
GS-3450
4,4'-dihydroxybenzophenone, analytical standard
AC7529
4,4`-dihydroxybenzophenone
CS-W014942
bp_14
Q4637052
bis(4-hydroxy)benzophenone
4,4?-dihydroxybenzophenone
PD005603
HY-W014226

Drug Classes (1)

ClassDescription
benzophenonesAny aromatic ketone in which the carbonyl group is bonded to 2 phenyl groups.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (18)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency70.97990.007215.758889.3584AID1224835
GLI family zinc finger 3Homo sapiens (human)Potency13.76140.000714.592883.7951AID1259369; AID1259392
AR proteinHomo sapiens (human)Potency29.95220.000221.22318,912.5098AID1259243; AID1259247; AID743035; AID743036; AID743063
estrogen receptor 2 (ER beta)Homo sapiens (human)Potency7.37400.000657.913322,387.1992AID1259377; AID1259394
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency36.09710.001022.650876.6163AID1224838; AID1224839; AID1224893
progesterone receptorHomo sapiens (human)Potency48.55770.000417.946075.1148AID1346795
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency23.93340.003041.611522,387.1992AID1159552; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency43.63580.000817.505159.3239AID1159527
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency19.70740.001530.607315,848.9004AID1224841; AID1224842; AID1224848; AID1224849; AID1259401; AID1259403
pregnane X nuclear receptorHomo sapiens (human)Potency54.48270.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency28.16420.000229.305416,493.5996AID1259383; AID743069; AID743075; AID743077; AID743078; AID743079
aryl hydrocarbon receptorHomo sapiens (human)Potency36.13810.000723.06741,258.9301AID743085; AID743122
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_aHomo sapiens (human)Potency30.63790.001723.839378.1014AID743083
Histone H2A.xCricetulus griseus (Chinese hamster)Potency89.76250.039147.5451146.8240AID1224845
histone deacetylase 9 isoform 3Homo sapiens (human)Potency40.10890.037617.082361.1927AID1259364; AID1259388
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Androgen receptorRattus norvegicus (Norway rat)IC50 (µMol)144.54400.00101.979414.1600AID255211
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Lanosterol 14-alpha demethylaseMycobacterium tuberculosis H37RvKd28.00000.20000.42001.3000AID351876
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID1798586Ligand Binding Assay from Article 10.1128/AAC.00311-07: \\Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.\\2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID255211Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)2005Journal of medicinal chemistry, Sep-08, Volume: 48, Issue:18
Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.
AID752867Inhibition of rabbit skeletal muscle sarco/endoplasmic reticulum calcium ATPase assessed as inhibition of ATP hydrolysis by spectrophotometric analysis2013Bioorganic & medicinal chemistry, Jul-01, Volume: 21, Issue:13
Structural requirements for inhibitory effects of bisphenols on the activity of the sarco/endoplasmic reticulum calcium ATPase.
AID351883Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP125 expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID475505Binding affinity to amyloid beta (1 to 42) oligomers by change in fluorescence at 100 uM after 10 mins2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
AID351884Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP130 expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID351882Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 F78L mutant expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID351879Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 200 uM after 4 days by alamar blue assay2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID763098Leishmanicidal activity against promastigote form of Leishmania amazonensis MHOM/BR/71973/M2269 after 72 hrs by cell counting2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones.
AID305980Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by microdilution resazurin assay2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.
AID763097Cytotoxicity against mouse peritoneal macrophages after 72 hrs by MTT assay2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Synthesis and biological evaluation against Leishmania amazonensis of a series of alkyl-substituted benzophenones.
AID351876Binding affinity to Mycobacterium tuberculosis His4-tagged recombinant CYP51 substrate binding site expressed in Escherichia coli HMS174(DE3) by UV-visible spectral titration method2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID475504Binding affinity to amyloid beta (1 to 42) fibrils by change in fluorescence at 100 uM after 10 mins2009Bioorganic & medicinal chemistry letters, Sep-01, Volume: 19, Issue:17
A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.
AID351878Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 100 uM after 4 days by alamar blue assay2007Antimicrobial agents and chemotherapy, Nov, Volume: 51, Issue:11
Small-molecule scaffolds for CYP51 inhibitors identified by high-throughput screening and defined by X-ray crystallography.
