Page last updated: 2024-08-05 15:37:54

cardiotoxic agent

A role played by a chemical compound exihibiting itself through the ability to induce damage to the heart and cardiomyocytes.

ChEBI ID: 50912

Members (5)

MemberDefinitionClass
adriamycinolA member of the class of tetracenequinones that is the major metabolite of the anthracycline doxorubicin, a chemotherapeutic agent effective against a broad range of malignant neoplasms. It is thought to exhibit cardiotoxic properties.doxorubicinol
fluoroacetaldehydeAn aldehyde that is acetaldehyde in which one of the hydrogens of the methyl group is replaced by fluorine.fluoroacetaldehyde
ponceau mxA naphthalenesulfonic acid that is naphthalene-2,7-disulfonic acid carrying additional hydroxy and (2,4-dimethylphenyl)diazenyl substituents at positions 3 and 4 respectively. The disodium salt is the biological stain 'acid red 26'.4-[(2,4-dimethylphenyl)diazenyl]-3-hydroxynaphthalene-2,7-disulfonic acid
t-2 toxinA trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.T-2 toxin
tilmicosinA macrolide antibiotic with formula C46H80N2O13. It is used for the treatment of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia haemolytica.tilmicosin

Research

Studies (189)

TimeframeStudies, Drugs with This Role(%)All Drugs %
pre-199060 (31.75)18.7374
1990's41 (21.69)18.2507
2000's42 (22.22)29.6817
2010's36 (19.05)24.3611
2020's10 (5.29)2.80

Study Types

Publication TypeStudies, Drugs with this Role (%)All Drugs (%)
Trials11 (5.42%)5.53%
Reviews0 (0.00%)6.00%
Case Studies4 (1.97%)4.05%
Observational1 (0.49%)0.25%
Other187 (92.12%)84.16%

Protein Targets (5)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)Drugs
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency5.011911
AR proteinHomo sapiens (human)Potency29.849311
cytochrome P450 2D6Homo sapiens (human)Potency23.918511
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Homo sapiens (human)Potency0.079422
Spike glycoproteinSevere acute respiratory syndrome-related coronavirusPotency6.309611