Page last updated: 2024-10-24

oligosaccharide metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [ISBN:0198506732]

Oligosaccharide metabolic process is a complex and essential biological process involving the synthesis, modification, and degradation of oligosaccharides. These are short chains of sugar molecules, typically consisting of 2 to 10 monosaccharides, linked by glycosidic bonds. Oligosaccharides play a crucial role in various cellular functions, including cell recognition, signaling, and protein folding.

The process begins with the synthesis of oligosaccharides from monosaccharides. This involves the enzymatic addition of monosaccharide units to a growing oligosaccharide chain. The enzymes involved in this process are known as glycosyltransferases, which exhibit high specificity for both the donor sugar and the acceptor molecule.

Once synthesized, oligosaccharides can undergo various modifications, such as the addition of phosphate, sulfate, or methyl groups. These modifications can alter the properties of the oligosaccharide, influencing its function.

Degradation of oligosaccharides is carried out by a group of enzymes called glycosidases. These enzymes break the glycosidic bonds between monosaccharide units, releasing individual sugars or smaller oligosaccharides. The degradation process can be either catabolic, releasing energy, or anabolic, providing building blocks for other molecules.

The metabolic process of oligosaccharides is tightly regulated, ensuring the proper synthesis, modification, and degradation of these important molecules. Dysregulation of this process can lead to various diseases, including cancer, diabetes, and genetic disorders.

Oligosaccharide metabolism is crucial for maintaining cellular function and overall organismal health. It plays a critical role in cell signaling, immune response, and development. The intricate network of enzymes involved in this process ensures the precise synthesis, modification, and degradation of oligosaccharides, contributing to the complexity and robustness of biological systems.'
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Proteins (4)

ProteinDefinitionTaxonomy
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidaseAn endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UKM7]Homo sapiens (human)
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5A 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q11128]Homo sapiens (human)
Alpha-amylase 1A A protein that is a translation product of the AMY1A gene in human. [PRO:DNx, UniProtKB:P0DUB6]Homo sapiens (human)
Alpha-galactosidase AAn alpha-galactosidase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:P06280]Homo sapiens (human)

Compounds (15)

CompoundDefinitionClassesRoles
1-deoxynojirimycin1-deoxy-nojirimycin: structure in first source

duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.
2-(hydroxymethyl)piperidine-3,4,5-triol;
piperidine alkaloid
anti-HIV agent;
anti-obesity agent;
bacterial metabolite;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
hepatoprotective agent;
hypoglycemic agent;
plant metabolite
acarbosetetrasaccharide derivativeEC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent
epigallocatechin gallate(-)-epigallocatechin 3-gallate : A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.

epigallocatechin gallate: a steroid 5alpha-reductase inhibitor and antimutagen in green tea (Camellia sinensis)
flavans;
gallate ester;
polyphenol
antineoplastic agent;
antioxidant;
apoptosis inducer;
geroprotector;
Hsp90 inhibitor;
neuroprotective agent;
plant metabolite
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.

pentagalloylglucose: pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent
gallate ester;
galloyl beta-D-glucose
anti-inflammatory agent;
antineoplastic agent;
geroprotector;
hepatoprotective agent;
plant metabolite;
radiation protective agent;
radical scavenger
migalastatmigalastat: a potent inhibitor of glycolipid biosynthesispiperidines
acarboseamino cyclitol;
glycoside
1,4-dideoxy-1,4-iminoarabinitol, (2r-(2alpha,3beta,4beta))-isomerpyrrolidines
4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenolsubstituted aniline
quercetin7-hydroxyflavonol;
pentahydroxyflavone
antibacterial agent;
antineoplastic agent;
antioxidant;
Aurora kinase inhibitor;
chelator;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
geroprotector;
phytoestrogen;
plant metabolite;
protein kinase inhibitor;
radical scavenger
luteolin3'-hydroxyflavonoid;
tetrahydroxyflavone
angiogenesis inhibitor;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
c-Jun N-terminal kinase inhibitor;
EC 2.3.1.85 (fatty acid synthase) inhibitor;
immunomodulator;
nephroprotective agent;
plant metabolite;
radical scavenger;
vascular endothelial growth factor receptor antagonist
fisetin3'-hydroxyflavonoid;
7-hydroxyflavonol;
tetrahydroxyflavone
anti-inflammatory agent;
antioxidant;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
geroprotector;
metabolite;
plant metabolite
myricetin7-hydroxyflavonol;
hexahydroxyflavone
antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
quercetagetinquercetagetin : A hexahydroxyflavone that is flavone substituted by hydroxy groups at positions 3, 5, 6, 7, 3' and 4' respectively.

quercetagetin: structure given in first source; inhibits aldose reductase in rat lens
flavonols;
hexahydroxyflavone
antioxidant;
antiviral agent;
plant metabolite
scutellareinscutellarein : Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.

scutellarein: aglycone of scutellarin from Scutellaria baicalensis; carthamidin is 2S isomer of scutellarein; do not confuse with isoscutellarein and/or isocarthamidin which are respective regioisomers, or with the scutelarin protein
tetrahydroxyflavonemetabolite
guanosine diphosphateGuanosine Diphosphate: A guanine nucleotide containing two phosphate groups esterified to the sugar moiety.guanosine 5'-phosphate;
purine ribonucleoside 5'-diphosphate
Escherichia coli metabolite;
mouse metabolite;
uncoupling protein inhibitor