AID305979Antimycobacterial activity against Mycobacterium smegmatis mc2155 after 48 hrs by microdilution resazurin assay2007Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue:5
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.
AID345022Binding affinity to human telomerase P2b RNA by STD NMR2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Discovery of ligands for a novel target, the human telomerase RNA, based on flexible-target virtual screening and NMR.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (71.43)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
chlordecone[no description available]medium10cyclic ketone;
organochlorine compound		insecticide;
persistent organic pollutant
hexachlorocyclohexane[no description available]medium10chlorocyclohexane
vanillin[no description available]medium10benzaldehydes;
monomethoxybenzene;
phenols		anti-inflammatory agent;
anticonvulsant;
antioxidant;
flavouring agent;
plant metabolite
2,4,5-trichlorophenoxyacetic acid[no description available]medium10chlorophenoxyacetic acid;
trichlorobenzene		defoliant;
phenoxy herbicide;
synthetic auxin
4-nonylphenol[no description available]medium10phenolsenvironmental contaminant
clomiphene[no description available]medium10tertiary amineestrogen antagonist;
estrogen receptor modulator
dichlorodiphenyl dichloroethylene[no description available]medium10chlorophenylethylene;
monochlorobenzenes		human xenobiotic metabolite;
persistent organic pollutant
ddt[no description available]medium10benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
benzophenone[no description available]medium20benzophenonesphotosensitizing agent;
plant metabolite
endosulfan[no description available]medium10cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
heptachlor[no description available]medium10cyclodiene organochlorine insecticideagrochemical;
antibacterial agent;
antifungal agent;
GABA-gated chloride channel antagonist;
persistent organic pollutant
methoxychlor[no description available]medium10organochlorine insecticide
nafoxidine[no description available]medium10benzenes;
naphthalenes;
ring assembly
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
prednisolone[no description available]medium1011beta-hydroxy steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(1),Delta(4)-steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		adrenergic agent;
anti-inflammatory drug;
antineoplastic agent;
drug metabolite;
environmental contaminant;
immunosuppressive agent;
xenobiotic
estriol[no description available]medium2016alpha-hydroxy steroid;
17beta-hydroxy steroid;
3-hydroxy steroid		estrogen;
human metabolite;
human xenobiotic metabolite;
mouse metabolite
spironolactone[no description available]medium103-oxo-Delta(4) steroid;
oxaspiro compound;
steroid lactone;
thioester		aldosterone antagonist;
antihypertensive agent;
diuretic;
environmental contaminant;
xenobiotic
aldosterone[no description available]medium1011beta-hydroxy steroid;
18-oxo steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid hormone;
mineralocorticoid;
primary alpha-hydroxy ketone;
steroid aldehyde		human metabolite;
mouse metabolite
androsterone[no description available]medium1017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
17-desoxyestradiol[no description available]medium103-hydroxy steroid;
phenolic steroid;
phenols		estrogen
ethinyl estradiol[no description available]medium1017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
chlordan[no description available]medium10cyclodiene organochlorine insecticideGABA-gated chloride channel antagonist;
persistent organic pollutant
testosterone propionate[no description available]medium10steroid ester
methyltestosterone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone		anabolic agent;
androgen;
antineoplastic agent
androstenedione[no description available]medium1017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
norethindrone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
terminal acetylenic compound;
tertiary alcohol		progestin;
synthetic oral contraceptive
norethynodrel[no description available]medium10oxo steroid
medroxyprogesterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
corticosteroid;
steroid ester		adjuvant;
androgen;
antineoplastic agent;
antioxidant;
female contraceptive drug;
inhibitor;
progestin;
synthetic oral contraceptive
dichlorodiphenyldichloroethane[no description available]medium10chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		xenobiotic metabolite
