Any inhibitor that interferes with the action of sodium-glucose transport protein subtype 2.
ChEBI ID: 73273
Member | Definition | Class |
---|---|---|
canagliflozin | A C-glycosyl compound that is used (in its hemihydrate form) for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2. | canagliflozin |
dapagliflozin | A C-glycosyl comprising beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-(4-ethoxybenzyl)phenyl group. Used (in the form of its propanediol monohydrate) to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes. | dapagliflozin |
empagliflozin | A C-glycosyl compound consisting of a beta-glucosyl residue having a (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl group at the anomeric centre. A sodium-glucose co-transporter 2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. | empagliflozin |
Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 17 (0.50) | 29.6817 |
2010's | 1,534 (44.92) | 24.3611 |
2020's | 1,864 (54.58) | 2.80 |
Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
---|---|---|
Trials | 875 (22.41%) | 5.53% |
Reviews | 728 (18.64%) | 6.00% |
Case Studies | 134 (3.43%) | 4.05% |
Observational | 89 (2.28%) | 0.25% |
Other | 2,079 (53.24%) | 84.16% |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 39.8107 | 1 | 1 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Sodium/glucose cotransporter 1 | Homo sapiens (human) | IC50 | 1.7486 | 15 | 18 |
Sodium/glucose cotransporter 2 | Homo sapiens (human) | IC50 | 0.0024 | 30 | 35 |
Sodium/myo-inositol cotransporter 2 | Homo sapiens (human) | IC50 | 0.3800 | 1 | 1 |
Solute carrier family 5 member 4 | Homo sapiens (human) | IC50 | 0.0014 | 1 | 1 |
Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
---|---|---|---|---|---|
Cholinesterase | Homo sapiens (human) | EC50 | 0.0024 | 1 | 1 |
Sodium/glucose cotransporter 1 | Homo sapiens (human) | EC50 | 1.6970 | 6 | 9 |
Sodium/glucose cotransporter 2 | Homo sapiens (human) | EC50 | 0.1407 | 7 | 10 |
Sodium/glucose cotransporter 2 | Rattus norvegicus (Norway rat) | EC50 | 0.0030 | 2 | 2 |