Page last updated: 2024-08-05 15:47:38

sodium-glucose transport protein subtype 2 inhibitor

Any inhibitor that interferes with the action of sodium-glucose transport protein subtype 2.

ChEBI ID: 73273

Members (3)

MemberDefinitionClass
canagliflozinA C-glycosyl compound that is used (in its hemihydrate form) for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2.canagliflozin
dapagliflozinA C-glycosyl comprising beta-D-glucose in which the anomeric hydroxy group is replaced by a 4-chloro-3-(4-ethoxybenzyl)phenyl group. Used (in the form of its propanediol monohydrate) to improve glycemic control, along with diet and exercise, in adults with type 2 diabetes.dapagliflozin
empagliflozinA C-glycosyl compound consisting of a beta-glucosyl residue having a (4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl group at the anomeric centre. A sodium-glucose co-transporter 2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.empagliflozin

Research

Studies (3,415)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (0.50)29.6817
2010's1,534 (44.92)24.3611
2020's1,864 (54.58)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials875 (22.41%)5.53%
Reviews728 (18.64%)6.00%
Case Studies134 (3.43%)4.05%
Observational89 (2.28%)0.25%
Other2,079 (53.24%)84.16%

Protein Targets (7)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency39.810711

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
Sodium/glucose cotransporter 1Homo sapiens (human)IC501.74861518
Sodium/glucose cotransporter 2Homo sapiens (human)IC500.00243035
Sodium/myo-inositol cotransporter 2Homo sapiens (human)IC500.380011
Solute carrier family 5 member 4Homo sapiens (human)IC500.001411

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
CholinesteraseHomo sapiens (human)EC500.002411
Sodium/glucose cotransporter 1Homo sapiens (human)EC501.697069
Sodium/glucose cotransporter 2Homo sapiens (human)EC500.1407710
Sodium/glucose cotransporter 2Rattus norvegicus (Norway rat)EC500.003022