bisphenol a[no description available]medium20bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
p-tert-amylphenol[no description available]medium10alkylbenzene
2-sec-butylphenol[no description available]medium10phenols
4-phenylphenol[no description available]medium10hydroxybiphenyls
propylparaben[no description available]medium10benzoate ester;
paraben;
phenols		antifungal agent;
antimicrobial agent
butylphen[no description available]medium10phenolsallergen
methylparaben[no description available]medium10parabenantifungal agent;
antimicrobial food preservative;
neuroprotective agent;
plant metabolite
monobenzone[no description available]medium10benzyl etherallergen;
dermatologic drug;
melanin synthesis inhibitor
3-chlorophenol[no description available]medium10monochlorophenol
2,4-dihydroxybenzophenone[no description available]medium20benzophenones
cyproterone acetate[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid;
acetate ester;
chlorinated steroid;
steroid ester		androgen antagonist;
geroprotector;
progestin
epitestosterone[no description available]medium1017alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen antagonist;
human metabolite
flavanone[no description available]medium20flavanones
androstenediol[no description available]medium1017beta-hydroxy steroid;
3beta-hydroxy-Delta(5)-steroid		androgen;
human metabolite;
mouse metabolite;
radiation protective agent
dihydrotestosterone[no description available]medium1017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
flavone[no description available]medium10flavonesmetabolite;
nematicide
4-cumylphenol[no description available]medium10diarylmethane
o,p'-ddt[no description available]medium10diarylmethane
4-hydroxybenzophenone[no description available]medium20benzophenones
4-chloro-2-cresol[no description available]medium10monochlorobenzenes;
phenols
4-octylphenol[no description available]medium10phenolsmetabolite;
surfactant;
xenoestrogen
2,4,2',4'-tetrachlorobiphenyl[no description available]medium10dichlorobenzene;
tetrachlorobiphenyl
ac 45594[no description available]medium10aromatic ether
promegestone[no description available]medium1020-oxo steroid;
3-oxo-Delta(4) steroid		antineoplastic agent;
progesterone receptor agonist;
progestin
2,4'-dichlorobiphenyl[no description available]medium10dichlorobiphenyl;
monochlorobenzenes
4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol[no description available]medium10stilbenoid
taleranol[no description available]medium10macrolide
bisphenol b[no description available]medium10bisphenol
alfatradiol[no description available]medium1017alpha-hydroxy steroid;
3-hydroxy steroid;
estradiol		estrogen;
geroprotector
6-hydroxyflavone[no description available]medium10hydroxyflavonoid
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane[no description available]medium10bisphenol
1,1-Dichloro-2,2-bis(4-hydroxyphenyl)ethylene[no description available]medium10diarylmethane
equol[no description available]medium10hydroxyisoflavans
androstan-3-ol[no description available]medium103-hydroxy steroidandrogen
3,3',5,5'-tetrachlorobiphenyl-4,4'-diol[no description available]medium10dichlorobenzene;
hydroxybiphenyls
3,3'-Dihydroxyhexestrol[no description available]medium10stilbenoid
4-hydroxy-2',3',4'-5'-tetrachlorobiphenyl[no description available]medium10biphenyls;
tetrachlorobenzene
Zearalanone[no description available]medium10macrolide;
resorcinols
4-androstene-3,17-diol[no description available]medium103-hydroxy steroidandrogen
4'-hydroxyflavanone[no description available]medium104'-hydroxyflavanones;
monohydroxyflavanone
2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene[no description available]medium10diarylmethane
2-hydroxyestradiol[no description available]medium1017beta-hydroxy steroid;
2-hydroxy steroid		carcinogenic agent;
human metabolite;
metabolite;
mouse metabolite;
prodrug
mibolerone[no description available]medium1017beta-hydroxy steroid;
3-oxo-Delta(4) steroid		anabolic agent;
androgen
metribolone[no description available]medium1017beta-hydroxy steroid;
3-oxo steroid;
anabolic androgenic steroid		androgen
diethylstilbestrol[no description available]medium10olefinic compound;
polyphenol		antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen
chalcone[no description available]medium20chalconeEC 3.2.1.1 (alpha-amylase) inhibitor
isoeugenol[no description available]medium10isoeugenol
tamoxifen[no description available]medium10stilbenoid;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
6-hydroxyflavanone[no description available]medium10monohydroxyflavanonefungal xenobiotic metabolite
dimethylstilbestrol[no description available]medium10stilbenoid
genistein[no description available]medium207-hydroxyisoflavonesantineoplastic agent;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
human urinary metabolite;
phytoestrogen;
plant metabolite;
tyrosine kinase inhibitor
coumestrol[no description available]medium10coumestans;
delta-lactone;
polyphenol		anti-inflammatory agent;
antioxidant;
plant metabolite
7-hydroxyflavone[no description available]medium10hydroxyflavonoid
4-hydroxyestradiol[no description available]medium104-hydroxy steroidmetabolite
4-hydroxychalcone[no description available]medium10chalcones;
phenols		antihypertensive agent;
plant metabolite
4'-hydroxychalcone[no description available]medium10chalcones;
phenols		anti-inflammatory agent;
antineoplastic agent
4,4'-dihydroxystilbene[no description available]medium10stilbene-4,4'-diol
4-hydroxystilbene[no description available]medium10stilben-4-ol
isoniazid[no description available]medium10carbohydrazideantitubercular agent;
drug allergen
fluconazole[no description available]medium10conazole antifungal drug;
difluorobenzene;
tertiary alcohol;
triazole antifungal drug		environmental contaminant;
P450 inhibitor;
xenobiotic
4(5)-phenylimidazole[no description available]medium10
quetiapine[no description available]medium10dibenzothiazepine;
N-alkylpiperazine;
N-arylpiperazine		adrenergic antagonist;
dopaminergic antagonist;
histamine antagonist;
second generation antipsychotic;
serotonergic antagonist
thioproperazine[no description available]medium10N-alkylpiperazine;
N-methylpiperazine;
phenothiazines;
sulfonamide		phenothiazine antipsychotic drug
4,4'-diaminobenzanilide[no description available]medium10
LSM-5894[no description available]medium10organic heterobicyclic compound;
organonitrogen heterocyclic compound
3-hydroxybenzaldehyde[no description available]medium10hydroxybenzaldehyde
salicylic acid[no description available]medium10monohydroxybenzoic acidalgal metabolite;
antifungal agent;
antiinfective agent;
EC 1.11.1.11 (L-ascorbate peroxidase) inhibitor;
keratolytic drug;
plant hormone;
plant metabolite
indole[no description available]medium10indole;
polycyclic heteroarene		Escherichia coli metabolite
indol-3-yl pyruvic acid[no description available]medium102-oxo monocarboxylic acid;
indol-3-yl carboxylic acid		plant metabolite;
Saccharomyces cerevisiae metabolite
melatonin[no description available]medium10acetamides;
tryptamines		anticonvulsant;
central nervous system depressant;
geroprotector;
hormone;
human metabolite;
immunological adjuvant;
mouse metabolite;
radical scavenger
tryptamine[no description available]medium10aminoalkylindole;
aralkylamino compound;
indole alkaloid;
tryptamines		human metabolite;
mouse metabolite;
plant metabolite
fenofibrate[no description available]medium10aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
indomethacin[no description available]medium10aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole		analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic
juglone[no description available]medium10hydroxy-1,4-naphthoquinonegeroprotector;
herbicide;
reactive oxygen species generator
masoprocol[no description available]medium10catechols;
lignan;
tetrol		antioxidant;
ferroptosis inhibitor;
geroprotector;
plant metabolite
perphenazine[no description available]medium10N-(2-hydroxyethyl)piperazine;
N-alkylpiperazine;
organochlorine compound;
phenothiazines		antiemetic;
dopaminergic antagonist;
phenothiazine antipsychotic drug
phenolsulfonphthalein[no description available]medium102,1-benzoxathiole;
arenesulfonate ester;
phenols;
sultone		acid-base indicator;
diagnostic agent;
two-colour indicator
p-dimethylaminoazobenzene[no description available]medium10azobenzenes
methylene blue[no description available]medium10organic chloride saltacid-base indicator;
antidepressant;
antimalarial;
antimicrobial agent;
antioxidant;
cardioprotective agent;
EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
EC 4.6.1.2 (guanylate cyclase) inhibitor;
fluorochrome;
histological dye;
neuroprotective agent;
physical tracer
tryptophan[no description available]medium10erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
anthrone[no description available]medium10anthracenoneradical scavenger
aminacrine[no description available]medium10aminoacridines;
primary amino compound		acid-base indicator;
antiinfective agent;
antiseptic drug;
fluorescent dye;
MALDI matrix material;
mutagen
acetophenone[no description available]medium10acetophenonesanimal metabolite;
photosensitizing agent;
xenobiotic
chloranil[no description available]medium101,4-benzoquinones;
organochlorine compound		EC 2.7.1.33 (pantothenate kinase) inhibitor;
metabolite
veratraldehyde[no description available]medium10benzaldehydes;
dimethoxybenzene		antifungal agent
2-vanillin[no description available]medium10benzaldehydes;
guaiacols		antimutagen;
plant metabolite
catechin[no description available]medium10catechinantioxidant;
plant metabolite
indole-3-carbaldehyde[no description available]medium10heteroarenecarbaldehyde;
indole alkaloid;
indoles		bacterial metabolite;
human xenobiotic metabolite;
marine metabolite;
plant metabolite
methyl red[no description available]medium10
1,2-naphthoquinone[no description available]medium101,2-naphthoquinonesaryl hydrocarbon receptor agonist;
carcinogenic agent
congo red[no description available]medium10bis(azo) compound
4,4'-bisphenol f[no description available]medium20bisphenol;
diarylmethane		environmental food contaminant;
xenoestrogen
azure a[no description available]medium10
pontamine sky blue[no description available]medium10
4-anisaldehyde[no description available]medium10benzaldehydesbacterial metabolite;
human urinary metabolite;
insect repellent;
plant metabolite
epigallocatechin gallate[no description available]medium10flavans;
gallate ester;
polyphenol		antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
neocuproine[no description available]medium10phenanthrolineschelator;
copper chelator
2,2'-Dihydroxybenzophenone[no description available]medium10benzophenones
2,3,4-trihydroxbenzophenone[no description available]medium10benzenetriol;
hydroxybenzophenone		drug metabolite;
EC 1.14.18.1 (tyrosinase) inhibitor;
human urinary metabolite;
quorum sensing inhibitor;
rat metabolite
epicatechin[no description available]medium10catechin;
polyphenol		antioxidant
5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)[no description available]medium10
chrysamine g[no description available]medium10
naringenin[no description available]medium10(2S)-flavan-4-one;
naringenin		expectorant;
plant metabolite
taxifolin[no description available]medium10taxifolinmetabolite
resveratrol[no description available]medium10resveratrolantioxidant;
phytoalexin;
plant metabolite;
quorum sensing inhibitor;
radical scavenger
ferulic acid[no description available]medium10ferulic acidsanti-inflammatory agent;
antioxidant;
apoptosis inhibitor;
cardioprotective agent;
MALDI matrix material;
plant metabolite
3-coumaric acid[no description available]medium103-coumaric acid
quercetin[no description available]medium107-hydroxyflavonol;
pentahydroxyflavone		antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
apigenin[no description available]medium10trihydroxyflavoneantineoplastic agent;
metabolite
kaempferol[no description available]medium107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
myricetin[no description available]medium107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
rosmarinic acid[no description available]medium10rosmarinic acidgeroprotector;
plant metabolite
ellagic acid[no description available]medium10catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
diferuloylputrescine[no description available]medium10hydroxycinnamic acid
3,4',5-trimethoxystilbene[no description available]medium10
phenyl-3-methoxy-4-hydroxystyryl ketone[no description available]medium10
dimethoxycurcumin[no description available]medium10
tetracycline[no description available]medium10
minocycline[no description available]medium10
meclan[no description available]medium10
rolitetracycline[no description available]medium10
azure c[no description available]medium10
oxybenzone[no description available]medium10hydroxybenzophenone;
monomethoxybenzene		dermatologic drug;
environmental contaminant;
protective agent;
ultraviolet filter;
xenobiotic
pentamidine[no description available]medium10aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
4,4'-dimethoxybenzophenone[no description available]medium10
4-methoxybenzophenone[no description available]medium10
amphotericin b[no description available]medium10antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
hexachlorophene[no description available]medium10bridged diphenyl fungicide;
polyphenol;
trichlorobenzene		acaricide;
antibacterial agent;
antifungal agrochemical;
antiseptic drug
tetrabromobisphenol a[no description available]medium10brominated flame retardant;
bromobisphenol
tetrachlorodian[no description available]medium10bisphenol
3,3'-Dimethylbisphenol A[no description available]medium10bisphenol
tetrabromobisphenol a diglycidyl ether[no description available]medium10
1,1-bis(4-hydroxyphenyl)cyclohexane[no description available]medium10diarylmethane
1,1-Bis(4-hydroxyphenyl)ethane[no description available]medium10diarylmethane
amfenac[no description available]low00amino acid;
benzophenones;
oxo monocarboxylic acid;
primary amino compound;
substituted aniline		antipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
ketoprofen[no description available]low00benzophenones;
oxo monocarboxylic acid		antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-steroidal anti-inflammatory drug;
xenobiotic
nizofenone[no description available]low00benzophenones
rilmazafone[no description available]low00benzophenones
michler's ketone[no description available]low00benzophenones
4,4'-dichlorobenzophenone[no description available]low00benzophenones
dioxybenzone[no description available]low00benzophenones
Methyl 2-benzoylbenzoate[no description available]low00benzophenones
(2-hydroxy-4-(octyloxy)phenyl)phenylmethanone[no description available]low00benzophenones
sulisobenzone[no description available]low00benzophenones
aminomebendazole[no description available]low00benzophenones
exifone[no description available]low00benzophenones
bromfenac[no description available]low00aromatic amino acid;
benzophenones;
organobromine compound;
substituted aniline		non-narcotic analgesic;
non-steroidal anti-inflammatory drug
maclurin[no description available]low00benzophenones
piketoprofen[no description available]low00benzophenones
mexenone[no description available]low00benzophenones
pitofenone[no description available]low00benzophenones
ketoprofen glucuronide[no description available]low00benzophenones
sulochrin[no description available]low00benzophenones;
carboxylic ester;
phenols		metabolite
[4-(4-hydroxyphenyl)phenyl]-phenylmethanone[no description available]low00benzophenones
dexketoprofen[no description available]low00benzophenones;
monocarboxylic acid		cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug
[3-fluoro-4-(4-morpholinyl)phenyl]-(4-methylphenyl)methanone[no description available]low00benzophenones
N,N-diethyl-4-[oxo-(2,4,6-trimethylphenyl)methyl]benzamide[no description available]low00benzophenones
N-[2-(2-benzoyl-4-bromoanilino)-2-oxoethyl]-2-chlorobenzamide[no description available]low00benzophenones
2-[(4-methylphenyl)-oxomethyl]benzoic acid [2-(3-nitroanilino)-2-oxoethyl] ester[no description available]low00benzophenones
N-[(4-fluorophenyl)methyl]-2-[4-[(4-fluorophenyl)-oxomethyl]phenoxy]acetamide[no description available]low00benzophenones
2-{4-[(2-aminophenyl)thio]-3-nitrobenzoyl}benzoic acid[no description available]low00benzophenones
2-[(4-chloro-3-nitrophenyl)-oxomethyl]benzoic acid [2-[di(propan-2-yl)amino]-2-oxoethyl] ester[no description available]low00benzophenones
2,5-dihydroxy-4-methoxybenzophenone[no description available]low00benzophenones
tolcapone[no description available]low002-nitrophenols;
benzophenones;
catechols		antiparkinson drug;
EC 2.1.1.6 (catechol O-methyltransferase) inhibitor
2-(4-benzoylphenoxy)-N-(4-methylcyclohexyl)acetamide[no description available]low00benzophenones
2-(4-benzoylphenoxy)-N-[4-(propan-2-ylsulfamoyl)phenyl]propanamide[no description available]low00benzophenones
nizofenone fumarate[no description available]low00benzophenones
[4-[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-[1,2,4]triazolo[4,3-a]quinoxalin-8-yl]-phenylmethanone[no description available]low00benzophenones
metrafenone[no description available]low00aromatic ether;
aryl phenyl ketone fungicide;
benzophenones;
organobromine compound		antifungal agrochemical
gw 1929[no description available]low00benzophenones
CB-13[no description available]low00benzophenones
[4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone[no description available]low00benzophenones
diethylamino hydroxybenzoyl hexyl benzoate[no description available]low00benzophenones
(8R)-7-[(2-benzoylphenyl)-oxomethyl]-3-[3-[(1-oxo-3,3-diphenylpropyl)amino]phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide[no description available]low00benzophenones
ConditionIndicatedRelationship StrengthStudiesTrials

Research Highlights

Bioavailability (1)

ArticleYear
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues.
Bioorganic & medicinal chemistry, Mar-01, Volume: 15, Issue: 5		2007
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]